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Dr Yellapragada SubbaRow was an Indian-born American biochemist who made numerous discoveries in various fields of science. Born in 1895 into a poor family, he went on to have medical training at the Madras Medical College, Chennai, Tamil Nadu, India. After many hardships, he arrived in the United States of America and earned a diploma in tropical medicine and a PhD in biochemistry from Harvard. His illustrious career began with the isolation of phosphorus in body fluids along with Fiske. They discovered phosphocreatine and adenosine triphosphate (ATP) as well. He later became the director of Lederle Laboratories, where he discovered the tetracycline antibiotic group, which saved many lives. He synthesized many vitamins, including folic acid, niacin, and biotin. In 1948, he discovered methotrexate (MTX) for childhood cancer, which paved the way for many chemotherapeutics and is also used in the management of several autoimmune conditions. Despite numerous medical advancements made by SubbaRow, awareness in the scientific world regarding his life and many contributions remains underrecognized. This article discusses SubbaRow's life, academics, and achievements in a nutshell.
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Bioquímica , História do Século XX , Índia , Bioquímica/história , História do Século XIX , Humanos , Estados UnidosRESUMO
This essay is in memoriam of Professor Mieczyslaw Chorazy (1925 - 2021). Eminent Man, outstanding scientist, soldier of the Warsaw Uprising, moral authority for generations of fellow researchers and an exceptionally warm person. His character and life works are recalled here against the background of the times he lived in.
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Bioquímica , História do Século XX , Polônia , História do Século XXI , Bioquímica/história , HumanosRESUMO
This essay is in memoriam of Ronald Hancock (1933 - 2022).
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Bioquímica , História do Século XX , História do Século XXI , Bioquímica/históriaRESUMO
This essay is in memoriam of Ronald Hancock (1933 - 2022).
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Bioquímica , História do Século XX , História do Século XXI , Bioquímica/históriaRESUMO
In 2024, it will be 140 years since the birth of Jan Karol Parnas, one of the most outstanding biochemists and one of the most outstanding Polish scientists of the first half of the 20th century. The article presents a synthetic biography of Prof. Parnas, his influence on the organization of scientific life in interwar Poland, and presents his students and collaborators who created the so-called "The School of Parnassus". It shows how this figure still influences the thinking of Polish biochemists about their Society and the attitude towards biochemical communities abroad, especially in Ukraine, which owes as much to Prof. Parnas as Poland does.
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Bioquímica , Polônia , História do Século XX , Bioquímica/história , Aniversários e Eventos Especiais , História do Século XXI , UcrâniaRESUMO
The role of biochemistry in the pharmacy curriculum has recently been questioned based on its relevance to the career of a working pharmacist. This commentary explores the historical background of pharmacy education and the central role of chemistry since the 19th century. Reasons for the importance of biochemistry and other sciences are introduced to demonstrate their role in the practice of pharmacy.
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Bioquímica , Currículo , Educação em Farmácia , Estudantes de Farmácia , Humanos , Bioquímica/educação , Bioquímica/história , História do Século XX , Farmacêuticos , História do Século XIXRESUMO
With deep sadness, we announce that on December 10, 2023, at the age of 86 passed away an outstanding Ukrainian scientist in the field of oncology, analytical enzymology, and pharmacology, a Laureate of the State Prize of Ukraine for Science and Technology, a member of the Federation of European Biochemical Societies, a member of the State Expert Center of the Ministry of Health of Ukraine, Doctor of Medical Sciences, Professor Volodymyr Oleksiyovych SHLYAKHOVENKO.
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Bioquímica , Oncologia , Bioquímica/história , UcrâniaRESUMO
An interview with James M. Ntambi, professor of biochemistry and the Katherine Berns Van Donk Steenbock Professor in Nutrition, College of Agricultural and Life Sciences, at the University of Wisconsin-Madison, took place via Zoom in April 2022. He was interviewed by Patrick J. Stover, director of the Institute for Advancing Health through Agriculture and professor of nutrition and biochemistry and biophysics at Texas A&M University. Dr. James Ntambi is a true pioneer in the field of nutritional biochemistry. He was among the very first to discover and elucidate the role that diet and nutrients play in regulating metabolism through changes in the expression of metabolic genes, focusing on the de novo lipogenesis pathways. As an African immigrant from Uganda, his love of science and his life experiences in African communities suffering from severe malnutrition molded his scientific interests at the interface of biochemistry and nutrition. Throughout his career, he has been an academic role model, a groundbreaking nutrition scientist, and an educator. His commitment to experiential learning through the many study-abroad classes he has hosted in Uganda has provided invaluable context for American students in nutrition. Dr. Ntambi's passion for education and scientific discovery is his legacy, and the field of nutrition has benefited enormously from his unique perspectives and contributions to science that are defined by his scientific curiosity, his generosity to his students and colleagues, and his life experiences. The following is an edited transcript.
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Agricultura , Bioquímica , Ciências da Nutrição , Humanos , Agricultura/história , Metabolismo/genética , Ciências da Nutrição/história , Estado Nutricional , Uganda , Estados Unidos , Wisconsin , População Africana , Desnutrição/genética , Desnutrição/metabolismo , Bioquímica/históriaAssuntos
Bioquímica , DNA , Pesquisadores , Sexismo , DNA/química , DNA/história , História do Século XX , Bioquímica/história , Pesquisadores/ética , Pesquisadores/história , Sexismo/históriaRESUMO
It is a great honor to be invited to write a reflections article on my scientific journey and lifelong bile acid research for the Journal of Biological Chemistry, in which I am proud to have published 24 articles. I have also published 21 articles in the Journal of Lipid Research, another journal of the American Society of Biochemistry and Molecular Biology. I begin my reflections from my early education in Taiwan, my coming to America for graduate study, and continue with my postdoctoral training in cytochrome P450 research, and my lifelong bile acid research career at Northeast Ohio Medical University. I have witnessed and helped in the transformation of this rural not so visible medical school to a well-funded leader in liver research. Writing this reflections article on my long and rewarding journey in bile acid research brings back many good memories. I am proud of my scientific contributions and attribute my academic success to hard work, perseverance, good mentoring, and networking. I hope these reflections of my academic career would help inspire young investigators to pursue an academic career in biochemistry and metabolic diseases.
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Ácidos e Sais Biliares , Bioquímica , Pesquisa Biomédica , Fígado , Humanos , Ácidos e Sais Biliares/metabolismo , Bioquímica/história , Fígado/enzimologia , Fígado/metabolismo , Fígado/patologia , Taiwan , Sistema Enzimático do Citocromo P-450 , Ohio , Pesquisa Biomédica/históriaAssuntos
Sinalização do Cálcio , Cálcio , História do Século XX , Cálcio/metabolismo , Bioquímica/história , BiologiaRESUMO
The Federation of Asian and Oceanian Biochemists and Molecular Biologists, Inc. (FAOBMB) celebrates its Golden Jubilee in 2022. Established in August 1972 as a regional grouping of three national societies of biochemists in Australia, India and Japan, it took the name Federation of Asian and Oceanian Biochemists (FAOB). The Federation rapidly grew to encompass another 12 national societies (or groups) of biochemists within 6 years, eventually increasing the number of Constituent Members to 21 by 2014. FAOB soon established regular scientific meetings, including triennial Congresses and annual Symposia; from 1980 FAOB Travel Fellowships enabled regional young scientists to participate in them. In 1992, FAOB was constituted as an Incorporated Association in Victoria, Australia, changing its name 1 year later (yielding the acronym FAOBMB). A printed Newsletter/Bulletin was distributed through each Constituent Society or Group from 1972 to 1999. With the advent of the internet and email in the late 1990s, communication rapidly improved, such that the first webpage of FAOBMB was set up in 1995. From the inception of the Federation, an international journal sponsored by FAOB was foreshadowed but only commenced in 1997, sadly lasting only 6 years. Education in biochemistry and molecular biology became prominent in FAOBMB from the 1990s. In the 21st century, awards to high-achieving scientists and educationists were introduced, the first being the Young Scientist Awards in 2006. The Fellowships program was extended to young educationists in 2018. FAOB(MB) has been supported by the International Union of Biochemistry (and Molecular Biology) almost its entire history, mostly for support of Congresses, Conferences and Symposia, but also for Young Scientist Programs. The most recent challenge to FAOBMB came with the COVID-19 pandemic. Executive Committee and the Constituent Members rapidly adapted to virtual communications for their administrative meetings and Education Symposia, and a memorable Congress was held totally on-line in 2021.
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COVID-19 , Pandemias , Humanos , História do Século XX , Bioquímica/história , Biologia Molecular , ÍndiaRESUMO
This article is dedicated to the late long-time Editor-in-Chief of Analytical Biochemistry, William Jakoby. As a graduate student, I remember reading many articles in Analytical Biochemistry and Methods in Enzymology, both volumes that Bill edited. I first met him as a graduate student presenting at the American Society of Biochemistry (and Molecular Biology) meetings. My Ph.D. advisor, Alton Meister, would bring over well-known biochemists and introduce me as Dr. Anderson, leaving me a bit tongue-tied being that I was still actually a humble graduate student! I next met Bill at my first Analytical Biochemistry Executive Editors meeting in San Diego when he was Editor-in-Chief Emeritus; I felt honored to be on the same board with him and serving the journal to which he had brought to prominence. His eyes were piercing and he was so sharp; his knowledge was both broad and deep. Since much of the large body of Bill's research was on glutathione S-transferases, my article focuses on the assay of the enzymes that synthesize glutathione, a substrate for glutathione S-transferases.
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Bioquímica , Glutationa , Bioquímica/história , Humanos , TransferasesRESUMO
The founding of the journal Biochemistry by the American Chemical Society 60 years ago was a highlight of the Society's growing commitment to chemically driven biochemistry. It was a commitment that was nearly an additional 60 years in the making. In that time, biological chemistry was becoming more molecularly focused. Its relationship to the traditional chemical disciplines became apparent to a generation of young chemists, who grappled with defining the field's core chemical principles and creating new areas of research for a new journal. The path to Biochemistry was exciting, but it was also complex and difficult. Even its naming was arguable.