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1.
J Prosthodont ; 31(5): 367-373, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35184343

RESUMO

Patients treated with segmental mandibulectomy often require complicated rehabilitation. Maintenance of mandibular continuity and provision of adequate soft and hard tissue volumes are two key factors required for good clinical outcomes. Moreover, excessive interocclusal restoration space is a common problem in these patients. This case report describes the process of prosthetic rehabilitation from extensive surgical excision to final rehabilitation by using a creative two-layer fixed implant prosthesis in a 70-year-old patient with oral squamous cell carcinoma.


Assuntos
Carcinoma de Células Escamosas , Implantes Dentários , Neoplasias Bucais , Idoso , Carcinoma de Células Escamosas/reabilitação , Carcinoma de Células Escamosas/cirurgia , Prótese Dentária Fixada por Implante , Humanos , Osteotomia Mandibular , Neoplasias Bucais/cirurgia
2.
Dis Colon Rectum ; 64(12): 1501-1510, 2021 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-34747916

RESUMO

BACKGROUND: Abdominoperineal resection is the standard curative surgical technique for locally advanced adenocarcinoma of the lower rectum and squamous cell carcinoma of the anal canal after chemoradiotherapy. However, it requires a definitive abdominal colostomy that modifies the body appearance. OBJECTIVE: The study aim was to evaluate the combination of abdominoperineal resection with perineal colostomy reconstruction and Malone antegrade continence enema. DESIGN: This was a retrospective study. SETTINGS: The study was conducted at the Toulouse Hospital Digestive Surgery Department. PATIENTS: All of the patients with advanced adenocarcinoma or squamous cell carcinoma who underwent abdominoperineal resection with perineal colostomy reconstruction and Malone antegrade continence enema (n = 80) between December 1999 and December 2016 were included. MAIN OUTCOME MEASURES: The main outcome was the 5-year overall survival rate. RESULTS: The 5-year overall survival was 74.89% (95% CI, 62.91%-83.50%), and the median recurrence-free survival was 107.6 months (95% CI, 65.1-198.1 mo). The median follow-up was 91.0 months (95% CI, 70.4-116.6 mo). R0 resection was obtained in 64 patients (80.0%). The median Cleveland Clinic Incontinence Score (to assess the functional outcomes) was 9.0 (interquartile range, 1.0-18.0), and it was lower in patients with advanced adenocarcinoma than with squamous cell carcinoma (7.0 (interquartile range, 2.0-18.0) vs 11.0 (interquartile range, 1.0-17.0); p = 0.01). Eleven patients (13.8%) reported perineal stains during the night, and 19 patients (23.8%) needed drugs to reduce colon motility. The rate of severe complications (Clavien-Dindo >II) was 11.7% (n = 9). Definitive colostomy was performed in 15 patients (18.8%). LIMITATIONS: This retrospective study included a small number of patients from a single center. Moreover, the functional outcome was tested with self-report questionnaires (risk of response bias). CONCLUSIONS: This study suggests that abdominoperineal resection associated with perineal reconstruction by perineal colostomy and Malone antegrade continence enema is safe and may improve patient quality of life. See Video Abstract at http://links.lww.com/DCR/B629. RESULTADOS ONCOLGICOS Y FUNCIONALES DE LA RECONSTRUCCIN PLVIPERINEAL MEDIANTE COLOSTOMA PERINEAL Y PROCEDIMIENTO DE MALONE DESPUS DE LA RESECCIN ABDOMINOPERINEAL: ANTECEDENTES:La resección abdominoperineal es la técnica quirúrgica curativa estándar para el tratamiento del adenocarcinoma localmente avanzado del recto inferior y el carcinoma a células escamosas del canal anal, después de radio-quimioterapia. Sin embargo, requiere una colostomía abdominal definitiva que modifica la apariencia corporal.OBJETIVO:El propósito del presente estudio fue el evaluar la combinación de la resección abdominoperineal con la confección de una colostomía perineal asociada a enemas de continencia anterógrada según Malone.DISEÑO:Estudio retrospectivo.AJUSTES:Servicio de Cirugía Digestiva del Hospital de Toulouse, Francia.PACIENTES:Se incluyeron todos los pacientes con adenocarcinoma avanzado o carcinoma de células escamosas que se sometieron a resección abdominoperineal con la confección de una colostomía perineal asociada a enemas de continencia anterógrada según Malone (n = 80) entre diciembre de 1999 y diciembre de 2016.PRINCIPALES MEDIDAS DE RESULTADO:El principal resultado fue la tasa de sobrevida global a 5 años.RESULTADOS:La sobrevida global a 5 años fue de 74,89% (IC del 95%, 62,91 a 83,50) y la mediana de supervivencia libre de recurrencia fue de 107,6 meses (IC del 95%, 65,1 a 198,1). La mediana de seguimiento fue de 91,0 meses (IC del 95%, 70,4-116,6). La resección R0 se obtuvo en 64 pacientes (80,0%). La mediana de puntuación de la escala de incontinencia de la Cleveland Clinic (para evaluar los resultados funcionales) fue de 9,0 [1,0; 18,0], y fue menor en pacientes con adenocarcinoma avanzado que con carcinoma de células escamosas (7,0 [2,0; 18,0] versus 11,0 [1,0; 17,0]; p = 0,01). Once pacientes (13,8%) refirieron manchado perineal nocurno y 19 pacientes (23,8%) necesitaron fármacos para reducir la motilidad del colon. La tasa de complicaciones graves (Clavien-Dindo > II) fue del 11,7% (n = 9). Se realizó colostomía definitiva en 15 (18,8%) pacientes.LIMITACIONES:Este estudio retrospectivo incluyó un pequeño número de pacientes y de un solo centro. Además, el resultado funcional se probó con cuestionarios de autoinforme (riesgo de sesgo de respuesta).CONCLUSIONES:Este estudio sugiere que la resección abdominoperineal asociada con la confección de una colostomía perineal asociada a enemas de continencia anterógrada según Malone es segura y puede mejorar la calidad de vida de los pacientes. Consulte Video Resumen en http://links.lww.com/DCR/B629.


Assuntos
Adenocarcinoma/cirurgia , Carcinoma de Células Escamosas/cirurgia , Colostomia/efeitos adversos , Períneo/cirurgia , Protectomia/métodos , Adenocarcinoma/diagnóstico , Adenocarcinoma/tratamento farmacológico , Adenocarcinoma/radioterapia , Adulto , Idoso , Canal Anal/patologia , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/tratamento farmacológico , Carcinoma de Células Escamosas/reabilitação , Quimiorradioterapia/efeitos adversos , Terapia Combinada/efeitos adversos , Incontinência Fecal/tratamento farmacológico , Incontinência Fecal/epidemiologia , Incontinência Fecal/prevenção & controle , Feminino , Seguimentos , França/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Períneo/patologia , Qualidade de Vida , Procedimentos de Cirurgia Plástica/métodos , Neoplasias Retais/patologia , Estudos Retrospectivos , Autorrelato/estatística & dados numéricos , Taxa de Sobrevida
3.
Clin Ter ; 172(4): 363-368, 2021 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-34247220

RESUMO

ABSTRACT: Laryngeal squamous cell carcinoma (LSCC) is the most common malignant neoplasms of the head and neck. Several treatment options exist for LSCC according to cancer location and stage at diagnosis; proposed treatments include surgery alone or in combination with chemotherapy and radiotherapy. In selected LSCC cases in the T2-T4 staging, supracricoid laryngectomy (SCL) is an organ-sparing surgical approach aimed at preserving the main laryngeal functions that has been proposed as an alternative to total laryngectomy. Rehabilitation for swallowing and respiratory functions plays a central role after SCL; functional outcomes after SCL may significantly vary among different centers but they are generally satisfactory when oncological radicality has been obtained and the rehabilitation protocol starts promptly. In this clinical review, we analyzed functional outcomes for swallowing and voice rehabilitation in patients after SCL, as well as the optimal SCL surgical technique, post-operative complications and comparison with total laryngectomy or radio-chemotherapy protocols.


Assuntos
Carcinoma de Células Escamosas/reabilitação , Carcinoma de Células Escamosas/cirurgia , Neoplasias Laríngeas/reabilitação , Neoplasias Laríngeas/cirurgia , Laringectomia/métodos , Complicações Pós-Operatórias/reabilitação , Reabilitação/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
4.
Eur Rev Med Pharmacol Sci ; 23(22): 9923-9930, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31799661

RESUMO

OBJECTIVE: To date, the treatment of patients affected by head and neck squamous cell carcinoma (HNSCC) is highly challenging for clinicians. Possible therapies are surgical resection of the tumor mass, radiotherapy, chemotherapy or, more often, a combined treatment that inevitably affects both normal and tumor cells. Consequently, patients' anatomy and functions become reduced or altered. Nowadays the functional restoration is significantly improved thanks to the innovation in prosthetic rehabilitation and in radiotherapy. The current IMRT (Intensity Modulated Radiation Therapy) allows planning adequate treatments evaluating different tissues' involvement and radiation dosage. It is possible to define the most suitable sites for implant insertion, using data provided by dose-volume histogram (DVH). This study aims to illustrate the idea of obtaining a unique CT image by blending radiation-planning CT and Cone Beam CT. PATIENTS AND METHODS: Five patients among 54 candidates were selected for this study. Selection criteria were: good general health (PS0-1), age between 18 and 72 years, absence of metastatic disease or local recurrence, disease-free interval of at least 18 months. Radiation planning CT scan and maxillo-facial CT Cone Beam of every patient were overlapped and merged. Only one CT for every evaluated patient was obtained in order to plan the most suitable areas for implant placement. RESULTS: The placement of 10 implants in 5 patients was programmed using the explained method. Patients (all male) were aged between 48 and 72 years old, with a median age of 64.4 years. In every case of this study, a modification of the initial program of implant placement was necessary. The new imaging method we are proposing was able to provide information about radiation isodoses received in the planned osseointegrated implants' positions. CONCLUSIONS: This new method allows operators to correct their own therapy plans and choices, customizing the treatment plan on the actual condition of the patient. Moreover, it makes all the rehabilitation process safer and can reduce the risk of failure, side effects and inconveniences for the patients.


Assuntos
Carcinoma de Células Escamosas/diagnóstico por imagem , Carcinoma de Células Escamosas/reabilitação , Neoplasias de Cabeça e Pescoço/diagnóstico por imagem , Neoplasias de Cabeça e Pescoço/reabilitação , Interpretação de Imagem Assistida por Computador/métodos , Idoso , Quimiorradioterapia , Tomografia Computadorizada de Feixe Cônico , Humanos , Masculino , Pessoa de Meia-Idade , Próteses e Implantes , Planejamento da Radioterapia Assistida por Computador , Radioterapia de Intensidade Modulada , Resultado do Tratamento
5.
BMC Cancer ; 19(1): 655, 2019 Jul 03.
Artigo em Inglês | MEDLINE | ID: mdl-31269918

RESUMO

BACKGROUND: Since 2011, a tailored, interdisciplinary head and neck rehabilitation (IHNR) program, covered by the basic healthcare insurance, is offered to advanced head and neck cancer (HNC) patients in the Netherlands Cancer Institute (NKI). This program is developed to preserve or restore patients' functioning, and to optimize health-related quality of life (HRQoL). It applies an integrated approach to define patients' individual goals and provide rehabilitation care throughout the cancer care continuum. The aim of the current study is to assess the (cost-) effectiveness of the IHNR approach compared to usual supportive care (USC) consisting of monodisciplinary and multidisciplinary care in advanced HNC patients. METHODS: This multicenter prospective observational study is designed to compare (cost-)effectiveness of the IHNR to USC for advanced HNC patients treated with chemoradiotherapy (CRT) or bioradiotherapy (BRT). The primary outcome is HRQoL represented in the EORTC QLQ-C30 summary score. Functional HRQoL, societal participation, utility values, return to work (RTW), unmet needs (UN), patient satisfaction and clinical outcomes are secondary outcomes, assessed using the EORTC QLQ-H&N35, USER-P, EQ-5D-5 L, and study-specific questionnaires, respectively. Both patient groups (required sample size: 64 per arm) are requested to complete the questionnaires at: diagnosis (baseline; T0), 3 months (T1), 6 months (T2), 9 months (T3) and 12 months (T4) after start of medical treatment. Differences in outcomes between the intervention and control group will be analyzed using mixed effects models, Chi-square test and descriptive statistics. In addition, a cost-effectiveness analysis (CEA) will be performed by means of a Markov decision model. The CEA will be performed using a societal perspective of the Netherlands. DISCUSSION: This prospective multicenter study will provide evidence on the effectiveness and cost-effectiveness of IHNR compared to USC. RTW and societal participation, included as secondary outcomes, have not been studied sufficiently yet in cancer rehabilitation. Interdisciplinary rehabilitation has not yet been implemented as usual care in all centers, which offers the opportunity to perform a controlled clinical study. If demonstrated to be (cost-)effective, national provision of the program can probably be advised. TRIAL REGISTRATION: The study has been retrospectively registered in the Netherlands Trial Registry on April 24th 2018 ( NTR7140 ).


Assuntos
Carcinoma de Células Escamosas/reabilitação , Neoplasias de Cabeça e Pescoço/reabilitação , Estudos Multicêntricos como Assunto , Estudos Observacionais como Assunto , Desenvolvimento de Programas/economia , Qualidade de Vida , Atividades Cotidianas , Carcinoma de Células Escamosas/patologia , Análise Custo-Benefício , Neoplasias de Cabeça e Pescoço/patologia , Neoplasias de Cabeça e Pescoço/terapia , Humanos , Países Baixos , Satisfação do Paciente , Estudos Prospectivos , Retorno ao Trabalho
6.
Otolaryngol Head Neck Surg ; 160(6): 1058-1064, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-30691352

RESUMO

OBJECTIVE: To apply a novel methodology with machine learning (ML) to a large national cancer registry to help identify patients who are high risk for delayed adjuvant radiation. STUDY DESIGN: Observational cohort study. SETTING: National Cancer Database (NCDB). SUBJECTS AND METHODS: A total of 76,573 patients were identified from the NCDB who had invasive head and neck cancer and underwent surgery, followed by radiation. The model was constructed from 80% of the patient data and subsequently evaluated and scored with the remaining 20%. Permutation feature importance analysis was used to understand the weighted model construction. RESULTS: A total of 76,573 patients met inclusion and exclusion criteria. Our ML model was able to predict whether patients would start adjuvant therapy beyond 50 days after surgery with an overall accuracy of 64.41% and a precision of 58.5%. The 2 most important variables used to build the model were treating facility and urban versus rural demographics. CONCLUSION: Statistics can provide inferences within an overall system, while ML is a novel methodology that can make predictions. We can identify patients who are "high risk" for delayed radiation using information from >75,000 patient experiences, which has the potential for a direct impact on clinical care. Our inability to achieve greater accuracy is due to limitations of the data captured by the NCDB, and we need to continue to identify new variables that are correlated with delayed radiation therapy. ML will prove to be a valuable clinical tool in years to come, but its utility is limited by available data.


Assuntos
Carcinoma de Células Escamosas/reabilitação , Carcinoma de Células Escamosas/cirurgia , Neoplasias de Cabeça e Pescoço/radioterapia , Neoplasias de Cabeça e Pescoço/cirurgia , Aprendizado de Máquina , Tempo para o Tratamento , Idoso , Algoritmos , Carcinoma de Células Escamosas/patologia , Estudos de Coortes , Bases de Dados Factuais , Feminino , Neoplasias de Cabeça e Pescoço/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Valor Preditivo dos Testes , Radioterapia Adjuvante , Fatores Socioeconômicos , Estados Unidos
7.
Microsurgery ; 39(3): 234-240, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30496605

RESUMO

INTRODUCTION: Composite and large head and neck defects requiring extensive skin-mucosa coverage are often reconstructed by combining flaps. Herein, we present a simple and reliable two-stage fibula osteocutaneous (FOC) flap technique to improve the survival of a large skin paddle for oromandibular reconstructions. METHODS: From October 2011 to September 2016, 47 patients with through-and-through oromandibular defects were reconstructed using FOC flaps with large skin paddles. To ensure optimum survival of skin paddles, temporary orocutaneous fistula were left in place and closed during the second stage operation via de-epithelialization of the skin paddle and suturing of mucosa. Demographic data, operative details, and postoperative complications were recorded. RESULTS: The skin paddle dimensions ranged from 20 to 31.5 cm in length and 12 to 17 cm in width with an average area of 430.4 cm2 (range 300-504). The average time between the two stages and hospital stay were 10 days and 14 days, respectively. Complications at the donor site included wound dehiscence (n = 3, 6.4%), partial skin graft loss (n = 3, 6.4%) and hematoma (n = 2, 4.3%). Recipient site complications included two (4.3%) early postoperative venous congestions that resolved after elevation and three (6.4%) partial skin flap necrosis (less than 5% surface area). All complications resolved with bedside conservative management. There was only one take-back for evacuation of recipient site hematoma (2.1%) but no flap loss. CONCLUSION: Two-staged large skin paddle FOC flaps can simplify reconstruction of extensive oromandibular defects by improving the reliability of the sizable skin paddle and negating the need for a second flap.


Assuntos
Carcinoma de Células Escamosas/reabilitação , Fístula Cutânea/cirurgia , Fíbula/cirurgia , Sobrevivência de Enxerto/fisiologia , Hospitais Universitários , Mandíbula/cirurgia , Neoplasias Bucais/reabilitação , Procedimentos de Cirurgia Plástica/métodos , Retalhos Cirúrgicos/patologia , Retalhos Cirúrgicos/transplante , Adulto , Carcinoma de Células Escamosas/cirurgia , Feminino , Seguimentos , Humanos , Hiperemia/etiologia , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/cirurgia , Necrose , Complicações Pós-Operatórias , Estudos Retrospectivos , Transplante de Pele , Retalhos Cirúrgicos/efeitos adversos , Taiwan , Sítio Doador de Transplante , Resultado do Tratamento
8.
Indian J Dent Res ; 29(6): 840-843, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30589017

RESUMO

Exenteration surgery greatly affects a person in terms of function, esthetics, and psychological trauma. In such cases, restoration by silicone orbital prosthesis is a well-accepted treatment option. However, this is a difficult task, necessitating personalized design of method for each patient. This case report describes the technique for fabrication of a silicone orbital prosthesis for a male patient with left orbital defect due to exenteration of a Grade 3 squamous cell carcinoma of the left eye and surrounding tissues. The patient was delivered with a satisfactory silicone orbital prosthesis having good retention and finish. Multidisciplinary management and team approach are crucial in providing precise and effective rehabilitation for improving the patient's quality of life and help them return to their normal social life.


Assuntos
Carcinoma de Células Escamosas/cirurgia , Prótese Maxilofacial , Órbita/anormalidades , Órbita/cirurgia , Neoplasias Orbitárias/cirurgia , Desenho de Prótese/métodos , Silicones , Retalhos Cirúrgicos , Carcinoma de Células Escamosas/reabilitação , Humanos , Comunicação Interdisciplinar , Masculino , Implante de Prótese Maxilofacial , Pessoa de Meia-Idade , Neoplasias Orbitárias/reabilitação , Equipe de Assistência ao Paciente , Qualidade de Vida , Transplante de Pele
9.
J Prosthodont ; 26(5): 483-488, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28383117

RESUMO

Obturator prosthesis is a common treatment method for maxillectomy patients for maintaining their oronasal separation and resuming their social lives. After tumor resection, the remaining anatomical structures have a significant effect on prosthesis retention. The present study describes the rehabilitation of two maxillectomy patients after cancer surgery using a prosthesis consisting of a denture and a special retentive obturator that is positioned in the anatomical undercuts of the nasal cavity. These patients have undergone total and subtotal maxillectomy surgery after the diagnosis of squamous cell carcinoma. The systemic and local health status of the total maxillectomy patient was not suitable for zygomatic implant surgery. Only one osseointegrated dental implant was placed into the left maxillary tuberosity area in the subtotal maxillectomy patient. In addition, the quality, vertical height, and horizontal width of the remaining bone structures in the maxilla limited the use of osseointegrated dental implants. Mechanical prosthesis retention was provided using a multiunit retentive mechanism composed of an orthodontic forsus fatigue resistant device (OFFRD), two Herbst appliances, and an acrylic piece associated with healthy keratinized mucosa. The OFFRD could easily apply a consistent force and push the acrylic pieces toward the retentive undercut under the control of the two Herbst appliances. Two OFFRD units in different directions were designed for the total maxillectomy patient, while only one OFFRD unit was placed on the opposite side of the osseointegrated implant in the subtotal maxillectomy patient. A sufficient retention was obtained for both patients. The patients were satisfied, and no major complications were observed in periodic controls.


Assuntos
Prótese Total , Maxila/cirurgia , Obturadores Palatinos , Carcinoma de Células Escamosas/reabilitação , Carcinoma de Células Escamosas/cirurgia , Planejamento de Prótese Dentária , Retenção em Prótese Dentária/métodos , Prótese Dentária Fixada por Implante/métodos , Planejamento de Dentadura , Retenção de Dentadura/métodos , Feminino , Humanos , Neoplasias Maxilares/reabilitação , Neoplasias Maxilares/cirurgia , Boca Edêntula
10.
J Prosthet Dent ; 117(6): 806-810, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27863860

RESUMO

Nasal carcinoma extending into the premaxilla requires radical surgical excision including rhinectomy and partial maxillectomy. Rehabilitation is complex and involves the use of removable prostheses. Three patients treated with zygomatic implants and custom-milled bars to retain an obturator and nasal prosthesis are presented.


Assuntos
Desenho Assistido por Computador , Maxila/cirurgia , Prótese Maxilofacial , Neoplasias Nasais/reabilitação , Nariz/cirurgia , Desenho de Prótese , Zigoma/cirurgia , Idoso , Carcinoma de Células Escamosas/reabilitação , Carcinoma de Células Escamosas/cirurgia , Desenho Assistido por Computador/instrumentação , Feminino , Humanos , Masculino , Neoplasias Nasais/cirurgia , Obturadores Palatinos , Desenho de Prótese/instrumentação
11.
J Laryngol Otol ; 131(1): 88-89, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27916009

RESUMO

BACKGROUND: Functional voice rehabilitation is becoming increasingly important following total laryngectomy and pharyngolaryngectomy. Tracheoesophageal voice via a shunt valve is currently regarded as the 'gold standard' for voice rehabilitation. Traditional techniques usually allow for the replacement of valves in the out-patient setting; however, patient factors such as altered anatomy may occasionally prevent this. OBJECTIVE: This paper describes a novel approach for speech valve insertion that is safe, quick and cost-effective, and which uses equipment commonly available in ENT wards and the operating theatre.


Assuntos
Laringe Artificial , Implantação de Prótese/métodos , Idoso , Carcinoma de Células Escamosas/reabilitação , Carcinoma de Células Escamosas/cirurgia , Humanos , Neoplasias Laríngeas/reabilitação , Neoplasias Laríngeas/cirurgia , Laringectomia/reabilitação , Masculino
12.
J Craniofac Surg ; 27(7): e685-e688, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27763947

RESUMO

OBJECTIVE: This report is to present the treatment procedure and clinical considerations of prosthodontic management of a patient who had undergone a partial mandibulectomy and fibular free flap surgery. DESIGN: A 59-year-old man with a squamous cell carcinoma received a partial mandibular resection. Microsurgical reconstruction with a fibular free flap surgery and implant-supported zirconia-fixed prosthesis produced by computer-aided manufacturing led to successful results for the oral rehabilitation of mandibular defects. CONCLUSIONS: The implant-supported zirconia-fixed prosthesis can be recommended for use in patients with mandibulectomy and fibular free flaps. Close cooperation between the surgeon and the prosthodontist is mandatory for the satisfaction of the patient.


Assuntos
Carcinoma de Células Escamosas/reabilitação , Prótese Dentária Fixada por Implante/métodos , Fíbula/transplante , Retalhos de Tecido Biológico , Mandíbula/cirurgia , Neoplasias Bucais/reabilitação , Procedimentos de Cirurgia Plástica/métodos , Transplante Ósseo/métodos , Carcinoma de Células Escamosas/cirurgia , Desenho Assistido por Computador , Ossos Faciais/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/cirurgia
13.
Radiother Oncol ; 120(2): 228-33, 2016 08.
Artigo em Inglês | MEDLINE | ID: mdl-27406441

RESUMO

BACKGROUND AND PURPOSE: Concurrent chemoradiation (CCRT) is the standard treatment for locally advanced anal canal carcinoma, although treatment-related side effects can affect patient quality of life (QOL). The purpose was to prospectively evaluate the effects of Tomotherapy (HT) based CCRT on patient reported QOL in locally advanced anal cancer. PATIENTS AND METHODS: Fifty-four patients treated with HT and concurrent 5-fluorouracil/mitomycin-C underwent QOL evaluation at baseline, after treatment, and during follow-up with EORTC core (QLQ-C30) and colorectal (QLQ-CR29) questionnaires. The QOL scores at baseline and post-treatment were compared. RESULTS: All C30 functional symptoms, except emotional and cognitive functioning, were impaired end-of-treatment and recovered by 3months follow-up. The majority of symptom scores were worse end-of-treatment but recovered by 3months except for fecal incontinence (FI), diarrhea, urinary incontinence (UI), and dyspareunia which persisted. FI returned to baseline at 12months while diarrhea, UI, and dyspareunia persisted. CONCLUSIONS: Most impaired functions and symptoms following HT based CCRT were temporary and improved by 3months post-therapy. Late complications affecting QOL were FI, sexual function, UI, and diarrhea. Our observations support routine use of IMRT and emphasize the significance of precise evaluation of sexual, urinary, and anorectal functions before starting CCRT and routine incorporation of QOL evaluations.


Assuntos
Neoplasias do Ânus/reabilitação , Carcinoma de Células Escamosas/reabilitação , Quimiorradioterapia/efeitos adversos , Qualidade de Vida , Radioterapia de Intensidade Modulada/efeitos adversos , Adulto , Idoso , Idoso de 80 Anos ou mais , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias do Ânus/terapia , Carcinoma de Células Escamosas/terapia , Incontinência Fecal/etiologia , Feminino , Fluoruracila/administração & dosagem , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Mitomicina/administração & dosagem , Psicometria , Radioterapia de Intensidade Modulada/métodos , Inquéritos e Questionários , Incontinência Urinária/etiologia
15.
Int J Prosthodont ; 28(6): 624-6, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26523724

RESUMO

This case history report describes two different devices, maxillary ramp prostheses (MRP) and mandibular guide flange prostheses (MGFP), prescribed for managing a hemimandibulectomy patient's deviated mandible. The patient was given muscle reprogramming exercises with coordinated use of both guidance prostheses for 2 months, leading to improvements in both postsurgical mandibular deviation and occlusal equilibration. A successful intercuspal position was eventually accomplished through the use of the combination therapy. MRP and MGFP can be a useful approach to avoid mandibular deviation and compromised function following a partial mandibular resection.


Assuntos
Oclusão Dentária Central , Planejamento de Dentadura , Mandíbula/cirurgia , Adulto , Carcinoma de Células Escamosas/reabilitação , Carcinoma de Células Escamosas/cirurgia , Seguimentos , Humanos , Masculino , Mandíbula/fisiologia , Neoplasias Mandibulares/reabilitação , Neoplasias Mandibulares/cirurgia , Terapia Miofuncional/instrumentação , Terapia Miofuncional/métodos , Ajuste Oclusal
16.
J Craniomaxillofac Surg ; 43(7): 1049-53, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26105813

RESUMO

Optimum functional and aesthetic facial reconstruction is still a challenge in patients who suffer from inborn or acquired facial deformity. It is known that functional and aesthetic impairment can result in significant psychosocial strain, leading to the social isolation of patients who are affected by major facial deformities. Microvascular techniques and increasing experience in facial transplantation certainly contribute to better restorative outcomes. However, these technologies also have some drawbacks, limitations and unsolved problems. Extensive facial defects which include several aesthetic units and dentition can be restored by combining dental prostheses and anaplastology, thus providing an adequate functional and aesthetic outcome in selected patients without the drawbacks of major surgical procedures. Referring to some representative patient cases, it is shown how extreme facial disfigurement after oncological surgery can be palliated by combining intraoral dentures with extraoral facial prostheses using individualized treatment and without the need for major reconstructive surgery.


Assuntos
Face , Próteses e Implantes , Idoso , Idoso de 80 Anos ou mais , Carcinoma/reabilitação , Carcinoma/cirurgia , Carcinoma de Células Escamosas/reabilitação , Carcinoma de Células Escamosas/cirurgia , Bochecha/cirurgia , Contraindicações , Prótese Total Superior , Revestimento de Dentadura , Estética , Neoplasias Faciais/reabilitação , Neoplasias Faciais/cirurgia , Transplante de Face , Feminino , Seguimentos , Humanos , Lábio/cirurgia , Imãs , Maxila/cirurgia , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/reabilitação , Recidiva Local de Neoplasia/cirurgia , Neoplasias Nasais/reabilitação , Neoplasias Nasais/cirurgia , Órbita/cirurgia , Obturadores Palatinos , Planejamento de Assistência ao Paciente , Retenção da Prótese/instrumentação
17.
World J Surg Oncol ; 13: 183, 2015 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-25966959

RESUMO

BACKGROUND: The purpose of this study was to investigate the reliability and outcome of using the transverse cervical vessel (TCV) as a recipient vessel for microvascular reconstruction in patients whose vessels in the neck region are unavailable because of previous surgery or radiotherapy. METHODS: Between January 2012 and August 2014, secondary head and neck reconstruction was performed using the TCV as a recipient vessel in eight patients who had undergone previous neck dissection and radiation therapy (n = 5). Five patients had a recurrent carcinoma, one had undergone an operation for scar release and two had been treated surgically for a second primary cancer. The anterolateral thigh flap (ALT), anteromedial thigh flap (AMT), and fibular flap were used for the reconstruction. Clinical data were recorded for each patient. RESULTS: All of the ipsilateral transverse cervical arteries were found to be free of disease. The second free flap was revascularized using the TCVs (n = 6) or the external (n = 1) or internal (n = 1) jugular vein. The free flaps used for the reconstruction included the ALT flap (n = 6), AMT flap (n = 2), and fibular flap (n = 1). All of the flaps survived without vascular events, and the patients healed without major complications. The mean follow-up time was 11 months. One patient died of distant metastases during follow-up. CONCLUSIONS: In patients who have previously undergone neck surgery with or without radiotherapy, the TCVs are reliable and easily accessible recipient vessels for microsurgical reconstruction in the oral and maxillofacial region. If the transverse cervical vein is unavailable, the internal or external jugular vein should be dissected carefully to serve as an alternative for microvascular anastomoses.


Assuntos
Cervicoplastia/métodos , Retalhos de Tecido Biológico/transplante , Neoplasias de Cabeça e Pescoço/reabilitação , Maxila/cirurgia , Microcirurgia/métodos , Procedimentos de Cirurgia Plástica/métodos , Cirurgia Bucal , Adulto , Idoso , Anastomose Cirúrgica , Carcinoma de Células Escamosas/reabilitação , Carcinoma de Células Escamosas/terapia , Terapia Combinada , Feminino , Seguimentos , Neoplasias de Cabeça e Pescoço/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Pescoço/irrigação sanguínea , Esvaziamento Cervical , Estadiamento de Neoplasias , Procedimentos Cirúrgicos Bucais , Prognóstico , Dosagem Radioterapêutica
18.
Rev. Soc. Odontol. La Plata ; 24(49): 27-32, nov.2014. ilus
Artigo em Espanhol | LILACS | ID: lil-758508

RESUMO

El carcinoma epidermoide, es una neoplasia maligna de mayor incidencia de la cavidad bucal que representa el 55 por ciento de todos los tumores de esta región. El 68-72 por ciento de estos pacientes presenta etapas locorregionales avanzadas en el momento del diagnóstico. El objetivo de este trabajo es el de presentar un caso de un carcinoma epidermoide semidiferenciado de piso de boca y reborde residual mandibular anterior, tratado con submandibulectomía segmentaria y reconstrucción con osteosíntesis rígida...


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Carcinoma de Células Escamosas/cirurgia , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/patologia , Soalho Bucal/patologia , Distribuição por Idade e Sexo , Carcinoma de Células Escamosas/classificação , Carcinoma de Células Escamosas/reabilitação , Fixadores Internos , Mandíbula/cirurgia , Procedimentos de Cirurgia Plástica/métodos
19.
J Cancer Res Clin Oncol ; 140(5): 817-21, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24531974

RESUMO

PURPOSE: Esophageal squamous cell carcinoma (ESCC) remains a significant cause of morbidity and mortality worldwide. The aim of the study was to investigate the effects of shorter dinner-to-bed time and post-dinner walk on ESCC risk. METHODS: A matched case-control study with 232 ESCC patients and 286 age- and gender-matched healthy controls enrolled was conducted. Conditional logistic regression was used to calculated odds ratio (OR) and 95 % confidence intervals (95 % CI). RESULTS: The adjusted ORs of ESCC for subjects with shorter dinner-to-bed time (<3 h) were 2.84 (95 % CI 1.64-4.29), relative to those with longer dinner-to-bed time (≥4 h). While post-dinner walk was associated with a decreased ESCC risk (adjusted OR 0.64; 95 % CI 0.41-0.89). What's more, when reflux symptom was added into the multivariate models, risk estimate for shorter dinner-to-bed time still remained statistically significant (p = 0.003), and risk estimate for post-dinner walk changed slightly. In the subgroup analysis stratified by post-dinner walk, subjects with shorter dinner-to-bed time experienced similar risk (adjusted ORs 2.71 vs. 2.82). CONCLUSIONS: Shorter dinner-to-bed time is a potential risk factor for ESCC and post-dinner walk is a protective factor, providing evidence for the effect of lifestyle factors on ESCC risk.


Assuntos
Carcinoma de Células Escamosas/epidemiologia , Neoplasias Esofágicas/epidemiologia , Refeições , Caminhada , Idoso , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/reabilitação , Neoplasias Esofágicas/patologia , Neoplasias Esofágicas/reabilitação , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Fatores de Risco
20.
J Prosthet Dent ; 112(2): 376-8, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24439105

RESUMO

An immediate surgical obturator is necessary for maxillectomy procedures to minimize functional disabilities in speech, swallowing, and egress of food and liquid into the surgical defect. Sometimes the extent of the tumor may be such that it may even require the removal of the maxillary sinus along with resection of the orbital floor. The resected orbital floor can be surgically reconstructed with autogenous soft and/or hard tissues or with alloplastic materials. This clinical report highlights one such situation where the surgical resection of the maxilla and the orbital floor were rehabilitated with an immediate surgical obturator extending to the orbital floor to support the visual apparatus.


Assuntos
Planejamento de Prótese Dentária , Seio Maxilar/cirurgia , Prótese Maxilofacial , Órbita/cirurgia , Obturadores Palatinos , Desenho de Prótese , Carcinoma de Células Escamosas/reabilitação , Carcinoma de Células Escamosas/cirurgia , Retenção em Prótese Dentária , Humanos , Magnetismo , Masculino , Neoplasias Maxilares/reabilitação , Neoplasias Maxilares/cirurgia , Neoplasias do Seio Maxilar/reabilitação , Neoplasias do Seio Maxilar/cirurgia , Pessoa de Meia-Idade , Neoplasias Orbitárias/reabilitação , Neoplasias Orbitárias/cirurgia , Osteotomia/métodos , Retenção da Prótese
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