RESUMO
Background: Studies of Pitted keratolysis (PK) treatment are limited. Objectives: To study cost-effectiveness and to compare the safety of 4% chlorhexidine scrub with 4% erythromycin gel, for PK infections. Materials and methods: This cohort study was conducted on naval rating cadets with a clinical diagnosis of PK at Chumpol Naval Rating School, Thailand in 2016. Participants were randomly treated with either 4% erythromycin gel or 4% chlorhexidine scrub for 4 weeks. The clinical examinations were evaluated at the baseline and at 1 and 2 months after treatment. A decision-tree model was used to evaluate the costs, resource utilization and outcomes as quality-adjusted life-years (QALYs). Results: Of 344 naval rating cadets, 125 (36.3%) were diagnosed with PK. Sixty-four were treated with erythromycin. Approximately 80% of participants had complete resolution Foot odor were significantly improved at 2 months (p < .001) for both groups. No adverse effects were reported. Total cost for 4 weeks' treatment with the erythromycin gel and chlorhexidine scrub was US$77.34, US$51.9, respectively. Chlorhexidine treatment and erythromycin gel had 0.1526 and 0.1425 QALYs, respectively. Conclusions: treatment of PK with either 4% chlorhexidine scrub or 4% erythromycin gel had similar outcomes. However, using chlorhexidine scrub was more cost-effective.
Assuntos
Clorexidina/uso terapêutico , Análise Custo-Benefício , Eritromicina/uso terapêutico , Ceratose/tratamento farmacológico , Clorexidina/efeitos adversos , Clorexidina/farmacocinética , Estudos de Coortes , Esquema de Medicação , Eritromicina/efeitos adversos , Eritromicina/farmacocinética , Géis/química , Meia-Vida , Humanos , Ceratose/economiaAssuntos
Deformidades Adquiridas do Pé/prevenção & controle , Dermatoses do Pé/terapia , Ceratose/terapia , Doenças da Unha/terapia , Comportamento Cooperativo , Tabela de Remuneração de Serviços , Deformidades Adquiridas do Pé/economia , Deformidades Adquiridas do Pé/etiologia , Dermatoses do Pé/diagnóstico , Dermatoses do Pé/economia , Dermatoses do Pé/etiologia , Alemanha , Humanos , Comunicação Interdisciplinar , Ceratose/diagnóstico , Ceratose/economia , Ceratose/etiologia , Doenças da Unha/diagnóstico , Doenças da Unha/economia , Doenças da Unha/etiologia , Unhas Malformadas/diagnóstico , Unhas Malformadas/economia , Unhas Malformadas/etiologia , Unhas Malformadas/terapia , Programas Nacionais de Saúde/economia , Podiatria , Mecanismo de Reembolso/economia , SapatosRESUMO
This was a cross-sectional study under taken to explore the socioeconomic perspective of the arsenicosis problem, carried out in arsenic contaminated Upazillas where at least 100 arsenicosis patients had been identified. Two of the Upazillas with significant arsenic mitigation intervention and three of the Upazillas with limited interventions were selected for the study. Seven hundred fifty respondents were included in the study from 25 villages of the 5 Upazillas. Arsenicosis became a serious problem for the affected communities. Majority (71.31%) of respondents obtained their drinking water from tubewells, almost one third (29%) of the respondents still knowingly using arsenic contaminated water. Primary reason identified for this practice was distance of safe water source. Majority (58.6%) of the respondents said to face economic and 17.9% said to face social problem of varied range. Patients of lower income group were particularly more likely to face economic problems (P< .001) as well as social problem (P< .01). About half (50.7%) of the arsenicosis patients faced difficulty whilst receiving treatment, particularly female patients were more likely to face problem than male (P< .05). Several concerns also were surfaced regarding the heath care service provider particularly to the women patients, some of which are: long waiting time for receiving treatment (15%), discrimination in service delivery (10.7%) and inadequate separate facility for female patients (14.3%). Moreover the issues of financial burden raised by the respondents seem to have emerged as significant in terms of health care access. Access to Health service was particularly difficult for poor patients, as they often had to face problems associated with accessing service like, non availability of medicines in the hospitals (50.7%), traveling long distance (26.7%), purchasing medicine in most cases (32.4%) etc. Their dissatisfaction was compounded by negligent behavior of health care staff and nature of treatment provided. Furthermore length of time needed for reversal of symptoms led to loosing faith on efficacy of treatment, which cascades to negligence of patient's part in seeking health care. Women are less likely to get treatment for arsenicosis than men (P< .01). As there appear to be specific difficulties for women particularly for poor women in accessing health care, social and cultural values make it difficult for them to attend to their own health needs and to travel to service providers. Study findings suggest that a significant proportion (79.9%) of arsenicosis patient was found to access alternative health care. This includes; Homeopath, village doctors, Kabiraj and local pharmacists. Respondents in high intervention Upazillas were significantly more likely to get treatment (P< .05), to face fewer problems and to be satisfied with the facility (P< .001). Provision of safe water options, periodic screening of water source for arsenic, availability of trained doctor, regular availability of medicine, doorstep treatment, follow up on severe patients were the suggestions came from community for improvement.
Assuntos
Arsênio/análise , Ceratose/epidemiologia , Melanose/epidemiologia , Poluentes Químicos da Água/intoxicação , Adolescente , Adulto , Idoso , Bangladesh/epidemiologia , Estudos Transversais , Monitoramento Ambiental/economia , Monitoramento Ambiental/estatística & dados numéricos , Monitoramento Epidemiológico , Feminino , Custos de Cuidados de Saúde , Necessidades e Demandas de Serviços de Saúde , Humanos , Ceratose/economia , Ceratose/prevenção & controle , Masculino , Melanose/economia , Melanose/prevenção & controle , Pessoa de Meia-Idade , Fatores Socioeconômicos , Poluentes Químicos da Água/análiseRESUMO
BACKGROUND: Various effective therapeutic options are currently available for the treatment of actinic keratosis (AK) and basal cell carcinoma (BCC), but none is perfect. Poor cosmesis resulting from surgical procedures and skin irritation induced by topical agents remain significant problems. OBJECTIVES: To evaluate the cost-effectiveness of a recent approach, methyl aminolaevulinate-based photodynamic therapy (MAL-PDT; Metvix; Galderma, Lausanne, Switzerland) in AK and BCC. METHODS: A medical decision tree was developed for simulation of all possible outcomes associated with the medical decision to apply MAL-PDT or a comparator. The time horizon was 1 year for AK and 5 years for BCC. The comparators were cryotherapy in AK and excision surgery in BCC. Clinical data for the model were obtained from the literature. Data on medical management resulted from a Delphi panel performed among 12 Belgian dermatologists. Based on the model, the cost per full responder was calculated, whereby a responder was defined as a patient with all lesions clinically responding and showing an excellent cosmetic result. RESULTS: MAL-PDT is a more expensive treatment compared with cryotherapy for AK. However, the cost per full responder is comparable with cryotherapy (euro363 and euro379, respectively). Incremental cost per extra full responder is euro401. Incremental cost per full responder is euro469 for nodular BCC and euro251 for superficial BCC, both compared with excision surgery. CONCLUSIONS: The results suggest that MAL-PDT is a cost-effective intervention in AK taking a 1-year time horizon, if society is willing to pay euro1.50 per day of response, and that MAL-PDT is better value for money than excision in BCC, taking a 5-year time horizon.
Assuntos
Ácido Aminolevulínico/análogos & derivados , Carcinoma Basocelular/economia , Ceratose/economia , Fotoquimioterapia/economia , Neoplasias Cutâneas/economia , Ácido Aminolevulínico/economia , Ácido Aminolevulínico/uso terapêutico , Bélgica , Carcinoma Basocelular/tratamento farmacológico , Carcinoma Basocelular/cirurgia , Análise Custo-Benefício , Criocirurgia/economia , Tomada de Decisões , Custos de Medicamentos/estatística & dados numéricos , Custos de Cuidados de Saúde/estatística & dados numéricos , Humanos , Ceratose/tratamento farmacológico , Ceratose/cirurgia , Modelos Econométricos , Fotoquimioterapia/métodos , Fármacos Fotossensibilizantes/economia , Fármacos Fotossensibilizantes/uso terapêutico , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Cutâneas/cirurgiaRESUMO
BACKGROUND: Actinic keratosis (AK) is a common lesion with its highest incidence in the aged population. Although treatment strategies for AK have continued to develop, the cost of such treatments has not been recently investigated. PURPOSE: The purpose of this article is to determine the frequency of visits for AK, the methods used to treat AK, and the cost of the treatments used annually. METHODS: Data from the Medicare Current Beneficiary Survey and National Ambulatory Medical Care Survey were used to determine the frequency of office visits for AK and the frequency of destructive procedures and topical treatment of AK. Medicare reimbursement rates were used to estimate the cost of the procedures performed. Costs of medications were based on published wholesale costs. RESULTS: There are an estimated 5.2 million AK visits annually, 60% of which are made by the Medicare population. A total of Dollars 920 million was spent on the treatment of AK annually, 6% being spent on topical therapy, 43% on office visits, and 51% on destructive procedures. CONCLUSIONS: Even though new topical therapies are evolving for the treatment of AK, destructive procedures remain the standard of care when considering frequency of use, efficacy, and cost control.
Assuntos
Custos e Análise de Custo , Ceratose/economia , Ceratose/terapia , Idoso , Idoso de 80 Anos ou mais , Humanos , Medicare/economia , Pessoa de Meia-Idade , Visita a Consultório Médico/estatística & dados numéricos , Lesões Pré-Cancerosas/economia , Lesões Pré-Cancerosas/terapia , Estados UnidosRESUMO
BACKGROUND: This study aimed to obtain clinical and economic information about patterns of treatment of solar keratoses (SKs) by general practitioners in Australia. The study design was a retrospective survey relating to the treatment of patients presenting to their doctor with previously untreated SKs. METHODS: Data were collected between May and June 2000, from a sample of doctors who were asked to randomly select two SK patients from their medical records and complete a self-administered postal questionnaire. Information about treatment types, number of visits, treatment complications, and specialist referrals were directly extracted from the patient records. RESULTS: A total of 156 patients were recruited to the study (61% male) who had been treated for a total of 251 SKs (average 1.6 lesions/patient). The most common treatment employed was cryotherapy (63%). Excision was also commonly used (18%). Five per cent of patients were treated with a mixture of excision and cryotherapy. Topical agents were not commonly employed. Of those patients who consulted a doctor, 9% were referred to a specialist for diagnosis or treatment, of which 57% were referred to a dermatologist. CONCLUSION: The typical number of doctor visits varied from 1.9 to 4.6 with a range of cost per patient of 55.13-249.70 Australian dollars depending on complexity of the case and the need for referral.
Assuntos
Medicina de Família e Comunidade/métodos , Ceratose/terapia , Padrões de Prática Médica , Lesões Pré-Cancerosas/terapia , Neoplasias Cutâneas/terapia , Austrália , Crioterapia , Feminino , Cabeça , Custos de Cuidados de Saúde , Pesquisas sobre Atenção à Saúde , Humanos , Ceratose/economia , Ceratose/etiologia , Masculino , Padrões de Prática Médica/economia , Lesões Pré-Cancerosas/economia , Lesões Pré-Cancerosas/etiologia , Encaminhamento e Consulta , Estudos Retrospectivos , Neoplasias Cutâneas/economia , Neoplasias Cutâneas/etiologia , Luz Solar/efeitos adversos , Extremidade SuperiorRESUMO
Vitamin D sufficiency is required for optimal health, and solar ultraviolet B (UVB) irradiance is an important source of vitamin D. UVB and/or vitamin D have been found in observational studies to be associated with reduced risk for over a dozen forms of cancer, multiple sclerosis, osteoporotic fractures, and several other diseases. On the other hand, excess UV irradiance is associated with adverse health outcomes such as cataracts, melanoma, and nonmelanoma skin cancer. Ecologic analyses are used to estimate the fraction of cancer mortality, multiple sclerosis prevalence, and cataract formation that can be prevented or delayed. Estimates from the literature are used for other diseases attributed to excess UV irradiation, additional cancer estimates, and osteoporotic fractures. These results are used to estimate the economic burdens of insufficient UVB irradiation and vitamin D insufficiency as well as excess UV irradiation in the United States for these diseases and conditions. We estimate that 50,000-63,000 individuals in the United States and 19,000-25,000 in the UK die prematurely from cancer annually due to insufficient vitamin D. The U.S. economic burden due to vitamin D insufficiency from inadequate exposure to solar UVB irradiance, diet, and supplements was estimated at $40-56 billion in 2004, whereas the economic burden for excess UV irradiance was estimated at $6-7 billion. These results suggest that increased vitamin D through UVB irradiance, fortification of food, and supplementation could reduce the health care burden in the United States, UK, and elsewhere. Further research is required to confirm these estimates.
Assuntos
Efeitos Psicossociais da Doença , Gastos em Saúde , Raios Ultravioleta , Vitamina D/fisiologia , Catarata/economia , Suplementos Nutricionais , Humanos , Ceratose/economia , Melanoma/economia , Melanoma/etiologia , Esclerose Múltipla/economia , Neoplasias/economia , Neoplasias/etiologia , Osteoporose/economia , Comportamento de Redução do Risco , Neoplasias Cutâneas/economia , Neoplasias Cutâneas/etiologia , Luz Solar , Raios Ultravioleta/efeitos adversos , Reino Unido , Estados Unidos , Vitamina D/farmacologiaRESUMO
Non-melanoma skin cancer (NMSC) and actinic keratosis are becoming an increasingly important healthcare problem. There are approximately 1 million cases of NMSC in the US each year, primarily basal cell carcinomas, and the incidence is increasing. Although NMSC is significant in terms of both health risk and the resource implications for treatment within healthcare systems, our understanding of the health economics of NMSC is limited. The purpose of this article was to systematically review and assess published health economic studies of the treatment of NMSC and actinic keratosis, taking into consideration key aspects of guidelines set by drug purchasers and key reimbursement agencies, and to provide recommendations for appropriate modelling approaches and data collection for health economic studies of NMSC and actinic keratosis. We systematically reviewed the published literature from 1965 to 2003 for health economic evaluations of treatments of NMSC and actinic keratosis using the search terms: ('skin cancer' or 'non melanoma skin cancer' or 'basal cell carcinoma' or 'actinic keratosis') and ('decision model' or 'decision theoretic' or 'decision analytic' or 'health economic' or 'cost effective'). Studies using one of the following methodologies were included: cost-effectiveness, cost-benefit, cost-utility, cost-minimisation, cost-of-illness, cost-consequence, and treatment cost analysis. We identified eight studies evaluating NMSC. One of these studies also evaluated actinic keratosis. Although several studies satisfied some of the basic requirements of health economic evaluations, the majority had serious shortcomings that limit their usefulness. There are a few high-quality health economic evaluations assessing treatments for NMSC or actinic keratosis. However, our analysis suggests that additional data on treatment practice patterns and epidemiology need to be collected, and incorporated with efficacy and safety data in a formal decision-analytic framework to assist decision makers in allocating scarce healthcare resources.
Assuntos
Custos de Cuidados de Saúde , Ceratose/economia , Transtornos de Fotossensibilidade/economia , Neoplasias Cutâneas/economia , Ensaios Clínicos como Assunto/economia , Humanos , Ceratose/epidemiologia , Transtornos de Fotossensibilidade/epidemiologia , Neoplasias Cutâneas/epidemiologiaRESUMO
BACKGROUND: Actinic keratoses are premalignant lesions resulting from exposure to carcinogens. Recently, some Medicare carriers have limited reimbursement for destruction of actinic keratoses to those lesions unresponsive to topical 5-fluorouracil treatment. OBJECTIVE: Our purpose was to determine whether this policy meets the community standard of care for treatment of actinic keratoses. METHODS: Data from the 1993 and 1994 National Ambulatory Medical Care Survey were used to determine the frequencies at which different treatments are used for actinic keratoses. These were compared with the frequencies at which procedures and medical therapies are used to treat control conditions (warts, psoriasis, acne, and dermatitis) to determine whether procedures are done because they are available or out of medical necessity. RESULTS: Procedures were performed during 78% of visits for actinic keratoses. 5-Fluorouracil was used at 3.6% of visits, and at 39% of these visits a procedure was also performed. There were no observations of use of 5-fluorouracil alone at a first visit for actinic keratosis. Procedures were less likely to be performed at visits for warts, psoriasis, acne, or dermatitis, which indicates that reimbursable procedures are performed not simply because they are available. CONCLUSION: Procedures are performed to destroy actinic keratoses out of medical need. Medicare policies mandating initial use of 5-fluorouracil as initial treatment of actinic keratoses do not represent the community standard of care for treatment of these lesions.
Assuntos
Ceratose/terapia , Medicare/economia , Padrões de Prática Médica/estatística & dados numéricos , Lesões Pré-Cancerosas/terapia , Mecanismo de Reembolso , Neoplasias Cutâneas/terapia , Antimetabólitos Antineoplásicos/administração & dosagem , Florida , Fluoruracila/administração & dosagem , Pesquisas sobre Atenção à Saúde , Humanos , Ceratose/economia , Ceratose/epidemiologia , Lesões Pré-Cancerosas/economia , Lesões Pré-Cancerosas/epidemiologia , Neoplasias Cutâneas/economia , Neoplasias Cutâneas/epidemiologia , Estados UnidosAssuntos
Ceratose/economia , Medicare , Idoso , Mau Uso de Serviços de Saúde , Humanos , Ceratose/cirurgia , Auditoria Médica , Estados UnidosRESUMO
This paper summarizes the findings of a NIOSH reported entitled "The Chronic Effects of Repeated Mechanical Trauma to the Skin: A Description of the Problem in the Workplace" (the Trauma Report). Medical literature and U.S. health statistics (population surveys and occupational health reports) were reviewed to determine the long-range impact of repeated mechanical trauma sustained in the workplace. Trauma was rarely recognized as contributing to dermatological disorders. Conventional sources of information were found to be inadequate for precise estimation of costs. A minimal estimate of the annual cost of cutaneous disorders resulting from repeated mechanical trauma to the skin is $15 million.