RESUMO
The porphyrias are a group of metabolic disorders resulting from an innate abnormality in haem biosynthesis, and the clinical settings of which vary according to the genetic enzyme abnormality in question. These are genetic disorders with autosomal dominant or recessive inheritance of varying penetrance, and whose clinical expression differs according to the preferential location of haem precursors. Different classifications have been proposed according to genetic inheritance, the enzyme anomaly at issue, and clinical expression. The clinical classification distinguishes between acute porphyria (acute intermittent porphyria, porphyria variegata, hereditary coproporphyria), bullous cutaneous porphyrias (porphyria cutanea tarda, porphyria variegata and hereditary coproporphyria), painful photosensitive acute cutaneous porphyrias (erythropoietic protoporphyria and X-linked dominant protoporphyria), and rare recessive porphyrias (congenital erythropoietic porphyria, Doss porphyria, hepatoerythropoietic porphyria and harderoporphyria). Treatment depends on the clinical expression of the disorder.
Assuntos
Porfirias , Dermatopatias Metabólicas , Biópsia , Coproporfiria Hereditária/diagnóstico , Coproporfiria Hereditária/genética , Coproporfiria Hereditária/terapia , Diagnóstico Diferencial , Heme/biossíntese , Humanos , Transtornos de Fotossensibilidade/complicações , Transtornos de Fotossensibilidade/diagnóstico , Transtornos de Fotossensibilidade/terapia , Porfiria Cutânea Tardia/diagnóstico , Porfiria Cutânea Tardia/genética , Porfiria Cutânea Tardia/terapia , Porfiria Eritropoética/diagnóstico , Porfiria Eritropoética/genética , Porfiria Eritropoética/terapia , Porfirias/classificação , Porfirias/diagnóstico , Porfirias/genética , Porfirias/terapia , Protoporfiria Eritropoética/diagnóstico , Protoporfiria Eritropoética/genética , Protoporfiria Eritropoética/terapia , Pele/patologia , Dermatopatias Metabólicas/classificação , Dermatopatias Metabólicas/diagnóstico , Dermatopatias Metabólicas/genética , Dermatopatias Metabólicas/terapiaRESUMO
Porphyrias comprise a heterogeneous group of predominantly genetically determined metabolic diseases which are due to a dysfunction in heme biosynthesis. Variegate porphyria and hereditary coproporphyria are referred to as neurocutaneous porphyrias because affected patients can develop both cutaneous symptoms on light-exposed body sites and potentially life-threatening acute neurovisceral symptoms, thereby mimicking several other diseases. In this overview, we provide an update on pathogenesis, clinical manifestation, diagnosis, and therapy of these two types of porphyria.
Assuntos
Coproporfiria Hereditária/diagnóstico , Coproporfiria Hereditária/terapia , Síndromes Neurocutâneas/diagnóstico , Síndromes Neurocutâneas/terapia , Porfiria Variegada/diagnóstico , Porfiria Variegada/terapia , Diagnóstico Diferencial , Medicina Baseada em Evidências , Humanos , Resultado do TratamentoRESUMO
BACKGROUND: The porphyrias are a group of disorders of the heme biosynthesis pathway that may present with acute life-threatening attacks, commonly exacerbated by a wide variety of medications. Many newer immunosuppressive medications, which are in use following kidney transplantation, have not been fully explored in acute porphyrias. CASE REPORT: A 53-year-old woman received a kidney from a deceased donor, after being on hemodialysis for 4 years. Hereditary coproporphyria was diagnosed at age 19 years. We administered tacrolimus, mycophenolate mofetil and steroid immunosuppression. In the immediate post-transplant periods she displayed abdominal pain and transient uroporphyrin elevation in parallel with slightly elevated (15 ng/mL) tacrolimus concentrations. As the target tacrolimus level was achieved, these findings disappeared. CONCLUSIONS: Tacrolimus, mycophenolate- mofetil, and steroid therapy for hereditery coproporphyri was safe, in the long term.
Assuntos
Coproporfiria Hereditária/complicações , Imunossupressores/administração & dosagem , Falência Renal Crônica/cirurgia , Transplante de Rim , Ácido Micofenólico/análogos & derivados , Tacrolimo/administração & dosagem , Dor Abdominal/etiologia , Coproporfiria Hereditária/diagnóstico , Coproporfiria Hereditária/terapia , Monitoramento de Medicamentos , Feminino , Humanos , Imunossupressores/efeitos adversos , Imunossupressores/sangue , Imunossupressores/farmacocinética , Falência Renal Crônica/diagnóstico , Falência Renal Crônica/etiologia , Pessoa de Meia-Idade , Ácido Micofenólico/administração & dosagem , Ácido Micofenólico/efeitos adversos , Ácido Micofenólico/sangue , Ácido Micofenólico/farmacocinética , Fatores de Risco , Tacrolimo/efeitos adversos , Tacrolimo/sangue , Tacrolimo/farmacocinética , Resultado do TratamentoRESUMO
INTRODUCTION: Acute hepatic porphyrias can mimic a range of unrelated diseases and conditions that may occur independently of porphyria and trigger their initial manifestations and further attacks. CASE REPORT: A 46-year-old female patient was subjected to cholecystectomy for biliary colic. Histopathological analysis revealed acute purulent exacerbation of chronic cholecystitis. On the 8th day post surgery, the patient was rehospitalized for nausea, abdominal pain, weakness and faintness, poor general condition, hypertension, tachycardia, apathy and profuse sweating. Laboratory findings revealed hyponatremia, hypokalemia, and metabolic alkalosis. Exploratory laparotomy did not detect a pathomorphological substrate. The patient was transferred to surgery department of the tertiary care institution. Due to metabolic imbalance, she was transferred to the Department of Endocrinology with signs of paleness, profuse sweating, tachycardia, and tachydyspnoea. The cardiologist performed echocardiography. The patient was diagnosed to have acute left ventricular failure and sub-acute myocardial infarction and transferred to the Department of Cardiology. Coronarography findings were normal. Cramps and pain in the legs with sensory loss, general weakness, apathy and mental confusion suggested acute hepatic porphyria. Thus, hereditary coproporphyria was diagnosed in the second month of illness. The treatment was continued at the Department of Gastroenterology. Clinical manifestations included polyneuropathy, flaccid paraparesis and acute brain syndrome, precordial oppressions and tachycardia. Haem arginate and hypertonic glucose were applied. The condition of the patient gradually improved. CONCLUSION: Porphyrias should always be taken into consideration in doubtful, frequently dramatic clinical pictures characterized by neurovisceral symptoms and precipitating factors of acute porphyria attacks must never be neglected.
Assuntos
Coproporfiria Hereditária/diagnóstico , Sintase do Porfobilinogênio/deficiência , Porfirias Hepáticas/diagnóstico , Colecistectomia , Colecistite/complicações , Colecistite/cirurgia , Doença Crônica , Cólica/etiologia , Cólica/cirurgia , Coproporfiria Hereditária/terapia , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
Acute porphyria, though rare, has well-known neurological sequelae. Vasospasm rarely complicates exacerbations of acute intermittent porphyria, but has not been previously reported in hereditary coproporphyria. We describe a porphyric crisis in a woman with previously undiagnosed hereditary coproporphyria (triggered by rifampicin), leading to vasospasm and stroke.
Assuntos
Coproporfiria Hereditária/complicações , Acidente Vascular Cerebral/etiologia , Vasoespasmo Intracraniano/etiologia , Adulto , Encéfalo/diagnóstico por imagem , Encéfalo/patologia , Coproporfiria Hereditária/induzido quimicamente , Coproporfiria Hereditária/terapia , Feminino , Humanos , Angiografia por Ressonância Magnética , Imageamento por Ressonância Magnética , Radiografia , Rifampina/efeitos adversos , Acidente Vascular Cerebral/diagnóstico , Vasoespasmo Intracraniano/diagnósticoRESUMO
Recent advances in the molecular understanding of the porphyrias now offer specific diagnosis and precise definition of the types of genetic mutations involved in the disease. Molecular diagnostic testing is powerful and very useful in kindred evaluation and genetic counselling when a disease-responsible mutation has been identified in the family. It is also the only way to properly screen asymptomatic gene carriers, facilitating correct treatment and appropriate genetic counselling of family members at risk. However, it should be noted that DNA-based testing is for the diagnosis of the gene carrier status, but not for the diagnosis of clinical syndrome or severity of the disease, e.g. an acute attack. For the diagnosis of clinically expressed porphyrias, a logical stepwise approach including the analysis of porphyrins and their precursors should not be underestimated, as it is still very useful, and is often the best from the cost-effective point of view.