RESUMO
A traditional balanced Korean diet (K-diet) may improve energy, glucose, and lipid metabolism. To evaluate this, we conducted a randomized crossover clinical trial, involving participants aged 30-40 years, who were randomly assigned to two groups-a K-diet or westernized Korean control diet daily, with an estimated energy requirement (EER) of 1900 kcal. After a 4-week washout period, they switched the diet and followed it for 4 weeks. The carbohydrate, protein, and fat ratios based on energy intake were close to the target values for the K-diet (65:15:20) and control diet (60:15:25). The glycemic index of the control diet and the K-diet was 50.3 ± 3.6 and 68.1 ± 2.9, respectively, and daily cholesterol contents in the control diet and K-diet were 280 and 150 mg, respectively. Anthropometric and biochemical parameters involved in energy, glucose, and lipid metabolism were measured while plasma metabolites were determined using UPLC-QTOF-MS before and after the 4-week intervention. After the four-week intervention, both diets improved anthropometric and biochemical variables, but the K-diet significantly reduced them compared to the control diet. Serum total cholesterol, non-high-density lipoprotein cholesterol, and triglyceride concentrations were significantly lower in the K-diet group than in the control diet group. The waist circumference (p = 0.108) and insulin resistance index (QUICKI, p = 0.089) tended to be lower in the K-diet group than in the control diet group. Plasma metabolites indicated that participants in the K-diet group tended to reduce insulin resistance compared to those in the control diet group. Amino acids, especially branched-chain amino acids, tyrosine, tryptophan, and glutamate, and L-homocysteine concentrations were considerably lower in the K-diet group than in the control diet group (p < 0.05). Plasma glutathione concentrations, an index of antioxidant status, and 3-hydroxybutyric acid concentrations, were higher in the K-diet group than in the control diet group. In conclusion, a K-diet with adequate calories to meet EER alleviated dyslipidemia by decreasing insulin resistance-related amino acids and increasing ketones in the circulation of obese women.
Assuntos
Dieta Saudável/etnologia , Dieta Saudável/métodos , Dislipidemias/dietoterapia , Índice Glicêmico , Obesidade/dietoterapia , Adulto , Colesterol/sangue , Dieta para Diabéticos/etnologia , Dieta para Diabéticos/métodos , Dieta com Restrição de Gorduras/etnologia , Dieta com Restrição de Gorduras/métodos , Dislipidemias/sangue , Dislipidemias/etiologia , Ingestão de Energia , Feminino , Humanos , Resistência à Insulina , Obesidade/sangue , Obesidade/complicações , República da Coreia , Resultado do Tratamento , Triglicerídeos/sangueRESUMO
Nutrition is crucial for maintaining normal growth, development, and glycemic control in young people with diabetes (PwD). Undue restrictions cause nutrient deficiencies as well as poor adherence to meal plans. Widespread availability of low-cost, ultra-processed, and hyperpalatable food is further damaging. Most families struggle to find ways to provide nutritious, yet attractive, food with a low glycemic index (GI). India is one of the oldest continuous civilizations with a rich and diverse cultural and culinary heritage. Traditional dietary practices, including the centuries-old 'Thali' (meaning plate) concept, emphasize combinations (grains, lentils, vegetables, dairy, spices, prebiotics and probiotics, and fats) of local, seasonal, and predominantly plant-based ingredients. These practices ensure that all of the necessary food groups are provided and fit well with current evidence-based recommendations, including the International Society for Pediatric and Adolescent Diabetes (ISPAD) 2018 Guidelines. Techniques for the preparation, cooking, and preservation of food further impact the GI and nutrient availability. These practices benefit nutrient density, diet diversity, and palatability and thus improve adherence to meal plans and glycemic control. This narrative review describes the ancient wisdom, food composition, and culinary practices from across India which are still valuable today. These may be of benefit worldwide to improve glycemic control as well as quality of life, especially in PwD.
Assuntos
Diabetes Mellitus/dietoterapia , Dieta para Diabéticos/etnologia , Comportamento Alimentar/etnologia , Controle Glicêmico/métodos , Adolescente , Criança , Feminino , Índice Glicêmico , Humanos , Índia/etnologia , Masculino , Política NutricionalRESUMO
BACKGROUND: Dietary modification is the primary intervention strategy for management of gestational diabetes mellitus (GDM), which usually occurs in the third trimester of pregnancy when women have extra nutritional needs. There is a high migration rate of ethnic Chinese people to Western countries, and those women present a high-risk group for GDM. Little is known about diet, dietary self-management, and nutritional supplementation use among ethnic Chinese migrant women with GDM compared with members of the host population with GDM. OBJECTIVE: This study aimed to compare the perceptions and experiences of dietary self-management and nutritional needs of ethnic Chinese migrants with those of Australian-born white women with GDM in Australia. DESIGN: A predominantly qualitative mixed methods approach with a quantitative component was used. Data collection involved in-depth, semistructured interviews, and 3-day 24-hour recall diaries collected concurrently. Data analysis and management relied on NVivo (QSR International Pty Ltd), FoodWorks (FoodWorks Professional 2017, Xyris Software), and SPSS (SPSS Inc). Pearson χ2 test, independent-samples t test, and Mann-Whitney U test were used to compare nutrient intakes between groups. The Pearson correlation was used to determine the relationship between dietary patterns and nutrient intake. PARTICIPANTS: A total of 44 ethnic Chinese and 39 Australian-born white participants with GDM were recruited from two large Australian maternity services located in tertiary hospitals. RESULTS: Ethnic differences in satisfaction with GDM education influenced GDM self-management. Ethnic Chinese women with GDM perceived dietary advice received from health professionals to be lacking in cultural relevance and detail and responded by restricting their dietary intake and relying on nutritional supplementation. The perceived benefits of specific supplements produced ethnic differences in the patterns of supplement use. Cultural dietary patterns influenced dietary adequacy in pregnancy. CONCLUSIONS: This study suggests the need for provision of more concrete, prescriptive, and culturally relevant dietary and supplementation advice for ethnic Chinese women with GDM.
Assuntos
Povo Asiático/psicologia , Diabetes Gestacional/etnologia , Dieta para Diabéticos/psicologia , Emigrantes e Imigrantes/psicologia , População Branca/psicologia , Adulto , Austrália/etnologia , China/etnologia , Comparação Transcultural , Diabetes Gestacional/dietoterapia , Diabetes Gestacional/psicologia , Dieta para Diabéticos/etnologia , Feminino , Humanos , Gravidez , Cuidado Pré-Natal/psicologia , Pesquisa Qualitativa , Autogestão/psicologiaRESUMO
BACKGROUND: UK African and Caribbean (AfC) communities are disproportionately burdened by type 2 diabetes (T2D). Promoting healthy eating and physical activity through structured education is the cornerstone of T2D care, however cultural barriers may limit engagement in these communities. In addition, changes in lifestyle behaviour are shaped by normative influences within social groups and contextual factors need to be understood to facilitate healthful behaviour change. The Behaviour Change Wheel (BCW) and associated COM-B framework offer intervention designers a systematic approach to developing interventions. The aim of this study was to apply the BCW in the design of a culturally sensitive self-management support programme for T2D in UK AfC communities. METHODS: An intervention development study was conducted. Focus groups were held with 41 AfC patients with T2D to understand healthful weight-management, diet and physical activity behaviours. The COM-B framework and BCW were used to evaluate the qualitative data, identify appropriate behaviour change techniques and specify the intervention components. RESULTS: Participants were motivated to avoid diabetes-related consequences although did not always understand the negative impact of their current health behaviours on long-term diabetes outcomes. Barriers to healthful behaviour included gaps in knowledge related to diet, physical activity and weight management guidance. In addition, motivation and social opportunity barriers included an acceptance of larger body sizes, rejection of body mass index for weight guidance and cultural identity being strongly linked to consumption of traditional starches. There was a lack of social opportunity to perform moderate to vigorous physical activity, although walking and dance were culturally acceptable. The resulting Healthy Eating & Active Lifestyles for Diabetes (HEAL-D) intervention uses social support, social comparison, credible sources and demonstration as key behaviour change techniques. CONCLUSION: Use of COM-B and the BCW highlighted the need for an intervention to address motivational and social opportunity barriers to engaging in healthful behaviours, as well as addressing key gaps in knowledge. This framework facilitated the linkage of theoretical behaviour constructs with evidence-based behaviour change techniques, which will enable us to evaluate operationalisation of our chosen BCTs and their impact on behaviour change in a future feasibility study.
Assuntos
Terapia Comportamental/educação , Assistência à Saúde Culturalmente Competente/métodos , Diabetes Mellitus Tipo 2/etnologia , Dieta para Diabéticos/métodos , Educação de Pacientes como Assunto/métodos , Autogestão/educação , Adulto , Terapia Comportamental/métodos , População Negra/educação , Região do Caribe/etnologia , Diabetes Mellitus Tipo 2/terapia , Dieta para Diabéticos/etnologia , Dieta Saudável/etnologia , Dieta Saudável/métodos , Exercício Físico , Feminino , Grupos Focais , Comportamentos Relacionados com a Saúde/etnologia , Estilo de Vida Saudável , Humanos , Masculino , Pessoa de Meia-Idade , Motivação , Avaliação de Programas e Projetos de Saúde , Autogestão/métodos , Apoio Social , Reino UnidoRESUMO
BACKGROUND: Disability is a key indicator implicating both overall morbidity and success of public health efforts to compress the period of morbidity among geriatrics for the overall population. Disabilities are more prevalent among diabetics than among those without diabetes. OBJECTIVE: This study aimed to determine self-monitoring practices, awareness to dietary modifications and barriers to medication adherence among physically disabled type 2 diabetes mellitus patients. METHODS: Interview sessions were conducted at diabetes clinic - Penang general hospital. The invited participants represented three major ethnic groups of Malaysia (Malay, Chinese & Indians). An openended approach was used to elicit answers from participants. Interview questions were related to participant's perception towards self-monitoring blood glucose practices, Awareness towards diet management, behaviour to diabetes medication and cues of action. RESULTS: A total of twenty-one diabetes patients between the ages 35 - 67 years with physical disability (P1-P21) were interviewed. The cohort of participants was dominated by Males (n=12) and also distribution pattern showed that majority of participants were Malay (n=10), followed by Chinese (n=7) and rest Indians (n=4). When the participants were asked in their opinion what was the preferred method of recording blood glucose tests, several participants from low socioeconomic status and either divorced or widowed denied to adapt telemontoring instead preferred to record manually. There were mixed responses about the barriers to control diet/calories. Even patients with high economic status, middle age 35-50 and diabetes history of 5-10 years were influenced towards alternative treatments. CONCLUSION: Study concluded that patients with physical disability required extensive care and effective strategies to control glucose metabolism.
Assuntos
Automonitorização da Glicemia , Diabetes Mellitus Tipo 2/terapia , Dieta para Diabéticos , Pessoas com Deficiência/psicologia , Conhecimentos, Atitudes e Prática em Saúde , Hipoglicemiantes/uso terapêutico , Adesão à Medicação , Percepção , Autocuidado , Adolescente , Adulto , Idoso , Povo Asiático/psicologia , Atitude Frente aos Computadores , Biomarcadores/sangue , Glicemia/efeitos dos fármacos , Glicemia/metabolismo , Automonitorização da Glicemia/métodos , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/etnologia , Diabetes Mellitus Tipo 2/psicologia , Dieta para Diabéticos/etnologia , Avaliação da Deficiência , Comportamento Alimentar , Feminino , Conhecimentos, Atitudes e Prática em Saúde/etnologia , Humanos , Entrevistas como Assunto , Masculino , Adesão à Medicação/etnologia , Pessoa de Meia-Idade , Preferência do Paciente , Pesquisa Qualitativa , Autocuidado/métodos , Fatores Socioeconômicos , Telemetria , Adulto JovemRESUMO
PURPOSE: Proper evaluation of polyphenols intake at the population level is a necessary step in order to establish possible associations with health outcomes. Available data are limited, and so far no study has been performed in people with diabetes. The aim of this work was to document the intake of polyphenols and their major food sources in a cohort of people with type 2 diabetes and in socio-demographic subgroups. METHODS: We studied 2573 men and women aged 50-75 years. Among others, anthropometry was measured by standard protocol and dietary habits were investigated by food frequency questionnaire (EPIC). The intake of polyphenols was evaluated using US Department of Agriculture and Phenol-Explorer databases. RESULTS: The mean total polyphenol intake was 683.3 ± 5.8 mg/day. Non-alcoholic beverages represented the main food source of dietary polyphenols and provided 35.5% of total polyphenol intake, followed by fruits (23.0%), alcoholic beverages (14.0%), vegetables (12.4%), cereal products and tubers (4.6%), legumes (3.7%) and oils (2.1%); chocolate, cakes and nuts are negligible sources of polyphenols in this cohort. The two most important polyphenol classes contributing to the total intake were flavonoids (47.5%) and phenolic acids (47.4%). Polyphenol intake increased with age and education level and decreased with BMI; furthermore, in the northern regions of Italy, the polyphenol intake was slightly, but significantly higher than in the central or southern regions. CONCLUSIONS: The study documents for the first time the intake of polyphenols and their main food sources in people with diabetes using validated and complete databases of the polyphenol content of food. Compared with published data, collected in people without diabetes, these results suggest a lower intake and a different pattern of intake in people with diabetes.
Assuntos
Antioxidantes/administração & dosagem , Diabetes Mellitus Tipo 2/dietoterapia , Dieta para Diabéticos , Dieta Saudável , Flavonoides/administração & dosagem , Cooperação do Paciente , Fenóis/administração & dosagem , Idoso , Antioxidantes/análise , Bebidas/análise , Cinamatos/administração & dosagem , Cinamatos/análise , Estudos de Coortes , Estudos Transversais , Bases de Dados Factuais , Diabetes Mellitus Tipo 2/etnologia , Dieta para Diabéticos/etnologia , Dieta Saudável/etnologia , Feminino , Flavonoides/análise , Frutas/química , Glicosídeos/administração & dosagem , Glicosídeos/análise , Humanos , Itália , Masculino , Pessoa de Meia-Idade , Valor Nutritivo , Cooperação do Paciente/etnologia , Fenóis/análise , Polifenóis/administração & dosagem , Polifenóis/análiseRESUMO
OBJECTIVES: To determine the awareness of HbA1c values and correlate this with educational levels, dietary intake and physical activity in type II diabetic population of Trinidad. METHODS: Total of 222 type II diabetic subjects were assessed via questionnaire evaluating their demographics, type and duration of diabetes, type and frequency of glucose testing, dietary intake and physical activity. HbA1c data was coded as patients who were aware versus patients who were not aware. RESULTS: Of the respondents, 41.9% were aware of the term HbA1c while 58.1% were unaware. Statistically, there were positive correlations (p < .05) between HbA1c awareness and level of education received by type II diabetic patients as well as between HbA1c awareness and intensity of exercise performed (p< .05). However, the relationship between dietary breakfast choices and HbA1c awareness was not significant. CONCLUSIONS: A significant correlation was established between HbA1c awareness, intensity of exercise and the level of education obtained.
Assuntos
Diabetes Mellitus Tipo 2/terapia , Exercício Físico , Hemoglobinas Glicadas/análise , Conhecimentos, Atitudes e Prática em Saúde , Hiperglicemia/prevenção & controle , Cooperação do Paciente , Autogestão , Automonitorização da Glicemia , Terapia Combinada , Complicações do Diabetes/etnologia , Complicações do Diabetes/prevenção & controle , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/etnologia , Dieta para Diabéticos/etnologia , Dieta Saudável/etnologia , Escolaridade , Feminino , Conhecimentos, Atitudes e Prática em Saúde/etnologia , Estilo de Vida Saudável , Humanos , Masculino , Cooperação do Paciente/etnologia , Esforço Físico , Autorrelato , Trinidad e TobagoRESUMO
Purpose The goals of this descriptive ethnographic study were to (1) describe the day-to-day selection, preparation, and consumption of food among African American women (AAW) with type 2 diabetes mellitus (T2DM); (2) identify their typical food selections and consumption practices when dining out at restaurants and at social gatherings (ie, church functions, holidays); (3) highlight the valued behaviors and beliefs that influence these women's food practices; and (4) determine how social interactions influence those food practices. Methods Symbolic interactionism, a sensitizing framework, guided this study. Purposeful sampling was used to recruit 20 AAW from 35 to 70 years of age diagnosed with T2DM who shopped and prepared meals for their families and attended church functions where food was served. Data collection consisted of one-on-one interviews and observations of participants during church fellowship dinners, grocery shopping, and food preparation. A social anthropological approach to content analysis was used to describe behavioral regularities in food practices. Results Informants exhibited a constant struggle in food practices, particularly within the home setting. Difficulties in making dietary modifications resulted from conflicts between the need to change dietary practices to control diabetes and personal food preferences, food preferences of family members, and AAW's emotional dedication to the symbolism of food derived from traditional cultural food practices passed down from generation to generation. Conclusions African American women are the gatekeepers for family food practices, holding the keys to healthy dietary practices. This study helps to fill the research gap regarding cultural dietary food practices within this population.
Assuntos
Negro ou Afro-Americano/psicologia , Cultura , Diabetes Mellitus Tipo 2/etnologia , Dieta para Diabéticos/etnologia , Comportamento Alimentar/etnologia , Adulto , Idoso , Culinária/métodos , Diabetes Mellitus Tipo 2/psicologia , Dieta para Diabéticos/psicologia , Família/psicologia , Comportamento Alimentar/psicologia , Feminino , Preferências Alimentares/etnologia , Preferências Alimentares/psicologia , Humanos , Pessoa de Meia-Idade , ReligiãoRESUMO
OBJECTIVE: The study aims were to (i) identify determinants of Nutrition Facts Panel (NFP) use and (ii) describe the association between NFP use and dietary intake among Latinos with type 2 diabetes. DESIGN: Baseline cross-sectional data from a clinical trial were used to assess the association between NFP use and dietary intake. Diet was measured using two methods: (i) a diet quality score (the Healthy Eating Index-2010) derived from a single 24 h recall and (ii) dietary pattern (exploratory factor analyses) from an FFQ. Multivariable logistic and non-parametric quantile regressions were conducted, as appropriate. Settings Hartford County, Connecticut, USA. SUBJECTS: Latino adults (n 203), ≥21 years of age, with diagnosed type 2 diabetes, glycosylated Hb≥7 %, and without medical conditions limiting physical activity. RESULTS: Participants' education level, diabetes-related knowledge and English speaking were positively associated with NFP use. At the higher percentiles of diet quality score, NFP use was significantly associated with higher diet quality. Similarly, NFP users were more likely to consume a 'healthy' dietary pattern (P=0·003) and less likely to consume a 'fried snack' pattern (P=0·048) compared with NFP non-users. CONCLUSIONS: The association between reported NFP use and diet quality was positive and significantly stronger among participants who reported consuming a healthier diet. While NFP use was associated with a healthier dietary pattern, not using NFP was associated with a less-healthy, fried snack pattern. Longitudinal studies are needed to understand whether improving NFP use could be an effective intervention to improve diet quality among Latinos with type 2 diabetes.
Assuntos
Diabetes Mellitus Tipo 2/dietoterapia , Dieta para Diabéticos , Dieta Saudável , Análise de Alimentos , Rotulagem de Alimentos , Conhecimentos, Atitudes e Prática em Saúde , Cooperação do Paciente , Idoso , Connecticut , Estudos Transversais , Diabetes Mellitus Tipo 2/etnologia , Dieta para Diabéticos/etnologia , Dieta Saudável/etnologia , Dieta Hiperlipídica/efeitos adversos , Dieta Hiperlipídica/etnologia , Análise Fatorial , Feminino , Preferências Alimentares/etnologia , Conhecimentos, Atitudes e Prática em Saúde/etnologia , Hispânico ou Latino , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação Nutricional , Valor Nutritivo , Cooperação do Paciente/etnologia , Lanches/etnologiaRESUMO
Purpose The purpose of the study was to investigate the effects of a family-based self-management support intervention for adults with type 2 diabetes (T2DM). Methods Using a 2-group, experimental repeated measures design, 157 dyads (participant with T2DM and family member) were randomly assigned to an intervention (education, social support, home visits, and telephone calls) or a wait list control group. Data were collected at baseline, postintervention (3 months), and 6 months postintervention. A series of 2 × 3 repeated measures ANOVAs were used to test the hypotheses with interaction contrasts to assess immediate and sustained intervention effects. Results Significant changes over time were reported in diet self-management, exercise self-management, total self-management, diabetes self-efficacy for general health and total diabetes self-efficacy, physician distress, regimen distress, interpersonal distress, and total distress. There were likewise sustained effects for diet self-management, total self-management, diabetes self-efficacy for general health, total self-efficacy, physician distress, regimen distress, and interpersonal distress. Conclusions Results support and extend prior research documenting the value of culturally relevant family-based interventions to improve diabetes self-management and substantiate the need for intensive, longer, tailored interventions to achieve glycemic control.
Assuntos
Assistência à Saúde Culturalmente Competente/métodos , Diabetes Mellitus Tipo 2/terapia , Terapia Familiar/métodos , Americanos Mexicanos/psicologia , Autogestão/métodos , Adulto , Assistência à Saúde Culturalmente Competente/etnologia , Diabetes Mellitus Tipo 2/etnologia , Diabetes Mellitus Tipo 2/psicologia , Dieta para Diabéticos/etnologia , Dieta para Diabéticos/psicologia , Feminino , Humanos , Masculino , Projetos de Pesquisa , Autoeficácia , Autogestão/psicologia , Apoio Social , Estresse Psicológico/etnologia , Estresse Psicológico/psicologiaRESUMO
Consuming a healthy diet forms an important component of diabetes management; however, adhering to a healthy diet is challenging. Dietary behaviour is often guided by socio-cultural, environmental and emotional factors, and not necessarily by physical and nutritional needs. This study explored Nepalese patients' perceptions of the impact of diet, diet management requirement for diabetes and how Nepalese food culture in particular influenced diet management. Interviews were conducted with Nepalese participants with type 2 diabetes in Sydney and Kathmandu; and data was thematically analysed. Diet was recognized as a cause of, and a key treatment modality, in diabetes. Besides doctors, participants in Nepal received a large amount of dietary information from the community. Dietary changes formed a major component of lifestyle modifications adopted after diagnosis, and mostly consisted of removal of foods with added sugar and foods with high total sugar content from the diet, and a reduction in overall quantity of foods consumed. Perceived dietary restriction requirements created social and emotional discomfort to patients. Most participants perceived the Nepalese food culture as a barrier to effective diet management. Meals high in carbohydrates, limited food choices, and food preparation methods were identified as barriers, particularly in Nepal. In Australia, participants reported greater availability and easier access to appropriate food, and healthier cooking options. The socio-cultural aspects of food behaviour, mainly, food practices during social events were identified as significant barriers. Although diet was acknowledged as an important component of diabetes care, and most adopted changes in their diet post-diagnosis, effective and sustained changes were difficult to achieve. Future public health campaigns and education strategies should focus on improving diet knowledge, awareness of food options for diabetes, and effective dietary management.
Assuntos
Cultura , Diabetes Mellitus Tipo 2/dietoterapia , Dieta para Diabéticos/etnologia , Comportamento Alimentar/etnologia , Percepção , Adulto , Idoso , Idoso de 80 Anos ou mais , Austrália , Diabetes Mellitus Tipo 2/etnologia , Diabetes Mellitus Tipo 2/psicologia , Dieta para Diabéticos/psicologia , Comportamento Alimentar/psicologia , Feminino , Preferências Alimentares/etnologia , Preferências Alimentares/psicologia , Humanos , Masculino , Pessoa de Meia-Idade , Nepal/etnologia , Cooperação do Paciente/etnologia , Cooperação do Paciente/psicologia , Pesquisa Qualitativa , Adulto JovemRESUMO
This study evaluated the efficacy and safety of 26 weeks of twice-daily (BID) alogliptin + metformin fixed-dose combination (FDC) therapy in Asian patients with type 2 diabetes. Patients aged 18 to 75 years with hemoglobin A1c (HbA1c) of 7.5% to 10.0% after ≥2 months of diet and exercise and a 4-week placebo run-in were enrolled. Eligible patients were randomized (1:1:1:1) to placebo, alogliptin 12.5 mg BID, metformin 500 mg BID or alogliptin 12.5 mg plus metformin 500 mg FDC BID. The primary endpoint was change in HbA1c from baseline to end of treatment (Week 26). In total, 647 patients were randomized. The least-squares mean change in HbA1c from baseline to Week 26 was -0.19% with placebo, -0.86% with alogliptin, -1.04% with metformin and -1.53% with alogliptin + metformin FDC. Alogliptin + metformin FDC was significantly more effective ( P < .0001) in lowering HbA1c than either alogliptin or metformin alone. The safety profile of alogliptin + metformin FDC was similar to that of the individual components alogliptin and metformin. The study demonstrated that treatment with alogliptin + metformin FDC BID resulted in better glycaemic control than either monotherapy and was well tolerated in Asian patients with type 2 diabetes.
Assuntos
Diabetes Mellitus Tipo 2/tratamento farmacológico , Inibidores da Dipeptidil Peptidase IV/uso terapêutico , Hiperglicemia/prevenção & controle , Hipoglicemia/prevenção & controle , Hipoglicemiantes/uso terapêutico , Metformina/uso terapêutico , Piperidinas/uso terapêutico , Uracila/análogos & derivados , China/epidemiologia , Terapia Combinada/efeitos adversos , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/etnologia , Diabetes Mellitus Tipo 2/terapia , Dieta para Diabéticos/etnologia , Inibidores da Dipeptidil Peptidase IV/efeitos adversos , Quimioterapia Combinada/efeitos adversos , Exercício Físico , Hemoglobinas Glicadas/análise , Humanos , Hiperglicemia/epidemiologia , Hipoglicemia/induzido quimicamente , Hipoglicemia/epidemiologia , Hipoglicemiantes/efeitos adversos , Imunidade nas Mucosas/efeitos dos fármacos , Incidência , Malásia/epidemiologia , Metformina/efeitos adversos , Pessoa de Meia-Idade , Piperidinas/efeitos adversos , República da Coreia/epidemiologia , Infecções Respiratórias/epidemiologia , Infecções Respiratórias/imunologia , Taiwan/epidemiologia , Uracila/efeitos adversos , Uracila/uso terapêuticoRESUMO
BACKGROUND & AIMS: The usefulness of low-carbohydrate diet (LCD) for Japanese patients with type 2 diabetes mellitus (T2DM) has not been fully investigated. Therefore, we compared the effectiveness and safety of LCD with calorie restricted diet (CRD). METHODS: This prospective, randomized, open-label, comparative study included 66 T2DM patients with HbA1c >7.5% even after receiving repeated education programs on CRD. They were randomly allocated to either the 130g/day LCD group (n = 33) or CRD group (n = 33). Patients received personal nutrition education of CRD or LCD for 30 min at baseline, 1, 2, 4, and 6 months. Patients of the CRD group were advised to maintain the intake of calories and balance of macronutrients (28× ideal body weight calories per day). Patients of the LCD group were advised to maintain the intake of 130 g/day carbohydrate without other specific restrictions. Several parameters were assessed at baseline and 6 months after each intervention. The primary endpoint was a change in HbA1c level from baseline to the end of the study. RESULTS: At baseline, BMI and HbA1c were 26.5 (24.6-30.1) and 8.3 (8.0-9.3), and 26.7 (25.0-30.0) kg/m2 and 8.0 (7.6-8.9) %, in the CRD and LCD, respectively. At the end of the study, HbA1c decreased by -0.65 (-1.53 to -0.10) % in the LCD group, compared with 0.00 (-0.68 to 0.40) % in the CRD group (p < 0.01). Also, the decrease in BMI in the LCD group [-0.58 (-1.51 to -0.16) kg/m2] exceeded that observed in the CRD group (p = 0.03). CONCLUSIONS: Our study demonstrated that 6-month 130 g/day LCD reduced HbA1c and BMI in poorly controlled Japanese patients with T2DM. LCD is a potentially useful nutrition therapy for Japanese patients who cannot adhere to CRD. This trial was registered at http://www.umin.ac.jp/english/ (University Hospital Medical Information Network: study ID number 000010663).
Assuntos
Diabetes Mellitus Tipo 2/dietoterapia , Dieta com Restrição de Carboidratos , Dieta para Diabéticos , Hiperglicemia/prevenção & controle , Hipoglicemia/prevenção & controle , Cooperação do Paciente , Medicina de Precisão , Idoso , Índice de Massa Corporal , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/etnologia , Dieta com Restrição de Carboidratos/etnologia , Dieta para Diabéticos/etnologia , Dieta Redutora/etnologia , Ingestão de Energia/etnologia , Feminino , Seguimentos , Hemoglobinas Glicadas/análise , Humanos , Japão , Masculino , Pessoa de Meia-Idade , Ciências da Nutrição/educação , Sobrepeso/sangue , Sobrepeso/complicações , Sobrepeso/dietoterapia , Sobrepeso/etnologia , Cooperação do Paciente/etnologia , Educação de Pacientes como Assunto , Redução de Peso/etnologiaRESUMO
BACKGROUND: Eggs are a major source of dietary cholesterol and their consumption has been sometimes discouraged. A relationship between egg consumption and the incidence of cardiovascular disease (CVD) has been suggested to be present exclusively among patients with type2 diabetes. AIMS: To assess the association between egg consumption and CVD in a large Mediterranean cohort where approximately 50% of participants had type 2 diabetes. METHODS: We prospectively followed 7216 participants (55-80 years old) at high cardiovascular risk from the PREDIMED (PREvención con DIeta MEDiterránea) study for a mean of 5.8 years. All participants were initially free of CVD. Yearly repeated measurements of dietary information with a validated 137-item food-frequency questionnaire were used to assess egg consumption and other dietary exposures. The endpoint was the rate of major cardiovascular events (myocardial infarction, stroke or death from cardiovascular causes). RESULTS: A major cardiovascular event occurred in 342 participants. Baseline egg consumption was not significantly associated with cardiovascular events in the total population. Non-diabetic participants who ate on average >4 eggs/week had a hazard ratio (HR) of 0.96 (95% confidence interval, 0.33-2.76) in the fully adjusted multivariable model when compared with non-diabetic participants who reported the lowest egg consumption (<2 eggs/week). Among diabetic participants, the HR was 1.33 (0.72-2.46). There was no evidence of interaction by diabetic status. HRs per 500 eggs of cumulative consumption during follow-up were 0.94 (0.66-1.33) in non-diabetics and 1.18 (0.90-1.55) in diabetics. CONCLUSIONS: Low to moderated egg consumption was not associated with an increased CVD risk in diabetic or non-diabetic individuals at high cardiovascular risk. This trial was registered at controlled-trials.com as ISRCTN35739639.
Assuntos
Doenças Cardiovasculares/prevenção & controle , Diabetes Mellitus Tipo 2/dietoterapia , Angiopatias Diabéticas/prevenção & controle , Cardiomiopatias Diabéticas/prevenção & controle , Dieta Mediterrânea , Ovos/efeitos adversos , Cooperação do Paciente , Idoso , Idoso de 80 Anos ou mais , Doenças Cardiovasculares/complicações , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/etiologia , Estudos de Coortes , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/etnologia , Angiopatias Diabéticas/epidemiologia , Angiopatias Diabéticas/etnologia , Angiopatias Diabéticas/etiologia , Cardiomiopatias Diabéticas/epidemiologia , Cardiomiopatias Diabéticas/etnologia , Cardiomiopatias Diabéticas/etiologia , Dieta para Diabéticos/efeitos adversos , Dieta para Diabéticos/etnologia , Dieta com Restrição de Gorduras/efeitos adversos , Dieta com Restrição de Gorduras/etnologia , Dieta Mediterrânea/efeitos adversos , Dieta Mediterrânea/etnologia , Feminino , Seguimentos , Nível de Saúde , Humanos , Incidência , Masculino , Região do Mediterrâneo/epidemiologia , Pessoa de Meia-Idade , Cooperação do Paciente/etnologia , Modelos de Riscos Proporcionais , Estudos Prospectivos , Fatores de Risco , AutorrelatoRESUMO
OBJECTIVE: To investigate dietary perceptions of adults with prediabetes and type 2 diabetes. METHODS: Three discussion groups (n = 12) were conducted to investigate how participants source dietary information and evaluate the healthfulness of foods. Participants were men and women with prediabetes or type 2 diabetes. White board notes were photographed and audio recordings transcribed. Codes were applied and themes generated using an inductive approach. RESULTS: Four themes emerged: (1) perception of food components, (2) factors perceived to influence the healthfulness of foods, (3) perceptions of dietary information, and (4) challenges to forming accurate perceptions. Participants perceived the healthfulness of food to be influenced largely by carbohydrates, fat, and sugar. CONCLUSIONS AND IMPLICATIONS: Perception of the healthfulness of food varied among participants and at times was contrary to dietary guidelines. Participants were wary of dietary advice and sought consistent, reliable, and up-to-date sources of information to guide food choices.
Assuntos
Diabetes Mellitus Tipo 2/dietoterapia , Dieta para Diabéticos , Dieta Saudável , Rotulagem de Alimentos , Alimentos em Conserva/efeitos adversos , Conhecimentos, Atitudes e Prática em Saúde , Estado Pré-Diabético/dietoterapia , Adulto , Idoso , Informação de Saúde ao Consumidor , Diabetes Mellitus Tipo 2/economia , Diabetes Mellitus Tipo 2/etnologia , Dieta para Diabéticos/economia , Dieta para Diabéticos/etnologia , Dieta Saudável/economia , Dieta Saudável/etnologia , Feminino , Grupos Focais , Alimentos em Conserva/análise , Conhecimentos, Atitudes e Prática em Saúde/etnologia , Humanos , Internet , Masculino , Pessoa de Meia-Idade , Avaliação das Necessidades , Nova Zelândia , Valor Nutritivo , Projetos Piloto , Estado Pré-Diabético/economia , Estado Pré-Diabético/etnologia , Pesquisa Qualitativa , Adulto JovemRESUMO
OBJECTIVE: To investigate the prevalence of depression symptoms among Latinos with diabetes following transition from hospital to home and the relationship of depressive symptoms to diabetes symptom severity and self-management activities. METHODS: 203 Latino patients with diagnosed diabetes completed a survey assessing depressive symptoms (PHQ-9), diabetes symptom severity, and diabetes self-management activities (SDSCA). Characteristics and diabetes outcomes between patients with and without probable major depression were compared. Associations between PHQ-9 scores and diabetes outcomes were assessed. Multivariate regression models evaluated the relationship between depressive symptoms and diabetes outcomes and exercise after controlling for patient characteristics. RESULTS: 31.5% of participants indicated probable major depression (PHQ-9≥10). More severe diabetes symptoms and less reported exercise were associated with higher PHQ-9 scores. Regression models showed no relationship between self-management and depression. More severe diabetes symptoms were significantly associated with being female, married, and having probable major depression. Odds of exercising were reduced by 6% for every one-unit increase in PHQ-9 score. CONCLUSIONS: The prevalence of probable depressive symptoms is high in this population. Having depressive symptoms is an indicator of poorer diabetes symptoms. Screening for depressive symptoms may help identify individuals who need additional support with diabetes symptom and self-management.
Assuntos
Depressão/epidemiologia , Transtorno Depressivo Maior/epidemiologia , Diabetes Mellitus Tipo 2/psicologia , Autocuidado , Saúde da População Urbana , Terapia Combinada/psicologia , Depressão/complicações , Depressão/etnologia , Transtorno Depressivo Maior/complicações , Transtorno Depressivo Maior/etnologia , Diabetes Mellitus Tipo 2/etnologia , Diabetes Mellitus Tipo 2/fisiopatologia , Diabetes Mellitus Tipo 2/terapia , Dieta para Diabéticos/etnologia , Dieta para Diabéticos/psicologia , Exercício Físico/psicologia , Feminino , Hispânico ou Latino , Humanos , Los Angeles/epidemiologia , Masculino , Pessoa de Meia-Idade , Política Nutricional , Cooperação do Paciente/etnologia , Cooperação do Paciente/psicologia , Pobreza/etnologia , Pobreza/psicologia , Prevalência , Estudos Retrospectivos , Risco , Autocuidado/psicologia , Índice de Gravidade de Doença , Cônjuges/etnologia , Cônjuges/psicologia , Saúde da População Urbana/etnologiaRESUMO
AIM: This pilot study evaluated the short-term benefits of a telemonitoring-supplemented focused diabetic education compared with education alone in participants with Type 2 diabetes who were fasting during Ramadan. METHODS: In this pilot mixed-method study, we identified 37 participants and randomly allocated them to either a telemonitoring group (n = 18) or a group receiving Ramadan-focused pre-education only (usual care; n = 19). The telemonitoring group received goal-setting and personalized feedback. RESULTS: The telemonitoring group was less likely to experience hypoglycaemia than the usual care group (odds ratio: 0.1273; 95% confidence interval: 0.0267-0.6059). No significant differences were noted in glycaemic control at the end of study. Participants viewed telemedicine as a more convenient alternative although technological barriers remain a concern. CONCLUSIONS: The results of this study reinforce the need for monitoring as well as educational initiatives for Muslims with diabetes who fast during Ramadan. Telemonitoring offers an attractive option requiring further research. (Clinical Trial Registry No. NCT02189135).
Assuntos
Diabetes Mellitus Tipo 2/dietoterapia , Dieta para Diabéticos/efeitos adversos , Jejum/efeitos adversos , Hipoglicemia/prevenção & controle , Educação de Pacientes como Assunto , Medicina de Precisão , Telemedicina , Adolescente , Adulto , Idoso , Aniversários e Eventos Especiais , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/etnologia , Dieta para Diabéticos/etnologia , Retroalimentação Psicológica , Objetivos , Humanos , Hipoglicemia/epidemiologia , Hipoglicemia/etiologia , Islamismo , Malásia/epidemiologia , Pessoa de Meia-Idade , Cooperação do Paciente/etnologia , Preferência do Paciente , Projetos Piloto , Risco , Adulto JovemRESUMO
AIM: The aim of this study was to explore and compare medication-taking experiences and associated issues in Arabic-speaking and Caucasian English-speaking patients with Type 2 diabetes in Australia. METHODS: Various healthcare settings in metropolitan Melbourne, Australia, were purposefully selected to obtain a diverse group of participants with Type 2 diabetes. Recruitment occurred at diabetes outpatient clinics in two tertiary referral hospitals, six primary care practices and ten community centres. Face-to-face semi-structured individual interviews and group interviews were employed. All interviews were audiotaped, transcribed and coded thematically. Data collection continued until saturation was reached. RESULTS: In total, 100 participants were recruited into two groups: 60 were Arabic-speaking and 40 were Caucasian English-speaking. Both groups had similar demographic and clinical characteristics. Only 5% of the Arabic-speaking participants had well-controlled diabetes compared with 17.5% of the participants in the English-speaking group. Arabic-speaking participants actively changed medication regimens on their own without informing their healthcare professionals. Arabic-speaking patients had more knowledge gaps about their prescribed treatments, compared with the English-speaking group. Their use of diabetes medicines was heavily influenced by peers with diabetes and family members; conversely, they feared revealing their diagnosis within the wider Arabic community due to stigma and collective negative social labelling of diabetes. Confidence in non-Arabic-speaking healthcare providers was lacking. CONCLUSIONS: Findings yielded new insights into medication-taking practices and associated factors in Arabic-speaking patients with diabetes. It is vital that healthcare professionals working with Arabic-speaking patients adapt their treatment approaches to accommodate different beliefs and views about medicines.
Assuntos
Barreiras de Comunicação , Diabetes Mellitus Tipo 2/tratamento farmacológico , Emigrantes e Imigrantes , Hipoglicemiantes/uso terapêutico , Insulina/uso terapêutico , Automedicação , Saúde da População Urbana , Árabes , Terapia Combinada , Diabetes Mellitus Tipo 2/dietoterapia , Diabetes Mellitus Tipo 2/etnologia , Diabetes Mellitus Tipo 2/terapia , Dieta para Diabéticos/etnologia , Relações Familiares/etnologia , Feminino , Grupos Focais , Conhecimentos, Atitudes e Prática em Saúde/etnologia , Humanos , Masculino , Pessoa de Meia-Idade , Atividade Motora , Cooperação do Paciente/etnologia , Influência dos Pares , Relações Profissional-Paciente , Pesquisa Qualitativa , Saúde da População Urbana/etnologia , Vitória , População BrancaRESUMO
Intuitive eating programs that improve self-efficacy and dietary habits could enhance glycemic control in African-American women with type 2 diabetes. The goal of our study was to investigate how current eating practices and beliefs of African-American women living with diabetes aligned with intuitive eating concepts. African-American women with type 2 diabetes referred for diabetes education class during 2009-2012 were recruited for a qualitative study using focus groups for data collection. Verbatim group transcriptions were analyzed by two independent reviewers for themes using a combined inductive-deductive approach. Participants (n=35) had an average age 52±9 years, mean body mass index 39±7, and mean time with a type 2 diabetes diagnosis of 10±10 years. Participants' self-reported dietary practices were poorly aligned with intuitive eating concepts. The women reported a lack of self-control with food and regularly eating in the absence of hunger, yet stated that the determinant factor for when to stop eating was to recognize a feeling of fullness. Participants reported knowing they were full when they felt physically uncomfortable or actually became sick. Women frequently cited the belief that individuals with diabetes have to follow a different diet than that recommended for the general public. Many women also discussed diabetes-related stigma from family/friends, and often did not tell others about their diabetes diagnosis. These findings demonstrate that intuitive eating techniques are not currently applied by the women in this sample. Future studies should assess the influence of intuitive eating interventions on dietary habits among low-income African-American women with type 2 diabetes.
Assuntos
Diabetes Mellitus Tipo 2/dietoterapia , Dieta para Diabéticos , Comportamento Alimentar , Intuição , Cooperação do Paciente , Negro ou Afro-Americano , Alabama , Atitude Frente a Saúde , Índice de Massa Corporal , Estudos de Coortes , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/etnologia , Dieta para Diabéticos/etnologia , Dieta Redutora/etnologia , Comportamento Alimentar/etnologia , Feminino , Grupos Focais , Seguimentos , Humanos , Hiperfagia/fisiopatologia , Hiperfagia/prevenção & controle , Refeições , Pessoa de Meia-Idade , Obesidade/complicações , Obesidade/dietoterapia , Obesidade/etnologia , Obesidade/etiologia , Cooperação do Paciente/etnologia , Estigma SocialRESUMO
OBJECTIVE: To describe the knowledge, attitudes and practices of type 2 diabetics in Yakeshi City and to assess the effect of implementation of nutritional and eating education in enhancing knowledge and practices regarding a healthy diet. DESIGN: A questionnaire-based survey was conducted with 162 diabetics to determine their nutrition knowledge, attitudes and practices; fifty-four participants received nutritional and eating education for 6 months. Diabetes-related nutrition knowledge, awareness, practice accuracy, dietary intake and glycaemic control were assessed before and after education. SETTING: Yakeshi, a remote city in northern China. SUBJECTS: A total of 162 type 2 diabetics recruited from three hospitals, fifty-four of whom were selected randomly to receive education. RESULTS: Among the 162 respondents, most diabetics (75%) considered that controlling diet was important in the methods of controlling blood glucose. Scores for knowledge, practices and overall KAP (knowledge-attitude-practice) were low, but scores for attitude were high. Participants with diabetes education experiences, practice duration over 1 year or high education level all had higher scores for KAP (P < 0·001, P < 0·05 and P < 0·001, respectively) than their counterparts. After education, patients' nutrition knowledge, awareness and practice accuracy improved significantly (P < 0·05). The rates of patients with recommended daily intake of vegetables, grains and dairy were boosted (P < 0·05). Various nutrient intakes increased (P < 0·05) but not protein, Fe, Zn and Se. Significant improvements were also found in glycaemic control (P < 0·05). CONCLUSIONS: Diabetics in Yakeshi had positive attitudes, but relatively poor nutrition knowledge and practices. Nutritional and eating education was effective in improving diabetics' nutrition knowledge and practices, and this optimal practice helped them control blood glucose effectively.