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1.
Tunis Med ; 102(9): 595-599, 2024 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-39287355

RESUMO

INTRODUCTION: Echinococcosis is a relatively widespread anthropozoonosis in endemic regions, preferentially affecting the liver and lungs. Although rare, it can sometimes be localized in the muscles. The clinical symptoms are insidious and not very indicative, often leading to a delayed diagnosis. We reported a case of a hydatid cyst located in the gluteal muscle. OBSERVATION: This was a 52-year-old female patient admitted for the appearance of a swelling in the left buttock region, progressively increasing in size. The radiological exam, revealed a large simple cyst originating from the gluteal muscle with purely liquid content. A surgical excision was performed, and the parasitological examination of the hydatid fluid confirmed the diagnosis. CONCLUSION: Hydatid cysts in soft tissues are rare, slow-developing tumors with local extension. This diagnosis should be considered, especially in individuals from endemic countries. The treatment is primarily surgical, but the best way to combat hydatid disease, regardless of its location, remains prevention.


Assuntos
Equinococose , Doenças Musculares , Humanos , Equinococose/diagnóstico , Equinococose/cirurgia , Feminino , Pessoa de Meia-Idade , Nádegas/parasitologia , Doenças Musculares/parasitologia , Doenças Musculares/diagnóstico , Doenças Musculares/cirurgia , Músculo Esquelético/parasitologia , Músculo Esquelético/patologia , Músculo Esquelético/cirurgia
2.
Acta Orthop Traumatol Turc ; 58(2): 135-139, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-39128070

RESUMO

 Calcific myonecrosis (CM), a rare post-traumatic sequel of the lower limb, is characterized by calcified lesions. A diagnosis of CM can be difficult owing to the longtime span from the emergence of the original trauma to the onset of the symptoms of CM. This case report aimed to feature a case of a 55-year-old gentleman who presented with a progressive painful swelling in the anterolateral aspect of the right lower leg with the initial trauma arising 11 years ago. In the conservative treatment, a fluid-filled mass was formed. The histological examination of the biopsy suggested a diagnosis of CM. The patient underwent a complete debridement operation, after which vacuum sealing drainage was used to manage the space left. Three weeks later, direct wound closure was achieved. Five-year follow-ups showed an excellent outcome without recurrence. Complete surgical debridement combined with primary closure is recommended to manage CM. Cite this article as: Wang C, Hao D, Wang S. Management of calcific myonecrosis using vacuum sealing drainage: A rare case report and 5-year follow-up. Acta Orthop Traumatol Turc., 2024;58(2):135-139.


Assuntos
Calcinose , Desbridamento , Drenagem , Necrose , Humanos , Masculino , Pessoa de Meia-Idade , Desbridamento/métodos , Necrose/cirurgia , Calcinose/cirurgia , Drenagem/métodos , Tratamento de Ferimentos com Pressão Negativa/métodos , Seguimentos , Músculo Esquelético/cirurgia , Doenças Musculares/cirurgia , Doenças Musculares/etiologia , Doenças Musculares/diagnóstico
3.
Skeletal Radiol ; 53(12): 2735-2740, 2024 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38528142

RESUMO

Endometriosis is a disorder that commonly affects females of reproductive age and is defined as the presence of endometrial glands or stroma outside the uterine cavity. Patients typically present with cyclical pain during menses. Endometriosis can be characterized as endopelvic or extrapelvic depending on the sites involved. We report a case of a 40-year-old, right-hand-dominant, female who presented with a painful mass in her right proximal forearm. She was ultimately diagnosed with intramuscular endometriosis and underwent surgical excision.


Assuntos
Endometriose , Antebraço , Imageamento por Ressonância Magnética , Humanos , Feminino , Endometriose/diagnóstico por imagem , Endometriose/cirurgia , Adulto , Antebraço/diagnóstico por imagem , Antebraço/cirurgia , Diagnóstico Diferencial , Doenças Musculares/diagnóstico por imagem , Doenças Musculares/cirurgia
4.
Ophthalmic Plast Reconstr Surg ; 40(1): 104-108, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38241622

RESUMO

PURPOSE: The authors report a technique of local application of anti-metabolite and corticosteroid mixture in the orbit for treatment of thyroid orbitopathy with moderate-severe inflammation and muscle involvement. METHODS: Patients of one orbital surgeon seen between March 2019 and May 2020 with active thyroid eye disease and restrictive strabismus were considered for local treatment of the myopathic component of the disease. A mixture of 1 ml 5-FU 50 mg/ml, 0.25 ml triamcinolone 40 mg/ml, and 1 ml lidocaine 2% is injected through the skin using a 25-gauge, 1.5-inch needle into the orbit adjacent to the affected extraocular muscle. Six patients were treated in the outpatient setting and 3 patients have been treated with this intervention intraoperatively at the time of orbital decompression. One was treated with the mixture reconstituted with hyaluronic acid (Healon GV) to address postoperative medial rectus fibrosis to the medial wall, this mixture was applied topically in the operative field and not injected. RESULTS: All patients had subjective improvement in the eye movement limitation and 2 patients had a change in motility on exam that was temporally correlated to injections. One patient did not disclose high-dose aspirin intake before injection and experienced a retrobulbar hemorrhage immediately following injection which was successfully treated. No complications were noted as a result of the medication itself. DISCUSSION: The combination of 5-fluorouracil and triamcinolone acetonide for orbital treatment may be a useful adjunct in treating patients with ongoing inflammatory activity, both in the office and in the operating room. The novel combination may optimize ophthalmic outcomes, modifying disease course in some patients.


Assuntos
Oftalmopatia de Graves , Doenças Musculares , Humanos , Triancinolona Acetonida , Oftalmopatia de Graves/complicações , Oftalmopatia de Graves/tratamento farmacológico , Oftalmopatia de Graves/induzido quimicamente , Glucocorticoides , Órbita/cirurgia , Doenças Musculares/induzido quimicamente , Doenças Musculares/tratamento farmacológico , Doenças Musculares/cirurgia , Descompressão Cirúrgica
5.
Heart Lung Circ ; 32(10): 1198-1206, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-37634968

RESUMO

BACKGROUND: Atrial myopathy may underlie the progression of atrial fibrillation (AF) from a treatable disease to an irreversible condition with poor ablation outcomes. Electrophysiological methods to unmask areas prone to re-entry initiation could be key to defining latent atrial myopathy. METHODS: Consecutive patients referred for AF ablation were prospectively included at four institutions. Decrement evoked potential mapping (DEEP) was performed in eight left atrial sites and five right atrial sites, from two different pacing locations (endocardially from the left atrial appendage, epicardially from the proximal coronary sinus). The electrograms (EGMs) during S1 600 ms drive and after an extra stimulus (S2 at +30 ms above atrial refractoriness) were studied at each location and assessed for decremental properties. Follow-up was 12 months. RESULTS: Seventy-four patients were included and 85% had persistent AF. A total of 17,614 EGMs were individually analysed and measured. Nine percent of the EGMs showed DEEP properties (local delay of >10 ms after S2) with a mean decrement of 33±26 ms. DEEPs were more frequent in the left atrium than the right atrium (9.4% vs 8.0%; p<0.001) and more prevalent in persistent AF patients than paroxysmal AF patients (9.8% vs 4.6% p=0.001). Atrial DEEPs were more frequently unmasked in normal bipolar voltage areas and by epicardial pacing than endocardial pacing (9.6% vs 8.4%, respectively; p=0.004). Within the left atrium, the roof had the highest prevalence of DEEP EGMs. CONCLUSIONS: DEEP mapping of both atria is useful for highlighting areas with a tendency for unidirectional block and re-entry initiation. Those areas are more easily unmasked by epicardial pacing from the coronary sinus and more prevalent in persistent AF patients than in paroxysmal AF patients.


Assuntos
Apêndice Atrial , Fibrilação Atrial , Ablação por Cateter , Doenças Musculares , Humanos , Átrios do Coração , Apêndice Atrial/cirurgia , Doenças Musculares/cirurgia , Potenciais Evocados
6.
J Orthop Sci ; 28(4): 821-828, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35490080

RESUMO

BACKGROUND: Multiple techniques have been developed for the repair of acute quadriceps and patellar tendon ruptures with the goal of optimizing clinical outcomes while minimizing complications and costs. The purpose of this study was to evaluate the biomechanical properties of transosseous tunnels and suture anchors for the repair of quadriceps and patellar tendon ruptures. METHODS: A systematic review of the PubMed and Embase databases was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines using specific search terms and eligibility criteria. Meta-analysis was performed by fixed-effects models for studies of low heterogeneity (I2 <25%) and random-effects models for studies of moderate to high heterogeneity (I2 ≥25%). RESULTS: A total of 392 studies were identified from the initial literature search with 7 studies meeting the eligibility criteria for quadriceps tendon repair and 8 studies meeting the eligibility criteria for patellar tendon repair. Based on the random-effects model for total gap formation and load to failure for quadriceps tendon repair, the mean difference was 8.88 mm (95% CI, -8.31 mm to 26.06 mm; p = 0.31) in favor of a larger gap with transosseous tunnels and -117.25N (95%CI, -242.73N to 8.23N; p = 0.07) in favor of a larger load to failure with suture anchors. A similar analysis for patellar tendon repair demonstrated a mean difference of 2.86 mm (95% CI, 1.08 mm to 4.64 mm; p = 0.002) in favor of a larger gap with transosseous tunnels and -56.34N (95% CI, -226.75 to 114.07N; p = 0.52) in favor of a larger load to failure with suture anchor repair. CONCLUSIONS: Transosseous tunnels are biomechanically similar to suture anchors for quadriceps tendon repair. Patellar tendon repair may benefit from reduced gap formation after cycling with suture anchor repair, but the load to failure for both techniques is biomechanically similar. Additional studies are necessary to evaluate these and alternative repair techniques. LEVEL OF EVIDENCE: Systematic review and meta-analysis of biomechanical studies, Level V.


Assuntos
Traumatismos do Joelho , Doenças Musculares , Ligamento Patelar , Traumatismos dos Tendões , Humanos , Âncoras de Sutura , Ligamento Patelar/cirurgia , Técnicas de Sutura , Fenômenos Biomecânicos , Traumatismos dos Tendões/cirurgia , Traumatismos do Joelho/cirurgia , Doenças Musculares/cirurgia , Cadáver
7.
Fertil Steril ; 118(6): 1194-1195, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-36369182

RESUMO

OBJECTIVE: To present different approaches used in the surgical management of diaphragmatic endometriosis using the Davinci Robotic system. DESIGN: A video article presenting patient positioning, port placement, and surgical techniques used in robotic excision of diaphragmatic endometriosis with concomitant pelvic disease. SETTING: Endometriosis center. PATIENT(S): Patients undergoing excision of diaphragmatic endometriosis. INTERVENTION(S): Systematic robotic approach to excise diaphragmatic lesions depending on the depth of invasion. MAIN OUTCOME MEASURES(S): The advantages and disadvantages of the lithotomy and the lateral decubitus approach were reviewed. Ports placements are illustrated according to the chosen approach. Diaphragmatic peritoneal stripping, diaphragmatic shaving, and diaphragmatic excision are different techniques used according to the depth of invasion. RESULTS(S): N/A. CONCLUSION(S): The choice of approach between the lithotomy position and the left lateral decubitus position depend on the extent of the diaphragmatic disease and the presence of concomitant pelvic lesions. Despite the lack of high-quality evidence, the advantages of the robotic system may improve the outcomes in such difficult cases in comparison with conventional laparoscopy.


Assuntos
Endometriose , Laparoscopia , Doenças Musculares , Procedimentos Cirúrgicos Robóticos , Feminino , Humanos , Endometriose/complicações , Endometriose/diagnóstico , Endometriose/cirurgia , Diafragma/cirurgia , Diafragma/patologia , Laparoscopia/efeitos adversos , Laparoscopia/métodos , Doenças Musculares/complicações , Doenças Musculares/patologia , Doenças Musculares/cirurgia , Pelve , Procedimentos Cirúrgicos Robóticos/efeitos adversos
8.
Pan Afr Med J ; 42: 242, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36303823

RESUMO

Endometriosis of the rectus abdominis muscle is an extremely rare form of extrapelvic localization of the disease. It is usually iatrogenic and develops after caesarean section or gynecological surgery. Preoperative diagnosis is very difficult and a challenge for gynecologists and surgeons; thus, the diagnosis is histological. The treatment of choice consists of wide local excision of the lesion on healthy margins. We cite a case of isolated endometriosis in the rectus abdominis muscles in a 46-year-old patient with a previous caesarean section, the diagnosis of which was made randomly when performing abdominal total hysterectomy for the treatment of chronic pelvic pain. Histological examination of the surgical specimen confirmed the diagnosis. Simultaneously, the surgical specimen of the uterus and ovaries was free of endometriosis. Postoperatively, the patient mentioned discharge of her symptoms. No further therapeutic intervention was deemed necessary, as it was considered that a complete resection of the endometrial tissue implantation from the muscles of abdominal wall was performed. The present case report lay emphasis on the significant difficulties involved in the preoperative diagnosis of endometriosis of the rectus abdominis muscle. Concurrently, it is pointed out that, despite its rarity, individual extrapelvic endometriosis located in the rectus abdominis muscle should be included among other pathological entities in the differential diagnosis of chronic pelvic pain in women of reproductive age, who gave birth by caesarean section or underwent gynecological surgery with abdominal or laparoscopic access.


Assuntos
Dor Crônica , Endometriose , Doenças Musculares , Humanos , Feminino , Gravidez , Pessoa de Meia-Idade , Reto do Abdome/cirurgia , Reto do Abdome/patologia , Endometriose/complicações , Endometriose/diagnóstico , Endometriose/cirurgia , Cesárea/efeitos adversos , Doenças Musculares/diagnóstico , Doenças Musculares/etiologia , Doenças Musculares/cirurgia , Dor Pélvica/etiologia , Dor Crônica/etiologia
9.
Curr Opin Obstet Gynecol ; 34(4): 204-209, 2022 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-35895962

RESUMO

PURPOSE OF REVIEW: Thoracic endometriosis is a rare disease that can lead to a variety of clinical manifestations. There are currently no guidelines for optimal diagnosis and management of the disease. The purpose of this review is to provide an overview of the diagnosis and surgical treatment of thoracic endometriosis. RECENT FINDINGS: Various imaging modalities, including computed tomography (CT), MRI and ultrasound, have been reported in the detection of thoracic endometriosis. MRI is the most sensitive imaging study and may aid in preoperative planning. Histopathology of a biopsied lesion remains the gold standard for diagnosis. Surgical management of thoracic endometriosis may involve laparoscopy and/or thoracoscopy, and surgical planning should include preparation for single ventilation capability. A multidisciplinary approach involving a gynaecologic surgeon and thoracic surgeon may be considered. Repairing diaphragm defects and pleurodesis are shown to decrease recurrent symptoms. SUMMARY: Although optimal diagnostic testing remains uncertain, a high clinical suspicion for thoracic endometriosis is critical to ensure prompt diagnosis and treatment in order to prevent recurrent symptoms and progression to more serious sequalae. Minimally invasive surgical techniques are becoming increasingly utilized and allow for thorough evaluation and treatment of thoracic endometriosis.


Assuntos
Endometriose , Laparoscopia , Doenças Musculares , Diafragma/patologia , Diafragma/cirurgia , Endometriose/diagnóstico , Endometriose/patologia , Endometriose/cirurgia , Feminino , Humanos , Procedimentos Cirúrgicos Minimamente Invasivos , Doenças Musculares/cirurgia
10.
BMJ Case Rep ; 14(3)2021 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-33674300

RESUMO

Axial myopathies with paraspinal predominance usually present with dropped head, abnormal posture or rigidity of the spine. Management of axial myopathy can be difficult and there is little data in the literature about surgical treatment. We discuss a case of axial myopathy with late-onset scoliosis and dropped head, focusing on the surgical management of the case.


Assuntos
Doenças Musculares , Escoliose , Cabeça , Humanos , Doenças Musculares/diagnóstico , Doenças Musculares/cirurgia , Procedimentos Neurocirúrgicos , Escoliose/diagnóstico por imagem , Escoliose/cirurgia , Coluna Vertebral
11.
Anesth Analg ; 132(6): 1692-1699, 2021 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-33651572

RESUMO

BACKGROUND: The aim of this study was to explore the associations of preoperative sarcopenia (muscle mass depletion) and myosteatosis (muscle quality attenuation) with the incidence of postinduction hypotension (PIH) and postoperative complications among patients undergoing major gynecologic surgery. METHODS: Based on a previous prospective surgical registry of gynecologic patients, we included patients with an available preoperative abdominal computed tomography (CT) scan performed within 3 months before surgery. The cross-sectional muscle mass and density at the third lumbar vertebra (L3) level were measured from the CT scan. The primary outcome was PIH, which was defined as a blood pressure reduction >30% from baseline. The secondary outcome was postoperative complications based on the Clavien-Dindo classification. Multivariable logistic regression analyses were performed to identify the associations between the muscle parameters and outcomes. RESULTS: Of the 167 gynecologic surgical patients included in this study, the mean (standard deviation [SD]) age was 53.0 (12.2) years. Sarcopenia was present in 86 (51.5%) patients. Fifty-six (33.5%) patients experienced PIH, and 89 (53.3%) patients experienced different degrees of postoperative complications. Multivariable analysis showed that myosteatosis was significantly associated with an increased risk of PIH (odds ratio [OR] = 2.95, 95% confidence interval [CI], 1.24-7.04; P = .015), and sarcopenia was associated with an increased risk of postoperative complications (OR = 2.30; 95% CI, 1.16-4.57; P = .018). CONCLUSIONS: Muscle assessments using preoperative CT scans may help identify high-risk patients and determine perioperative management strategies among gynecologic patients.


Assuntos
Procedimentos Cirúrgicos em Ginecologia/efeitos adversos , Força Muscular/fisiologia , Doenças Musculares/diagnóstico por imagem , Doenças Musculares/cirurgia , Complicações Pós-Operatórias/diagnóstico por imagem , Adulto , Idoso , Estudos de Coortes , Feminino , Procedimentos Cirúrgicos em Ginecologia/tendências , Humanos , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/diagnóstico por imagem , Doenças Musculares/epidemiologia , Complicações Pós-Operatórias/epidemiologia , Estudos Prospectivos , Estudos Retrospectivos , Sarcopenia/diagnóstico por imagem , Sarcopenia/epidemiologia , Sarcopenia/cirurgia , Resultado do Tratamento
12.
Front Immunol ; 11: 595480, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33329585

RESUMO

Chronic tonsillitis has been attracted attention as a source of abnormal immune responses and a possible trigger of autoimmune diseases such as IgA nephritis, IgA vasculitis, palmoplantar pustulosis, psoriasis, rheumatoid arthritis, Behçet's disease, and myositis. Here we present the first report of anti-signal recognition particle antibody-associated necrotizing myopathy (anti-SRP myopathy) with IgA nephropathy and chronic tonsillitis in which the therapeutic response to intravenous immunoglobulin (IVIG) treatment was dramatically improved after tonsillectomy and accompanied by a rapid increase in ΔIgG, defined as the change in serum IgG levels 2 weeks after the start of IVIG treatment relative to pre-treatment levels. Moreover, serum anti-SRP antibody titers became undetectable after tonsillectomy even though the resected tonsils did not produce anti-SRP antibodies. Tonsillectomy should be considered when chronic tonsillitis is observed in patients with autoimmune diseases showing poor response to treatment, including anti-SRP myopathy.


Assuntos
Glomerulonefrite por IGA/cirurgia , Doenças Musculares/cirurgia , Partícula de Reconhecimento de Sinal/imunologia , Tonsilectomia , Tonsilite/cirurgia , Doença Crônica , Feminino , Glomerulonefrite por IGA/tratamento farmacológico , Humanos , Imunoglobulinas Intravenosas/uso terapêutico , Pessoa de Meia-Idade , Doenças Musculares/tratamento farmacológico , Tonsilite/tratamento farmacológico
13.
An Sist Sanit Navar ; 43(3): 405-409, 2020 12 22.
Artigo em Inglês | MEDLINE | ID: mdl-33275125

RESUMO

We present the case of a 14-year-old female patient with a big muscle hernia in the thigh after extraction of a fascia lata strip to repair bilateral congenital ptosis. After three weeks, a progressive emergence of a large bulge between the two thigh incisions in a standing position was noticeable, with local discomfort, dull pain on exertion and unsightly ap-pearance that worried the patient. On surgery three months later, a large tear in the fascia lata and muscle herniation was revealed. The fascial tear was debrided and a synthetic mesh was applied. Ten years later, the patient confirmed her continued asymptomatic condition. Muscular hernia of significant size as a consequence of a fascia lata strip harvest is extremely infrequent in adoles-cents. Surgical repair of big muscular hernias in extremities with synthetic mesh, usually used in groin hernia repair, is an infrequent orthopaedic tool but is safe, easy to apply and inexpensive.


Assuntos
Doenças Musculares , Telas Cirúrgicas , Coxa da Perna/cirurgia , Adolescente , Feminino , Hérnia , Humanos , Músculos , Doenças Musculares/cirurgia
14.
Sci Rep ; 10(1): 17410, 2020 10 15.
Artigo em Inglês | MEDLINE | ID: mdl-33060848

RESUMO

The present study assessed test-retest and inter-observer reliability of diffusion tensor imaging (DTI) in cervical spondylotic myelopathy (CSM), as well as the agreement among measurement methods. A total 34 patients (12 men, 22 women; mean age, 58.7 [range 45-79] years) who underwent surgical decompression for CSM, with pre-operative DTI scans available, were retrospectively enrolled. Four observers independently measured fractional anisotropy (FA) values twice, using three different measurement methods. Test-retest and inter-observer reliability was assessed using intraclass correlation coefficients (ICCs). Overall, inter-observer agreements varied according to spinal cord level and the measurement methods used, and ranged from poor to excellent agreement (ICC = 0.374-0.821), with relatively less agreement for the sagittal region of interest (ROI) method. The radiology resident and neuro-radiologist group showed excellent test-retest reliability at almost every spinal cord level (ICC = 0.887-0.997), but inter-observer agreements varied from fair to good (ICC = 0.404-0.747). Despite excellent test-retest reliability of the ROI measurements, FA measurements in patients with CSM varied widely in terms of inter-observer reliability. Therefore, DTI parameter data should be interpreted carefully when applied clinically.


Assuntos
Vértebras Cervicais/diagnóstico por imagem , Imagem de Tensor de Difusão/normas , Doenças Musculares/diagnóstico por imagem , Espondilose/diagnóstico por imagem , Idoso , Vértebras Cervicais/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Musculares/cirurgia , Reprodutibilidade dos Testes , Espondilose/cirurgia
15.
PLoS One ; 15(9): e0239152, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32956427

RESUMO

Volumetric muscle loss (VML) is the loss of skeletal muscle that results in significant and persistent impairment of function. The unique characteristics of craniofacial muscle compared trunk and limb skeletal muscle, including differences in gene expression, satellite cell phenotype, and regenerative capacity, suggest that VML injuries may affect craniofacial muscle more severely. However, despite these notable differences, there are currently no animal models of craniofacial VML. In a previous sheep hindlimb VML study, we showed that our lab's tissue engineered skeletal muscle units (SMUs) were able to restore muscle force production to a level that was statistically indistinguishable from the uninjured contralateral muscle. Thus, the goals of this study were to: 1) develop a model of craniofacial VML in a large animal model and 2) to evaluate the efficacy of our SMUs in repairing a 30% VML in the ovine zygomaticus major muscle. Overall, there was no significant difference in functional recovery between the SMU-treated group and the unrepaired control. Despite the use of the same injury and repair model used in our previous study, results showed differences in pathophysiology between craniofacial and hindlimb VML. Specifically, the craniofacial model was affected by concomitant denervation and ischemia injuries that were not exhibited in the hindlimb model. While clinically realistic, the additional ischemia and denervation likely created an injury that was too severe for our SMUs to repair. This study highlights the importance of balancing the use of a clinically realistic model while also maintaining control over variables related to the severity of the injury. These variables include the volume of muscle removed, the location of the VML injury, and the geometry of the injury, as these affect both the muscle's ability to self-regenerate as well as the probability of success of the treatment.


Assuntos
Traumatismos Faciais/cirurgia , Músculos Faciais/cirurgia , Regeneração Tecidual Guiada/métodos , Doenças Musculares/cirurgia , Engenharia Tecidual/métodos , Animais , Modelos Animais de Doenças , Face/cirurgia , Traumatismos Faciais/complicações , Músculos Faciais/fisiopatologia , Feminino , Humanos , Masculino , Doenças Musculares/etiologia , Recuperação de Função Fisiológica , Regeneração/fisiologia , Ovinos , Alicerces Teciduais
16.
J Clin Endocrinol Metab ; 105(12)2020 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-32882010

RESUMO

CONTEXT: Glucocorticoid-induced myopathy is a characteristic symptom of endogenous Cushing's syndrome (CS). Its long-term outcome is largely unknown. OBJECTIVE: To evaluate long-term muscle function following the remission of endogenous CS. STUDY DESIGN: Observational longitudinal cohort study. SETTING: Tertiary care hospitals and a specialized outpatient clinic. PATIENTS: As part of the prospective multicenter German Cushing's Registry, we assessed muscle strength in patients with overt endogenous CS. We studied the patients at the time of diagnosis (n = 88), after 6 months (n = 69), and thereafter annually, following surgical remission over a period of up to 4 years (1 year: n = 55; 2 years: n = 34; 3 years: n = 29; 4 years: n = 22). Muscle function was evaluated by hand grip strength and by chair rising test. RESULTS: Grip strength was decreased to 83% of normal controls (100%) at the time of diagnosis. It further decreased to 71% after 6 months in remission (P ≤ 0.001) and showed no improvement during further follow-up compared with baseline. Chair rising test performance improved initially (8 seconds at baseline vs 7 seconds after 6 months, P = 0.004) but remained at this reduced level thereafter (7 seconds after 3 years vs 5 seconds in controls, P = 0.038). In multivariate analysis, we identified, as predictors for long-term muscle dysfunction, age, waist-to-hip ratio, and hemoglobin A1c at baseline. Furthermore, muscle strength during follow-up was strongly correlated with quality of life. CONCLUSION: This study shows that CS-associated myopathy does not spontaneously resolve during remission. This calls for action to identify effective interventions to improve muscle dysfunction in this setting.


Assuntos
Síndrome de Cushing/complicações , Síndrome de Cushing/cirurgia , Doenças Musculares/etiologia , Adulto , Biomarcadores/análise , Estudos de Casos e Controles , Estudos de Coortes , Síndrome de Cushing/diagnóstico , Síndrome de Cushing/fisiopatologia , Feminino , Alemanha , Força da Mão/fisiologia , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Força Muscular/fisiologia , Doenças Musculares/diagnóstico , Doenças Musculares/fisiopatologia , Doenças Musculares/cirurgia , Prognóstico , Qualidade de Vida , Indução de Remissão , Fatores de Tempo , Resultado do Tratamento
17.
Pediatr Int ; 62(12): 1369-1373, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32558048

RESUMO

BACKGROUND: Data about percutaneous endoscopic gastrostomy (PEG) insertions in small infants are limited, and most studies include older children. We aimed to evaluate the safety of PEG placement in infants weighing ≤5 kg together with their follow-up results. METHODS: A retrospective evaluation was made of records between January 2005 and December 2019. RESULTS: A total of 43 infants were ≤5 kg at the time of PEG insertion. The mean age was 5 ± 3 (19 days-16 months) months and the mean weight was 4.3 ± 0.6 (2.7-5.0) kg. The primary diagnoses were neurological disorders in 25, metabolic disorders in nine, cleft palates in four, muscular disorders in four, and a cardiac disorder in one. All procedures were completed successfully. A self-resolving pneumoperitoneum developed in one (2.3%). The tube was extruded in six (14%) patients postoperatively which required suture-approximation of the skin and subcuticular tissues. The tube was removed in four (9%) patients with achievement of oral feeds on the long-term. Eighteen (42%) died of primary diseases. The tubes were in situ for a median of 12.4 (17 days-73 months) months in these patients. A total of 20 (46.5%) patients are currently being followed up and their tubes are in situ for a median of 50.3 (4.7 month-9.8 years) months. CONCLUSIONS: Percutaneous endoscopic gastrostomy placement is safe in small infants with associated morbidities. Complications related to the procedure are within acceptable limits. The accidental extrusion of the tube was a special consideration in this patient group. The overall mortality was high because of underlying primary diseases.


Assuntos
Transtornos de Deglutição/cirurgia , Endoscopia Gastrointestinal/métodos , Gastrostomia/métodos , Fissura Palatina/epidemiologia , Fissura Palatina/cirurgia , Transtornos de Deglutição/epidemiologia , Endoscopia Gastrointestinal/efeitos adversos , Nutrição Enteral/métodos , Feminino , Gastrostomia/efeitos adversos , Cardiopatias/epidemiologia , Cardiopatias/cirurgia , Humanos , Lactente , Recém-Nascido , Masculino , Doenças Metabólicas/epidemiologia , Doenças Metabólicas/cirurgia , Morbidade , Doenças Musculares/epidemiologia , Doenças Musculares/cirurgia , Doenças do Sistema Nervoso/epidemiologia , Doenças do Sistema Nervoso/cirurgia , Pneumoperitônio/epidemiologia , Pneumoperitônio/etiologia , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Estudos Prospectivos , Estudos Retrospectivos
18.
J Craniofac Surg ; 31(6): 1827-1828, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32371708

RESUMO

Various surgical methods have been used to treat cryptotia; however, there is a drawback of these methods in that they leave a permanent scar. The authors describe a 7-year-old child who missed the optimal corrective time for cryptotia. Minimally invasive surgery was planned as a 3rd alternative to external splinting or invasive surgery by taking advantage of 2 methods. Silly putty was prefabricated as an auricular sulcus retainer, and fixation sutures between the deep dermis and temporal fascia were placed through small incisions along the future auricular sulcus. Then the prefabricated auricular sulcus retainer was maintained for 2 months. After 6 months, the corrected ear shape remained stable with the inconspicuous scar. With minimally invasive correction, a successful treatment effect can be expected while minimizing scarring in patients who are not expected to have a therapeutic effect with a simple reduction.


Assuntos
Orelha Externa/cirurgia , Doenças Musculares/cirurgia , Criança , Cicatriz , Fáscia , Humanos , Procedimentos Cirúrgicos Minimamente Invasivos , Procedimentos de Cirurgia Plástica , Retalhos Cirúrgicos/cirurgia , Suturas
19.
Bone Joint J ; 102-B(3): 352-359, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32114822

RESUMO

AIMS: Few risk factors for rotator cuff disease (RCD) and corresponding treatment have been firmly established. The aim of this study was to evaluate the relationship between numerous risk factors and the incidence of surgery for RCD in a large cohort. METHODS: A population-based cohort of people aged between 40 and 69 years in the UK (the UK Biobank) was studied. People who underwent surgery for RCD were identified through a link with NHS inpatient records covering a mean of eight years after enrolment. Multivariate Cox proportional hazards regression was used to calculate hazard ratios (HRs) as estimates of associations with surgery for RCD accounting for confounders. The risk factors which were considered included age, sex, race, education, Townsend deprivation index, body mass index (BMI), occupational demands, and exposure to smoking. RESULTS: Of the 421,894 people who were included, 47% were male. The mean age at the time of enrolment was 56 years (40 to 69). A total of 2,156 people were identified who underwent surgery for RCD. Each decade increase in age was associated with a 55% increase in the incidence of RCD surgery (95% confidence interval (CI) 46% to 64%). Male sex, non-white race, lower deprivation score, and higher BMI were significantly associated with a higher risk of surgery for RCD (all p < 0.050). Greater occupational physical demands were significantly associated with higher rates of RCD surgery (HR = 2.1, 1.8, and 1.4 for 'always', 'usually', and 'sometimes' doing heavy manual labour vs 'never', all p < 0.001). Former smokers had significantly higher rates of RCD surgery than those who had never smoked (HR 1.23 (95% CI 1.12 to 1.35), p < 0.001), while current smokers had similar rates to those who had never smoked (HR 0.94 (95% CI 0.80 to 1.11)). Among those who had never smoked, the risk of surgery was higher among those with more than one household member who smoked (HR 1.78 (95% CI 1.08 to 2.92)). The risk of RCD surgery was not significantly related to other measurements of secondhand smoking. CONCLUSION: Many factors were independently associated with surgery for RCD, including older age, male sex, higher BMI, lower deprivation score, and higher occupational physical demands. Several of the risk factors which were identified are modifiable, suggesting that the healthcare burden of RCD might be reduced through the pursuit of public health goals, such as reducing obesity and modifying occupational demands. Cite this article: Bone Joint J 2020;102-B(3):352-359.


Assuntos
Doenças Musculares/cirurgia , Exposição Ocupacional/efeitos adversos , Procedimentos Ortopédicos/estatística & dados numéricos , Vigilância da População , Manguito Rotador/cirurgia , Fumar/efeitos adversos , Adulto , Idoso , Índice de Massa Corporal , Feminino , Seguimentos , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Doenças Musculares/epidemiologia , Doenças Musculares/etiologia , Prevalência , Estudos Prospectivos , Fatores de Risco , Reino Unido/epidemiologia
20.
Ann Ital Chir ; 92020 Mar 09.
Artigo em Inglês | MEDLINE | ID: mdl-32161184

RESUMO

INTRODUCTION: Echinococcus is a parasitic disease that affects all organs and tissues. The most commonly affected are liver (70-80%) and lungs (10-25%), while very rarely, in about 5% of cases, it can be found in the spleen, kidneys, brain, heart, pancreas, muscles and skeleton. CASE REPORT: Although localization of hydatid cyst in muscle is rare, it is important to consideredPORT it in the differential diagnosis of a cystic mass in the muscle. Clinical diagnosis of cystic echinococcosis is based on general ultrasound imaging, CT, MRI, differentiation of Echinococcus-Ag, ELISA testing, immunoelectrophoresis (IEP), counterimmunoelectrophoresis (CIE). DISCUSSION: Surgery is the primary treatment for muscle hydatidosis. We present our experience in treating the case of an infected hydatid cyst on transverse abdominal muscle, with infection extending to the right diaphragm and subcutaneous tissue of abdomen and thorax between the transverse abdominal and internal sternal abdominal muscles. CONCLUSION: The goal of the surgical treatment is total evacuation of the parasite, "sterilization" of the residual cavity and handling of intraoperartive complications. The post-operative course was normal and the patient was discharged to home care ten days after surgery in good general and local condition. KEY WORDS: Abscess, Echinococcus, Infection, Muscle.


Assuntos
Músculos Abdominais , Equinococose , Doenças Musculares/parasitologia , Equinococose/diagnóstico , Equinococose/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Doenças Musculares/diagnóstico , Doenças Musculares/cirurgia
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