Assuntos
Produtos Biológicos , Esofagite Eosinofílica , Humanos , Produtos Biológicos/uso terapêutico , Enterite/tratamento farmacológico , Enterite/terapia , Esofagite Eosinofílica/tratamento farmacológico , Esofagite Eosinofílica/terapia , Esofagite/tratamento farmacológico , Esofagite/terapia , Gastrite/tratamento farmacológico , Gastrite/terapiaRESUMO
AIM: Black esophagus, or acute esophageal necrosis, is a rare entity with multifactorial aetiology. Modern theories suggest a combination of ischemia, compromised mucosa defences and corrosive agent's injury. MATERIAL AND METHODS: We investigated black esophagus by means of a retrospective review of 26 cases in literature. A Medline overview is performed until May 2021 by considering the Italian results. The search terms were "black esophageal syndrome in Italy", "black esophagus in Italy", "black esophageal necrosis in Italy", and "Gurvits syndrome in Italy". To complete these case reports, we illustrate our first experience of the syndrome successfully treated with esophagectomy, cervical diversion and gastrostomy. RESULTS: Black esophagus is common in adult males (M/F: 21/5) (Range: 47-89 years; Average: 70.6 year-old). The most common symptoms are hematemesis, epigastric pain and dysphagia. Endoscopically, diffuse involvement of acute esophageal necrosis is diagnosed in 42.3% of cases. The treatment consisted on red blood cell transfusions, sucralfate administration, proton pump-inhibition, enteral nutrition and antimicrobial agents. Overall mortality was 38.4% and only one case underwent surgery for acute bleeding. CONCLUSIONS: Black esophagus is often reversible both anatomically and functionally. Its treatment is based on supported therapies and hemodynamic resuscitation. This syndrome shows high mortality related to the coexisted medical conditions rather than acute esophageal necrosis. Only in selected cases, surgical treatment is indicated. KEY WORDS: Acute necrotizing esophagitis, Black esophagus, Ischemia.
Assuntos
Doenças do Esôfago , Esofagite , Adulto , Idoso , Humanos , Masculino , Doença Aguda , Doenças do Esôfago/etiologia , Doenças do Esôfago/cirurgia , Esofagite/etiologia , Esofagite/terapia , Esofagite/diagnóstico , Isquemia , NecroseRESUMO
This review summarizes our current understanding of lymphocytic esophagitis (LE), a novel form of chronic esophagitis that incorporates distinctive histologic, clinical, and endoscopic features. First described as a histologic entity, a diagnosis of LE requires intraepithelial lymphocytosis without significant granulocytic inflammation and some evidence of epithelial damage; the rationale for and studies supportive of these histologic criteria are discussed within. Clinically, the majority of patients who present with histologically confirmed LE are older women or patients with underlying immunologic abnormalities, such as Crohn disease, rheumatologic disorders, or common variable immunodeficiency. The most common presenting symptom of LE is dysphagia, and the endoscopic findings can vary from normal mucosa to mucosal changes that resemble eosinophilic esophagitis: edema, rings, furrows, and plaques. The incidence of luminal strictures and the persistent dysphagia and/or lymphocytosis present in some patients provide evidence that LE is a chronic inflammatory disorder, at least within a subset of individuals. Several histologic mimics of LE are examined, as are disagreements surrounding the LE diagnosis.
Assuntos
Mucosa Esofágica/patologia , Esofagite/patologia , Linfócitos/patologia , Linfocitose/patologia , Animais , Biópsia , Deglutição , Transtornos de Deglutição/etiologia , Diagnóstico Diferencial , Mucosa Esofágica/imunologia , Esofagite/complicações , Esofagite/imunologia , Esofagite/terapia , Esofagoscopia , Humanos , Linfócitos/imunologia , Linfocitose/complicações , Linfocitose/imunologia , Linfocitose/terapia , Valor Preditivo dos Testes , Prognóstico , Avaliação de SintomasAssuntos
Azitromicina/administração & dosagem , Anormalidades Cardiovasculares , Transtornos de Deglutição , Infecções por Mycoplasma , Prednisona/administração & dosagem , Artéria Subclávia/anormalidades , Anel Vascular , Antibacterianos/administração & dosagem , Anormalidades Cardiovasculares/diagnóstico , Anormalidades Cardiovasculares/fisiopatologia , Criança , Transtornos de Deglutição/diagnóstico , Transtornos de Deglutição/etiologia , Transtornos de Deglutição/fisiopatologia , Transtornos de Deglutição/terapia , Diagnóstico Diferencial , Ecocardiografia/métodos , Endoscopia do Sistema Digestório/métodos , Esofagite/diagnóstico , Esofagite/etiologia , Esofagite/fisiopatologia , Esofagite/terapia , Hemorragia Gastrointestinal/diagnóstico por imagem , Hemorragia Gastrointestinal/etiologia , Glucocorticoides/administração & dosagem , Humanos , Masculino , Infecções por Mycoplasma/diagnóstico , Infecções por Mycoplasma/tratamento farmacológico , Infecções por Mycoplasma/fisiopatologia , Mycoplasma pneumoniae/isolamento & purificação , Recidiva , Artéria Subclávia/fisiopatologia , Resultado do Tratamento , Anel Vascular/diagnóstico , Anel Vascular/fisiopatologiaRESUMO
Descending necrotizing mediastinitis is a life-threatening disease that extends into the pretracheal, perivascular, retrovisceral, and/or prevertebral spaces, generally sparing the esophagus. We report a case of deep neck abscess complicated by phlegmonous esophagitis and mediastinitis. The patient was successfully treated with antibiotics and surgery, combining transcervical and bilateral thoracoscopic transthoracic mediastinal drainage. However, a pseudo-lumen with a large amount of pus remained in the esophagus. The septum between the true and the pseudo-lumen was cut endoscopically, after which the patient recovered well without any complications.
Assuntos
Abscesso/complicações , Celulite (Flegmão)/microbiologia , Esofagite/microbiologia , Firmicutes , Infecções por Bactérias Gram-Positivas/complicações , Mediastinite/microbiologia , Abscesso/terapia , Celulite (Flegmão)/terapia , Esofagite/terapia , Feminino , Infecções por Bactérias Gram-Positivas/terapia , Humanos , Mediastinite/terapia , Pessoa de Meia-Idade , PescoçoAssuntos
Falso Aneurisma/etiologia , Duodenite/etiologia , Esofagite/etiologia , Isquemia/etiologia , Pancreatite/etiologia , Poliarterite Nodosa/complicações , Idoso , Falso Aneurisma/diagnóstico , Falso Aneurisma/terapia , Duodenite/diagnóstico , Duodenite/terapia , Endoscopia Gastrointestinal , Esofagite/diagnóstico , Esofagite/terapia , Feminino , Humanos , Isquemia/diagnóstico , Isquemia/terapia , Pancreatite/diagnóstico , Pancreatite/terapia , Poliarterite Nodosa/diagnóstico , Poliarterite Nodosa/terapia , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
Among the many causes of the inflammatory process in the esophagus, infectious diseases are becoming increasingly important due to their steady growth. Previously esophageal infections have traditionally been associated with immunodeficiency syndromes, but now in clinical practice, these disorders are becoming increasingly recognized in immunocompetent individuals. Early diagnosis of infectious esophagitis is necessary to develop effective treatment tactics, and, as a result, reduce the risk of complications and adverse outcomes of the disease. This study reviewed the most clinical relevant pathogens of infectious esophagitis, both among patients with immunodeficiency and among healthy individuals. Specific diagnostic, risk factors, clinical presentation and therapeutic features were considered depending on the immune status of patients.
Assuntos
Doenças do Esôfago , Esofagite , Herpes Simples , Esofagite/diagnóstico , Esofagite/terapia , Humanos , Hospedeiro ImunocomprometidoRESUMO
We herein report four patients with desquamative esophagitis that developed one to nine days after peripheral blood stem cell transplantation (PBSCT). Three patients underwent allogeneic PBSCT for leukemia, and the other underwent autologous PBSCT for pineoblastoma. Esophagogastroduodenoscopy revealed mucosal sloughing and fresh blood in the esophagus. Fasting and intravenous proton pump inhibitor therapy in addition to blood transfusion improved the esophageal lesions within five to seven days in three patients. These cases indicate that desquamative esophagitis can occur in patients who receive hematopoietic stem cell transplantation. Although blood transfusions may be required, it can be resolved within seven days.
Assuntos
Transfusão de Sangue/métodos , Esofagite/etiologia , Esofagite/fisiopatologia , Esofagite/terapia , Jejum , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Inibidores da Bomba de Prótons/uso terapêutico , Adolescente , Adulto , Feminino , Humanos , Japão , Masculino , Resultado do Tratamento , Adulto JovemRESUMO
Caustic ingestion represents a serious social-medical problem due to the devastating and irreversible consequences it can produce in the upper digestive tract. In Ibero-America, there are no published reliable data on the incidence or prevalence of caustic-induced injuries, and most of the available information on clinical presentation, diagnosis, treatment, and prognosis is based on retrospective clinical series and, indeed, its clinical management is often based primarily on expert opinion. Re cently as an initiative of the Latin American Society for Pediatric Gastroenterology, Hepatology and Nutrition (LASPGHAN) and with the cooperation of the Spanish Society for Pediatric Gastroente rology, Hepatology and Nutrition (SEGHNP), we have designed a Clinical Practice Guideline that include a series of statements and recommendations aimed at optimizing patient medical care which is based on the systematic review of evidence. Two (2) successive papers focused on the evaluation of physiopathological and clinical-endoscopic diagnostic features of caustic esophagitis in children (1st. Paper) and, on the other hand, the most relevant therapeutic considerations (2nd. Paper). We expect this guideline to become a useful tool for the physician in the difficult decision-making process when assessing patients after caustic ingestion.
Assuntos
Queimaduras Químicas , Cáusticos/toxicidade , Esofagite , Adolescente , Queimaduras Químicas/diagnóstico , Queimaduras Químicas/etiologia , Queimaduras Químicas/fisiopatologia , Queimaduras Químicas/terapia , Criança , Pré-Escolar , Esofagite/diagnóstico , Esofagite/etiologia , Esofagite/fisiopatologia , Esofagite/terapia , Humanos , Lactente , PediatriaRESUMO
Caustic ingestion represents a serious social-medical problem due to the devastating and irreversible consequences it can produce in the upper digestive tract. In Ibero-America, there are no published reliable data on the incidence or prevalence of caustic-induced injuries, and most of the available information on clinical presentation, diagnosis, treatment, and prognosis is based on retrospective clinical series and, indeed, its clinical management is often based primarily on expert opinion. Re cently as an initiative of the Latin American Society for Pediatric Gastroenterology, Hepatology and Nutrition (LASPGHAN) and with the cooperation of the Spanish Society for Pediatric Gastroente rology, Hepatology and Nutrition (SEGHNP), we have designed a Clinical Practice Guideline that include a series of statements and recommendations aimed at optimizing patient medical care which is based on the systematic review of evidence. Two (2) separate papers focused on the evaluation of physiopathological and clinical-endoscopic diagnostic features of caustic esophagitis in children (1st. Paper) and, on the other hand, the most relevant therapeutic considerations (2nd. Paper). We expect this guideline to become a useful tool for the physician in the difficult decision-making process when assessing patients after caustic ingestion.
Assuntos
Queimaduras Químicas/etiologia , Cáusticos/toxicidade , Esofagite/induzido quimicamente , Esôfago/lesões , Queimaduras Químicas/diagnóstico , Queimaduras Químicas/fisiopatologia , Queimaduras Químicas/terapia , Tomada de Decisão Clínica/métodos , Esofagite/diagnóstico , Esofagite/fisiopatologia , Esofagite/terapia , Esôfago/fisiopatologia , Humanos , América Latina , EspanhaRESUMO
Resumen: La ingestión de cáusticos representa un grave problema médico-social por las consecuencias devastadoras e irreversibles que puede producir en el tracto digestivo superior. En Iberoamérica no se han publicado datos fidedignos sobre la incidencia o la prevalencia de lesiones inducidas por cáusticos. La información disponible sobre la presentación clínica, diagnóstico, tratamiento y pronóstico se basa en series retrospectivas de casos y, de hecho, su manejo clínico se sustenta en muchos casos fundamentalmente en la opinión de expertos. Recientemente como una iniciativa de la Sociedad Latinoamericana de Gastroenterología, Hepatología y Nutrición Pediátrica (SLAGHNP) y con la co laboración de colegas de la Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediá trica (SEGHNP), hemos diseñado una Guía de Práctica Clínica (GPC) la cual incluye una serie de enunciados y recomendaciones dirigidos a optimizar la atención a los pacientes y que se basan en la revisión sistemática de la evidencia. En dos (2) manuscritos sucesivos nos hemos enfocado primero, en los aspectos fisiopatológicos y de diagnóstico clínico-endoscópico de la esofagitis cáustica en niños (1a. Parte) y en segundo lugar, en los aspectos más relevantes del tratamiento (2a. Parte). Esperamos esta guía se convierta en una herramienta útil para el clínico en el difícil proceso de toma de decisio nes a la hora de evaluar un paciente posterior a la ingesta de una sustancia cáustica.
Abstract: Caustic ingestion represents a serious social-medical problem due to the devastating and irreversible consequences it can produce in the upper digestive tract. In Ibero-America, there are no published reliable data on the incidence or prevalence of caustic-induced injuries, and most of the available information on clinical presentation, diagnosis, treatment, and prognosis is based on retrospective clinical series and, indeed, its clinical management is often based primarily on expert opinion. Re cently as an initiative of the Latin American Society for Pediatric Gastroenterology, Hepatology and Nutrition (LASPGHAN) and with the cooperation of the Spanish Society for Pediatric Gastroente rology, Hepatology and Nutrition (SEGHNP), we have designed a Clinical Practice Guideline that include a series of statements and recommendations aimed at optimizing patient medical care which is based on the systematic review of evidence. Two (2) separate papers focused on the evaluation of physiopathological and clinical-endoscopic diagnostic features of caustic esophagitis in children (1st. Paper) and, on the other hand, the most relevant therapeutic considerations (2nd. Paper). We expect this guideline to become a useful tool for the physician in the difficult decision-making process when assessing patients after caustic ingestion.
Assuntos
Humanos , Queimaduras Químicas/etiologia , Cáusticos/toxicidade , Esofagite/induzido quimicamente , Esôfago/lesões , Espanha , Queimaduras Químicas/diagnóstico , Queimaduras Químicas/fisiopatologia , Queimaduras Químicas/terapia , Esofagite/diagnóstico , Esofagite/fisiopatologia , Esofagite/terapia , Esôfago/fisiopatologia , Tomada de Decisão Clínica/métodos , América LatinaRESUMO
Background: Drug-induced esophagitis is an uncommon diagnosis in the pediatric population. The following is a report of six adolescents with L-arginine-induced esophagitis. Case reports: All patients were under treatment with L-arginine for short stature. After using the prescribed medication for 1-3 months, all cases started with severe retrosternal pain, odynophagia, and dysphagia. The upper gastrointestinal endoscopies showed ulcers located in the mid esophageal mucosa. Conclusions: In the presence of acute severe odynophagia, dysphagia, and retrosternal pain, drug-induced esophagitis should be considered as a possible diagnosis. Treatment includes liquid diet, pain control, sucralfate, omeprazole, and interruption of L-arginine. In addition, the physician should explain preventive measures focused on patient and family education on the drug side effects and precise instructions on how to take medications, as well as a careful balance of risk and benefits of any medication. At present, there are no clinical trials that support the use of L-arginine in treatment of short stature.
Introducción: La esofagitis inducida por medicamentos es un diagnóstico poco frecuente en pacientes pediátricos. A continuación, se describe una serie de seis casos de pacientes menores de 15 años con esofagitis inducida por L-arginina. Casos clínicos: Los seis casos se encontraban en tratamiento con L-arginina por talla baja e iniciaron con dolor retroesternal, odinofagia y disfagia de rápida instalación. Cuatro de ellos acudieron al servicio de urgencias por la intensidad de los síntomas. Los hallazgos en la endoscopia del tubo digestivo alto fueron úlceras en la mucosa del esófago a la altura del tercio medio, zona de estrechez natural por la compresión del bronquio izquierdo. Conclusiones: En presencia de odinofagia, disfagia, dolor retroesternal y el antecedente de la ingesta de L-arginina, la esofagitis inducida por fármacos debe considerarse como una posibilidad diagnóstica. El tratamiento está basado en el manejo del dolor, sucralfato, omeprazol, así como la suspensión del medicamento y medidas preventivas centradas en la educación del paciente y los familiares sobre los riesgos y beneficios de un medicamento y la forma correcta de administrarlo.
Assuntos
Arginina/efeitos adversos , Mucosa Esofágica/efeitos dos fármacos , Esofagite/induzido quimicamente , Adolescente , Arginina/administração & dosagem , Dor no Peito/etiologia , Criança , Transtornos de Deglutição/etiologia , Mucosa Esofágica/patologia , Esofagite/diagnóstico , Esofagite/terapia , Feminino , Humanos , Masculino , Omeprazol/administração & dosagem , Sucralfato/administração & dosagem , Úlcera/etiologiaRESUMO
Abstract Background: Drug-induced esophagitis is an uncommon diagnosis in the pediatric population. The following is a report of six adolescents with L-arginine-induced esophagitis. Case reports: All patients were under treatment with L-arginine for short stature. After using the prescribed medication for 1-3 months, all cases started with severe retrosternal pain, odynophagia, and dysphagia. The upper gastrointestinal endoscopies showed ulcers located in the mid esophageal mucosa. Conclusions: In the presence of acute severe odynophagia, dysphagia, and retrosternal pain, drug-induced esophagitis should be considered as a possible diagnosis. Treatment includes liquid diet, pain control, sucralfate, omeprazole, and interruption of L-arginine. In addition, the physician should explain preventive measures focused on patient and family education on the drug side effects and precise instructions on how to take medications, as well as a careful balance of risk and benefits of any medication. At present, there are no clinical trials that support the use of L-arginine in treatment of short stature.
Resumen Introducción: La esofagitis inducida por medicamentos es un diagnóstico poco frecuente en pacientes pediátricos. A continuación, se describe una serie de seis casos de pacientes menores de 15 años con esofagitis inducida por L-arginina. Casos clínicos: Los seis casos se encontraban en tratamiento con L-arginina por talla baja e iniciaron con dolor retroesternal, odinofagia y disfagia de rápida instalación. Cuatro de ellos acudieron al servicio de urgencias por la intensidad de los síntomas. Los hallazgos en la endoscopia del tubo digestivo alto fueron úlceras en la mucosa del esófago a la altura del tercio medio, zona de estrechez natural por la compresión del bronquio izquierdo. Conclusiones: En presencia de odinofagia, disfagia, dolor retroesternal y el antecedente de la ingesta de L-arginina, la esofagitis inducida por fármacos debe considerarse como una posibilidad diagnóstica. El tratamiento está basado en el manejo del dolor, sucralfato, omeprazol, así como la suspensión del medicamento y medidas preventivas centradas en la educación del paciente y los familiares sobre los riesgos y beneficios de un medicamento y la forma correcta de administrarlo.
Assuntos
Adolescente , Criança , Feminino , Humanos , Masculino , Arginina/efeitos adversos , Esofagite/induzido quimicamente , Mucosa Esofágica/efeitos dos fármacos , Arginina/administração & dosagem , Úlcera/etiologia , Dor no Peito/etiologia , Omeprazol/administração & dosagem , Sucralfato/administração & dosagem , Transtornos de Deglutição/etiologia , Esofagite/diagnóstico , Esofagite/terapia , Mucosa Esofágica/patologiaRESUMO
Resumen: La ingestión de cáusticos representa un grave problema médico-social por las consecuencias devastadoras e irreversibles que puede producir en el tracto digestivo superior. En Iberoamérica no se han publicado datos fidedignos sobre la incidencia o la prevalencia de lesiones inducidas por cáusticos. La información disponible sobre la presentación clínica, diagnóstico, tratamiento y pronóstico se basa en series retrospectivas de casos y, de hecho, su manejo clínico se sustenta en muchos casos fundamentalmente en la opinión de expertos. Recientemente como una iniciativa de la Sociedad Latinoamericana de Gastroenterología, Hepatología y Nutrición Pediátrica (SLAGHNP) y con la co laboración de colegas de la Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediá trica (SEGHNP), hemos diseñado una Guía de Práctica Clínica (GPC) la cual incluye una serie de enunciados y recomendaciones dirigidos a optimizar la atención a los pacientes y que se basan en la revisión sistemática de la evidencia. En dos (2) manuscritos sucesivos nos hemos enfocado primero, en los aspectos fisiopatológicos y de diagnóstico clínico-endoscópico de la esofagitis cáustica en niños (1a. Parte) y en segundo lugar, en los aspectos más relevantes del tratamiento (2a. Parte). Esperamos esta guía se convierta en una herramienta útil para el clínico en el difícil proceso de toma de decisio nes a la hora de evaluar un paciente posterior a la ingesta de una sustancia cáustica.
Abstract: Caustic ingestion represents a serious social-medical problem due to the devastating and irreversible consequences it can produce in the upper digestive tract. In Ibero-America, there are no published reliable data on the incidence or prevalence of caustic-induced injuries, and most of the available information on clinical presentation, diagnosis, treatment, and prognosis is based on retrospective clinical series and, indeed, its clinical management is often based primarily on expert opinion. Re cently as an initiative of the Latin American Society for Pediatric Gastroenterology, Hepatology and Nutrition (LASPGHAN) and with the cooperation of the Spanish Society for Pediatric Gastroente rology, Hepatology and Nutrition (SEGHNP), we have designed a Clinical Practice Guideline that include a series of statements and recommendations aimed at optimizing patient medical care which is based on the systematic review of evidence. Two (2) successive papers focused on the evaluation of physiopathological and clinical-endoscopic diagnostic features of caustic esophagitis in children (1st. Paper) and, on the other hand, the most relevant therapeutic considerations (2nd. Paper). We expect this guideline to become a useful tool for the physician in the difficult decision-making process when assessing patients after caustic ingestion.
Assuntos
Humanos , Lactente , Pré-Escolar , Criança , Adolescente , Queimaduras Químicas/diagnóstico , Queimaduras Químicas/etiologia , Queimaduras Químicas/fisiopatologia , Queimaduras Químicas/terapia , Cáusticos/toxicidade , Esofagite/diagnóstico , Esofagite/etiologia , Esofagite/fisiopatologia , Esofagite/terapia , PediatriaRESUMO
Acute necrotizing esophagitis ("black esophagus") is defined as complete necrosis of the esophageal mucosa, which typically affects the entire circumference. We report a case of a healthy 62-year-old woman, who became hemodynamically unstable due to stress cardiomyopathy with acute right heart failure. Transfusion-dependent anemia occurred 24â¯h later and an upper gastrointestinal endoscopy revealed a black discoloured mucosa of the distal esophagus. After hemodynamic stabilization and treatment with proton pump inhibitors and sucralfate, complete healing of the esophageal mucosa was achieved.
Assuntos
Cardiomiopatias , Esofagite/diagnóstico , Esofagite/tratamento farmacológico , Esofagite/terapia , Cardiomiopatia de Takotsubo , Doença Aguda , Feminino , Humanos , Pessoa de Meia-IdadeAssuntos
Budesonida/uso terapêutico , Estenose Esofágica/terapia , Esofagite/terapia , Glucocorticoides/uso terapêutico , Linfocitose/terapia , Terapia Combinada , Dilatação/métodos , Estenose Esofágica/patologia , Esofagite/patologia , Feminino , Humanos , Linfocitose/patologia , Pessoa de Meia-IdadeRESUMO
Esophageal candidiasis (EC) is the most common type of infectious esophagitis. In the gastrointestinal tract, the esophagus is the second most susceptible to candida infection, only after the oropharynx. Immunocompromised patients are most at risk, including patients with HIV/AIDS, leukemia, diabetics, and those who are receiving corticosteroids, radiation, and chemotherapy. Another group includes those who used antibiotics frequently and those who have esophageal motility disorder (cardiac achalasia and scleroderma). Patients complained of pain on swallowing, difficulty swallowing, and pain behind the sternum. On physical examination, there is a plaque that often occurs together with oral thrush. Endoscopic examination is the best approach to diagnose this disease by directly observing the white mucosal plaque-like lesions and exudates adherent to the mucosa. These adherent lesions cannot be washed off with water from irrigation. This disease is confirmed histologically by taking the biopsy or brushings of yeast and pseudohyphae invading mucosal cells. The treatment is by systemic antifungal drugs given orally in a defined course. It is important to differentiate esophageal candidiasis from other forms of infectious esophagitis such as cytomegalovirus, herpes simplex virus, gastroesophageal reflux disease, medication-induced esophagitis, radiation-induced esophageal injury, and inflammatory conditions such as eosinophilic esophagitis. Except for a few complications such as necrotizing esophageal candidiasis, fistula, and sepsis, the prognosis of esophageal candidiasis has been good.
Assuntos
Candidíase/diagnóstico , Candidíase/terapia , Esofagite/diagnóstico , Esofagite/terapia , Antifúngicos/uso terapêutico , Candidíase/complicações , Esofagite/microbiologia , HumanosAssuntos
Esofagite/diagnóstico por imagem , Esofagoscopia , Hemorragia Gastrointestinal/diagnóstico por imagem , Alcoolismo/complicações , Pseudo-Obstrução do Colo/complicações , Esofagite/complicações , Esofagite/terapia , Alimentos Formulados , Hemorragia Gastrointestinal/etiologia , Hemorragia Gastrointestinal/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Necrose , Omeprazol/uso terapêutico , Nutrição Parenteral , Sepse/complicações , Fumar/efeitos adversos , Infecções Urinárias/complicaçõesRESUMO
Esophagitis dissecans (ESD) is an uncommon disease that is associated with eosinophilic esophagitis (EoE), candidiasis and/or drugs. We aim to characterize the clinical, endoscopic and histological damage of the mucosal in subjects with dysphagia, its relation to concomitant entities and the treatment response. This is a retrospective observational study in patients with dysphagia and esophageal mucosal damage We included 23 patients (mean age = 55 years) who had GERD symptoms, dysphagia and/or odynophagia. There were 10, 9 and 4 cases of esophagitis dissecans, desquamative/esfacelante (ESD/ES) and fibrostenotic, respectively. ESD/SE is a rare entity with variable clinical, endoscopic and histological spectrum. The association with GERD was frequent.
La esofagitis disecante (ESD) es una enfermedad rara que puede asociarse a esofagitis eosinofílica, candidiásica o medicamentos. Se analizaron las características clinico-endoscópicas e histopatológicas en sujetos con disfagia de corta evolución asociada a afecciones concurrentes. Estudio observacional de cohorte retrospectiva con disfagia y daño mucoso. Se ingresaron 23 pacientes con edad media de 55 años. Todos tuvieron síntomas de reflujo gastroesofágico (ERGE), disfagia y odinofagia. Fueron 10, 9 y 4 casos de ESD, descamativa/esfacelante (ESD/ES) y fibroestenosis, respectivamente. La ESD/SE es una afección rara, con un espectro clínico, endoscópico e histológico variable.
Assuntos
Transtornos de Deglutição/etiologia , Esofagite/complicações , Doença Aguda , Adolescente , Corticosteroides/uso terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Candidíase Bucal/complicações , Esofagite Eosinofílica/complicações , Estenose Esofágica/etiologia , Esofagite/diagnóstico , Esofagite/patologia , Esofagite/terapia , Esofagoscopia , Feminino , Refluxo Gastroesofágico/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Mucosa/patologia , Inibidores da Bomba de Prótons/uso terapêutico , Estudos Retrospectivos , Adulto JovemRESUMO
Because of its high incidence gastroesophageal reflux disease (GERD) is at the forefront of medical attention. On the other hand, vigilance for rare inflammatory diseases of the esophagus, such as herpes esophagitis, radiation-induced esophagitis, eosinophilic esophagitis, pseudodiverticulosis and Crohn's disease is low. Moreover, these entities are rarely distinguishable from GERD by clinical features alone. For all atypical and treatment refractory supposedly reflux diseases, the diagnosis should therefore be questioned and re-evaluated by endoscopy. When the macroscopic findings of esophagoscopy are ambiguous biopsies can be performed and histological examination then often leads to a definitive diagnosis. This is particularly important because the required treatment of rare forms of esophagitis often significantly differs from that of GERD.