RESUMO
The non-invasive treatment of glioblastoma (GBM) is of great significance and can greatly reduce the complications of craniotomy. Sonodynamic therapy (SDT) is an emerging tumor therapeutic strategy that overcomes some fatal flaws of photodynamic therapy (PDT). Different from PDT, SDT has deep tissue penetration and can be applied in the non-invasive treatment of deep-seated tumors. However, effective sonosensitizers that can be used for SDT of GBM are still very rare. Herein, we have prepared a suitable assembly based on a hypocrellin derivative (CTHB) with good biocompatibility. Excitedly, the hypocrellin-based assembly (CTHB NPs) can effectively produce reactive oxygen species under ultrasound stimulation. The inherent fluorescence and photoacoustic imaging characteristics of the CTHB NPs are conducive to the precise positioning of the tumors. It has been proved both in subcutaneous and in intracranial tumor models that CTHB NPs can be used as an effective sonosensitizer to inhibit tumor growth under ultrasound irradiation. This hypocrellin-based assembly has a good clinical prospect in the non-invasive treatment of GBM.
Assuntos
Antineoplásicos/farmacologia , Materiais Biocompatíveis/farmacologia , Glioblastoma/tratamento farmacológico , Perileno/análogos & derivados , Fenol/farmacologia , Quinonas/farmacologia , Terapia por Ultrassom , Antineoplásicos/síntese química , Antineoplásicos/química , Materiais Biocompatíveis/síntese química , Materiais Biocompatíveis/química , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Ensaios de Seleção de Medicamentos Antitumorais , Glioblastoma/patologia , Humanos , Teste de Materiais , Estrutura Molecular , Tamanho da Partícula , Perileno/síntese química , Perileno/química , Perileno/farmacologia , Fenol/síntese química , Fenol/química , Quinonas/síntese química , Quinonas/química , Ondas UltrassônicasRESUMO
Although benzbromarone (BBR) is a conventional, highly potent uricosuric drug, it is not a standard medicine because it causes rare but fatal fulminant hepatitis. We transformed the bis-aryl ketone structure of BBR to generate novel monocyclic amide-linked phenol derivatives that should possess uric acid excretion activity without adverse properties associated with BBR. The derivatives were synthesized and tested for uric acid uptake inhibition (UUI) in two assays using either urate transporter 1-expressing cells or primary human renal proximal tubule epithelial cells. We also evaluated their inhibitory activity against mitochondrial respiration as a critical mitochondrial toxicity parameter. Some derivatives with UUI activity had no mitochondrial toxicity, including compound 3f, which effectively lowered the plasma uric acid level in Cebus apella. Thus, 3f is a promising candidate for further development as a uricosuric agent.
Assuntos
Amidas/química , Fenol/síntese química , Ácido Úrico/metabolismo , Uricosúricos/síntese química , Animais , Benzobromarona/química , Benzobromarona/farmacologia , Avaliação Pré-Clínica de Medicamentos , Proteínas Facilitadoras de Transporte de Glucose/metabolismo , Humanos , Mitocôndrias/efeitos dos fármacos , Fenol/efeitos adversos , Fenol/farmacologia , Pirróis/química , Sapajus apella , Transdução de Sinais , Relação Estrutura-Atividade , Ácido Úrico/sangue , Uricosúricos/efeitos adversos , Uricosúricos/farmacocinéticaRESUMO
Hypocrellin B (HB) derived from naturally produced hypocrellins has attracted considerable attention in photodynamic therapy (PDT) because of its excellent photosensitive properties. However, the weak absorption within a "phototherapy window" (600-900â nm) and poor water solubility of HB have limited its clinical application. In this study, two HB derivatives (i. e., HE and HF) were designed and synthesized for the first time by introducing two different substituent groups into the HB structure. The obtained derivatives showed a broad absorption band covering the near-infrared (NIR) region, NIR emission (peaked at 805â nm), and singlet oxygen quantum yields of 0.27/0.31. HE-PEG-NPs were also prepared using 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-2000] (DSPE-mPEG2000) to achieve excellent dispersion in water and further explored their practical applications. HE-PEG-NPs not only retained their 1 O2 -generating ability, but also exhibited a photothermal conversion efficiency of 25.9%. In vitro and inâ vivo therapeutic results revealed that the synergetic effect of HE-PEG-NPs on PDT and photothermal therapy (PTT) could achieve a good performance. Therefore, HE-PEG-NPs could be regarded as a promising phototheranostic agent.
Assuntos
Antineoplásicos/farmacologia , Perileno/análogos & derivados , Fenol/farmacologia , Fármacos Fotossensibilizantes/farmacologia , Terapia Fototérmica , Quinonas/farmacologia , Animais , Antineoplásicos/síntese química , Antineoplásicos/química , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Feminino , Raios Infravermelhos , Neoplasias Mamárias Experimentais/diagnóstico por imagem , Neoplasias Mamárias Experimentais/tratamento farmacológico , Camundongos , Imagem Óptica , Perileno/síntese química , Perileno/química , Perileno/farmacologia , Fenol/síntese química , Fenol/química , Fármacos Fotossensibilizantes/síntese química , Fármacos Fotossensibilizantes/química , Quinonas/síntese química , Quinonas/química , Nanomedicina TeranósticaRESUMO
A mild and efficient method for the vanadium-catalyzed intramolecular coupling of tethered free phenols is described. The corresponding phenol-dienone products are prepared directly in good yields with low catalyst loadings. Electronically diverse tethered phenol precursors are well tolerated, and the catalytic method was effectively applied as the key step in syntheses of three natural products and a synthetically useful morphinan alkaloid precursor.
Assuntos
Alcenos/síntese química , Produtos Biológicos/síntese química , Fenol/síntese química , Vanádio/química , Alcenos/química , Produtos Biológicos/química , Catálise , Estrutura Molecular , Oxirredução , Fenol/químicaRESUMO
In this work, we proved the efficient synthesis of a bio-based hyper-branched polyphenol from a modified lignin degradation fragment. Protocatechuic acid was readily obtained from vanillin, a lignin degradation product, via alkaline conditions, and further polymerised to yield high molecular weight hyperbranched phenol terminated polyesters. Vanillic acid was also subjected to similar polymerisation conditions in order to compare polymerisation kinetics and differences between linear and hyperbranched polymers. Overall, protocatechuic acid was faster to polymerise and more thermostable with a degradation temperature well above linear vanillic acid polyester. Both polymers exhibited important radical scavenging activity (RSA) compared to commercial antioxidant and present tremendous potential for antioxidant applications.
Assuntos
Técnicas de Química Sintética , Lignina/química , Fenol/química , Polímeros/química , Antioxidantes/síntese química , Antioxidantes/química , Fenol/síntese química , Polimerização , Polímeros/síntese química , Polifenóis/síntese química , Polifenóis/química , Termodinâmica , TermogravimetriaRESUMO
AIM AND OBJECTIVE: To study the structural difference, optimization, molecular docking and development of new benzoyl amino phenoxy phenol derivatives as anti-prostate cancer agents. MATERIALS AND METHODS: Strategies towards the identification of novel benzoyl amino phenoxy phenol (BAPP), molecular docking was performed with the designed Androgen Receptor (AR) blockers. Pharmacophore-based studies revealed that the nitro- or cyano-substituted anilide groups have influenced the activity profiles of non-steroidal AR antagonists, followed by the molecular docking studies with five AR receptors. Molecular docking studies were carried out using Maestro from Schrödinger. Absorption, Distribution, Metabolism, and Excretion (ADME) properties of the BAPP derivatives were evaluated for the predictive bioavailability/drug-likeness. These studies supported vital information for designing new anti-prostate cancer agents. RESULTS AND DISCUSSION: There are 125 compounds were screened and best fit compounds (12 entries) were well-synthesized in good to excellent yields and anticancer activities were evaluated. The compounds, 6i showed the highest activities of this series (14.65 ± 1.35 µM). CONCLUSION: The present approach is simple and efficient for the synthesis of BAPP derivatives and the observed IC50 values of BAPPs were in good agreement with the glide scores obtained from the molecular docking. We, further, intend to carry out in vitro and in vivo AR binding studies for the active compounds.
Assuntos
Antagonistas de Receptores de Andrógenos/química , Antineoplásicos/química , Simulação de Acoplamento Molecular , Fenol/farmacologia , Simulação por Computador , Desenho de Fármacos , Humanos , Masculino , Fenol/síntese química , Neoplasias da Próstata/tratamento farmacológicoRESUMO
The ortho-hydroxy-protected aryl sulfate (OHPAS) linker is composed of a diaryl sulfate backbone equipped with a latent phenol moiety at the ortho position of one of the aryl units. The Ar-OH released when the ortho phenol undergoes intramolecular cyclization and displaces the second aryl unit can be viewed as a payload. We have shown in the preceding paper that the OHPAS linkers are highly stable chemically and in various plasmas, yet release payloads when exposed to suitable triggering conditions. As an extension of the OHPAS system, we employed a para-hydroxy benzyl (PHB) spacer for coupling to nonphenolic payloads; this tactic again provided a highly stable system capable of smooth release of appended payloads. The PHB modification works beautifully for tertiary amine and N-heterocycle payloads.
Assuntos
Aminas/química , Compostos de Benzil/química , Compostos Heterocíclicos/química , Fenol/química , Sulfatos/química , Álcoois/síntese química , Álcoois/química , Aminas/síntese química , Compostos de Benzil/síntese química , Ciclização , DNA/síntese química , DNA/química , Compostos Heterocíclicos/síntese química , Fenol/síntese química , RNA/síntese química , RNA/química , Sulfatos/síntese químicaRESUMO
Semisynthetic phenol derivatives were obtained from the natural phenols: thymol, carvacrol, eugenol, and guaiacol through catalytic oxychlorination, Williamson synthesis, and aromatic Claisen rearrangement. The compounds characterization was carried out by 1H NMR, 13C NMR, and mass spectrometry. The natural phenols and their semisynthetic derivatives were tested for their antimicrobial activity against the bacteria: Staphylococcus aureus, Escherichia coli, Listeria innocua, Pseudomonas aeruginosa, Salmonella enterica Typhimurium, Salmonella enterica ssp. enterica, and Bacillus cereus. Minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values were determined using concentrations from 220 to 3.44 µg mL-1. Most of the tested compounds presented MIC values ≤220 µg mL-1 for all the bacteria used in the assays. The molecular properties of the compounds were computed with the PM6 method. Through principle components analysis, the natural phenols and their semisynthetic derivatives with higher antimicrobial potential were grouped.
Assuntos
Antibacterianos/síntese química , Antibacterianos/farmacologia , Fenol/farmacologia , Antibacterianos/química , Cimenos , Escherichia coli/efeitos dos fármacos , Eugenol/química , Eugenol/farmacologia , Listeria/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Monoterpenos/química , Monoterpenos/farmacologia , Fenol/síntese química , Fenol/química , Salmonella typhimurium/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacos , Timol/química , Timol/farmacologiaRESUMO
Thirty-seven phytophenolics and their synthetic analogues were evaluated for activity against two protozoal pathogens, Leishmania donovani and Plasmodium falciparum (D6 and W2 clones), respectively. 4,6-Dimethoxyaurone demonstrated the highest activity with IC50 values of 13.2 and 16.9 µm against L. donovani and P. falciparum (W2 clone), respectively, without undesired cytotoxicity against VERO cells. The moiety having two benzene rings was critical to maintain the antiprotozoal activities based on the observation that both coumaranones and chromones were inactive while other test compounds, including coumarans and aurones, remained active. There was no correlation between antiprotozoal activities and previously evaluated insect antifeedant activity against common cutworms (Spodoptera litura). Flavonoids, including aurones, pterocarpans, and lignan like dihydrobenzofurans, structural analogues of coumarans, are abundant in fruits and vegetables, so these phytophenolics may act as natural antiprotozoal agents in humans.
Assuntos
Antimaláricos/síntese química , Antiprotozoários/síntese química , Fenol/química , Animais , Antimaláricos/química , Antimaláricos/farmacologia , Antiprotozoários/química , Antiprotozoários/farmacologia , Benzofuranos/síntese química , Benzofuranos/química , Benzofuranos/farmacologia , Sobrevivência Celular/efeitos dos fármacos , Chlorocebus aethiops , Leishmania donovani/efeitos dos fármacos , Lignanas/síntese química , Lignanas/química , Lignanas/farmacologia , Fenol/síntese química , Plasmodium falciparum/efeitos dos fármacos , Relação Estrutura-Atividade , Células VeroRESUMO
Trapping of arynes with various nucleophiles provides a range of heteroatom-functionalized arene derivatives, but the corresponding reaction with water does not provide phenol derivatives. Silver trifluroacetate (AgO2CCF3) can nicely solve this problem. It was found that in typical organic solvent, AgO2CCF3 readily reacts with arynes to generate trifluoroacetoxy organosilver arene intermediate, which, upon treating with silica gel, provides phenolic products. This protocol can be extended to the synthesis of α-halofunctionalized phenol derivatives by simply adding NBS (N-bromosuccinimides) or NIS (N-iodosuccinimides) to the reaction along with silver trifluroacetate, which provided α-bromo or α-iodophenol derivatives in good yield. However, the similar reactions with NCS (N-chlorosuccinimides) afforded only the protonated product instead of the expected α-chlorophenols derivatives. Interestingly, substrates containing silyl substituents on 1,3-diynes resulted in α-halotrifluoroacetates rather than their hydrolyzed product. Additionally, trapping the same arynes with other oxygen-based nucleophiles containing silver counter cation, along with NXS (N-halosuccinimides), generated α-halooxyfunctionalized products.
Assuntos
Fenol/química , Fenol/síntese química , Estrutura Molecular , Estereoisomerismo , Ácido Trifluoracético/químicaRESUMO
We have synthesized artepillin C, a diprenylated p-hydroxycinnamate originally isolated from Brazilian propolis and exhibiting antioxidant and antitumor activities, from 2,6-diallylphenol. Replacement of the terminal vinyl with 2,2-dimethylvinyl group by olefin cross-metathesis and subsequent transformation yielded 2,6-diprenyl-1,4-hydroquinone diacetate. Candida antarctica lipase B-catalyzed deacetylation in 2-propanol regioselectively removed the less hindered acetyl group to give 2,6-diprenyl-1,4-hydroquinone 1-monoacetate. After triflation of the liberated 4-hydroxy group, a three-carbon side chain was introduced by palladium-mediated alkenylation with methyl acrylate. Final hydrolysis of the esters furnished artepillin C.
Assuntos
Biocatálise , Proteínas Fúngicas/metabolismo , Lipase/metabolismo , Fenol/química , Fenol/síntese química , Fenilpropionatos/química , Fenilpropionatos/síntese química , Prenilação , Acetilação , Anisóis/química , Técnicas de Química Sintética , Estereoisomerismo , Especificidade por SubstratoRESUMO
Althought there are several reported synthetic routes to strychnine, one of the most widely recognized alkaloids, we report an unexplored route with an oxidative dearomatizing process mediated by hypervalent iodine as the key step. The new syntheses of isostrychnine and strychnine have been achieved from an readily available phenol in nine and ten steps. In addition to the key step, these syntheses involve an aza Michael-ether-enol tandem transformation, two heck type cyclizations, a reductive isomerization, and a double reductive amination in cascade leading to the alkaloid main core.
Assuntos
Iodo/química , Estricnina/síntese química , Ciclização , Indicadores e Reagentes/química , Isomerismo , Oxirredução , Fenol/síntese química , Fenol/química , Estricnina/química , Strychnos nux-vomica/químicaRESUMO
The selectivity of photocatalytic phenol production from the direct oxidation of benzene can be enhanced by fine adjustment of the morphology and composition of Au-Pd metal nanoparticles supported on titanium dioxide thereby suppressing the decomposition of benzene and evolution of phenolic compounds.
Assuntos
Ligas/química , Benzeno/química , Nanopartículas Metálicas/química , Fenol/síntese química , Titânio/química , Catálise , Ouro/química , Radical Hidroxila/química , Oxirredução , Paládio/química , Fenol/química , Raios UltravioletaRESUMO
A novel trinuclear Ni(II) complex [{NiL(n-PrOH)(µ-OAc)}2Ni]·n-PrOH·H2O with an asymmetric Salamo-type ligand, 5-methoxy-4'-bromo-2,2'-[ethylenedioxybis(nitrilomethylidyne)]diphenol (H2L), has been synthesized and characterized by elemental analyses, IR, UV/Vis and fluorescence spectra and molar conductance measurement. The crystal structure of the Ni(II) complex has been determined by single-crystal X-ray diffraction. Two acetate groups coordinating to three Ni(II) ions through NiOCONi bridges and four µ-phenoxo oxygen atoms from two [NiL(n-PrOH)] units also coordinating to Ni(II) ions. In the Ni(II) complex, two n-propanol molecules are coordinated to the two terminal Ni(II) ions having slightly distorted octahedral coordination geometries and form a trinuclear structure, There are also one non-coordinated n-propanol and one non-coordinated water molecule. In the crystal structure, the Ni(II) complex is linked by intermolecular hydrogen bonds into an infinite 1D supramolecular chain-like structure.
Assuntos
Complexos de Coordenação/química , Complexos de Coordenação/síntese química , Níquel/química , Fenol/química , Fenol/síntese química , Cristalografia por Raios X , Condutividade Elétrica , Ligação de Hidrogênio , Conformação Molecular , Espectrometria de Fluorescência , Espectrofotometria Infravermelho , Espectrofotometria UltravioletaRESUMO
Azo-azomethine dyes 2-((4-amino-1,2,5-oxadiazol-3-ylimino)methyl)-4-(phenyl diazenyl)phenols (2a-h) have been synthesized by condensation reaction of 3,4-diamino-1,2,5-oxadiazole with 2-hydroxy-5-[(E)-(aryldiazenyl)]benzaldehyde (1a-h) in methanol. The structures of dyes have been characterized by elemental analysis, mass, IR, UV-Vis, 1H and 13С NMR spectroscopy. UV-Vis absorption spectra indicated enol-keto tautomeric and positive solvatochromism in compounds 2a-h which is dependent on the substitution, solvent, pH and environment temperature. The synthesized compounds were investigated for their in vitro antioxidant activity by diphenylpicrylhydrazyl assay. Compounds substituted with electron donating groups, such as, alkyl and methoxy groups showed moderate antioxidant activity. The in vitro antibacterial activity of all compounds was determined by disk diffusion method. The test compounds showed varying degree of inhibition against B. cereus and S. aureus strains.
Assuntos
Oxidiazóis/síntese química , Oxidiazóis/farmacologia , Fenol/síntese química , Fenol/farmacologia , Fenóis/síntese química , Fenóis/farmacologia , Solventes/química , Antibacterianos/farmacologia , Bactérias/efeitos dos fármacos , Espectroscopia de Ressonância Magnética Nuclear de Carbono-13 , Dimetil Sulfóxido/química , Dimetilformamida/química , Elétrons , Furanos/química , Testes de Sensibilidade Microbiana , Modelos Moleculares , Oxidiazóis/química , Fenol/química , Fenóis/química , Espectroscopia de Prótons por Ressonância Magnética , Teoria Quântica , Espectrofotometria Ultravioleta , Espectroscopia de Infravermelho com Transformada de Fourier , TemperaturaRESUMO
Seven novel ARIs (3a-c, 4a-c and 5) were synthesized with the implementation of an optimized and, partially, selective synthetic procedure, via a Friedel-Crafts acylation reaction. The synthesized ARIs have values of IC(50)(ALR2) ranging from 0.19µM (in case of compound 3b) to 2.3µM (in case of compound 4a), while the values of selectivity index towards ALR1 range from 1 (in case of compound 3b) to 238 (in case of compound 3a). Finally, we found out that the presence of an additional (secondary) aromatic area is not a prerequisite feature for ARI activity.
Assuntos
Aldeído Redutase/antagonistas & inibidores , Inibidores Enzimáticos/síntese química , Fenol/química , Pirróis/química , Aldeído Redutase/metabolismo , Animais , Inibidores Enzimáticos/química , Inibidores Enzimáticos/metabolismo , Feminino , Masculino , Fenol/síntese química , Fenol/metabolismo , Ligação Proteica , RatosRESUMO
A series of alkali metal complexes supported by two bulky tetraphenols were synthesized and characterized. The reactions of α,α,α',α'-tetra(3,5-di-tert-butyl-2-hydroxyphenyl)-p-xylene(para-tetraphenol) with (n)BuLi, sodium, and KSi(NMe(2))(3) gave bimetallic complexes 1, 2, and 3, respectively. Treatments of the α,α,α',α'-tetra(3,5-di-tert-butyl-2-hydroxyphenyl)-m-xylene(meta-tetraphenol) with 2 or 4 equiv of (n)BuLi afforded complexes 4 or 5, while the reactions of meta-tetraphenol with sodium and KSi(NMe(2))(3) gave only trimetallic complexes 6 and 7 for the additional p-π interaction. Complexes 1-7 were all characterized by single-crystal X-ray diffraction techniques. In the presence of benzyl alcohol, all complexes are active catalysts for the ring-opening polymerization of L-lactide. Comparatively, bimetallic complexes 1, 2, and 3 are more efficient catalysts because of their symmetric structures, in which complex 3 presents as a rare highly active potassium catalyst for the ring-opening polymerization of lactide, leading to polymers with good molecular weight control and narrow molecular weight distributions.
Assuntos
Complexos de Coordenação/síntese química , Dioxanos/química , Metais Alcalinos/química , Fenol/química , Álcool Benzílico/química , Complexos de Coordenação/química , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Fenol/síntese química , Polimerização , Difração de Raios XRESUMO
A homologous series of four molecules in which a phenol unit is linked covalently to a rhenium(I) tricarbonyl diimine photooxidant via a variable number of p-xylene spacers (n = 0-3) was synthesized and investigated. The species with a single p-xylene spacer was structurally characterized to get some benchmark distances. Photoexcitation of the metal complex in the shortest dyad (n = 0) triggers release of the phenolic proton to the acetonitrile/water solvent mixture; a H/D kinetic isotope effect (KIE) of 2.0 ± 0.4 is associated with this process. Thus, the shortest dyad basically acts like a photoacid. The next two longer dyads (n = 1, 2) exhibit intramolecular photoinduced phenol-to-rhenium electron transfer in the rate-determining excited-state deactivation step, and there is no significant KIE in this case. For the dyad with n = 1, transient absorption spectroscopy provided evidence for release of the phenolic proton to the solvent upon oxidation of the phenol by intramolecular photoinduced electron transfer. Subsequent thermal charge recombination is associated with a H/D KIE of 3.6 ± 0.4 and therefore is likely to involve proton motion in the rate-determining reaction step. Thus, some of the longer dyads (n = 1, 2) exhibit photoinduced proton-coupled electron transfer (PCET), albeit in a stepwise (electron transfer followed by proton transfer) rather than concerted manner. Our study demonstrates that electronically strongly coupled donor-acceptor systems may exhibit significantly different photoinduced PCET chemistry than electronically weakly coupled donor-bridge-acceptor molecules.
Assuntos
Substâncias Luminescentes/química , Oxidantes Fotoquímicos/química , Fenol/química , Rênio/química , Cristalografia por Raios X , Técnicas Eletroquímicas , Elétrons , Iminas/síntese química , Iminas/química , Substâncias Luminescentes/síntese química , Modelos Moleculares , Oxidantes Fotoquímicos/síntese química , Oxirredução , Fenol/síntese química , Prótons , Xilenos/síntese química , Xilenos/químicaRESUMO
Multifunctional Ag@Au@ phenol formaldehyde resin (PFR) particles loaded with folic acids (FA) have been designed for killing tumor cells through photothermy conversion under the irradiation of near-infrared (NIR) light. Possessing the virtue of good fluorescence, low toxicity, and good targeting, the nanocomposite consists of an Ag core, an Au layer, a PFR shell, and folic acids on the PFR shell. The Ag@PFR core-shell structure can be prepared with a simple hydrothermal method after preheating. We then filled the PFR shell with a layer of Au by heating and modified the shell with polyelectrolyte to change its surface charge state. To capture tumor cells actively, FA molecules were attached onto the surface of the Ag@Au@PFR particles in the presence of 1-ethyl-3-(3-dimethly aminopropyl) carbodiimide (EDAC) and N-hydroxysuccinimide (NHS). Owing to the excellent property of Au NPs and Ag NPs as photothermal conversion agents, the Ag@Au@ PFR@FA particles can be utilized to kill tumor cells when exposed to NIR light.
Assuntos
Ácido Fólico/química , Formaldeído/química , Formaldeído/síntese química , Nanopartículas Metálicas/química , Nanopartículas Metálicas/uso terapêutico , Fenol/química , Fenol/síntese química , Fenóis/química , Fenóis/síntese química , Polímeros/química , Polímeros/síntese química , Prata/química , Prata/uso terapêutico , Fotometria , Fototerapia , Espectroscopia de Luz Próxima ao Infravermelho , Succinimidas/químicaRESUMO
Several α-(1H-imidazol-1-yl)-ω-phenylalkanes were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). These compounds were found to be potent and selective for the stress-induced isozyme HO-1, showing mostly weak activity toward the constitutive isozyme HO-2. The introduction of an oxygen atom in the alkyl linker produced analogues with decreased potency toward HO-1, whereas the presence of a sulfur atom in the linker gave rise to analogues with greater potency toward HO-1 than the carbon-containing analogues. The most potent compounds studied contained a five-atom linker between the imidazolyl and phenyl moieties, whereas the most HO-1-selective compounds contained a four-atom linker between these groups. The compounds with a five-atom linker containing a heteroatom (O or S) were found to be the most potent inhibitors of HO-2; 1-(N-benzylamino)-3-(1H-imidazol-1-yl)propane dihydrochloride, with a nitrogen atom in the linker, was found to be inactive.