RESUMO
Natural rubber latex is a widely used industrial raw material to produce many consumer and commercial products. Chronic exposures to latex allergenic proteins residual in the finished products can promote hypersensitive immune responses, which affects millions of workers and the general public worldwide. Research has shown the average prevalence of latex allergy worldwide remains approximately 10% among healthcare workers, 7% among susceptible patients, and 4% among general population. Although most effective in preventing latex allergy, completely avoiding contact to latex-derived products is extremely challenging, given the fact that millions of products possibly contain latex, but few are regulated and properly labeled. Due to the difficulty to assure a product completely absent of latex allergens, the United States Food and Drug Administration has recommended to stop using labels like "latex-free" or "does not contain latex." Here we evaluate published data, industrial standards and regulations, identify possible countermeasures, and propose an integrated strategy, including some more practicable approaches (e.g., education/training, product labeling, the use of proper personal protective equipment, occupational selection, and searchable product database) and novel medical treatments (e.g., immunotherapy) to help decreasing latex allergy prevalence.
Assuntos
Hipersensibilidade ao Látex , Humanos , Hipersensibilidade ao Látex/epidemiologia , Hipersensibilidade ao Látex/prevenção & controle , Borracha , Alérgenos , Indústrias , Pessoal de SaúdeRESUMO
Natural rubber latex (NRL) has prophylactic properties and is used to make pathogen-isolating products like condoms and surgical gloves. However, obtaining NRL and casting it into durable products are challenging. Consequently, progress in the research and development of medical NRL products has been slow. This study aims to strengthen NR and induce it with bactericidal properties. In this regard, we introduce inorganic whiskers into the NRL and synthesize whiskers/NR composites with strong mechanical and antibacterial properties. The method proposed herein is a template method, which can rapidly and efficiently reveal the antibacterial effect of the composite latex, providing convenience for research institutions and factories studying antibacterial latex. A complete system is established for studying the antibacterial medical NRL, and a precedent is set for the relevant products.
Assuntos
Hipersensibilidade ao Látex , Borracha , Humanos , Látex , Hipersensibilidade ao Látex/prevenção & controle , Alérgenos , Antibacterianos/farmacologiaRESUMO
PURPOSE OF REVIEW: The present review addresses the secondary prevention in healthcare worker, healthcare setting, and in patients outside the healthcare setting. RECENT FINDINGS: There is sufficient knowledge of the broad aetiology of latex allergy for secondary preventive programmes to be widely adopted. Currently, avoidance of latex-containing surgical products is mandatory in the care of sensitized patients. They should also have a list of occult sources of natural rubber latex exposure and cross-reacting fruits. During all health-care procedures latex allergic patients should be treated in a 'latex-free' environment. Specific sublingual immunotherapy has been suggested as a suitable therapeutic option. It can be offered, in addition to symptomatic treatment, to selected patients, when avoidance measures are not feasible or effective. The use of omalizumab could also be extended as an adjunct to latex immunotherapy. SUMMARY: Despite of the progress made in the secondary prevention of latex allergy, the disease still continues to be a global health problem.
Assuntos
Hipersensibilidade ao Látex , Frutas , Humanos , Imunoterapia/métodos , Hipersensibilidade ao Látex/prevenção & controle , Borracha/efeitos adversos , Prevenção SecundáriaRESUMO
A growing number of students with health conditions, many of which carry with them the potential for an emergency, increases the likelihood of adverse events occurring in the school setting. An adverse event can be either preventable or nonpreventable. This article reviews a preventable adverse event which took place in a second-grade classroom of a student with spina bifida. Children with spina bifida are at increased risk for the development of latex allergy and subsequent anaphylaxis. The seriousness of accumulated exposure to latex necessitated initiation of a quality improvement plan with the goal of decreasing the risk of future exposures and increasing the quality of collaboration among school staff in meeting student health needs. The article describes the adverse event and discusses the five factors that were addressed in the quality improvement plan: communication deficit, knowledge deficit, hierarchical culture, product labeling, and data collection.
Assuntos
Anafilaxia , Hipersensibilidade ao Látex , Serviços de Enfermagem Escolar , Disrafismo Espinal , Anafilaxia/induzido quimicamente , Anafilaxia/prevenção & controle , Criança , Humanos , Hipersensibilidade ao Látex/prevenção & controle , Fatores de Risco , Instituições Acadêmicas , Disrafismo Espinal/complicaçõesRESUMO
Sterile protective gloves are used to reduce the risk of infection for patients and clinicians in all healthcare settings. This is particularly important in operating theatres, where surgical site infection is a common and serious complication for perioperative patients. These gloves have traditionally been made from natural rubber latex and dusted with cornstarch powder. However, frequent use of latex gloves can lead to a hypersensitivity or allergy to latex. A latex allergy causes discomfort and inconvenience, and it may reduce productivity, impose significant financial burdens and even be life threatening. There has not been sufficient evidence to ban the clinical use of latex; however, in cases of suspected latex allergy, guidelines recommend the use of either latex-free gloves or powder-free, low-protein latex gloves. The use of these alternative gloves has typically been limited to cases of allergy, because they have previously been associated with reduced dexterity and durability compared with latex gloves. This article presents four case studies, in which health professionals in a perioperative setting compare the advantages and disadvantages of using traditional latex surgical gloves with those of latex-free gloves manufactured by Cardinal Health. The findings of these case studies suggest that these latex-free gloves are equal to latex gloves in terms of establishing asepsis and providing comfort and dexterity to the wearer, without presenting the risk of developing latex sensitivity and/or allergy.
Assuntos
Luvas Protetoras/normas , Luvas Cirúrgicas/normas , Hipersensibilidade ao Látex/induzido quimicamente , Hipersensibilidade ao Látex/prevenção & controle , Doenças Profissionais/prevenção & controle , Salas Cirúrgicas/normas , Infecção da Ferida Cirúrgica/prevenção & controle , Adulto , Idoso , Feminino , Luvas Protetoras/efeitos adversos , Luvas Cirúrgicas/efeitos adversos , Guias como Assunto , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Reino Unido , Adulto JovemRESUMO
PURPOSE OF REVIEW: During the 1980s, natural rubber latex (NRL) emerged as a major cause of occupational allergy and asthma, especially in healthcare workers using powdered NRL gloves. Increased recognition of NRL allergies and transfer of research findings into prevention strategies resulted into an almost elimination of this health problem. Here, the current knowledge on allergens, their use in diagnostics, prevalence data of occupational NRL allergy and the status of prevention strategy are summarized. RECENT FINDINGS: While the current studies conducted in high-income countries show that prevention measures have reduced NRL allergy, this does not yet apply worldwide. For latex allergy diagnosis, it is important that recombinant allergens as reliable tools are available, because in several European countries and the United States, NRL skin prick test extracts and powdered latex gloves for bronchial challenge test are no longer commercially available, leading to a deficit in diagnostic tools. Due to the fact that latex is suitable with good properties as a raw material for gloves, alternatives with significantly lower protein content and without cross-reactive structures to latex proteins are sought. SUMMARY: Awareness of the sensitization risk associated with the use of latex gloves should still be present in all occupational settings.
Assuntos
Alérgenos/imunologia , Carga Global da Doença , Hipersensibilidade ao Látex/epidemiologia , Doenças Profissionais/epidemiologia , Borracha/efeitos adversos , Alérgenos/efeitos adversos , Reações Cruzadas , Luvas Protetoras/efeitos adversos , Pessoal de Saúde/estatística & dados numéricos , Humanos , Hipersensibilidade ao Látex/diagnóstico , Hipersensibilidade ao Látex/imunologia , Hipersensibilidade ao Látex/prevenção & controle , Doenças Profissionais/diagnóstico , Doenças Profissionais/imunologia , Doenças Profissionais/prevenção & controle , Exposição Ocupacional/efeitos adversos , Exposição Ocupacional/prevenção & controle , Prevalência , Testes CutâneosRESUMO
INTRODUCTION: Hypersensitivity reactions to natural rubber latex are well-characterized occupational concerns for health care personnel. Health care providers are at increased risk for exposure and possibly transmission of vaccine preventable diseases. Therefore, many health care facilities require providers to be vaccinated against these diseases to maintain employment. Mandatory vaccination for these health care providers presents potential challenges and safety concerns. MATERIALS AND METHODS: Using a commercial Latex Allergen ELISA Assay kit for Hev b 1, we evaluated the latex content of HAVRIX, ENGERIX-B, TWINRIX, and BOOSTRIX all manufactured by GlaxoSmithKline. RESULTS: These data demonstrate undetectable Hev b 1 content among all of the vaccines tested. This study provides the first known data regarding natural rubber latex content in adult vaccines. CONCLUSIONS: Our study revealed undetectable levels of Hev b 1 natural rubber latex content in the tested adult vaccines. These data provide evidence for prospective studies into the safety of vaccinating latex allergic patients.
Assuntos
Hipersensibilidade ao Látex , Vacinas , Adulto , Alérgenos , Antígenos de Plantas , Humanos , Hipersensibilidade ao Látex/prevenção & controle , Estudos Prospectivos , BorrachaRESUMO
Despite the introduction and use of latex-free gloves, natural rubber latex hypersensitivity is still an issue in hospital medicine both for patients and healthcare professionals. Clear understanding of the groups at risk as well as perioperative assessment and management is key to reducing complications and improving safety. In this literature review, we cover the perioperative management of patients with latex hypersensitivity, as well as the implications for healthcare professionals. We also review the cost analyses of latex hypersensitivity in the healthcare system and the evidence available.
Assuntos
Luvas Protetoras/efeitos adversos , Hipersensibilidade ao Látex/prevenção & controle , Assistência Perioperatória , Custos e Análise de Custo , Pessoal de Saúde , Humanos , Hipersensibilidade ao Látex/economia , Hipersensibilidade ao Látex/etiologia , Pacientes , Fatores de RiscoAssuntos
Hipersensibilidade ao Látex/prevenção & controle , Salas Cirúrgicas/normas , Segurança do Paciente , Complicações Pós-Operatórias/prevenção & controle , Adulto , Feminino , Humanos , Látex/efeitos adversos , Hipersensibilidade ao Látex/epidemiologia , Hipersensibilidade ao Látex/etiologia , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Guias de Prática Clínica como Assunto , Avaliação de Programas e Projetos de Saúde , Estudos Prospectivos , Fatores de RiscoRESUMO
: The Pennsylvania Patient Safety Reporting System is a confidential, statewide Internet reporting system to which all Pennsylvania hospitals, outpatient-surgery facilities, birthing centers, and abortion facilities must file information on incidents and serious events.Safety Monitor is a column from Pennsylvania's Patient Safety Authority, the authority that informs nurses on issues that can affect patient safety and presents strategies they can easily integrate into practice. For more information on the authority, visit www.patientsafety.pa.gov. For the original article discussed in this column or for other articles on patient safety, click on "Advisories and Events" and then "Pennsylvania Patient Safety Advisory" in the top navigation menu.
Assuntos
Hipersensibilidade ao Látex/enfermagem , Humanos , Hipersensibilidade ao Látex/prevenção & controle , Segurança do Paciente , PennsylvaniaRESUMO
Reduction in the prevalence of IgE-mediated allergy to latex proteins from gloves in patients may lead to lax attention by health care personnel to avoid use of latex products in latex-allergic subjects. Recent evidence from the Pennsylvania Patient Safety Reporting System shows an alarming continuation of adverse events mostly from latex urinary catheters. We are strongly advocating that health care personnel must continue to pay close attention to avoidance of latex in patients with a history of latex allergy.
Assuntos
Hipersensibilidade ao Látex/epidemiologia , Equipamentos e Provisões , Luvas Protetoras , Humanos , Hipersensibilidade ao Látex/prevenção & controle , RiscoRESUMO
PURPOSE: Occupational asthma (OA), a common respiratory disorder in Western countries, is caused by exposures at the workplace. It is part of a broader definition of work-related asthma (WRA) that also includes pre-existing asthma aggravated by substances present in the workplace environment, and it is potentially preventable. The purpose of this paper is to illustrate preventive measures for occupational asthma by case studies. METHODS: In three case studies we discuss preventive measures that have been associated with reductions in incidence of occupational asthma from natural rubber latex and from diisocyanates as supported by published literature. We also discuss challenges in relation to asthma from cleaning products in healthcare work. RESULTS AND CONCLUSIONS: Several preventive measures have been associated with reduction in incidence of occupational asthma from natural rubber latex and from diisocyanates, and may provide lessons for prevention of other causes of occupational asthma. Cleaning products remain an unresolved problem at present with respect to asthma risks but potential measures include the use of safer products and safer applications such as avoidance of spray products, use of occupational hygiene methods such as improving local ventilation, and when appropriate, the use of personal protective devices.
Assuntos
Asma Ocupacional/induzido quimicamente , Detergentes/toxicidade , Exposição Ambiental/prevenção & controle , Política de Saúde , Irritantes/toxicidade , Hipersensibilidade ao Látex/prevenção & controle , Doenças Profissionais/prevenção & controle , Exposição Ocupacional/prevenção & controle , Asma Ocupacional/epidemiologia , Humanos , Incidência , Doenças Profissionais/etiologia , Local de TrabalhoRESUMO
INTRODUCTION: Latex allergy is common in the hospital setting. OBJETIVE: To describe the clinical situation of three pediatric interns with latex allergy and the prevention strategies implemented during clinical clerkships in pediatric and neonatal intensive care units. PATIENTS, METHODS, AND OUTCOMES: The three interns referred symptom exacerbation during their internship program. Diagnosis was confirmed based on a compatible history and positive specific immunoglobulin E. A semi-structured interview was done to describe perceptions about prevention strategies, the personnel were trained, and nitrile gloves were provided for carrying out procedures. Interns completed their clinical clerkships without having allergic reactions. Positive aspects referred by interns were that they felt cared for and experienced an improved quality of life; negative aspects were a bad predisposition and resistance against change among some other interns. Strategies designed to this end permitted interns to continue their internship program.
INTRODUCCIÓN: La alergia al látex es frecuente en ámbitos hospitalarios. OBJETIVO: Describir la situación clínica de tres residentes de Pediatría con alergia al látex y las estrategias de prevención en las rotaciones de Terapia Intensiva Pediátrica y Neonatal. PACIENTES, MÉTODOS Y RESULTADOS: Las tres profesionales manifestaron exacerbación de síntomas durante la residencia. Se confirmó el diagnóstico con historia compatible e inmunoglobulina E específica positiva. Se realizó una entrevista semiestructurada para describir sus percepciones en relación con las estrategias de prevención, se capacitó al personal y se incorporaron guantes de nitrilo para los procedimientos. Las residentes realizaron las rotaciones sin presentar manifestaciones alérgicas. Refirieron como aspectos positivos sentirse cuidadas y mejor calidad de vida; como aspectos negativos, mala predisposición y resistencia al cambio en algunos compañeros. Las estrategias diseñadas permitieron que las residentes pudieran continuar su programa de formación.
Assuntos
Internato e Residência , Hipersensibilidade ao Látex/prevenção & controle , Pediatria/educação , Adulto , Dermatoses da Mão/etiologia , Dermatoses da Mão/prevenção & controle , Humanos , Hipersensibilidade ao Látex/diagnóstico , Hipersensibilidade ao Látex/psicologiaRESUMO
Providing a safe environment for students at risk for anaphylaxis from a latex allergy requires care coordination and collaboration of all members of the school community. Strategies for allergy management include educating the school community, identifying potential exposure to latex, preparing to respond in an emergency, and creating a plan for the future. With the student at the center of sound planning, the school can provide a secure and healthy environment.
Assuntos
Exposição Ambiental/prevenção & controle , Hipersensibilidade ao Látex/prevenção & controle , Papel do Profissional de Enfermagem , Assistência Centrada no Paciente , Criança , Tratamento de Emergência , Humanos , Hipersensibilidade ao Látex/enfermagem , Serviços de Saúde Escolar , Serviços de Enfermagem Escolar , EstudantesRESUMO
Natural rubber latex (NRL) allergy is caused by the extractable latex proteins in dipped rubber products. It is a major concern for the consumers who are sensitive to the allergenic extractable proteins (EP) in products such as NRL gloves. Objective of this research was to develop an economical method to reduce the EP in finished dipped NRL products. In order to reduce the EP levels, two natural proteases, bromelain from pineapple and papain from papaya, were extracted and partially purified using (NH4)2SO4. According to the newly developed method, different glove samples were treated with a 5% solution of each partially purified enzyme, for 2 hours at 60°C. Residual amounts of in treated samples were quantified using the modified Lowry assay (ASTM D5712-10). Bromelain displayed a 54 (±11)% reduction of the EP from the dipped rubber products, whereas it was 58 (±8)% with papain. These results clearly indicate that the selected natural proteases, bromelain, and papain contribute significantly towards the reduction of the total EP in finished NRL products. Application of bromelain enzyme for the aforementioned purpose has not been reported up to date, whereas papain has been used to treat raw NRL towards reducing the EP.
Assuntos
Luvas Protetoras/efeitos adversos , Hipersensibilidade ao Látex/prevenção & controle , Látex/química , Borracha/efeitos adversos , Alérgenos/efeitos adversos , Alérgenos/química , Ananas/enzimologia , Bromelaínas/química , Bromelaínas/farmacologia , Carica/enzimologia , Humanos , Látex/efeitos adversos , Hipersensibilidade ao Látex/induzido quimicamente , Hipersensibilidade ao Látex/fisiopatologia , Papaína/química , Papaína/farmacologia , Proteínas/química , Proteínas/farmacologia , Borracha/químicaRESUMO
PURPOSE OF REVIEW: Allergy to natural rubber latex (NRL) reached epidemic proportions during the nineties and led to intense preventive efforts. The aim of this review was to provide a comprehensive compilation of the current status of occupational NRL allergy. RECENT FINDINGS: Recent advances led to the characterization of 15 NRL allergens and the development of assays for measuring the allergen content of NRL materials and specific IgE antibodies against NRL allergen components. Preventive measures aimed at reducing workplace exposure to NRL allergens were associated with decreasing incidence rates of NRL allergy. However, a pooled analysis of epidemiological surveys published during the last 10 years provided prevalence estimates of NRL sensitization and allergy similar to those derived from studies conducted before 2003. Substantial progress has been made in the understanding and prevention of NRL allergy, although the disease may still remain a worldwide cause of concern.