RESUMO
Hormones are known to influence various body systems that include skeletal, cardiac, digestive, excretory, and immune systems. Emerging investigations suggest the key role played by secretions of endocrine glands in immune cell differentiation, proliferation, activation, and memory attributes of the immune system. The link between steroid hormones such as glucocorticoids and inflammation is widely known. However, the role of peptide hormones and amino acid derivatives such as growth and thyroid hormones, prolactin, dopamine, and thymopoietin in regulating the functioning of the immune system remains unclear. Here, we reviewed the findings pertinent to the functional role of hormone-immune interactions in health and disease and proposed perspective directions for translational research in the field.
Assuntos
Doenças do Sistema Endócrino/metabolismo , Sistema Endócrino/metabolismo , Hormônio do Crescimento/metabolismo , Doenças do Sistema Imunitário/metabolismo , Sistema Imunitário/metabolismo , Prolactina/metabolismo , Timócitos/metabolismo , Animais , Comunicação Celular , Citocinas/genética , Citocinas/imunologia , Citocinas/metabolismo , Dopamina/genética , Dopamina/imunologia , Dopamina/metabolismo , Sistema Endócrino/citologia , Sistema Endócrino/imunologia , Doenças do Sistema Endócrino/genética , Doenças do Sistema Endócrino/imunologia , Doenças do Sistema Endócrino/patologia , Glucocorticoides/genética , Glucocorticoides/imunologia , Glucocorticoides/metabolismo , Hormônio do Crescimento/genética , Hormônio do Crescimento/imunologia , Humanos , Sistema Imunitário/citologia , Sistema Imunitário/imunologia , Doenças do Sistema Imunitário/genética , Doenças do Sistema Imunitário/imunologia , Doenças do Sistema Imunitário/patologia , Lactotrofos/citologia , Lactotrofos/imunologia , Lactotrofos/metabolismo , Prolactina/genética , Prolactina/imunologia , Receptores Dopaminérgicos/genética , Receptores Dopaminérgicos/imunologia , Receptores Dopaminérgicos/metabolismo , Somatotrofos/citologia , Somatotrofos/imunologia , Somatotrofos/metabolismo , Timócitos/citologia , Timócitos/imunologia , Hormônios Tireóideos/genética , Hormônios Tireóideos/imunologia , Hormônios Tireóideos/metabolismoRESUMO
CONTEXT: Isolated prolactin (PRL) deficiency is a rare entity of unknown etiology manifesting as failure of puerperal lactogenesis. OBJECTIVE: The aim of the study was to determine the cause of isolated PRL deficiency in an affected woman. DESIGN AND SETTING: We examined genetic and autoimmune causes of isolated PRL deficiency at academic medical centers. PATIENT: The patient was a 39-year-old woman with puerperal alactogenesis after two deliveries and undetectable PRL. The other pituitary axes, serum calcium levels, and cranial magnetic resonance imaging were normal. INTERVENTION: Recombinant human PRL (r-hPRL) was administered to the patient. MAIN OUTCOME MEASURES: We measured the sequencing of candidate genes and immunofluorescence analysis of autoantibodies directed against pituitary endocrine cells. RESULTS: There were no rare sequence variants in the genes encoding for PRL, putative PRL-releasing peptide, putative PRL-releasing peptide receptor, or in other genes important for lactotroph lineage development (POU1F1, PROP1, LHX3, LHX4, HESX1, OTX2, and LSD1). The patient serum, on the contrary, contained autoantibodies that specifically recognized a subset of PRL-secreting cells but not PRL itself or any other pituitary cells or hormones. The mother was able to lactate fully after 17 days of treatment with r-hPRL 60 µg/kg every 12 hours, but alactogenesis resumed after treatment was completed. CONCLUSIONS: These studies report a new autoimmune etiology for women with isolated PRL deficiency and puerperal alactogenesis.