Efficacy of isobutylamido thiazolyl resorcinol for prevention of laser-induced post-inflammatory hyperpigmentation: A randomized, controlled trial.

BACKGROUND: Q-switched (QS) Nd: YAG laser is one of the treatment options for solar lentigines (SLs). However, the incidence of post-inflammatory hyperpigmentation (PIH) is a common complication, especially in dark-complexioned skin. Isobutylamido thiazolyl resorcinol (ITR) has been reported as a preventive modality for ultraviolet B (UVB)-induced hyperpigmentation. AIMS: This study aims to evaluate the efficacy and safety of ITR for the prevention of laser-induced PIH. PATIENTS/METHODS: A randomized, evaluator-blinded study including 24 subjects with SLs was conducted. Three SLs of each patient were randomized into three groups, which were to apply ITR twice daily, once daily, and no application for 2 weeks. Thereafter, 532-nm QS Nd: YAG laser was performed. Incidence of laser-induced PIH, relative melanin index (RMI), mean luminance score (L*), hyperpigmentation score, and adverse events were recorded for 2 months post-laser. RESULTS: The incidence of PIH at the 4th week after laser treatment was significantly lower in the ITR twice-daily group compared to the no-application group (20.83% vs. 50%, p = 0.028). There was no statistically significant difference in RMI, mean L*, and hyperpigmentation score between treatments at all visits. No serious adverse events were reported regarding ITR application and laser treatment. CONCLUSION: Two-week application of ITR prior to QS: Nd YAG laser treatment may potentially reduce the incidence of PIH. A longer duration of application, including after the laser procedure, may be more beneficial for the prevention of laser-induced PIH.

Inhibitory effect of Phalaenopsis orchid extract on WNT1-induced immature melanocyte precursor differentiation in a novel in vitro solar lentigo model.

Recently, it has been reported that increased expression of WNT1 accelerates the differentiation of melanocyte stem cells (McSCs) in solar lentigines (SLs), hyperpigmented maculae commonly seen on sun-exposed areas of the skin. In this study, to establish an in vitro SL model, human epidermal squamous carcinoma cell line HSC-1, which expresses higher levels of WNT1 than normal human epidermal keratinocytes, was co-cultured with early passage normal human epidermal melanocytes (NHEMs) as an in vitro McSC model. As a result, mRNA expression levels of melanocyte differentiation-related genes MITF and TYR in NHEMs were significantly increased by co-culturing with HSC-1 cells. Furthermore, Phalaenopsis orchid extract (Phex) inhibited McSCs differentiation by suppressing WNT1 expression via down-regulation of DLX2, a transcriptional activator of WNT1, in HSC-1 cells. Therefore, our finding suggested that extracts such as Phex, which suppresses WNT1 expression, may be useful as a novel treatment of SLs.

Lentigo benigno facial: manejo quirúrgico a propósito de un caso / Benígn facíallentígo: surgícal management a purpose case

El lentigo benigno es un trastorno de la pigmentación de la piel, que se caracteriza por la presencia de manchas pigmentadas en la piel, de distintos tamaños y cuyo número varía de unas cuantas lesiones a varias. Se localizan preferentemente en zonas de exposición solar, su color generalmente es marrón claro, de bordes regulares y simétricos. Se presenta el caso de un paciente de 71 años, procedente de Chimbote, quien es enviado para evaluación y tratamiento con el diagnóstico presuntivo de melanoma. Presenta mancha de color marrón en mejilla izquierda, en algunas áreas con tonalidades más oscuras, asimétrico y de borde irregular. Se presenta este caso, para mostrar el manejo quirúrgico efectuado, con un buen resultado estético.

Benign lentigo is a pigmentation disorder of the skin, characterized by the presence of pigmented spots on the skin, of different sizes and the number of which varies from a few lesions to several. Are preferentially located in areas of sun exposure, its color is usually light brown, regular and symmetrical edges. The case of a 71 year old from Chimbote, who is sent for evaluation and treatment with the presumptive diagnosis of melanoma, is presented. He presents a brown spot on left cheek, in some areas with darker, asymmetric and irregular edge tones. This case is presented to show surgical management performed, with a good cosmetic result.

Protective effect of red orange extract supplementation against UV-induced skin damages: photoaging and solar lentigines.

BACKGROUND: Exposure of the skin to solar ultraviolet (UV) radiations causes important oxidative damages that result in clinical and hystopathological changes, contributing to premature skin aging. Hyperpigmented lesions, also known as age spots, are one of the most visible alterations in skin photoaging. Skin is naturally equipped with antioxidant systems against UV-induced ROS generation; however, these antioxidant defenses are not completely efficient during exposure to sunlight. Oral antioxidants are able to counteract the harmful effects of UV radiation and to strengthen the physiological skin antioxidant defenses. AIMS: The present study was performed to evaluate the in vivo skin photo-protecting and anti-aging effects of a red orange (Citrus sinensis varieties Moro, Tarocco and Sanguinello) extract supplementation. Previous studies showed that red orange extracts possess strong in vitro free radical scavenging/antioxidant activity and photo-protective effects on human skin. MATERIALS/METHODS: The photo-protective effects of red orange extract intake against UV-induced skin erythema and melanin production in solar lentigo was evaluated on healthy volunteers by an objective instrumental method (reflectance spectrophotometry). RESULTS: Data obtained from in vivo studies showed that supplementation of red orange extract (100 mg/daily) for 15 days brought a significant reduction in the UV-induced skin erythema degree. Moreover, skin age spots pigmentation (melanin content) decreased from 27% to 7% when subjects were exposed to solar lamp during red orange extract supplementation. CONCLUSIONS: Red orange extract intake can strengthen physiological antioxidant skin defenses, protecting skin from the damaging processes involved in photo-aging and leading to an improvement in skin appearance and pigmentation.

[Consensus document on bath-PUVA therapy. The Spanish Photobiology Group of the Spanish Academy of Dermatology and Venereology]. / Documento de consenso sobre la modalidad terapéutica del baño-PUVA. Grupo Español de Fotobiología de la Academia Española de Dermatología and Venereología.

Bath PUVA is a variant of phototherapy as efficacious as oral PUVA therapy that avoids many of the adverse effects associated to this treatment. Nevertheless, the special features and the specialized equipment required for its employment have limited its application in the dermatologic clinics of our country. Following the trend initiated after the publication of the consensus document on oral PUVA therapy and narrow band (NB) UVB therapy, the Spanish Photobiology Group from the Spanish Academy of Dermatology and Venereology has developed a therapeutic guideline for bath PUVA therapy based on the literature review and the experience of its members. The document aims to be a practical reference guide for those dermatological centres that include phototherapy among their services. It reviews the concept and indications of this type of treatment and proposes recommendations concerning therapeutic procedures, drug associations of interest and prophylaxis and management of adverse effects.

[Prevention and early diagnosis of malignant melanoma]. / Forebygging og tidlig diagnostisering av malignt melanom.

A Norwegian melanoma project was carried out in 1989-1993 as a joint study by the dermatological, surgical, oncological, and pathological departments at the five university hospitals in Norway, Of 4,582 patients (2,894 women, 1,688 men) diagnosed and treated at the Department of Dermatology, Ullevål Hospital, 1,347 patients (833 women, 514 men) were included in the analysis, which consisted of a clinical evaluation and pathological investigation of their excised pigmented lesions. In all, 66 malignant melanomas were diagnosed, including 50 superficial spreading melanomas, seven lentigo maligna melanomas, eight nodular melanomas, and one acral lentiginous melanoma. Persons with red hair and skin type I/II were at increased risk of developing malignant melanoma. Superficial spreading melanomas excised during the study period had a significant lower histological thickness compared with those lesions excised before the study period.