Assuntos
Pesquisa Biomédica , Tecnologia Disruptiva , Nefrologia , Injúria Renal Aguda/terapia , Pesquisa Biomédica/economia , Financiamento Governamental , Humanos , Colaboração Intersetorial , National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)/economia , Insuficiência Renal Crônica/terapia , Estados UnidosAssuntos
Nefropatias , National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) , Nefrologia , Pesquisa Translacional Biomédica , Animais , Comportamento Cooperativo , Financiamento Governamental , Humanos , Comunicação Interdisciplinar , Nefropatias/diagnóstico , Nefropatias/fisiopatologia , Nefropatias/terapia , National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)/economia , Nefrologia/economia , Apoio à Pesquisa como Assunto , Pesquisa Translacional Biomédica/economia , Estados UnidosRESUMO
The focus of this article is to review the available funding opportunities for the nephrology workforce at all career levels and review the current challenges involved in the career of a physician-scientist. While the scarcity of nephrology fellows for training programs is a continuing challenge, increased funding for the National Institutes of Health is encouraging particularly for early career investigators. In addition to National Institutes of Health funding, other funding sources are also discussed as they provide much needed bridge funding during key transition periods for young careers. Recent initiatives such as the Advancing American Kidney Health, KidneyX, and National Institute of Diabetes and Digestive and Kidney Diseases' Kidney Precision Medicine Project offer new research opportunities for bringing much needed innovation to improve lives of people with kidney diseases. The time is now for us to seize the opportunity and ensure that a strong workforce will be able to take advantage of these potential game changers for nephrology.
Assuntos
Pesquisa Biomédica/economia , Pesquisa Biomédica/tendências , Financiamento Governamental/tendências , Nefropatias , National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)/economia , Nefrologia , Fundações/economia , Mão de Obra em Saúde , Humanos , Nefropatias/diagnóstico , Nefropatias/terapia , Empresa de Pequeno Porte/economia , Sociedades Médicas/economia , Estados Unidos , United States Department of Veterans Affairs/economiaRESUMO
PURPOSE: We reviewed large-budget, National Institutes of Health (NIH)-supported randomized controlled trials (RCTs) with behavioral interventions to assess (1) publication rates, (2) trial registration, (3) use of objective measures, (4) significant behavior and physiological change, and (5) effect sizes. METHODS: We identified large-budget grants (>$500,000/year) funded by NIH (National Heart Lung and Blood Institute (NHLBI) or National Institute of Diabetes & Digestive and Kidney Diseases (NIDDK)) for cardiovascular disease (dates January 1, 1980 to December 31, 2012). Among 106 grants that potentially met inclusion criteria, 20 studies were not published and 48 publications were excluded, leaving 38 publications for analysis. ClinicalTrials.gov abstracts were used to determine whether outcome measures had been pre-specified. RESULTS: Three fourths of trials were registered in ClinicalTrials.gov and all published pre-specified outcomes. Twenty-six trials reported a behavioral outcome with 81 % reporting significant improvements for the target behavior. Thirty-two trials reported a physiological outcome. All were objectively measured, and 81 % reported significant benefit. Seventeen trials reported morbidity outcomes, and seven reported a significant benefit. Nine trials assessed mortality, and all were null for this outcome. CONCLUSIONS: Behavioral trials complied with trial registration standards. Most reported a physiological benefit, but few documented morbidity or mortality benefits.