RESUMO
There are numerous common and rare macroscopic fat-containing masses found in the abdomen and pelvis. These include benign masses, such as lipoleiomyoma, ovarian teratoma, mesenteric teratoma, and lipoma, as well as malignant masses, including liposarcoma and malignant transformation of benign entities. Any mass may become symptomatic due to the development of a complication which may range from ovarian torsion to intussusception to hemorrhage. Imaging plays a vital role in diagnosis and treatment planning when confronted with a symptomatic fat-containing mass.
Assuntos
Abdome/diagnóstico por imagem , Neoplasias Lipomatosas/complicações , Neoplasias Lipomatosas/diagnóstico por imagem , Pelve/diagnóstico por imagem , Diagnóstico Diferencial , HumanosRESUMO
A 66-year-old man with recurrent stroke within a short period of time was referred to our department from the neurology department to rule out any malignancy. An endoscopic examination revealed a white depressed lesion in the body of the stomach, and computed tomography revealed a high-density area in the mesentery around the stomach. A mucosa-associated lymphoid tissue (MALT) lymphoma was detected from both the stomach biopsy and resected mesenteric specimen. Systemic chemotherapy was administered for the MALT lymphoma (Lugano classification stage IV). Cerebral infarction did not occur after the treatment. We concluded that Trousseau syndrome associated with the MALT lymphoma disseminated to the mesenteric adipose tissue. A MALT lymphoma has a small probability of occurring in Trousseau syndrome.
Assuntos
Linfoma de Zona Marginal Tipo Células B/complicações , Linfoma de Zona Marginal Tipo Células B/patologia , Mesentério , Neoplasias Lipomatosas/complicações , Neoplasias Lipomatosas/patologia , Neoplasias Peritoneais/complicações , Neoplasias Peritoneais/patologia , Acidente Vascular Cerebral/etiologia , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Ciclofosfamida/administração & dosagem , Humanos , Linfoma de Zona Marginal Tipo Células B/diagnóstico por imagem , Linfoma de Zona Marginal Tipo Células B/tratamento farmacológico , Masculino , Mesentério/diagnóstico por imagem , Invasividade Neoplásica , Neoplasias Lipomatosas/diagnóstico por imagem , Neoplasias Lipomatosas/tratamento farmacológico , Neoplasias Peritoneais/diagnóstico por imagem , Neoplasias Peritoneais/tratamento farmacológico , Prednisona/administração & dosagem , Recidiva , Rituximab/administração & dosagem , Síndrome , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Vincristina/administração & dosagemRESUMO
Fatty tissues lesions are the most frequent of both benign (lipoma) and malignant tumor (liposarcoma) of soft tissues in the adult. We here describe the case of female patient having a fatty tissue mass of the ankle corresponding to an hemosiderotic fibrohistiocytic lipomatous lesion (HFHLL). This very rare tumour of recent description is specific of the ankle/foot area of the middle age women. These lesions are always benign and frequently recur following incomplete resection. This tumor may have invasive local growth and metastases have not been described so far. We describe the anatomopathologist's key points of their diagnostic. We discuss the main differentials diagnosis and treatment.
Assuntos
Hemossiderose/complicações , Transtornos Histiocíticos Malignos/complicações , Transtornos Histiocíticos Malignos/patologia , Leiomioma/complicações , Leiomioma/patologia , Lipoma/complicações , Lipoma/patologia , Neoplasias Lipomatosas/complicações , Neoplasias Lipomatosas/patologia , Adulto , Feminino , Pé , Transtornos Histiocíticos Malignos/cirurgia , Humanos , Leiomioma/cirurgia , Lipoma/cirurgia , Neoplasias Lipomatosas/cirurgiaRESUMO
OBJECTIVE: To highlight a strategy for potential detection of mesenchymal tumors in oncogenic malacia, as illustrated by 3 cases. METHODS: Three case reports are presented in which successful localization of the offending neoplasm was accomplished by using whole-body Tc 99m sestamibi scanning. Alternative localization techniques are also reviewed. RESULTS: Oncogenic osteomalacia occurs infrequently and is caused by neoplasms that secrete phosphatonins, substances that interfere with proximal tubular resorption of phosphorus and can result in phosphaturia, hypophosphatemia, reduced 1,25-dihydroxyvitamin D concentration, and osteomalacia. Removal of the underlying neoplasm results in complete resolution of all biochemical, pathologic, and physical manifestations of this disorder, as shown in our 3 patients. Because the neoplasms are small and can occur in any tissue compartment, they are difficult to localize, a feature that often results in therapeutic failure. CONCLUSION: We conclude that use of whole-body Tc 99m sestamibi scanning may be an appropriate and cost-effective initial strategy for the localization of peripheral phosphatonin-secreting tumors.
Assuntos
Neoplasias Ósseas/diagnóstico por imagem , Neoplasias Lipomatosas/diagnóstico por imagem , Neoplasias de Tecido Conjuntivo/diagnóstico por imagem , Osteomalacia/diagnóstico por imagem , Tecnécio Tc 99m Sestamibi , Idoso , Neoplasias Ósseas/complicações , Neoplasias Ósseas/patologia , Neoplasias Ósseas/cirurgia , Feminino , Seguimentos , Humanos , Masculino , Mesoderma/patologia , Pessoa de Meia-Idade , Neoplasias Lipomatosas/complicações , Neoplasias Lipomatosas/patologia , Neoplasias Lipomatosas/cirurgia , Neoplasias de Tecido Conjuntivo/complicações , Neoplasias de Tecido Conjuntivo/patologia , Neoplasias de Tecido Conjuntivo/cirurgia , Osteomalacia/etiologia , Osteomalacia/patologia , Cintilografia , Medição de Risco , Estudos de Amostragem , Sensibilidade e Especificidade , Índice de Gravidade de DoençaRESUMO
Obesity is one of the most common disorders in clinical practice. The prevalance of obesity has increased by more than 60% since 1990. Adipose tissue acts as an endocrine organ secreting many factors into the blood, known as adipokines, including leptin, adipsin, acylation-stimulating protein, adiponectin, etc. This article examines the hypothesis that obesity may be evaluated as an endocrine tumor, regarding its genetic basis, hyperplasia and hypertrophy of adipocytes, neovascularisation within the adipose tissue associated with growth, and beneficisal metabolic effects of surgical removal of excess adipose tissue by liposuction. Assuming obesity as an endocrine tumor may bring out new treatment modalities. Liposuction as "cytoreductive surgery", antiangiogenic teraphy or anti-neoplastic drugs may be important components of obesity treatment in future.
Assuntos
Neoplasias das Glândulas Endócrinas/complicações , Neoplasias das Glândulas Endócrinas/fisiopatologia , Lipectomia/métodos , Modelos Biológicos , Neoplasias Lipomatosas/complicações , Neoplasias Lipomatosas/fisiopatologia , Obesidade/fisiopatologia , Ensaios Clínicos como Assunto , Medicina Baseada em Evidências , Humanos , Neoplasias Lipomatosas/cirurgia , Obesidade/etiologia , Obesidade/cirurgia , Resultado do TratamentoRESUMO
BACKGROUND: Lipoblastoma and lipoblastomatosis are rare pediatric adipose tumors that sometimes affect the neck or spinal cord. This case is the third report of lipoblastoma extending into the spinal canal, the first report of intradural tumor extension, and the first report of hemiparesis resulting from lipoblastoma compressing the spinal cord. METHODS: A 13-month-old boy was seen by a pediatrician for a firm, supraclavicular neck mass on the left side. After being evaluated by CT and MRI scanning, the tumor was partially resected. RESULTS: Postoperative microscopic examination of the tumor showed adipose cells with mature nuclei and well-formed fat vacuoles interspersed with fibrovascular septa, a finding consistent with maturing lipoblastoma. CONCLUSIONS: Although lipoblastomatous tumors are treated with complete surgical resection when possible, location of these tumors in the neck may dictate partial resection to avoid intraoperative injury to the spinal cord.
Assuntos
Neoplasias de Cabeça e Pescoço/complicações , Lipomatose/complicações , Neoplasias Lipomatosas/complicações , Paresia/etiologia , Compressão da Medula Espinal/etiologia , Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias de Cabeça e Pescoço/cirurgia , Humanos , Lactente , Lipomatose/diagnóstico , Lipomatose/cirurgia , Imageamento por Ressonância Magnética , Masculino , Neoplasias Lipomatosas/diagnóstico , Neoplasias Lipomatosas/cirurgia , Paresia/diagnóstico , Paresia/cirurgia , Compressão da Medula Espinal/diagnóstico , Compressão da Medula Espinal/cirurgia , Tomografia Computadorizada por Raios XRESUMO
INTRODUCTION: In recent years there has been increasing interest in isolated trigeminal sensory neuropathy. We present a case with an unusual association of this neuropathy and a fatty tumour of Meckel's cavum. CLINICAL CASE: A 24 year old man consulted for occasional episodes (during the previous two months) of dysesthesia of the right maxillary region. These were self-limiting and lasted only a few minutes. There was no lacrimation, apparent trigger factor, conjunctival injection or reduction in level of consciousness. There were no abnormal findings either on general or on full neurological examination. On cranial CT there was no signal from the tip of the right petrous temporal bone, but no space-occupying lesion nor pathological uptake of contrast material. On cranial MR there was an extra-axial lesion in the superior part of the tip of the right petrous temporal bone of 2 x 2 cm, localized to Meckel's cavum and right cavernous sinus, with a small lobule in the right lateral part of the prepontine cisterna. CONCLUSIONS: Trigeminal sensory neuropathy has been described in association with different connective tissue disorders, infections of the central nervous system, vascular dilatations and very varied types of tumours, particularly meningioma. The commonest site for lesions related to this clinical condition is the posterior fossa. A tumour in Meckel's cavum is rarely found in relation to this diagnosis, and from our review of the literature, involvement of fatty tumours seems to be rare.