Assuntos
Rinorreia de Líquido Cefalorraquidiano/líquido cefalorraquidiano , Infecções Estafilocócicas/líquido cefalorraquidiano , Transferrina/líquido cefalorraquidiano , Biomarcadores/sangue , Biomarcadores/líquido cefalorraquidiano , Vazamento de Líquido Cefalorraquidiano , Rinorreia de Líquido Cefalorraquidiano/sangue , Rinorreia de Líquido Cefalorraquidiano/etiologia , Rinorreia de Líquido Cefalorraquidiano/microbiologia , Feminino , Humanos , Pessoa de Meia-Idade , Neuraminidase/líquido cefalorraquidiano , Neuraminidase/metabolismo , Infecções Estafilocócicas/sangue , Infecções Estafilocócicas/etiologia , Infecções Estafilocócicas/microbiologia , Staphylococcus aureus/enzimologia , Staphylococcus aureus/isolamento & purificaçãoRESUMO
Poor prognosis in Pneumococcal meningitis may be associated with high pneumolysin levels in cerebrospinal fluid (CSF). In patient samples we showed that pneumolysin levels in CSF remained high after 48 hours in nonsurvivors of meningitis compared with survivors. Selective antipneumolysin treatment may present a novel therapeutic option.
Assuntos
Meningite Pneumocócica/líquido cefalorraquidiano , Meningite Pneumocócica/mortalidade , Estreptolisinas/líquido cefalorraquidiano , Carga Bacteriana , Proteínas de Bactérias/líquido cefalorraquidiano , Líquido Cefalorraquidiano/microbiologia , Humanos , Neuraminidase/líquido cefalorraquidianoRESUMO
The intracisternal administration of a Type I pneumococcus to mongrel dogs resulted in spinal fluid abnormalities and clinical course and outcome similar to those of meningitis in humans. In order to define the pathogenic role of pneumococcal neuraminidase and other pneumococcal extracts in experimental meningitis, the following preparations were derived from the same Type I pneumococcus: crude neuraminidase, partially purified neuraminidase, heat-inactivated crude neuraminidase, and heat-killed pneumococci. These preparations were administered intracisternally daily for 5 days to a series of mongrel dogs. These substances did not produce clinical morbity similar to that observed in infected animals, even though there was significant decrease in the NANA content of cortical brain subcellular structures in the neuraminidase-treated dogs. It was concluded that the substances investigated were not responsible for morbidity and mortality in experimental pneumococcal meningitis. Both heat-killed pneumococci and the crude neuraminidase preparation elicited significant alterations in spinal fluid glucose and protein concentrations which were similar to those recorded in infected animals; however these abnormalities were not associated with significant morbidity. It is proposed that spinal fluid glucose and protein abnormalities may not be directly linked to brain damage or dysfunction in this experimental model, or in man.