Assuntos
Neuroborreliose de Lyme/tratamento farmacológico , Idoso , Animais , Antibacterianos/uso terapêutico , Borrelia burgdorferi , Ceftriaxona/uso terapêutico , Feminino , Humanos , Neuroborreliose de Lyme/diagnóstico , Neuroborreliose de Lyme/parasitologia , Masculino , Pessoa de Meia-Idade , Convulsões/etiologiaRESUMO
We report the case of a 23-year-old male patient who suddenly developed right hemiparesis, cerebellar ataxia, dysarthria, and bilateral dysmetria. Brain magnetic resonance (MR) examination demonstrated hyperacute ischaemic lesions within the pons. CSF analysis revealed a high protein content, lymphocytic pleocytosis, and oligoclonal IgG bands not present in the serum. Elevated IgM and IgG anti-Borrelia burgdorferi antibodies were shown in both serum and CSF samples, associated with an intrathecal synthesis of these antibodies. Ischaemic CNS lesions have been rarely observed as the first manifestation of Lyme neuroborreliosis. The putative mechanism for parenchymal ischaemia is the local extension of inflammatory changes from meninges to the wall of penetrating arterioles.
Assuntos
Borrelia burgdorferi/imunologia , Isquemia Encefálica/etiologia , Neuroborreliose de Lyme/complicações , Ponte/patologia , Doença Aguda , Diagnóstico Diferencial , Humanos , Imunoglobulina G/sangue , Imunoglobulina G/líquido cefalorraquidiano , Imunoglobulina M/sangue , Imunoglobulina M/classificação , Neuroborreliose de Lyme/diagnóstico , Neuroborreliose de Lyme/parasitologia , Imageamento por Ressonância Magnética/métodos , Masculino , Adulto JovemRESUMO
Lyme disease is a multisystemic disease caused by a spirochete, Borrelia Burgdorferi that is transmitted by ticks. A clinical diagnosis is easy when a tick bite is followed 3 weeks later by erythema migrans, than by involvement of nervous system, joints or heart. In case of neuroborreliosis, serological tests, performed in blood and cerebro-spinal fluid, support the diagnosis and patients recover rapidly with antibacterial treatments. However an accurate diagnosis remains sometimes problematic, especially distinction between a coincidental positive serologic test and a nervous system Lyme borreliosis which require antibiotics. Furthermore, the role of autoimmunity in the pathophysiology of late Lyme disease, antibiotic choice in early disease, duration of treatment, and utility of vaccination are discussed.
Assuntos
Neuroborreliose de Lyme/terapia , Animais , Humanos , Vacinas contra Doença de Lyme/uso terapêutico , Neuroborreliose de Lyme/parasitologia , Neuroborreliose de Lyme/patologia , Neuroborreliose de Lyme/prevenção & controleRESUMO
A case of a male patient with chronic Lyme borreliosis running with marked neurological symptoms (Garin-Bujardoux-Bannwarth syndrome) is reported. Two years before the disease manifestation the patient was infected by the tick with both borrelia and Rickettsia sibirica. The latter infection provoked an acute fever in tick-borne rickettsiosis immediately after the tick's bite. This masked development of Lyme borreliosis which manifested only 5 months later as a neurological disease. It is thought necessary to propose a rational scheme of antibiotic treatment of patients with tick-transmissible diseases.