RESUMO
A 6-year-old female-neutered vaccinated Cocker Spaniel presented for preadoption neurological evaluation due to abnormal left-eye movements that had been noticed since young age. Clinical examination revealed left-eye cataract with a nonvisible left and a normal right retina on ophthalmoscopy. Neurological examination revealed absent left-sided menace response and cataract-related ipsilateral visual impairment, and intermittent left-sided abnormal eye movements consisted of intermittent, slow, coarse, variable amplitude, vertical movements of the eye that they were giving the impression of random movements of the eye within the globe as it was floating ("wandering" eye) interchangeable with periods of rest. Blood and infectious diseases tests were unremarkable. Magnetic resonance imaging of the brain was unremarkable, whilst cerebrospinal fluid analysis revealed mildly inflammatory in the light of blood contamination. A presumptive diagnosis of meningoencephalitis of unknown origin was established and trial with dexamethasone was performed, however nystagmus remained unchanged 2 weeks post-treatment. Therefore, based on the fact that monocular nystagmus existed since youth and remained static, and the dog was otherwise neurological-sign-free regardless the discontinuation of steroids, the diagnosis of meningoencephalitis was considered as unlikely and a presumptive diagnosis of Heimann - Bielschowsky phenomenon of the left eye due to cataract-related ipsilateral visual impairment was established. This vergence eye movement abnormality also known as searching, wandering or amaurotic nystagmus is a constant or intermittent benign eye movement abnormality mostly related with vision impairment due to ophthalmological or neurological disease. Heimann - Bielschowsky phenomenon is an underreported eye abnormality in veterinary medicine. Although the most common type of eye movement abnormalities seen in veterinary practice is the bilateral conjugate jerk nystagmus, monocular nystagmus representing Heimann - Bielschowsky phenomenon exists in animals, it has been related with partial or complete vision impairment and it should be recognised by the clinicians.
Assuntos
Catarata/veterinária , Doenças do Cão/diagnóstico , Nistagmo Patológico/veterinária , Animais , Cegueira/complicações , Cegueira/veterinária , Catarata/complicações , Cães , Feminino , Nistagmo Patológico/diagnósticoRESUMO
A 6.5-year-old male neutered Trailhound was admitted for hyperacute, nonprogressive, left-sided hemiparesis. Physical and neurologic examination revealed nonpainful, left-sided poorly ambulatory hemiparesis, decreased left-sided postural reactions and thoracic limbs hyporeflexia. Neuroanatomic localisation was consistent with a left-sided C6-T2 myelopathy. Haematology and biochemistry revealed nonspecific abnormalities. Magnetic resonance imaging of the neck revealed a focal intramedullary lesion at the level of C6-C7 vertebrae compatible with acute hydrated noncompressive nucleus pulposus extrusion or ischemic myelopathy. During the second day of hospitalization, the dog developed convergence-retraction nystagmus, up-gaze palsy and eyelid retraction (Collier's sign) compatible with dorsal midbrain syndrome. Magnetic resonance imaging of the brain revealed a focal lesion compatible with dorsal midbrain ischemic infarct. Further clinicopathologic testing, thoracic and abdominal imaging were unremarkable. Ischemic encephalopathy of unknown etiology was additionally diagnosed. Physiotherapy was performed therapeutically. At 1-year follow-up the dog was normal. This is an unusual report of a dog with myelopathy followed by ischemic encephalopathy with manifestation of convergence-retraction nystagmus in the absence of vestibular signs. This saccadic intrusion is a characteristic clinical manifestation of a dorsal midbrain syndrome localization. The importance of a complete differential diagnoses list formation in a dog with ischemic encephalopathy which leads to a thorough diagnostic investigation plan is highlighted. Moreover, this report contributes to the enrichment of the clinical reasoning veterinary literature on convergence-retraction nystagmus. To the authors' knowledge, this is the second case report (fourth dog) to describe convergence-retraction nystagmus in dogs as a manifestation of dorsal midbrain syndrome.
Assuntos
Isquemia Encefálica/veterinária , Doenças do Cão/patologia , Nistagmo Patológico/veterinária , Doenças da Medula Espinal/veterinária , Animais , Encéfalo/diagnóstico por imagem , Isquemia Encefálica/diagnóstico por imagem , Doenças do Cão/diagnóstico por imagem , Cães , Imageamento por Ressonância Magnética/veterinária , Masculino , Pescoço/diagnóstico por imagem , Paresia/diagnóstico , Paresia/veterinária , Modalidades de Fisioterapia/veterináriaAssuntos
Anestesia/veterinária , Anestésicos Intravenosos/efeitos adversos , Cães/fisiologia , Midazolam/efeitos adversos , Nistagmo Patológico/veterinária , Animais , Malformação de Arnold-Chiari/diagnóstico por imagem , Malformação de Arnold-Chiari/veterinária , Diagnóstico Diferencial , Doenças do Cão/diagnóstico por imagem , Feminino , Imageamento por Ressonância Magnética/veterinária , Nistagmo Patológico/induzido quimicamente , Nistagmo Patológico/diagnósticoRESUMO
Lilies are considered nephrotoxic only to domestic cats, which belong to the family Felidae of the suborder Feliformia. However, a 7-month-old female meerkat, belonging to the family Herpestidae of the suborder Feliformia, presented with oliguria, seizure, tachypnea, self-biting, and nystagmus after it ingested lilies. The meerkat died approximately 40 hr after lily ingestion. Gross and histopathologic lesions consistent with acute renal failure were conspicuous in the animal. The renal lesions were acute tubular necrosis, corresponding to the typical pathological changes of lily toxicosis in cats. In addition, massive hepatocyte necrosis and pulmonary congestion/edema were observed. These findings suggest that lily toxicosis in meerkats is characterized by pulmonary and hepatic failure, in addition to the renal failure observed in domestic cats.
Assuntos
Herpestidae/metabolismo , Lilium/intoxicação , Intoxicação por Plantas/veterinária , Animais , Feminino , Nistagmo Patológico/etiologia , Nistagmo Patológico/veterinária , Oligúria/etiologia , Oligúria/veterinária , Intoxicação por Plantas/diagnóstico , Intoxicação por Plantas/etiologia , Convulsões/etiologia , Convulsões/veterinária , Taquipneia/etiologia , Taquipneia/veterináriaAssuntos
Doenças do Cão/diagnóstico , Mesencéfalo , Nistagmo Patológico/veterinária , Acidente Vascular Cerebral/veterinária , Animais , Diagnóstico Diferencial , Cães , Imageamento por Ressonância Magnética/veterinária , Masculino , Nistagmo Patológico/etiologia , Acidente Vascular Cerebral/complicações , Acidente Vascular Cerebral/diagnóstico , Acidente Vascular Cerebral/diagnóstico por imagemRESUMO
A 10-year-old male koala started to fall from the tree while sleeping. Subsequently, the koala often fell down while walking and showed a gait abnormality, abnormal nystagmus and hypersalivation. At 12 years of age, the koala became ataxic and seemed blind. At 13 years of age, the koala exhibited signs of dysstasia and was euthanased. Necropsy revealed marked symmetrical atrophy of the cerebellum. Histopathologically, a severe loss of Purkinje and granule cells was evident in the cerebellum, while the molecular layer was more cellular than normal with cells resembling small neurons, which were positively stained with parvalbumin immunohistochemistry. Reactive Bergmann glial cells (astrocytes) were present adjacent to the depleted Purkinje cell zone. The very late onset and slow progression of the cerebellar cortical degeneration in this case is particularly interesting and appears to be the first report in the koala.
Assuntos
Cerebelo/fisiopatologia , Nistagmo Patológico/fisiopatologia , Nistagmo Patológico/veterinária , Phascolarctidae/fisiologia , Animais , Animais de Zoológico , Cerebelo/citologia , Evolução Fatal , Imuno-Histoquímica/veterinária , Masculino , Células de Purkinje/patologiaRESUMO
OBJECTIVE: To determine the frequency of specific signs of neurologic dysfunction in dogs with central vestibular disease (CVD) or peripheral vestibular disease (PVD) and whether the degree of head tilt, rate of nystagmus, and number of beats of postrotatory nystagmus can be used to help distinguish CVD from PVD. DESIGN: Prospective clinical study. ANIMALS: 40 client-owned dogs with vestibular system dysfunction. PROCEDURE: A standard neurologic examination was performed, along with an expanded vestibular system examination that assessed the degree of head tilt, rate of nystagmus, and number of beats of postrotatory nystagmus. RESULTS: Dogs with CVD were significantly more likely to be nonambulatory than were dogs with PVD. Dogs with PVD were significantly more likely to veer or lean in 1 direction and to have resting nystagmus than were dogs with CVD. Median rate of resting nystagmus was significantly higher for dogs with PVD, but no significant differences between groups were detected in regard to presence or degree of head tilt, presence of positional ventral strabismus, and number of beats of postrotatory nystagmus. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that nonambulatory tetraparesis is significantly more common in dogs with CVD and veering and leaning are significantly more common in dogs with PVD. Although neither the degree of head tilt nor the number of beats of postrotatory nystagmus could be used to distinguish CVD from PVD, rate of resting nystagmus may be useful in distinguishing the 2 conditions.
Assuntos
Doenças do Cão/diagnóstico , Doenças Vestibulares/veterinária , Animais , Ataxia/diagnóstico , Ataxia/etiologia , Ataxia/veterinária , Diagnóstico Diferencial , Doenças do Cão/fisiopatologia , Cães , Feminino , Imageamento por Ressonância Magnética/veterinária , Masculino , Exame Neurológico/veterinária , Nistagmo Patológico/diagnóstico , Nistagmo Patológico/etiologia , Nistagmo Patológico/veterinária , Postura , Estudos Prospectivos , Tomografia Computadorizada por Raios X/veterinária , Doenças Vestibulares/diagnóstico , Doenças Vestibulares/fisiopatologiaRESUMO
The authors encountered a dachshund dog, presenting vestibular disorder. On magnetic resonance (MR) imaging, a mass showing isointensity on the T1- and T2-weighted images and enhanced by contrast medium, was observed in the right cerebellum. In addition, the periphery of the mass showed isointensity on the T1-weighted image and hyperintensity on the T2-weighted image, suggesting sever oedema. Although the dog underwent surgery, it died. The mass was diagnosed pathologically as a granulomatous meningoencephalitis.
Assuntos
Doenças Cerebelares/veterinária , Doenças do Cão/patologia , Meningoencefalite/veterinária , Animais , Ataxia/etiologia , Ataxia/veterinária , Doenças Cerebelares/complicações , Doenças Cerebelares/patologia , Diagnóstico Diferencial , Cães , Imageamento por Ressonância Magnética/veterinária , Masculino , Meningoencefalite/complicações , Meningoencefalite/patologia , Nistagmo Patológico/etiologia , Nistagmo Patológico/veterináriaRESUMO
A 5-year-old Staffordshire terrier exhibited slowly progressive signs of cerebellar disease, including nystagmus and dysmetria. After a 30-month course, the dog was euthanized. Grossly, the cerebellum was small and comprised only 5% of the brain weight. Histopathological examination of the brain documented diffuse degeneration. Purkinje cells were most depleted, but granular cells and the molecular layer of cerebellum were also depleted. The history and necropsy examination were evidence of late-onset primary cerebellar degeneration.
Assuntos
Doenças do Cão/diagnóstico , Degenerações Espinocerebelares/veterinária , Animais , Ataxia Cerebelar/etiologia , Ataxia Cerebelar/veterinária , Diagnóstico Diferencial , Doenças do Cão/patologia , Cães , Feminino , Nistagmo Patológico/etiologia , Nistagmo Patológico/veterinária , Degenerações Espinocerebelares/complicações , Degenerações Espinocerebelares/diagnósticoRESUMO
The use of ocular motor data as the basis for the development of both nonsurgical and surgical therapies for congenital nystagmus (CN) has been underway since the mid-1960s. This paper presents three nonsurgical therapies (composite prisms, soft contact lenses, and afferent stimulation) and a new surgical therapy (four-muscle tenotomy) hypothesized from analysis of ocular motor data. The expanded nystagmus acuity function test was developed to both predict and measure the effectiveness of CN therapies and for intersubject comparisons. Base-out prisms may be used to damp CN during distance fixation in patients whose CN damps during near fixation and who are binocular (i.e., they have no strabismus). Soft contact lenses may be used in those whose CN damps with afferent stimulation of the ophthalmic division of the trigeminal nerve. Cutaneous afferent stimulation (rubbing, vibration, or electricity) of the forehead or neck damps CN in some individuals. Finally, as first demonstrated in an achiasmic Belgian sheepdog and later in humans, tenotomy of the four horizontal rectus muscles and reattachment at their original sites may also damp CN. Taken together, these findings suggest the existence of one or more proprioceptive feedback loops acting to change the small-signal gain of the extraocular plant. Four-muscle tenotomy provides a needed therapeutic option for the many individuals with CN for whom other surgical therapies are contraindicated. Tenotomy may also prove useful in see-saw nystagmus (it abolished it in the aforementioned canine) or other types of nystagmus; further studies of the latter are required.
Assuntos
Nistagmo Congênito/terapia , Animais , Doenças do Cão/fisiopatologia , Cães , Movimentos Oculares/fisiologia , Humanos , Nistagmo Congênito/cirurgia , Nistagmo Patológico/fisiopatologia , Nistagmo Patológico/veterináriaRESUMO
We applied new methods for canine eye-movement recording to the study of achiasmatic mutant Belgian Sheepdogs, documenting their nystagmus waveforms and comparing them to humans with either congenital nystagmus (CN) alone or in conjunction with achiasma. A sling apparatus with head restraints and infrared reflection with either earth- or head-mounted sensors were used. Data were digitized for later evaluation. The horizontal nystagmus (1-6 Hz) was similar to that of human CN. Uniocular and disconjugate nystagmus and saccades were recorded. See-saw nystagmus (SSN), not normally seen with human CN, was present in all mutants (0.5-6 Hz) and in the one human achiasmat studied thus far. This pedigree is an animal model of CN and the SSN caused by achiasma or uniocular decussation. Given the finding of SSN in all mutant dogs and in a human, achiasma may be sufficient for the development of congenital SSN and, in human infants, SSN should alert the clinician to the possibility of either achiasma or uniocular decussation. Finally, the interplay of conjugacy and disconjugacy suggests independent ocular motor control of each eye with variable yoking in the dog.
Assuntos
Doenças do Cão/congênito , Nistagmo Patológico/veterinária , Quiasma Óptico/anormalidades , Animais , Doenças do Cão/fisiopatologia , Cães , Movimentos Oculares/fisiologia , Feminino , Humanos , Masculino , Nistagmo Patológico/congênito , Fatores de TempoRESUMO
A two-year-old, neutered male Labrador retriever was anesthetized with intravenous propofol for bronchoscopy to remove a bronchial foreign body. The dog previously had been diagnosed with idiopathic epilepsy. During anesthetic recovery, the dog exhibited excitatory movements characterized by forelimb extensor rigidity, opisthotonos, generalized tremors, paddling, horizontal nystagmus, and facial twitching. Intravenous administration of pentobarbital temporarily stopped the motor activity. The excitatory movements persisted for 20 hours. The dog went on to recover completely, although he remained an epileptic, having one brief, generalized grand mal seizure every three-to-four months.
Assuntos
Anestésicos Intravenosos/efeitos adversos , Atividade Motora/efeitos dos fármacos , Propofol/efeitos adversos , Animais , Broncoscopia/métodos , Broncoscopia/veterinária , Doenças do Cão/induzido quimicamente , Doenças do Cão/fisiopatologia , Cães , Epilepsia/induzido quimicamente , Epilepsia/fisiopatologia , Epilepsia/veterinária , Masculino , Atividade Motora/fisiologia , Nistagmo Patológico/induzido quimicamente , Nistagmo Patológico/fisiopatologia , Nistagmo Patológico/veterinária , Tremor/induzido quimicamente , Tremor/fisiopatologia , Tremor/veterináriaRESUMO
A closely inbred line of Chow Chows affected with congenital cataracts was studied. Sixteen dogs were examined including 1 adult male, 2 adult females, and 13 pups. Twelve of the pups were from 6 different litters, out of 6 different bitches, all sired by 1 adult male. The exact relationship of the thirteenth pup was undetermined. Clinical evaluation included slit-lamp biomicroscopy, biomicroscopic photography, and indirect ophthalmoscopy. Clinical appearance of the cataracts was variable, ranging from incipient nuclear or capsular lesions to advanced cortical opacity. The lens nucleus was most consistently affected, with variable involvement of the lens cortex. Concurrent ocular anomalies of some eyes included wandering nystagmus, entropion, microphthalmia, persistent pupillary membrane remnants, and multifocal retinal folds. A correlation was not apparent between the character or severity of the cataracts and the finding of the other anomalies. Histologic examination of 12 lenses revealed posterior displacement of the lens nucleus, retained lens epithelial cell nuclei in the nuclear and cortical lens, anterior capsular irregularity and duplication, anterior lens epithelial duplication, and posterior subcapsular migration of epithelium. The high incidence of cataract in this family of Chow Chows suggested an inherited defect, although the inheritance pattern was undetermined.
Assuntos
Catarata/veterinária , Doenças do Cão/genética , Anormalidades do Olho/veterinária , Animais , Catarata/complicações , Catarata/congênito , Catarata/genética , Doenças do Cão/congênito , Cães , Entrópio/complicações , Entrópio/veterinária , Anormalidades do Olho/complicações , Feminino , Endogamia , Masculino , Microftalmia/complicações , Microftalmia/veterinária , Nistagmo Patológico/complicações , Nistagmo Patológico/veterinária , Oftalmoscopia/veterinária , Estudos ProspectivosRESUMO
Diseases affecting the vestibular system cause ataxia, characterized by head tilt, circling, falling, and rolling to the side of the lesion. Nystagmus occurs initially but may resolve. These clinical signs occur regardless of whether the lesion affects the peripheral or central portion of the vestibular system. Peripheral and central vestibular disorders are distinguished based on additional signs of brain stem involvement in the latter, as discussed in The Neurologic Examination and Lesion Localization on page 309. This distinction is critical in establishing both a differential diagnosis and prognosis in affected cats.
Assuntos
Ataxia/veterinária , Doenças do Gato/etiologia , Nistagmo Patológico/veterinária , Doenças Vestibulares/veterinária , Animais , Ataxia/etiologia , Doenças do Gato/diagnóstico , Doenças do Gato/terapia , Gatos , Nistagmo Patológico/etiologia , Doenças Vestibulares/complicações , Doenças Vestibulares/diagnóstico , Doenças Vestibulares/terapiaAssuntos
Córtex Cerebelar/patologia , Doenças dos Macacos/patologia , Papio , Animais , Atrofia , Cegueira/patologia , Cegueira/veterinária , Modelos Animais de Doenças , Masculino , Mioclonia/patologia , Mioclonia/veterinária , Nistagmo Patológico/patologia , Nistagmo Patológico/veterinária , Células de Purkinje/patologiaRESUMO
Idiopathic feline vestibular syndrome, a peripheral vestibular deficit of unknown cause, was diagnosed in 75 cats at the New York State College of Veterinary Medicine Teaching Hospital from July 1975 to October 1984. Review of the medical records of these cats indicated that the syndrome was seen in more cats in July and August (P less than 0.001) than in other months. Clinical signs included head tilt, ataxia, rolling, rotatory or horizontal nystagmus, and occasional vomiting.
Assuntos
Doenças do Gato/etiologia , Nervo Vestibular , Doenças do Nervo Vestibulococlear/veterinária , Fatores Etários , Animais , Gatos , Ataxia Cerebelar/etiologia , Ataxia Cerebelar/veterinária , Feminino , Masculino , Nistagmo Patológico/etiologia , Nistagmo Patológico/veterinária , Estações do Ano , Caracteres Sexuais , Síndrome , Doenças do Nervo Vestibulococlear/etiologiaAssuntos
Ataxia/veterinária , Doenças do Cão/tratamento farmacológico , Tremor/veterinária , Animais , Ataxia/tratamento farmacológico , Diazepam/uso terapêutico , Cães , Quimioterapia Combinada , Feminino , Furosemida/uso terapêutico , Nistagmo Patológico/tratamento farmacológico , Nistagmo Patológico/veterinária , Orfenadrina/uso terapêutico , Papiledema/tratamento farmacológico , Papiledema/veterinária , Prednisolona/uso terapêutico , Tremor/tratamento farmacológicoRESUMO
In a survey of 2,932 mature dairy cattle performed over a 1-month period, we found 15 with rapid oscillation in 1 or both eyes. Nystagmus had been present since shortly after birth in 2 animals, and the age at onset was unknown in the others. The nystagmus was not associated with any other physical or neurologic problem. Pendular nystagmus apparently is benign and should not be mistaken for a sign of serious neurologic disease.