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2.
Hum Pathol ; 95: 99-112, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31521627

RESUMO

The last 50 years have witnessed an explosion in our understanding of the pathology of pancreatic diseases. Entities known to exist 50 years ago have been defined more precisely and are now better classified. New entities, previously not recognized, have been discovered and can now be treated. Importantly, new tools have been developed that have unraveled the fundamental biological drivers of a number of pancreatic diseases. Many of these same tools have also been applied clinically, supplementing the tried and true hematoxylin and eosin stained slide with a plethora of new, highly sensitive and specific tests that improve diagnostic accuracy and delineate best treatments. As exciting as these many advances are, our knowledge of pancreatic pathology remains incomplete, and there is much to be learned.


Assuntos
Pâncreas/patologia , Pancreatopatias/patologia , Patologia Molecular , Difusão de Inovações , Predisposição Genética para Doença , História do Século XX , História do Século XXI , Humanos , Pancreatopatias/genética , Pancreatopatias/história , Patologia Molecular/história , Patologia Molecular/tendências , Fenótipo , Valor Preditivo dos Testes
4.
J Hepatobiliary Pancreat Sci ; 26(1): 1-8, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30575328

RESUMO

The 30th meeting of the JSHBPS is the first domestic meeting of our society to have been organized completely in English. In that sense, we have established the theme of the 30th meeting of the JSHBPS as "The Second Opening of Japan on the Way to a Bright Future". Last 30 years, several strategies have been undertaken to battle hepatobiliary (HPB) malignancies, such as aggressive operative procedures, operative planning using state-of-the-art technologies, neoadjuvant therapy, conversion surgery for initially unresectable diseases, and immunomodulation. According to the rapid development of precision medicine, HBP surgeons should have a literacy for individualized therapy. Here, I review recent improvements in regard to HBP surgery. In addition, education for the next generations should be our highest priority. Collaboration with foreign researchers is the most effective tool to promote personal growth.


Assuntos
Doenças Biliares/história , Hepatopatias/história , Pancreatopatias/história , Doenças Biliares/cirurgia , História do Século XIX , História do Século XX , História do Século XXI , Humanos , Japão , Hepatopatias/cirurgia , Pancreatopatias/cirurgia
6.
Dig Dis Sci ; 63(5): 1102-1122, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-29549474

RESUMO

MRI has transformed from the theoretical, investigative realm to mainstream clinical medicine over the past four decades and has become a core component of the diagnostic toolbox in the practice of gastroenterology (GI). Its success is attributable to exquisite contrast and the ability to isolate specific proton species through the use of different pulse sequences (i.e., T1-weighted, T2-weighted, diffusion-weighted) and exploiting extracellular and hepatobiliary contrast agents. Consequently, MRI has gained preeminence in various GI clinical applications: liver and pancreatic lesion evaluation and detection, liver transplantation evaluation, pancreatitis evaluation, Crohn's disease evaluation (using MR enterography) rectal cancer staging and perianal fistula evaluation. MR elastography, in concert with technical innovations allowing for fat and iron quantification, provides a noninvasive approach, or "MRI virtual liver biopsy" for diagnosis and management of chronic liver diseases. In the future, the arrival of ultra-high-field MR systems (7 T) and the ability to perform magnetic resonance spectroscopy in the abdomen promise even greater diagnostic insight into chronic liver disease.


Assuntos
Gastroenteropatias/história , Hepatopatias/história , Imageamento por Ressonância Magnética/história , Imageamento por Ressonância Magnética/métodos , Pancreatopatias/história , Europa (Continente) , Gastroenteropatias/diagnóstico por imagem , História do Século XX , História do Século XXI , Humanos , Hepatopatias/diagnóstico por imagem , Pancreatopatias/diagnóstico por imagem , Estados Unidos
8.
Pancreatology ; 15(6): 611-5, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26481054

RESUMO

The George E Palade Medal is the highest honor awarded by the International Association of Pancreatology and is given to an individual who has made outstanding contributions to the understanding of the pancreas and pancreatic diseases. Professor David C Whitcomb, University of Pittsburgh, is the 2015 recipient. The Palade Lecture, presented in Shanghai, China on August 28, 2015, included 5 personal stories that provide perspective from a life-time of achievement: "My life in a nutshell"; "Two old ladies"; "7777"; "I helped put a man on the moon"; and "Rugby". Together, the stories provide encouragement to a younger generation, struggling to find their way as physicians and scientists who are working on pancreatic or other diseases in a challenging world.


Assuntos
Distinções e Prêmios , Gastroenterologia/história , Pancreatopatias , História do Século XX , História do Século XXI , Humanos , Relações Interpessoais , Satisfação no Emprego , Pancreatopatias/genética , Pancreatopatias/história , Pancreatopatias/terapia , Pesquisa , Estados Unidos
9.
Biomed Res Int ; 2015: 128095, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26180777

RESUMO

This review presents the history of discoveries concerning the pancreas. In antiquity and the Middle Ages knowledge about the anatomy of the pancreas was very limited and its function was completely unknown. Significant progress was first made in the seventeenth and eighteenth centuries. Johann Georg Wirsüng, the prosector of the University of Padua, discovered the main pancreatic duct, and Giovanni Santorini discovered the accessory duct. Regnier de Graaf was the first to perform pancreatic exocrine studies, and Paul Langerhans's 1869 discovery of pancreatic islets was the first step toward recognizing the pancreas as an endocrine gland. The twentieth century brought the discovery of insulin and other pancreatic hormones. To date, histochemical staining, transmission electron microscopy, and immunohistochemistry enabled the discovery of five cell types with identified hormonal products in adult human pancreatic islets. Twentieth-century pancreatic studies led to crucial advances in scientific knowledge and were recognized, among other things, with seven Nobel Prizes. The first of these went to Ivan Pavlov in 1904 for his work on the physiology of digestion. The most recent was awarded to Günter Blobel in 1999 for discovering signaling mechanisms that govern the transport and localization of proteins within pancreatic acinar cells.


Assuntos
Pesquisa Biomédica/história , Pâncreas , Pancreatopatias/história , História do Século XIX , História do Século XX , História do Século XXI , Humanos
15.
Pancreatology ; 7(5-6): 393-5, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17898527

RESUMO

Tadashi Takeuchi is a Professor Emeritus of the Tokyo Women's Hospital University, one of the founders of the Japan Pancreas Society and first Editor-in-Chief of its official journal. His research contributed enormously to the understanding of the role of gastrointestinal hormones in pancreatic physiology as well as disease. In this interview, Professor Takeuchi discusses the importance of mentorship during career development.


Assuntos
Mentores/história , Pâncreas , Pesquisa Biomédica/história , História do Século XX , História do Século XXI , Humanos , Japão , Pâncreas/fisiologia , Pancreatopatias/história , Pancreatopatias/fisiopatologia
16.
Pol Arch Med Wewn ; 117(3): 57-8, 2007 Mar.
Artigo em Polonês | MEDLINE | ID: mdl-17718055

RESUMO

Professor Józef Waclaw Grott (1894-1973), an outstanding Polish internist developed three methods of pancreas palpation (1935, 1947, 1948) that were of much diagnostic value in the twentieth century.


Assuntos
Palpação/história , História do Século XX , Humanos , Pancreatopatias/diagnóstico , Pancreatopatias/história , Polônia
17.
Pancreatology ; 7(4): 311-3, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17627094

RESUMO

In the current interview Prof. Lucio Gullo, a worldwide-recognized pancreatologist for his contribution on the understanding of the pathogenesis and clinical aspects of a number of pancreatic diseases including benign pancreatic hyperenzymemia, shares with Pancreatology his life experiences as a scientist in pancreatic research.


Assuntos
Pesquisa Biomédica/normas , Pancreatopatias/diagnóstico , Pesquisa Biomédica/história , História do Século XX , Humanos , Itália , Pâncreas/fisiologia , Pancreatopatias/história
18.
J R Coll Physicians Edinb ; 37(3): 264-72, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-18348506

RESUMO

Positioned in the posterior abdomen, the pancreas remained little observed until nineteenth century advances in physiology, followed later in the century by abdominal surgery, brought the organ into the clinical domain. The discovery of pancreatic stimulating hormones during the twentieth century culminated in the description of pancreozymin by Harper and Raper in Manchester in 1943. After World War II, Henry T Howat was appointed physician in that city and was able to analyse the results of hormonal stimulation in pancreatic disorders. He became the first doctor in Britain to specialise in pancreatology. His collaboration with colleagues in Britain and in Europe, through the evolution of specialist societies, encouraged the coordination of basic science, medicine, pathology, radiology and surgery, to further research in, and management of, pancreatic disease. Academic recognition by Manchester University resulted in his being appointed its first Professor of Gastroenterology and originator of a gastrointestinal research unit. As he pointed out, continuing scientific and technological advances influenced the concepts of disease, and moved the management of pancreatic disease from the general physician and surgeon to gastroenterologists. Howat's career illustrates the continuing specialisation witnessed in the latter half of the twentieth century.


Assuntos
Gastroenterologia/história , Pancreatopatias/história , História do Século XIX , História do Século XX , Humanos , Pâncreas , Pancreatopatias/diagnóstico , Pancreatopatias/terapia , Sociedades Médicas/história , Reino Unido
20.
Pancreatology ; 5(4-5): 312-3, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-15980660

RESUMO

In the current interview, Professor Seiki Matsuno shares his experience and provides career advice to young investigators initiating in pancreatic research. Professor Matsuno is internationally recognized for his contributions to different areas of pancreatology, including the clinical characterization and treatment of pancreatic diseases.


Assuntos
Pesquisa Biomédica/métodos , Medicina Clínica/métodos , Pancreatopatias , Pesquisa Biomédica/história , Medicina Clínica/história , História do Século XX , Humanos , Pancreatopatias/história
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