RESUMO
We studied the dynamics of respiratory function in rats during intratracheal poisoning with diisopropyl fluorophosphate and pentylenetetrazole in doses corresponding to the LD50 in humans. The maximum of external respiration impairment was recorded in 30 min after poisoning. Administration of diazepam and atropine both separately and in combination during the development of the first signs of poisoning did not significantly affect the respiration parameters, but reduced the incidence of seizures and contributed to a decrease in the rate of animal death. Intratracheal administration of cholinolytic, ß2-adrenomimetic, or glutamate receptors antagonist promoted correction of the respiratory function. It was found that the maximum therapeutic effect in case of diisopropyl fluorophosphates poisoning was achieved after intratracheal administration of ipratropium bromide (0.086 mg/kg), salbutamol (0.086 mg/kg), and MK-801 (0.1 mg/kg), while in case of pentylenetetrazole poisoning, intratracheal administration of ipratropium bromide (0.086 mg/kg) was most effective.
Assuntos
Broncodilatadores/administração & dosagem , Isoflurofato/intoxicação , Pentilenotetrazol/intoxicação , Transtornos Respiratórios/induzido quimicamente , Transtornos Respiratórios/tratamento farmacológico , Convulsões/tratamento farmacológico , Administração por Inalação , Albuterol/administração & dosagem , Animais , Atropina/administração & dosagem , Convulsivantes/intoxicação , Diazepam/administração & dosagem , Epilepsia/complicações , Epilepsia/tratamento farmacológico , Epilepsia/patologia , Ipratrópio/administração & dosagem , Masculino , Ratos , Transtornos Respiratórios/complicações , Transtornos Respiratórios/patologia , Mecânica Respiratória/efeitos dos fármacos , Convulsões/complicações , Convulsões/patologiaRESUMO
The circadian rhythms of acute toxicity of N-methyl D-aspartic acid, picrotoxin, pentetrazol, strychnine, chlorpromazine and Na-methylhexabital in dd-mice were investigated. The drugs were injected into mice on the hour at 2, 6, 10, 14, 18 or 22 in one day, after which the cumulative mortalities were calculated for 72 hours. Regarding central stimulants, the mortality of mice injected at 22 (o'clock) was lowest, and when injections were given at 2, 10 or 18 (o'clock), the mortality was higher than at any other time. On the other hand, regarding central depressants, the mortality was lowest at 10, and highest at 14 or at 18 o'clock. Thus, the administration time of central stimulants showing the lowest mortality was shifted about 12 hours in comparison with central depressants. As compared to the central depressants, the mortality rate as the result of central stimulants showed a great contrast when injected at 10 o'clock.