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1.
J Pak Med Assoc ; 73(4): 937-938, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-37052022

RESUMO

This communication proposes the term "hidden obesity" to describe normal weight obesity, or increased adiposity without a corresponding increase in body mass index. It uses the concept of hidden hunger to craft semantics which will generate greater attention to this condition from all stake-holders, including policymakers and planners. The article describes simple tools which can be used to suspect and confirm the diagnosis of hidden obesity. This phenotype is very commonly seen in the south Asian population.


Assuntos
Adiposidade , Peso Corporal , Obesidade , População do Sul da Ásia , Humanos , Adiposidade/etnologia , Índice de Massa Corporal , Obesidade/classificação , Obesidade/diagnóstico , Obesidade/etnologia , Peso Corporal/etnologia , Peso Corporal/fisiologia
2.
Cancer Med ; 10(12): 4097-4106, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33998145

RESUMO

INTRODUCTION: Compared to non-Hispanic Whites, Japanese Americans, Native Hawaiians, and African Americans have higher incidences of pancreatic cancer (PCa) that are not entirely explained by rates of obesity but may be explained by weight changes throughout adulthood. METHODS: The multiethnic cohort is a population-based prospective cohort study that has followed 155,308 participants since its establishment between 1993 and 1996. A total of 1,328 incident cases with invasive PCa were identified through 2015. We conducted separate multivariable Cox proportional hazards models for self-reported weight-change and BMI-change (age 21 to cohort entry) to determine the association with PCa risk, adjusting for potential confounders including weight or BMI at age 21. RESULTS: The mean age at cohort entry was 59.3 years (SD 8.9). An increased risk of PCa was associated with: 1) weight (HR per10 lbs = 1.06; 95% CI = 1.03-1.09) or BMI (HR per kg/m2  = 1.04; 95% CI = 1.02-1.05) at age 21; and 2) weight (HR per 10 lbs = 1.03; 95% CI = 1.01-1.05) or BMI (HR = 1.02; 95% CI = 1.00-1.03) at cohort entry. We found increased risk of PCa between weight (HR per 10 lbs = 1.03; 95% CI = 1.01-1.05) and BMI (HR per 5 kg/m2  = 1.08; 95% CI = 1.01-1.15) change from age 21 to baseline. There were significant interactions between race/ethnicity and weight (p = 0.008) or BMI (p = 0.03) at baseline, and weight (p = 0.02) or BMI (p = 0.02) change. Weight and BMI change through adulthood significantly increased the risk of PCa for Japanese Americans and Latinos, but not for African American, White, or Hawaiian participants. CONCLUSION: Our findings indicate that weight or BMI gain has a significant and independent impact on PCa risk, specifically among Latinos and Japanese Americans.


Assuntos
Índice de Massa Corporal , Peso Corporal/etnologia , Neoplasias Pancreáticas/epidemiologia , Adulto , Intervalos de Confiança , Escolaridade , Etnicidade , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Neoplasias Pancreáticas/etnologia , Modelos de Riscos Proporcionais , Estudos Prospectivos , Grupos Raciais , Estados Unidos/epidemiologia , Estados Unidos/etnologia , Adulto Jovem
3.
Nutr Hosp ; 38(2): 345-351, 2021 Apr 19.
Artigo em Espanhol | MEDLINE | ID: mdl-33371707

RESUMO

INTRODUCTION: Introduction: in children the use of therapeutic interventions, which includes the administration of medications, is based on body weight. Objective: to validate the equations proposed by "Advanced Pediatric Life Support - APLS" in 2011 (APLS 1) and 2001 (APLS 2) to estimate weight in Ecuadorian girls and boys, considering their ethnic diversity and age groups. Methods: a cross-sectional study which included 21,735 girls and boys belonging to three ethnic groups: mestizo, indigenous, and other (white, black, and mulatto), with ages between 0 and 12 years, who participated in the ENSANUT-ECU study. Differences, Spearman's correlation, Bland-Altman graphs, and percentage error (PE) were calculated. Data were processed and analyzed using R. Results: APLS 1 tends to overestimate weight whereas APLS 2 underestimates it. The estimated weight bias was greater for the classical equation. The indigenous and "other" ethnic groups presented the highest differences with respect to measured weight. The differences between estimated weight and measured weight increased progressively with age. With APLS 1, the percentage of individuals with a PE > 10 % was greater than with APLS 2. Conclusions: APLS does not accurately estimate weight in the Ecuadorian pediatric population. The difference between estimated weight and measured weight is sensitive to ethnic and age differences.


INTRODUCCIÓN: Introducción: en niños y niñas, la aplicación de intervenciones terapéuticas, lo que incluye la administración de medicamentos, se basa en el peso corporal. Objetivo: validar las ecuaciones propuestas por "Advanced Pediatric Life Support ­ APLS" en 2011 (APLS 1) y 2001 (APLS 2) para estimar el peso de las niñas y niños ecuatorianos, considerando la diversidad étnica y los grupos de edad. Métodos: estudio transversal que incluyó 21.735 niñas y niños pertenecientes a tres grupos étnicos ­mestizo, indígena y otro (blancos, negros y mulatos)­ con edades comprendidas entre 0 y 12 años y que habían participado en el estudio ENSANUT-ECU. Se calcularon las diferencias, la correlación de Spearman, los gráficos de Bland-Altman y el porcentaje error (PE). Los datos se procesaron y analizaron usando R. Resultados: la APLS 1 tiende a sobrestimar el peso mientras que la APLS 2 lo subestima. El sesgo del peso estimado fue mayor para la ecuación clásica. Los grupos étnicos indígena y otro presentaron las diferencias más altas con respecto al peso medido. Las diferencias de peso estimado con respecto al medido aumentaron progresivamente con la edad. Con la APLS 1, el porcentaje de individuos con un PE > 10 % fue mayor que con la APLS 2. Conclusiones: la APLS no estima con exactitud el peso en la población pediátrica ecuatoriana. La diferencia entre el peso estimado y el peso medido es sensible a las diferencias étnicas y de edad.


Assuntos
Fatores Etários , Peso Corporal/etnologia , Etnicidade , Suporte Vital Cardíaco Avançado , Criança , Pré-Escolar , Estudos Transversais , Equador/etnologia , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Fatores Sexuais
4.
Artigo em Inglês | MEDLINE | ID: mdl-32751821

RESUMO

The tendency of misperceiving one's body image was found to be higher among those at normal body mass index (BMI). Thus, the present study aims to provide basic data to seek solutions for ideal physical activities and right body image perception by comparing health-related behaviors of women at normal BMI. Among the 39,225 respondents from the Korea National Health and Nutrition Examination Survey (KNHNES) conducted from 2013 to 2017, 10,798 adult women with World Health Organization (WHO) BMI Classifications of 18.5 ≤ BMI < 25 (Asia-Pacific) were considered, from which pregnant and breast-feeding women and women whose body image perception was not identified were excluded, leading to a total of 9288 women. Data were analyzed utilizing SAS ver. 9.4 for frequency analysis, cross tabulation, GLM (generalized linear model), and logistic regression analysis with complex samples design, in conformity with the guidelines of the KNHNES. The results showed that approximately most (87.6%) of adult Korean women misperceived their body image. Misperception of body image was related to inappropriate health-related behaviors such as smoking, insufficient sleeping, and excessive body weight management; those who had underestimated their body image (≤64 odds ratio (OR) (0.718 (confidence interval (C.I.) 0.594-0.866))) carried out fewer health-related behaviors, while women aged 65 or above engaged in more health-related behaviors when they perceived themselves as obese (OR 1.683 (C.I. 1.260-2.248; overestimation)). To sum up, it was found that lack of health management, inappropriate body weight control, and health-related behaviors are related to body image misperception compared with real BMI. As such, it is necessary to have educational programs to encourage building proper perception of one's body image and body weight, and to carry out health-related behaviors.


Assuntos
Imagem Corporal/psicologia , Peso Corporal/etnologia , Comportamentos Relacionados com a Saúde/etnologia , Adulto , Idoso , Ásia , Povo Asiático , Índice de Massa Corporal , Estudos Transversais , Feminino , Humanos , Inquéritos Nutricionais , República da Coreia
5.
Matern Child Health J ; 24(9): 1130-1137, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32632842

RESUMO

OBJECTIVES: Previous obesity prevention studies in preschool-age children have included non-Hispanic Black (NHB) children, but few have investigated between-subgroup differences even though there may be cultural risk and protective practice differences, challenging the generalizability of findings. The purpose of this study was to examine differences in early childhood obesity-related factors in NHB subgroups (Haitian, other Caribbean Islander and African-American [AA]) children. METHODS: Baseline data from two randomized controlled trials in 52 childcare centers of which 35 had data to test a preschool-based obesity prevention intervention was analyzed. The sub-sample included 370 caregiver-child dyads; 209 self-identified as AA, 120 as Haitian and 41 as Caribbean Islander/West Indian or mixed race. Multilevel regression models generated outcome estimates for group differences in body mass index (BMI) percentile, birthweight, breastfeeding initiation and duration, bottle feeding duration and age when solid foods were introduced. RESULTS: Mean BMI percentile was similar for AA, Haitian and Caribbean Islander/West Indian/Multiracial (60.1th percentile, 60.8th percentile, 62.8th percentile, respectively) as was birthweight (6.3, 6.8, and 6.6 lb, respectively). Children of US-born caregivers had significantly lower BMI percentiles (9.13 percentile points) versus foreign-born caregivers. Haitian women were significantly more likely to initiate breastfeeding (64.9%) versus AA (47.6%) and Caribbean Islander/West Indian/Multiracial (62.2%) (p < .01). No significant group differences were found in breastfeeding or bottle feeding duration or age solid foods were introduced. CONCLUSIONS: Findings here suggest that NHB race classification can identify important subgroup behavioral similarities which in turn may inform culturally sensitive strategies to promote early childhood healthy weight. Foreign-born caregivers may benefit from healthy weight promotion information, and as early as possible in their child's development.


Assuntos
Peso Corporal/etnologia , Etnicidade/estatística & dados numéricos , Obesidade/etnologia , Aumento de Peso/etnologia , Adulto , Negro ou Afro-Americano/estatística & dados numéricos , População Negra/estatística & dados numéricos , Índice de Massa Corporal , Criança , Cuidado da Criança , Pré-Escolar , Estudos Transversais , Feminino , Haiti/etnologia , Humanos , Masculino , Fatores Socioeconômicos , Estados Unidos/epidemiologia , Índias Ocidentais/etnologia
6.
Tunis Med ; 98(5): 413-419, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32548845

RESUMO

BACKGROUND: Anthropometry is the one and only universally applicable, inexpensive and non-invasive method for studying the proportions of the human body. Anthropometric measurements reflect nutritional status and health, but can also be used to predict skills, health status and survival. It is therefore a reliable tool, but currently underused, to guide public health policies. AIM: Therefore, this study investigated anthropometric characters of Tunisian people and compared it with those of other nationalities. METHODS: 429 subjects have participated in this study (322 men and 107 women), aged between 20 and 85. Anthropometric measurements used in this study were body mass, body size, thigh circumference, lower limbs length and body mass index. RESULTS: With an average body size of 171 cm for men and 157 cm for women, Tunisians were close to neighboring countries. Nevertheless, with a body mass of 77.23 kg and 72.66 kg and a BMI of 26.48 and 29.18 respectively for men and women, Tunisia has the highest prevalence of obesity in the region, especially for women. Several anthropometric correlations have also been noticed such as relationships between thigh circumference, BMI, body mass, lower limbs length, and body size. CONCLUSION: Obesity is proving to be a public health problem for which effective strategies and measures are needed.


Assuntos
Pesos e Medidas Corporais/estatística & dados numéricos , Adulto , Idoso , Idoso de 80 Anos ou mais , Antropometria , Composição Corporal , Índice de Massa Corporal , Peso Corporal/etnologia , Feminino , Geografia , Humanos , Masculino , Pessoa de Meia-Idade , População , Tunísia/epidemiologia , Circunferência da Cintura/etnologia , Adulto Jovem
7.
Biodemography Soc Biol ; 65(2): 97-118, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32432935

RESUMO

When traditional measures for material and economic welfare are scarce or unreliable, height and the body mass index (BMI) are now widely accepted measures that represent cumulative and current net nutrition in development studies. However, as the ratio of weight to height, BMI does not fully isolate the effects of current net nutrition. After controlling for height as a measure for current net nutrition, this study uses the weight of a sample of international men in US prisons. Throughout the late 19th- and early-20th centuries, individuals with darker complexions had greater weights than individuals with fairer complexions. Mexican and Asian populations in the US had lower weights and reached shorter statures. Black and white weights stagnated throughout the late 19th- and early-20th centuries. Agricultural workers' had greater weights than workers in other occupations.


Assuntos
Peso Corporal/fisiologia , Estado Nutricional/fisiologia , Fatores Socioeconômicos , Estatura/etnologia , Estatura/fisiologia , Peso Corporal/etnologia , História do Século XIX , História do Século XX , Humanos , Estado Nutricional/etnologia , Prisioneiros/estatística & dados numéricos , Grupos Raciais/etnologia , Grupos Raciais/estatística & dados numéricos , Estados Unidos/etnologia
8.
Women Health ; 60(8): 851-862, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32375577

RESUMO

This study aimed to rigorously assess body weight perceptions according to several body image dimensions in rural, employed African women. One hundred and thirty-two employed black African women were recruited at a rural South African university. Participants were asked to choose their 'ideal' and 'feel' perceived body size from nine standardized body image silhouettes, varying according to body size. Three body image dimensions of interest were measured, (1) 'feel' minus 'ideal' index (FID), (2) perceived minus the actual weight status (PAD) index and (3) valorization of stoutness index (participants that chose silhouettes corresponding to overweight/obesity). Using the FID dimension, older obese women had significantly higher desire for leanness, with small effects, compared with lean and younger obese women (p = .001). Those women who correctly perceived body weight (PAD = 0), were mostly obese and older (p < .0001), with moderate effects, than non-obese women. Social valorization of stoutness was observed in 58.3% of the sample, but was higher in older obese women, with small effects, compared with lean women (p = .0001). This study has shown that the majority of the study population demonstrated a social valorization of stoutness, despite a desire to be thinner and the ability to adequately perceive their own body weight in accordance with BMI.


Assuntos
Imagem Corporal/psicologia , Peso Corporal , Magreza , Adulto , População Negra , Índice de Massa Corporal , Peso Corporal/etnologia , Peso Corporal/fisiologia , Estudos Transversais , Exercício Físico , Feminino , Humanos , Pessoa de Meia-Idade , População Rural , Autoimagem , Classe Social , Magreza/etnologia , Universidades , Percepção de Peso
9.
Cerebrovasc Dis ; 49(2): 152-159, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32208397

RESUMO

INTRODUCTION: The safety of prasugrel in elderly and/or low body weight Japanese patients with ischemic stroke who have a relatively high bleeding risk with antiplatelet therapy remains unknown. OBJECTIVE: We aimed to investigate the safety and efficacy of long-term prasugrel monotherapy for stroke prevention compared with clopidogrel in elderly and/or low body weight Japanese patients with non-cardioembolic ischemic stroke. METHODS: In this randomized, double-blind, comparative, phase III study, elderly (age ≥75 years) and/or low body weight (≤50 kg) Japanese patients with a previous history of non-cardioembolic ischemic stroke were assigned to a prasugrel 3.75 mg (PRA3.75) group, a prasugrel 2.5 mg (PRA2.5) group, or a clopidogrel 50 mg (CLO50) group and followed up for 48 weeks. The primary safety endpoint was the combined incidence of primary safety events, defined as life-threatening, major, and other clinically relevant bleeding. The efficacy endpoint was a composite of ischemic stroke, myocardial infarction, and death from other vascular causes. RESULTS: A total of 654 patients (age 76.4 ± 7.3 years, body weight 55.6 ± 9.3 kg, women 43.9%) from 74 medical institutions within Japan were enrolled. The combined incidence (95% CI) of primary safety events was 4.2% (1.9-7.8%), 1.9% (0.5-4.7%), and 3.6% (1.6-6.9%) in the PRA3.75 group (n = 216), PRA2.5 group (n = 215), and CLO50 group (n = 223), respectively (hazard ratios [HR] PRA3.75/CLO50, 1.13 [0.44-2.93]; PRA2.5/CLO50, 0.51 [0.15-1.69]). The incidences of bleeding leading to treatment discontinuation (95% CI) were 2.3% (0.8-5.3%), 0.9% (0.1-3.3%), and 2.2% (0.7-5.2%) in the PRA3.75, PRA2.5, and CLO50 groups, respectively (HRs PRA3.75/CLO50, 1.01 [0.29-3.48]; PRA2.5/CLO50, 0.41 [0.08-2.12]). There was no significant difference in all bleeding events between groups. The incidence of ischemic stroke, myocardial infarction, and death from other vascular causes was lower, but not significantly so, in patients treated with prasugrel than in patients treated with clopidogrel: PRA3.75, 0.0% (0/216); PRA2.5, 3.3% (7/215); and CLO50, 3.6% (8/223; HRs PRA3.75/CLO50, 0.00 [0.00-0.00]; PRA2.5/CLO50, 0.90 [0.32-2.47]). CONCLUSIONS: Elderly and/or low body weight -Japanese patients with previous non-cardioembolic ischemic stroke who received PRA3.75 showed similar results in terms of primary safety endpoint, and a numerically lower incidence of ischemic stroke, myocardial infarction, and death from other vascular causes, compared with those who received CLO50.


Assuntos
Peso Corporal , Isquemia Encefálica/tratamento farmacológico , Clopidogrel/uso terapêutico , Inibidores da Agregação Plaquetária/uso terapêutico , Cloridrato de Prasugrel/uso terapêutico , Acidente Vascular Cerebral/tratamento farmacológico , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Povo Asiático , Peso Corporal/etnologia , Isquemia Encefálica/diagnóstico , Isquemia Encefálica/etnologia , Isquemia Encefálica/mortalidade , Clopidogrel/efeitos adversos , Método Duplo-Cego , Feminino , Nível de Saúde , Hemorragia/induzido quimicamente , Humanos , Incidência , Japão , Masculino , Inibidores da Agregação Plaquetária/efeitos adversos , Cloridrato de Prasugrel/efeitos adversos , Recidiva , Medição de Risco , Fatores de Risco , Acidente Vascular Cerebral/diagnóstico , Acidente Vascular Cerebral/etnologia , Acidente Vascular Cerebral/mortalidade , Fatores de Tempo , Resultado do Tratamento
10.
Soc Psychiatry Psychiatr Epidemiol ; 55(1): 45-56, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30859237

RESUMO

PURPOSE: Psychosocial stress is associated with obesity in some populations, but it is unclear whether the association is related to migration. This study explored associations between psychosocial stress and obesity among Ghanaian migrants in Europe and non-migrant Ghanaians in Ghana. METHODS: Cross-sectional data from the RODAM study were used, including 5898 Ghanaians residing in Germany, the UK, the Netherlands, rural Ghana, and urban Ghana. Perceived discrimination, negative life events and stress at work or at home were examined in relation to body mass index (BMI) and waist circumference (WC). Linear regression analyses were performed separately for migrants and non-migrants stratified by sex. RESULTS: Perceived discrimination was not associated with BMI and WC in both migrants and non-migrants. However, negative life events were positively associated with BMI (ß = 0.78, 95% CI 0.34-1.22) and WC (ß = 1.96, 95% CI 0.79-3.12) among male Ghanaian migrants. Similarly, stress at work or at home was positively associated with BMI (ß = 0.28, 95% CI 0.00-0.56) and WC (ß = 0.84, 95% CI 0.05-1.63) among male Ghanaian migrants. Among non-migrant Ghanaians, in contrast, stress at work or at home was inversely associated with BMI and WC in both males (ß = - 0.66, 95% CI - 1.03 to - 0.28; ß = - 1.71 95% CI - 2.69 to - 0.73, respectively) and females (ß = - 0.81, 95% CI - 1.20 to - 0.42; ß = - 1.46, 95% CI - 2.30 to - 0.61, respectively). CONCLUSIONS: Negative life events and stress at work or at home are associated with increased body weight among male Ghanaians in European settings, whereas stress at work or at home is associated with reduced body weight among Ghanaians in Ghana. More work is needed to understand the underlying factors driving these differential associations to assist prevention efforts.


Assuntos
Peso Corporal/etnologia , Obesidade/psicologia , Estresse Ocupacional/etnologia , Estresse Psicológico/etnologia , Migrantes/psicologia , Adulto , Índice de Massa Corporal , Estudos Transversais , Feminino , Alemanha , Gana/etnologia , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Países Baixos , Obesidade/etnologia , Estresse Ocupacional/complicações , População Rural , Estresse Psicológico/complicações , Reino Unido , População Urbana
11.
Ethn Health ; 25(2): 289-304, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-29096529

RESUMO

Objective(s): The prevalence of adolescent obesity is high among the various ethnic groups native to the Pacific region (European, Melanesian and Polynesian). An important factor of weight gain or loss is body size satisfaction; however, little is known about adolescent body self-perception in the Pacific region.Design: Body dissatisfaction was evaluated using the Stunkard Figure Rating Scale in a sample of 699 adolescents from rural and urban areas of New Caledonia. The socio-demographic factors associated with higher body dissatisfaction were determined by multiple linear regression modeling.Results: Our results showed a high rate of body dissatisfaction (over 70%) in the adolescents. Body dissatisfaction was strongly related to the body mass index z-score. Melanesians boys had higher body dissatisfaction scores when they felt 'too thin' while Melanesian girls showed lower body dissatisfaction when they felt 'too fat.'.Conclusion: These results showed that social pressure for thinness or musculature may be different among adolescents living in New Caledonia. These results should be taken into account in education overweight prevention programs.


Assuntos
Insatisfação Corporal/psicologia , Peso Corporal , Havaiano Nativo ou Outro Ilhéu do Pacífico/estatística & dados numéricos , Obesidade Infantil , Adolescente , Índice de Massa Corporal , Peso Corporal/etnologia , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Nova Caledônia/epidemiologia , Obesidade Infantil/epidemiologia , Obesidade Infantil/etnologia , Prevalência , Fatores Sexuais
12.
J Am Coll Health ; 68(7): 704-711, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-31039082

RESUMO

Objective: To examine sex and racial/ethnic differences in sleep quality and the association between sleep quality and body weight status among US college students. Participants: A nationally representative sample (N = 324,767) of college students from 2011 to 2015. Methods: A secondary data analysis of cross-sectional data. Results: Women showed poorer sleep quality (nights per week getting enough sleep to feel rested) than men (4.00 versus 4.34 days; p < .001). In both men and women, compared with non-Hispanic whites, racial/ethnic minorities showed lower sleep quality (p < .001). Compared with normal weight participants, overweight participants had poorer sleep quality (p = .007) among men, and both overweight (p = .004) and obese participants (p < .001) had lower sleep quality among women. Conclusions: Understanding sex and racial/ethnic sleep differences and the association between sleep and body weight status is important for colleges to promote college students' healthy sleep.


Assuntos
Peso Corporal/etnologia , Sobrepeso/etnologia , Distúrbios do Início e da Manutenção do Sono/etnologia , Adolescente , Estudos Transversais , Etnicidade/estatística & dados numéricos , Feminino , Humanos , Masculino , Grupos Minoritários/estatística & dados numéricos , Obesidade/etnologia , Abstinência Sexual , Sono/fisiologia , Estudantes , Estados Unidos , Universidades , Adulto Jovem
13.
J Clin Endocrinol Metab ; 105(2)2020 02 01.
Artigo em Inglês | MEDLINE | ID: mdl-31769496

RESUMO

CONTEXT: Variations in the prevalence and etiology of type 2 diabetes (T2D) across race and ethnicity may affect treatment responses. Semaglutide is a glucagon-like peptide-1 analog approved for once-weekly, subcutaneous treatment of T2D. OBJECTIVE: To compare semaglutide efficacy and safety in race and ethnicity subgroups across the SUSTAIN trials. DESIGN: Post hoc analysis of data from phase 3 randomized SUSTAIN 1-5 and 7 (pooled), and SUSTAIN 6 trials. PARTICIPANTS: 3074 subjects (SUSTAIN 1-5 and 7) and 1648 subjects (SUSTAIN 6). INTERVENTIONS: Semaglutide 0.5 or 1.0 mg, placebo, or active comparator (sitagliptin 100 mg, exenatide extended release 2.0 mg, insulin glargine 100IU/ml and dulaglutide 0.75 or 1.5 mg). MAIN OUTCOME MEASURES: Change in hemoglobin A1C (HbA1c) and body weight from baseline to weeks 30, 40 and 104, and other efficacy and safety endpoints. RESULTS: HbA1c was reduced from baseline by 1.0 to 1.5 percentage points and 1.3 to 2.0 percentage points, and body weight was reduced by 2.3 to 4.7 kg and 3.6 to 6.1 kg with semaglutide 0.5 and 1.0 mg, respectively, across race and ethnicity subgroups. Minor changes in blood pressure and lipid profiles were observed. Adverse events (AEs) were reported in similar proportions of subjects across trials. More Asian versus other race subgroups discontinued treatment prematurely due to AEs. The most commonly reported AEs were gastrointestinal disorders. CONCLUSIONS: In this SUSTAIN trials post hoc analysis, semaglutide was associated with consistent and clinically relevant reductions in HbA1c and body weight in subjects with T2D, with minor variations in efficacy and safety outcomes associated with race or ethnicity.


Assuntos
Diabetes Mellitus Tipo 2/tratamento farmacológico , Etnicidade/estatística & dados numéricos , Peptídeos Semelhantes ao Glucagon/administração & dosagem , Hipoglicemiantes/administração & dosagem , Grupos Raciais/estatística & dados numéricos , Adulto , Glicemia/efeitos dos fármacos , Peso Corporal/efeitos dos fármacos , Peso Corporal/etnologia , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/etnologia , Feminino , Peptídeos Semelhantes ao Glucagon/análogos & derivados , Hemoglobinas Glicadas/efeitos dos fármacos , Humanos , Fragmentos Fc das Imunoglobulinas/administração & dosagem , Insulina Glargina/administração & dosagem , Masculino , Pessoa de Meia-Idade , Proteínas Recombinantes de Fusão/administração & dosagem , Resultado do Tratamento
14.
Nutrients ; 11(12)2019 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-31757075

RESUMO

The objective of the current study was to examine micronutrient intake from foods in women of childbearing age and to better understand potential nutritional problems varied by body weight status in minority women. A sample of women aged 19-39 years from the National Health and Nutrition Examination Surveys (NHANES) 2003-2014 was analyzed. Dietary intakes of 13 micronutrients were estimated using the National Cancer Institute method. Mexican-American and non-Hispanic Black women were categorized into normal/under-weight, overweight, or obese groups according to their body mass index (BMI). Mexican-American and non-Hispanic Black women had lower dietary intakes for vitamins A, B2, B6, B12, and D, folate, calcium, and magnesium than non-Hispanic Whites. Among Mexican-Americans, obese women had the lowest dietary intake of vitamins A, B2, C and D. Obese non-Hispanic Black women had significantly lower dietary intakes of iron and zinc than their normal/under-weight counterparts. Comparable percentages (>30%) of Mexican-American and non-Hispanic Black women had dietary intake less than the Estimated Average Requirements (EARs) for several key nutrients including vitamin A, C and D, folate, calcium and magnesium, and the percentages varied by body weight status. These results indicate micronutrient inadequacies persist among and within racial/ethnic and body weight groups.


Assuntos
Negro ou Afro-Americano , Peso Corporal/etnologia , Dieta/etnologia , Americanos Mexicanos , Micronutrientes/administração & dosagem , Estado Nutricional/etnologia , Valor Nutritivo , Obesidade/etnologia , Adulto , Fatores Etários , Índice de Massa Corporal , Estudos Transversais , Feminino , Humanos , Inquéritos Nutricionais , Obesidade/diagnóstico , Obesidade/fisiopatologia , Prevalência , Recomendações Nutricionais , Fatores Sexuais , Fatores de Tempo , Estados Unidos/epidemiologia , Adulto Jovem
15.
PLoS One ; 14(11): e0224612, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31682622

RESUMO

OBJECTIVE: Adult women are disproportionately affected by overweight and obesity in Sub-Saharan African (SSA) countries. Existing evidence on the sociocultural context remains unconsolidated. In this qualitative research synthesis, we aggregate research literature on contextual factors that potentially predispose adult women and adolescent girls to overweight and obesity to inform research, policies and programs over the life course. METHODS: PubMed, CINAHL, PsychInfo, ProQuest Central, EMBASE, and Web of Science were searched to locate qualitative research articles conducted in SSA countries beginning in the year 2000. After assessment for eligibility and critical appraisal, 17 studies were included in the synthesis. Textual data and quotes were synthesized using meta-aggregation methods proposed by the Joanna Briggs Institute. RESULTS: The synthesized studies were conducted in South Africa, Ghana, Kenya and Botswana. The three overarching themes across these studies were body size and shape ideals, barriers to healthy eating, and barriers to physical activity, with cultural and social factors as cross-cutting influences within the major themes. Culturally, the supposedly ideal African woman was expected to be overweight or obese, and voluptuous, and this was associated with their identity. Although being overweight or obese was not acceptable to adolescent girls, they desired to be voluptuous. Healthy food choices among women and adolescent girls were hampered by several factors including affordability of nutritious foods and peer victimization. Both adult women and adolescent girls experienced ageism as a barrier to physical activity. SIGNIFICANCE: This is the first qualitative research synthesis to amplify the voices of women and girls in SSA countries highlighting the challenges they face in maintaining a healthy body weight. Sociocultural, institutional and peer-related factors were powerful forces shaping body size preferences, food choices and participation in physical activity. Our study findings provide insights for the design of contextually appropriate obesity prevention interventions and lay the foundation for further research studies.


Assuntos
Peso Corporal/etnologia , Cultura , Obesidade/epidemiologia , Sobrepeso/epidemiologia , Adolescente , Adulto , África Subsaariana/epidemiologia , Peso Corporal/fisiologia , Exercício Físico/psicologia , Feminino , Preferências Alimentares/etnologia , Preferências Alimentares/fisiologia , Humanos , Obesidade/prevenção & controle , Obesidade/psicologia , Sobrepeso/prevenção & controle , Sobrepeso/psicologia , Influência dos Pares , Pesquisa Qualitativa , Fatores de Risco , Fatores Socioeconômicos , Adulto Jovem
16.
Cad Saude Publica ; 35Suppl 3(Suppl 3): e00073918, 2019 Aug 19.
Artigo em Espanhol | MEDLINE | ID: mdl-31433032

RESUMO

The aim of this study was to conduct a review of the health and nutritional status of Chilean indigenous children, specifically Mapuche children, as published in the literature and specific population-based studies. The searches were conducted in PubMed and LILACS in the last 15 years. From 2006 to 2015, the poverty rate was higher in the indigenous population, with a decrease in the gap from 16% in 2006 to 7.7% in 2015 (p < 0.001). In the first decade of this century, infant mortality in indigenous children was 17.1/1,000 live births, while in non-indigenous children it was 8.8/1,000, and the gap was maintained in the five-year follow-up (p < 0.001). Newborns with birthweight < 2,500g in the year 2000 did not reach 6% (5.6% in non-indigenous and 5.2% in indigenous children). Low height at first school enrollment was 8.4% in indigenous schoolchildren and 3.1% in non-indigenous children, decreasing to 3.7% in indigenous children and 2.6% in non-indigenous children in 2004, while obesity increased more in indigenous children, reaching 24.2% in indigenous and 25.3% in non-indigenous children (p < 0.001). Menarche appeared four months later on average in indigenous girls (12.7 years), and body mass index, waist circumference, and fat mass were significantly greater in indigenous girls at the time of thelarche, as was the overweight rate (55%, vs. 42% in non-indigenous). Mapuche children show favorable health and nutritional status compared to indigenous children elsewhere in Latin America, but there is still an adverse gap compared to non-indigenous Chilean children. This inequality affecting indigenous Chilean children should be acknowledged and corrected.


El objetivo de este trabajo fue realizar una revisión de la situación de salud y nutrición del niño indígena chileno, específicamente del Mapuche, en lo publicado en las bases de datos de referencias bibliográficas y en investigaciones específicas que tienen base poblacional. Para este trabajo se buscó lo publicado en PubMed, LILACS, organismos nacionales e internacionales, durante los últimos 15 años. Desde el 2006 hasta el 2015 la proporción de pobres era mayor en los indígenas, con disminución de la brecha de 16% el 2006 a 7,7% el 2015 (p < 0,001). En la primera década de este siglo la mortalidad infantil en los niños indígenas tenía una tasa de 17,1/1.000 nacidos vivos, mientras en los no indígenas era de de 8,8/1.000 y, en el seguimiento de cinco años, la brecha se mantuvo (p < 0,001). Los recién nacidos con peso < 2,500g el año 2000 no superaban el 6% (5,6% en no indígenas y 5,2% en los indígenas). La talla baja al ingreso a la escuela era 8,4% en los escolares indígenas y 3,1% en los no indígenas, disminuyendo a 3,7 en los indígenas y 2,6% en los no indígenas el 2004, la obesidad en cambio aumentó más en los indígenas, llegando a 24,2 y 25,3% en los no indígenas (p < 0,001). La menarquia se presentó cuatro meses más tarde en las indígenas (12,7 años) y el índice de masa corporal, circunferencia de cintura y el porcentaje de grasa, fueron significativamente mayores en las indígenas en el momento de la telarquia, así como la frecuencia de exceso de peso (55% vs. 42% en las no indígenas). Los niños Mapuche presentan una condición de salud y nutrición favorable, comparada con los indígenas de otros países del continente, sin embargo, aun existe una brecha adversa -comparada con los no indígenas-, en que la desigualdad desfavorece al niño indígena y esta debe ser reconocida y corregida.


O objetivo deste trabalho foi realizar una revisão da situação da saúde e nutrição da criança indígena chilena, especificamente da Mapuche, nas publicações relacionadas em bases de dados de referências bibliográficas e em pesquisas específicas que têm base populacional. A pesquisa foi realizada em publicações relacionadas: PubMed, LILACS, organismos nacionais e internacionais, nos últimos 15 anos. Desde 2006 até 2015 a proporção de pobres era maior nos indígenas, com diminuição de uma diferença de 16% em 2006 a 7,7% em 2015 (p < 0.001). Na primeira década de este século a mortalidade infantil nas crianças indígenas teve una taxa de 17,1/1.000 nascidas vivas, enquanto nos não indígenas era de 8,8/1.000 e, em um acompanhamento de cinco anos, a diferença se manteve (p < 0,001). Os recém-nascidos com peso < 2.500g no ano de 2000 não superavam 6% (5,6% em não indígenas e 5,2% nos indígenas). A baixa estatura ao momento do ingresso na escola era 8,4% nos escolares indígenas e 3,1% nos não indígenas, diminuindo a 3,7 nos indígenas e 2,6% nos não indígenas em 2004, a obesidade pelo contrário teve um aumento maior nos indígenas, chegando a 24,2 e 25,3% nos não indígenas (p < 0,001). A menarca ocorreu quatro meses mais tarde nas indígenas (12,7 anos) e o índice de massa corporal, circunferência da cintura e a porcentagem da gordura, foram significativamente maiores nas indígenas no período da telarca, à semelhança da frequência do sobrepeso (55% vs. 42% nas não indígenas). As crianças Mapuche apresentam uma condição de saúde e nutrição favorável, comparada com os indígenas de outros países do continente, no entanto, ainda existe uma brecha adversa - comparada com os não indígenas - , onde a desigualdade desfavorece a criança indígena e por isso deve ser reconhecida e corrigida.


Assuntos
Peso ao Nascer , Indígenas Sul-Americanos/estatística & dados numéricos , Estado Nutricional , Grupos Populacionais/estatística & dados numéricos , Estatura/etnologia , Peso Corporal/etnologia , Criança , Mortalidade da Criança/etnologia , Chile , Humanos , Estado Nutricional/etnologia , Fatores Socioeconômicos
17.
Appetite ; 142: 104354, 2019 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-31295505

RESUMO

INTRODUCTION: This study aimed to explore the role of ethnicity and maternal perceived weight status in the association between maternal child feeding practices and childhood Body Mass Index (BMI) at the age of 11-12 years in a multi-ethnic population. METHODS: We collected data on child feeding practices by the validated Child Feeding Questionnaire (CFQ) among 2398 mothers of adolescents (Mage = 11.2, SDage = 0.6). Multivariate linear analyses were used to determine the cross-sectional association between child feeding practices ('Restriction', 'Pressure to eat', and 'Monitoring'), maternal perception of child's weight status, SDS-BMI, and ethnicity. RESULTS: 'Restriction' (ß = 0.16; 95% CI [0.11; 0.20]) and 'Pressure to eat' (ß = -0.32 [-0.36;-0.28]) were significantly associated with child SDS-BMI. Both associations were strongly influenced by the mother's perception of child's weight status. Besides, non-native Dutch mothers performed significantly higher levels of 'Restriction' (M±SD = 12.17 ±â€¯4.41) and 'Pressure to eat' (10.75 ±â€¯4.03) compared to native Dutch mothers (11.25 ±â€¯4.15 and 9.99 ±â€¯3.83, respectively). Native Dutch mothers performed higher levels of 'Monitoring' (17.15 ±â€¯2.54) compared to non-native Dutch mothers (16.73 ±â€¯3.01). Furthermore, children of non-native Dutch mothers had a 0.15 (0.27; 0.46) higher SDS-BMI. Finally, results showed that the association between 'Pressure to eat' and SDS-BMI was stronger in native Dutch mothers (ß = -0.20; 95% CI [-0.24; -0.15]) compared to non-native Dutch mothers (ß = -0.11; 95% CI [-0.18; -0.04]). DISCUSSION AND CONCLUSION: Ethnic differences in childhood BMI seemed to be partially attributable to the maternal perception of her child's weight status. Besides, maternal perception of child's weight appeared to play an important role in the association between maternal child feeding practices and childhood SDS-BMI. Hence, our findings contribute to the growing evidence concerning the bi-directional association between child feeding practices and childhood BMI.


Assuntos
Índice de Massa Corporal , Peso Corporal/etnologia , Etnicidade/psicologia , Métodos de Alimentação/psicologia , Comportamento Materno/etnologia , Comportamento Materno/psicologia , Adulto , África/etnologia , Criança , Estudos Transversais , Dieta/psicologia , Feminino , Humanos , Pessoa de Meia-Idade , Marrocos/etnologia , Mães , Países Baixos , Percepção , Inquéritos e Questionários , Turquia
18.
Health Place ; 58: 102147, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31234123

RESUMO

Weight among immigrants in the United States (US) is lower than among the US-born on average, but higher among long-term immigrants than the newly arrived. Neighborhood coethnic concentration-the proportion of neighborhood residents of the same ethnic background-may influence weight among immigrants via behavioral norms and market-driven community resources. However, the relevant exposure timeframe may be far longer than is captured by existing cross-sectional and short-term studies. Using detailed historical residential address information on 1449 older Latino and Chinese long-term immigrants, we investigated associations of 10-20-year neighborhood coethnic concentration trajectories with current waist circumference and weight-related behaviors (diet, physical activity, and sedentary time). Among Chinese participants, compared to persistent low coethnic concentration, increasing coethnic concentration was associated with higher waist circumference (difference = 1.45 cm [0.51, 2.39]). In contrast, both increasing coethnic concentration and persistent high coethnic concentration were associated with a healthier diet. Among Latino participants, trajectories characterized by higher coethnic concentration were associated with higher waist circumference (e.g., difference = 2.11 cm [0.31, 3.91] for persistent high vs. persistent low) and low physical activity. Long-term patterns of neighborhood coethnic concentration may affect weight-related outcomes among immigrants in complex ways that differ by ethnicity and outcome.


Assuntos
Peso Corporal/etnologia , Emigrantes e Imigrantes/estatística & dados numéricos , Etnicidade/estatística & dados numéricos , Características de Residência , Negro ou Afro-Americano , Idoso , Idoso de 80 Anos ou mais , Asiático , Feminino , Hispânico ou Latino , Humanos , Estilo de Vida , Masculino , Pessoa de Meia-Idade , Estados Unidos , População Urbana , Circunferência da Cintura , População Branca
19.
Appetite ; 140: 180-189, 2019 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-31077772

RESUMO

Disordered eating behaviors are prevalent in Mexican-American college-enrolled women and contribute to compromised physical and psychological health. Although disordered eating behaviors are multi-determined, few studies have examined individual difference factors that contribute to disordered eating behaviors in Mexican women beyond acculturation. Evidence suggests that individual differences in the constellation of identities may be an important factor influencing the disordered eating behaviors. We hypothesized that individual differences in the collection of identities (self-schemas) increases susceptibility to defining oneself as fat (fat self-schema) and contribute to disordered eating behaviors over time in Mexican American college women. A 12-month longitudinal design was used to measure the level of disordered eating behaviors at 5 points over 12 months in 477 Mexican American women. Identity properties (i.e., positive self-schemas, negative self-schemas, fat self-schema) were measured at baseline. Controlling for relevant covariates, latent growth curve models showed that Mexican American women with few positive and many negative self-schemas were more likely to define themselves as fat, which in turn, predicted purging and fasting/restricting behaviors across the year. However, identity properties were not predictive of binge eating and excessive exercise episodes. Interventions focused on development of positive self-schemas that reflect areas of interest and competence and the revision of negative self-schemas may protect against purging and fasting/restricting in Mexican American college-enrolled women.


Assuntos
Comportamento Alimentar/etnologia , Transtornos da Alimentação e da Ingestão de Alimentos/etnologia , Americanos Mexicanos/psicologia , Autoimagem , Estudantes/psicologia , Adolescente , Adulto , Arizona/epidemiologia , Peso Corporal/etnologia , Cultura , Comportamento Alimentar/psicologia , Transtornos da Alimentação e da Ingestão de Alimentos/epidemiologia , Transtornos da Alimentação e da Ingestão de Alimentos/psicologia , Feminino , Humanos , Estudos Longitudinais , Michigan/epidemiologia , Prevalência , Universidades , Adulto Jovem
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