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1.
J Cataract Refract Surg ; 49(10): 1061-1067, 2023 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-37144642

RESUMO

The impact refractive surgery has on preoperative horizontal strabismus is rapidly evolving, and this knowledge can provide valuable clinical context when considering refractive surgery as a treatment for strabismus. 515 studies were identified, of which 26 met the inclusion criteria. Analysis indicated that refractive surgery resulted in an overall decrease in the mean uncorrected postoperative angle of deviation caused partially or fully due to refractive error and highlighted the varied outcome of refractive surgery on nonaccommodative horizontal strabismus with limited evidence to suggest refractive surgery for this type of strabismus. Efficacy of refractive surgery in reducing concomitant horizontal strabismus depends on several factors: type of horizontal ocular deviation, patient age, and extent of refractive error. Refractive surgery can be an effective treatment for refractive accommodative horizontal strabismus in patients with stable, mild to moderate myopia or hyperopia and should be considered with careful patient selection for optimum outcome.


Assuntos
Erros de Refração , Procedimentos Cirúrgicos Refrativos , Estrabismo , Humanos , Acuidade Visual , Estrabismo/cirurgia , Estrabismo/complicações , Refração Ocular , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Estudos Retrospectivos
2.
Int Ophthalmol ; 43(7): 2477-2486, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-36869982

RESUMO

PURPOSE: To perform a systematic evaluation of the efficacy and safety of loteprednol etabonate (LE) 0.5% versus fluorometholone (FML) 0.1% for treating patients after corneal refractive surgery with the aim of providing an evidence-based rationale for clinical drug selection. METHODS: Electronic databases (PubMed, EMBASE, Cochrane Library, Web of Science, WanFang, and CNKI) were searched (from inception to December 2021) for comparative clinical studies that evaluated LE versus FML treatment for post-corneal refractive surgery patients. Meta-analysis was performed using the RevMan 5.3 software. The pooled risk ratio (RR) and weighted mean difference (WMD) with corresponding 95% confidence interval (CI) were calculated. RESULTS: Nine studies with a total sample size of 2677 eyes were included in this analysis. FML 0.1% and LE 0.5% produced a similar incidence of corneal haze within 6 months after surgery (P = 0.13 at 1 month, P = 0.66 at 3 months, and P = 0.12 at 6 months). There was no statistically significant difference between the two groups in terms of the mean logMAR postoperative uncorrected distance visual acuity (WMD: - 0.00; 95% CI: - 0.01 to 0.00; P = 0.29) and spherical equivalent (WMD: 0.01; 95% CI: - 0.01 to 0.03; P = 0.35). LE 0.5% appears to have a higher tendency to reduce the incidence of ocular hypertension compared FML 0.1%, but there was no statistical significance (RR: 0.63; 95% CI: 0.27 to 1.50; P = 0.30). CONCLUSION: This meta-analysis demonstrated that LE 0.5% and FML 0.1% had comparable efficacy in preventing corneal haze and corticosteroid-induced ocular hypertension, with no difference in visual acuity in patients after corneal refractive surgery.


Assuntos
Opacidade da Córnea , Hipertensão Ocular , Procedimentos Cirúrgicos Refrativos , Humanos , Etabonato de Loteprednol/efeitos adversos , Fluormetolona/uso terapêutico , Córnea/cirurgia , Procedimentos Cirúrgicos Refrativos/efeitos adversos
3.
Int Ophthalmol ; 43(7): 2335-2340, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-36592262

RESUMO

PURPOSE: To evaluate factors that may influence the direction and extent of long-term refractive error after cataract surgery. METHODS: This was a retrospective observational study conducted across two private practices in Sydney, NSW, Australia. The study population consisted of patients who underwent cataract phacoemulsification surgery between January 1 and December 31, 2018. Patients who received cataract surgery combined with another procedure were excluded. Demographic and biometric data including anterior chamber depth (ACD), keratometry, central corneal thickness, axial length (AL) and lens thickness were obtained pre-operatively. Spherical equivalent (SEQ) refraction was measured at 2 months and 3 years after surgery and compared with target refraction. Factors associated with refractive error were analyzed. RESULTS: This study included 221 eyes of 122 patients. A refractive error within 1.00 D was achieved in 217 eyes (98.2%) at 3 years post-operatively. Mean prediction error decreased significantly between 2 months and 3 years after surgery irrespective of whether eyes were more myopic (p < 0.001) or more hypermetropic than predicted (p < .0001). Pre-operative ACD and ACD-to-AL ratio were significantly associated with SEQ prediction error. CONCLUSION: After cataract surgery, refractive outcomes may be influenced by ACD and ACD-to-AL ratio. The pre-operative assessment of these risk factors may better inform IOL selection in individual patients. Prospective studies in a larger cohort are required.


Assuntos
Catarata , Lentes Intraoculares , Facoemulsificação , Erros de Refração , Procedimentos Cirúrgicos Refrativos , Humanos , Implante de Lente Intraocular/efeitos adversos , Estudos Prospectivos , Lentes Intraoculares/efeitos adversos , Erros de Refração/complicações , Refração Ocular , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Facoemulsificação/efeitos adversos , Facoemulsificação/métodos , Estudos Retrospectivos , Córnea , Catarata/complicações , Biometria/métodos
4.
Int Ophthalmol ; 43(4): 1413-1435, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36083561

RESUMO

PURPOSE: The main objective of this work is to present an updated review of the different surgical procedures for the correction of residual refractive errors following deep anterior lamellar keratoplasty (DALK) surgery. METHODS: A review of the literature was conducted using PubMed, Web of Science, and Scopus databases. The search was conducted in January 2022 and was limited to articles published in peer-reviewed journals. The information extracted from each publication included sample size, mean follow-up time, pre- and post-operative uncorrected (UDVA) and corrected distance visual acuity (CDVA), pre- and post-operative refraction and spherical equivalent (SE), safety and efficacy indexes and complications. RESULTS: Residual ametropias, mainly high astigmatism and myopia, and the resulting anisometropia are likely to occur following DALK. They become a limiting factor and may lead to unsatisfactory visual restoration, therefore affecting patients' quality of vision and life. Alternative surgical interventions may be required to treat this residual ametropia, such as corneal refractive surgery or intraocular lens implantation. A total of 47 relevant articles were studied in detail. Different refractive surgery techniques have been shown to be effective and safe for the correction of ametropia following the DALK procedure and to improve the patient's quality of vision, although more research is needed to confirm long-term results. CONCLUSION: The final refractive technique will depend on different factors, such as the amount of ametropia, the condition of the cornea or the patient's individual needs, economics, and occupational demands.


Assuntos
Astigmatismo , Transplante de Córnea , Erros de Refração , Procedimentos Cirúrgicos Refrativos , Humanos , Ceratoplastia Penetrante/métodos , Erros de Refração/etiologia , Acuidade Visual , Refração Ocular , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Astigmatismo/cirurgia , Transplante de Córnea/métodos , Resultado do Tratamento
5.
J Cataract Refract Surg ; 48(12): 1403-1407, 2022 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-36449673

RESUMO

PURPOSE: To determine the trends in anesthesia techniques for cataract surgery over the past decade and their relationship to surgical complications. SETTING: Clinics affiliated with the European Registry of Quality Outcomes for Cataract and Refractive Surgery (EUREQUO). DESIGN: Retrospective cross-sectional register-based study. METHODS: Variables include patient demographics, visual acuity, ocular comorbidities, surgery characteristics, intraoperative complications, and postoperative complications for the study period from January 2008, to December 2018. The anesthesia methods registered in the EUREQUO and included in the study are topical, combined topical and intracameral, sub-Tenon, regional, and general anesthesia. Multivariate logistic regression models for each complication were constructed to estimate the adjusted odds ratio (OR) and 95% CIs. RESULTS: Complete data were available of 1 354 036 cataract surgeries. Topical anesthesia increased significantly over time (from 30% to 76%, P < .001). Sub-Tenon and regional anesthesia decreased (from 27% and 38% to 16% and 6%, respectively, P < .001), and general and combined topical and intracameral anesthesia remained stable (around 2%). Sub-Tenon (OR, 0.80; 95% CI, 0.71-0.91, P < .001), regional (0.74; 95% CI, 0.71-0.78, P < .001), general (0.53; 95% CI, 0.50-0.56, P < .001), and intracameral anesthesia (0.76; 95% CI, 0.64-0.90, P = .001) carried a significantly decreased risk of posterior capsule rupture (PCR), with and without dropped nucleus, compared with topical anesthesia. The risk of endophthalmitis was significantly lower with regional anesthesia compared with topical anesthesia (OR, 0.60; 95% CI, 0.44-0.82, P = .001). CONCLUSIONS: The use of topical anesthesia for cataract surgery increased over time. Topical anesthesia is associated with an increased risk of PCR with and without dropped nucleus, and endophthalmitis.


Assuntos
Catarata , Endoftalmite , Procedimentos Cirúrgicos Refrativos , Humanos , Estudos Retrospectivos , Estudos Transversais , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Anestesia Local/efeitos adversos , Sistema de Registros , Endoftalmite/epidemiologia , Endoftalmite/etiologia
6.
Ocul Surf ; 26: 63-74, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-35934280

RESUMO

PURPOSE: To describe the clinical characteristics of patients suffering from chronic dry eye (DE) and pain after refractive surgery (RS). METHODS: Cross-sectional, observational, single-visit study. DE-, pain- and psychological-related symptoms were evaluated with specific questionnaires. DE-related tests evaluated tear osmolarity, conjunctival hyperemia, Meibomian gland dysfunction, tear stability and production, and ocular surface staining. Corneal mechanical sensitivity (Cochet-Bonnet) was measured pre/post topical anesthesia, and symptomatic variation post-anesthesia (anesthetic challenge test) was recorded. When pain was present, it was further categorized as neuropathic or nociceptive based on published criteria. RESULTS: We recruited 104 patients (39.5 ± 9.5 years). Most, 85.6%, had corneal RS as opposed to intraocular RS. Migraines, anxiety, depression (p < 0.0001), and central sensitization syndromes (p = 0.0214) were more frequent post-RS than pre-RS. Persistent DE-symptoms, severe in 86.5% patients, developed in a range of 0-204 months post-RS. Dryness and pain were the two most frequent symptoms. The only DE-related tests showing abnormal values were tear osmolarity (315.2 ± 17.1 mOsm/L; normal ≤308) and tear break-up time (4.1 ± 2.5 s; normal >7). Corneal sensitivity was 55.4 ± 7.0 mm, and decreased (p < 0.0001) after topical anesthesia, 6.0 ± 10.4 mm. However, it remained pathologically elevated, ≥10 mm in 61 (58.7%) patients. The normal symptomatic post-anesthesia improvement was absent in 58 (55.7%) patients. Ocular pain was present in 82 (78.8%) patients, and it was categorized as neuropathic in 66 (80.5%) of them, 63.5% of the entire cohort. CONCLUSIONS: Chronic ocular pain and its neuropathic subtype were diagnosed in 78.8% and 63.5% respectively of patients seeking consultation for persistent symptomatic DE post-RS.


Assuntos
Síndromes do Olho Seco , Procedimentos Cirúrgicos Refrativos , Humanos , Síndromes do Olho Seco/diagnóstico , Síndromes do Olho Seco/epidemiologia , Síndromes do Olho Seco/etiologia , Estudos Transversais , Lágrimas , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Dor Ocular/diagnóstico , Dor Ocular/etiologia , Dor
7.
Klin Monbl Augenheilkd ; 239(11): 1354-1360, 2022 Nov.
Artigo em Inglês, Alemão | MEDLINE | ID: mdl-35790199

RESUMO

With an estimated incidence of 0.011%, the SMILE procedure seems to have the lowest risk of postoperative keratectasia among contemporary keratorefractive procedures. Nevertheless, due to the novelty of the procedure as well as the lack of data, no clear superiority over femto-LASIK or PRK can be stated at this time. In this respect, application of the identical tomographic screening criteria previously developed for excimer-based procedures is of paramount importance to minimize the risk of corneal ectasia. As an adjunct to conventional corneal tomography, newer imaging modalities such as OCT-based epithelial mapping should be used for preoperative screening before keratorefractive surgery. Corneal crosslinking is an established treatment modality for post-SMILE keratectasia, which promises high success rates especially in early stages. The present case report illustrates these diagnostic and therapeutic considerations.


Assuntos
Colágeno , Córnea , Doenças da Córnea , Miopia , Procedimentos Cirúrgicos Refrativos , Humanos , Colágeno/metabolismo , Córnea/diagnóstico por imagem , Córnea/metabolismo , Córnea/cirurgia , Doenças da Córnea/etiologia , Doenças da Córnea/metabolismo , Doenças da Córnea/terapia , Substância Própria/cirurgia , Dilatação Patológica , Ceratomileuse Assistida por Excimer Laser In Situ/efeitos adversos , Ceratomileuse Assistida por Excimer Laser In Situ/métodos , Lasers de Excimer/uso terapêutico , Miopia/diagnóstico por imagem , Miopia/cirurgia , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Procedimentos Cirúrgicos Refrativos/métodos
8.
Comput Math Methods Med ; 2022: 8437066, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35309847

RESUMO

Objective: In order to analyze changes in retinal vessel flow after small incision lenticule extraction (SMILE). Methods: A total of 32 patients (62 eyes) who underwent SMILE were enrolled in this prospective study. Optical parameters, including vessel density (VD), and perfusion density (PD) of foveal, parafoveal, and perifoveal regions, respectively, were measured before surgery and at 1 day, 1 week, 1 month, and 3 months postoperation. Preoperative parameters and surgical parameters were recorded. Results: Significant decreases in VD and PD on postoperative day 1 were detected in all quadrants, both in 3 mm and in 6 mm regions (P < 0.001). One month after surgery, VD returned to preoperative levels. None of the preoperative and surgical parameters were significantly correlated with the VD and PD fluctuations (all P > 0.05). Conclusion. VD may decrease significantly with regional disparity 1 day after SMILE while recovering at 1 month. Elevation of intraocular pressure due to suction may account for such changes.


Assuntos
Miopia/fisiopatologia , Miopia/cirurgia , Procedimentos Cirúrgicos Refrativos/métodos , Vasos Retinianos/fisiopatologia , Adulto , Biologia Computacional , Feminino , Humanos , Masculino , Miopia/diagnóstico por imagem , Período Pós-Operatório , Estudos Prospectivos , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Fluxo Sanguíneo Regional , Vasos Retinianos/diagnóstico por imagem , Fatores de Tempo , Tomografia de Coerência Óptica/estatística & dados numéricos , Adulto Jovem
10.
Ophthalmic Res ; 64(2): 224-229, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-32485706

RESUMO

OBJECTIVE: The aim of this study was to determine the prevalence of preoperative dry eye disease and evaluate tear film function in refractive surgery candidates in China. METHODS: In this prospective noninterventional cross-sectional study, refractive surgical candidates from 13 preselected eye hospitals in China were recruited from July 2015 to February 2016. Patient histories, subjective symptoms, tear film breakup time (TBUT), ocular surface fluorescein staining, and Schirmer I tests (SIT), were assessed to conduct subgroup analysis. RESULTS: A total of 1,849 patients were recruited, 41.4% were diagnosed with dry eye disease (766/1,849) and 44.9% (830/1,849) of subjects had a positive history of contact lens (CL) wear. The overall mean TBUT and SIT values were 7.3 ± 3.7 s and 15.2 ± 8.8 mm, respectively. The total prevalence of ocular surface fluorescein staining was 23.46% (422/1,849); 44.62% of patients had TBUT <5 s and 23.20% of patients had SIT <5 mm. CL wearers were observed to have a higher prevalence of dry eye than non-CL wearers (54.1 vs. 35.2%, OR = 2.17, 95% CI: 1.77-2.65). CONCLUSIONS: In this study, the most common abnormal finding in dry eye disease was tear film instability. A high proportion of refractive surgery candidates have preexisting dry eye disease and a history of CL wear prior to surgery. Careful attention should be given to the evaluation of preoperative dry eye in refractive surgery candidates.


Assuntos
Síndromes do Olho Seco/epidemiologia , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Adolescente , Adulto , China/epidemiologia , Estudos Transversais , Síndromes do Olho Seco/diagnóstico , Síndromes do Olho Seco/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Prospectivos , Adulto Jovem
11.
PLoS One ; 15(12): e0243740, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33315894

RESUMO

PURPOSE: To numerically evaluate and compare the tolerance to misalignment and tilt of aspheric intraocular lenses (IOLs) designed for three eyes: with standard cornea and with simulated corneas after myopic and hyperopic laser ablation surgery. METHODS: Three aspheric IOLs of +20.00 diopter (D) with different spherical aberration (SA) ([Formula: see text]) values have been designed using a theoretical model eye. Drastic changes on the theoretical eye anterior corneal asphericity have been performed to simulate myopic and hyperopic refractive surgeries. The effect of IOL misalignment and tilt on the image quality has been evaluated using a commercial optical software design for the three eye models. Image quality was assessed from the modulation transfer function (MTF), root mean square (RMS) values of defocus, astigmatism, coma and spherical aberration ([Formula: see text]), and retinal images obtained from a visual simulator using an aleatory optotype of 0.00 LogMar visual acuity (VA). RESULTS: IOL misalignment and tilt reduced MTF values in general, and increased wavefront aberrations errors. Aberration-free IOLs maintained best the MTF values when misalignments were applied, together with good on-axis optical quality. IOLs with negative SA ([Formula: see text]) correction decreased the MTF value under 0.43 for misalignments values higher than 0.50 mm with the three corneas. The effect of misalignment on RMS astigmatism and coma was correlated with the IOL SA ([Formula: see text]) and with the three corneas. CONCLUSIONS: This theoretical study shows that the largest degradation in image quality arises for the IOL with the highest amount of spherical aberration ([Formula: see text]). Moreover, it has been found that the aspherical design has a more influential role in misalignment tolerance than in tilt tolerance.


Assuntos
Córnea/cirurgia , Implante de Lente Intraocular , Lentes Intraoculares , Córnea/fisiopatologia , Humanos , Implante de Lente Intraocular/efeitos adversos , Implante de Lente Intraocular/métodos , Lentes Intraoculares/efeitos adversos , Erros de Refração/fisiopatologia , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Procedimentos Cirúrgicos Refrativos/métodos
12.
Rev. cuba. oftalmol ; 33(3): e863,
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1139096

RESUMO

RESUMEN Los errores refractivos altos son difíciles de corregir óptica y quirúrgicamente. Los pacientes que los padecen se encuentran incómodos con las gafas, ya que la calidad de su visión es deficitaria. Las lentes de contacto proporcionan mejor agudeza visual; sin embargo, en ocasiones requieren diseños especiales para ser adaptadas y pueden asociarse a complicaciones severas. La cirugía refractiva como subespecialidad busca mejorar la agudeza visual no corregida y disminuir la dependencia a gafas o lentes de contacto. Las opciones van desde los procedimientos queratorrefractivos hasta el implante de una lente intraocular, ya sea con la extracción del cristalino transparente o en un ojo fáquico. Este último ofrece ventajas al mantener la acomodación, obtener una mejor calidad óptica y cierta reversibilidad. En el mundo se han realizado múltiples trabajos en pacientes con lentes fáquicos de diferentes modelos y estos han demostrado que son seguros y confiables, aunque no son muchos los estudios sobre la calidad de vida a largo plazo; de ahí la motivación para realizar una búsqueda actualizada de diversos artículos publicados, con el objetivo de describir los resultados visuales y la calidad de vida en pacientes con implante de lentes fáquicos. Se utilizó la plataforma Infomed, específicamente la Biblioteca Virtual de Salud, con todos sus buscadores(AU)


ABSTRACT High refractive errors are difficult to correct both optically and surgically. Patients suffering from them feel uncomfortable with their eyeglasses, since their visual quality is poor. Contact lenses provide better visual acuity, but they sometimes require special designs to be adjusted and may be associated to severe complications. The subspecialty of refractive surgery seeks to improve uncorrected visual acuity and reduce dependence on eyeglasses or contact lenses. Options range from keratorefractive procedures to intraocular lens implantation, be it with removal of the transparent crystalline lens or in phakic eyes. The latter provides the advantages of maintaining accommodation, obtaining better visual quality and affording a certain degree of reversibility. A great many studies have been conducted worldwide of patients with phakic lenses of various models, and these have proved to be safe and reliable. However, not many studies are available about long-term quality of life. Hence the motivation to perform an updated search for published papers about the subject, with the purpose of describing the visual results and quality of life of patients with phakic lens implants. Use was made of the Infomed platform, particularly the Virtual Health Library with all its search engines(AU)


Assuntos
Humanos , Qualidade de Vida , Erros de Refração/etiologia , Implante de Lente Intraocular/métodos , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Estresse Psicológico , Óculos/efeitos adversos
13.
Exp Eye Res ; 193: 107976, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-32081669

RESUMO

Neuropathic dry eye is one of the most frequently seen complications after corneal refractive surgery, however, its incidence decreases in a significant manner along the first six months postoperative, reaching between 10 and 45% incidence. However, little is known on the inflammatory status of the ocular surface during this recovery process. We aim to analyze the clinical and tear molecule concentration changes along six months after advanced surface ablation for myopia correction, in a prospective study including 18 eyes of 18 subjects who bilaterally underwent advanced surface ablation corneal refractive surgery. Clinical variables (uncorrected distance visual acuity, symptoms, conjunctival hyperemia, tear osmolarity, tear stability, corneal fluorescein staining, conjunctival lissamine staining, Schirmer test, and corneal esthesiometry) and a panel of 23 pro and anti-inflammatory cytokines/chemokines concentration in tears preoperatively and at 1, 3 and 6 months postoperatively were evaluated. We found that uncorrected distance visual acuity improved significantly from baseline at 1-month visit, symptoms improved and tear osmolarity decreased significantly from baseline at 3-month visit and there was a decrease in mechanical corneal threshold between 1-month and 3- and 6-month visits. Regarding tear molecules, IL-4, IL-5, IL-6, IL-13, IL-17A, and IFN-γ tear levels were significantly increased at all the three visits, compared to preoperative levels at V0; IL-2 and VEGF were also significantly increased at 1-month and 6-month visits, but not at 3-month visit, whereas IL-9 IL-10 and IL-12 were only significantly increased at 6-month visit. Although we found that there is a recovery in clinical variables at 6 months postoperatively (i.e. neuropathic dry eye was not developed in the sample), ocular surface homeostasis is not completely restored, as it can be seen by the changes in concentration of some pro and anti-inflammatory molecules measured in tears.


Assuntos
Citocinas/metabolismo , Síndromes do Olho Seco/metabolismo , Terapia a Laser/efeitos adversos , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Lágrimas/metabolismo , Adulto , Biomarcadores/metabolismo , Síndromes do Olho Seco/diagnóstico , Síndromes do Olho Seco/etiologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Concentração Osmolar , Estudos Prospectivos , Fatores de Tempo , Acuidade Visual
14.
Cornea ; 39(2): 254-257, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31688202

RESUMO

PURPOSE: To report a case of pressure-induced interlamellar stromal keratitis (PISK) after small-incision lenticule extraction (SMILE) for the correction of myopic astigmatism in the United States. METHODS: We report the case of a 27-year-old man who underwent uneventful SMILE surgery and presented with pressure-induced stromal keratitis. Anterior and posterior segment examination, uncorrected distance visual acuity, refraction, intraocular pressure, and pachymetry values are reported from this time period. RESULTS: Three weeks postoperatively, examination revealed new-onset central corneal haze and edema in both eyes, more significant in the right eye. The patient was given a presumptive diagnosis of diffuse lamellar keratitis. Intensive corticosteroid treatment was administered, causing a significant decline in uncorrected distance visual acuity OD from 20/25 to 20/250 and OS from 20/20 to 20/60, with a significant myopic shift of -3.0 D and -1.0 D, respectively. In our case, pachymetry measurements revealed 78 µm OD and 43 µm OS of additional corneal thickness. Pressure readings were 25 mm Hg OD and 19 mm Hg OS, respectively. He was diagnosed with PISK, and after 4 days of steroid discontinuation and Brimonidine-Timolol administration, his symptoms had improved with resolution of corneal edema. CONCLUSIONS: Clinicians should be aware that PISK is a potential complication of SMILE. Postoperative intraocular pressure measurements are an important aspect of the management of postcorneal refractive surgery patients because the differentiation of PISK from diffuse lamellar keratitis, as well as the early detection and treatment of PISK, can avoid severe complications.


Assuntos
Astigmatismo/cirurgia , Substância Própria/patologia , Pressão Intraocular , Ceratite/etiologia , Miopia/cirurgia , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Adulto , Astigmatismo/fisiopatologia , Paquimetria Corneana , Humanos , Ceratite/diagnóstico , Ceratite/fisiopatologia , Masculino , Miopia/fisiopatologia , Refração Ocular/fisiologia , Tomografia de Coerência Óptica , Acuidade Visual/fisiologia
15.
Cornea ; 38(12): 1589-1594, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31453878

RESUMO

PURPOSE: To review clinical aspects and cellular and molecular steps in the development of long-term glaucoma after corneal surgery or acute trauma-especially the pivotal role of tumor necrosis factor alpha (TNF-α), the rapidity of the secondary damage to the retinal ganglion cells, and the clinical promise of early antiinflammatory intervention. METHODS: A series of laboratory studies on post-injury and post-surgery glaucoma have been compared to clinical outcome studies on the subject, focusing particularly on the vulnerability of the retinal ganglion cells. Alkali burn to the cornea of mice and rabbits served as the main experimental model. TNF-α titer, ganglion cell apoptosis, and depletion of optic nerve axons have been examined. Anti-TNF-α antibodies or corticosteroids have been used to protect the retinal ganglion cells. Intraocular pressure (IOP) postburn was recorded by manometric methods. RESULTS: In animals with alkali burn to the cornea, damage to the retina can occur within 24 to 72 hours. This is not because of a direct pH change posteriorly-the alkali is effectively buffered at the iris-lens level. Rather, TNF-α (and other inflammatory cytokines), generated anteriorly, rapidly diffuses posteriorly to cause apoptosis of the ganglion cells. During this time, the IOP remains much lower than the reported values required to cause ganglion cell damage. The TNF-α antibody infliximab or corticosteroids, if administered promptly, are markedly protective of the ganglion cells. CONCLUSIONS: A rapidly initiated, inflammatory (TNF-α mediated), IOP-independent pathway to glaucoma, resulting from acute anterior segment trauma or surgery, has been identified in laboratory studies. Prompt prophylactic treatment with antiinflammatory agents has been shown to be markedly neuroprotective of retinal ganglion cells, presumably capable of reducing the risk of late glaucoma.


Assuntos
Doenças da Córnea/cirurgia , Lesões da Córnea/complicações , Glaucoma/etiologia , Pressão Intraocular/fisiologia , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Fator de Necrose Tumoral alfa/metabolismo , Animais , Queimaduras Químicas/etiologia , Queimaduras Químicas/metabolismo , Doenças da Córnea/metabolismo , Lesões da Córnea/metabolismo , Queimaduras Oculares/induzido quimicamente , Queimaduras Oculares/metabolismo , Glaucoma/metabolismo , Camundongos , Coelhos , Células Ganglionares da Retina/metabolismo , Tonometria Ocular
16.
Acta Ophthalmol ; 97(2): e145-e155, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30218490

RESUMO

To review binocular and accommodative disorders documented after corneal or intraocular refractive surgery, in normal healthy prepresbyopic patients. A bibliographic revision was performed; it included works published before 1st July 2017 where accommodation and/or binocularity was assessed following any type of refractive surgical procedure. The search in Pubmed yielded 1273 papers, 95 of which fulfilled the inclusion criteria. Few publications reporting binocular vision and/or accommodative changes after refractive surgery in normal subjects were found. The reduction in fusional vergence is the most frequently reported alteration. Anisometropia is an important risk factor for postoperative binocular vision-related complaints. Most diplopia-related visual complaints, irrespective of the surgical procedure, were in fact misdiagnosed preoperative disorders. The preoperative evaluation of patients seeking spectacle/contact lens independence should include a complete binocular and accommodation assessment where parameters such as the phoric posture, accommodative amplitude and facility, near point of convergence, fusional reserves and accommodative convergence/accommodation coefficient are measured. This would allow the identification of risk factors that could compromise the success of the refractive surgery and cause clinical symptoms.


Assuntos
Extração de Catarata/efeitos adversos , Diplopia/fisiopatologia , Complicações Pós-Operatórias , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Visão Binocular/fisiologia , Acomodação Ocular , Diplopia/etiologia , Humanos , Testes Visuais
17.
J Biophotonics ; 12(2): e201800253, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30191680

RESUMO

The purpose of this study was to evaluate the tomographic features of postrefractive surgery eyes. This was a retrospective evaluation of clinical data. Three patients with post-LASIK (laser-assisted in situ keratomileusis) and two patients with post-SMILE (small incision lenticule extraction) ectasia were imaged with Scheimpflug imaging (SI, Pentacam) and optical coherence tomography (OCT, RTVue). Curvature and wavefront aberrations of the air-epithelium interface (A-E) and epithelium-Bowman's layer interface (E-B) were derived. OCT of normal and keratoconic eyes from an earlier study were compared with the data of the ectasia eyes. Curvature and aberrometry of the A-E interfaces were statistically similar between SI and OCT. However, OCT revealed a steeper and more aberrated E-B interface than A-E though correlation between them was inferior to the correlation for keratoconic eyes. Furthermore, the magnitude of differences between the A-E and E-B interfaces was greater in the ectasia eyes than the keratoconic eyes. OCT could possibly assist better in selecting appropriate treatment plan for postrefractive surgery ectasia eyes than conventional tomographers.


Assuntos
Córnea/diagnóstico por imagem , Córnea/cirurgia , Dilatação Patológica/diagnóstico por imagem , Dilatação Patológica/etiologia , Complicações Pós-Operatórias/diagnóstico por imagem , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Tomografia de Coerência Óptica , Humanos , Complicações Pós-Operatórias/etiologia
18.
Rev. cuba. oftalmol ; 31(4): 74-81, oct.-dic. 2018. ilus
Artigo em Espanhol | LILACS | ID: biblio-991115

RESUMO

La cirugía refractiva incisional ha mostrado a lo largo de los años resultados impredecibles y fluctuantes. Se ha apreciado hipercorrección y astigmatismo no convencional en un número elevado de pacientes. Se presentan dos casos de ectasia corneal posquirúrgica, quienes refirieron empeoramiento progresivo de la visión. Al examen biomicroscópico se apreció apertura a nivel de las incisiones corneales por queratotomía radial y arcuata. Se muestran los resultados refractivos obtenidos en la corrección de dicha complicación mediante la utilización de suturas corneales. Se concluye que esta técnica induce resultados satisfactorios que deberíamos evaluar con certeza en el seguimiento posoperatorio de los casos(AU)


ABSTRACT Incisional refractive surgery has shown fluctuating and unpredictable results throughout the years. Hypercorrection and unconventional astigmatism have been observed in a high number of patients. Here are two patients with postsurgical corneal ectasia, who reported progressive worsening of vision. When making the biomicroscopic examination, it was observed that there was an opening at the level of corneal incisions through radial and arcuate ketatotomy. This study showed the refractive results achieved in the correction of this complication by using corneal sutures. It was concluded that this technique leads to satisfactory results that we should evaluate with certainty in the postoperative follow-up of patients(AU)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Ceratotomia Radial/métodos , Procedimentos Cirúrgicos Refrativos/efeitos adversos , Facoemulsificação/métodos
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