Assuntos
Degeneração Hepatolenticular/história , Neurologia/história , Quelantes/história , Quelantes/uso terapêutico , Dimercaprol/história , Dimercaprol/uso terapêutico , Descoberta de Drogas/história , Descoberta de Drogas/métodos , Degeneração Hepatolenticular/tratamento farmacológico , História do Século XXRESUMO
Advances in drug therapy for patients with kidney disease have contributed to increased exercise capacity, reduced cardiovascular disease, decreased renal bone disease, improved quality of life, and most importantly, reduced morbidity and mortality. New insights into the pathophysiology of chronic kidney disease (CKD) have helped lead to the development of many novel drugs and treatments. The purpose of this article is to highlight some of the developments in nephrology pharmacotherapy that occurred during the first 40 years of the American Nephrology Nurses' Association.
Assuntos
Tratamento Farmacológico/história , Falência Renal Crônica/história , Nefrologia/história , Especialidades de Enfermagem/história , Anemia Ferropriva/história , Quelantes/história , Distúrbio Mineral e Ósseo na Doença Renal Crônica/história , Hematínicos/história , História do Século XX , História do Século XXI , Humanos , Imunossupressores/história , Transplante de Rim/históriaAssuntos
Antirreumáticos/química , Antirreumáticos/história , Quelantes/química , Quelantes/história , Penicilamina/química , Penicilamina/história , Farmacologia/história , Adulto , Antirreumáticos/uso terapêutico , Quelantes/uso terapêutico , Cobre/metabolismo , Feminino , Degeneração Hepatolenticular/tratamento farmacológico , Degeneração Hepatolenticular/metabolismo , Degeneração Hepatolenticular/fisiopatologia , História do Século XX , Humanos , Fígado/metabolismo , Fígado/fisiopatologia , Penicilamina/uso terapêutico , Reino UnidoRESUMO
Emergency physicians are familiar with British anti-Lewisite (BAL) because it is a heavy metal-chelating agent that is recommended in some cases of metal poisoning, especially arsenic. Although there are more modern chelating agents, the fact that BAL is still recommended and stocked by hospital pharmacies more than 60 years after its initial synthesis is itself remarkable. During World War II, BAL minimized the risk to the Allied infantry of injury or death from Lewisite, a very potent arsenic-based chemical warfare agent. Once developed, BAL revolutionized the treatment of heavy metal poisonings, both accidental and iatrogenic (eg, toxicity from treatment of arthritis with gold salts). In 1951, BAL was used to treat Wilson's disease with striking success. Today, BAL might again become prominent should terrorists or governments use Lewisite against civilians or military forces.