Assuntos
Dermatite Alérgica de Contato , Sulfonamidas , Humanos , Dermatite Alérgica de Contato/etiologia , Sulfonamidas/efeitos adversos , Testes do Emplastro , Formaldeído/efeitos adversos , Feminino , Resinas Sintéticas/efeitos adversos , Resinas Sintéticas/química , Tolueno/efeitos adversos , MasculinoRESUMO
BACKGROUND: This study aims to assess the safety and efficacy of direct hemoperfusion using a new polymyxin B-immobilized resin column (disposable endotoxin adsorber, KCEA) in an endotoxin/ lipopolysaccharide (LPS)-induced sepsis model. METHODS: Eighteen beagles were randomized into 1 intervention group (KCEA group, n = 6) and 2 control groups (sham group and model group, n = 6 each). Sepsis was induced by continuous intravenous application of 0.5 mg/kg body weight of endotoxin for 60 min. An extracorporeal hemoperfusion device made with KCEA for endotoxin adsorption was used. Model group beagles received standard treatment with fluids and vasoactive drugs, KCEA group beagles received standard treatment and direct hemoperfusion of KCEA for 2 h, and sham group beagles were treated with standard treatment and direct hemoperfusion of a sham column for 2 h. RESULTS: Good blood compatibility of KCEA was confirmed by assessing clinical parameters. Blood endotoxin peak levels in the KCEA group were significantly lower, resulting in a significant suppression of IL-6, TNF-α and procalcitonin, which improved mean arterial pressure and significantly lowered vasopressor demand, thereby protecting organ function and improving survival time and rate. In the KCEA group, MAP was significantly higher over 6 h than those recorded both in the sham group and model group. The 7-day survival rates of the KCEA, sham and model groups were 50%, 0% and 0%, respectively. CONCLUSION: KCEA hemoadsorption was effective at detoxifying circulatory endotoxin and inflammatory mediators and contributed to the decreased mortality rate in the sepsis beagles.
Assuntos
Resinas Sintéticas , Sepse , Animais , Cães , Endotoxinas , Hemoperfusão , Lipopolissacarídeos/toxicidade , Polimixina B , Resinas Sintéticas/efeitos adversos , Resinas Sintéticas/uso terapêutico , Sepse/induzido quimicamente , Sepse/tratamento farmacológico , Resultado do TratamentoRESUMO
BACKGROUND: Shoe contact allergy can be difficult to diagnose and manage. OBJECTIVE: The aim of the study was to characterize demographics, clinical characteristics, patch test results, and occupational data for the North American Contact Dermatitis Group patients with shoe contact allergy. METHODS: This is a retrospective study of 33,661 patients, patch tested from 2005 to 2018, with a shoe source, foot as 1 of 3 sites of dermatitis, and final primary diagnosis of allergic contact dermatitis. RESULTS: Three hundred fifty-two patients met the inclusion criteria. They were more likely to be male (odds ratio = 3.36, confidence interval = 2.71-4.17) and less likely to be older than 40 years (odds ratio = 0.49, confidence interval = 0.40-0.61) compared with others with positive patch test reactions. The most common relevant North American Contact Dermatitis Group screening allergens were potassium dichromate (29.8%), p-tert-butylphenol formaldehyde resin (20.1%), thiuram mix (13.3%), mixed dialkyl thioureas (12.6%), and carba mix (12%). A total of 29.8% (105/352) had positive patch test reactions to supplemental allergens, and 12.2% (43/352) only had reactions to supplemental allergens. CONCLUSIONS: Shoe contact allergy was more common in younger and male patients. Potassium dichromate and p-tert-butylphenol formaldehyde resin were the top shoe allergens. Testing supplemental allergens, personal care products, and shoe components should be part of a comprehensive evaluation of suspected shoe contact allergy.
Assuntos
Alérgenos/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Dermatoses do Pé/diagnóstico , Sapatos/efeitos adversos , Adulto , Corantes/efeitos adversos , Estudos Transversais , Dermatite Alérgica de Contato/etiologia , Feminino , Dermatoses do Pé/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , América do Norte , Testes do Emplastro/métodos , Resinas Sintéticas/efeitos adversos , Estudos Retrospectivos , Borracha/efeitos adversos , Adulto JovemRESUMO
BACKGROUND: Dermatological services in Laos, South East Asia are limited to the capital and patch testing is currently not available, so no data exists regarding the common cutaneous allergens in this population. OBJECTIVES: The aim of this study was to document positive patch tests in medical students without evidence of contact dermatitis in Laos. PATIENTS/MATERIALS/METHODS: One hundred and fifty medical students were patch tested using TRUE Test® panels 1 to 3 (35 allergens). Readings were taken at Days 2 and 4. RESULTS: Thirty-eight students (25.3%) had a positive reaction to at least one allergen, accounting for 52 reactions in total. The proportion of the students with positive patch test reading was significantly higher in the female [33/96 (34%)] than in the male [5/54 (9%)], p<0.001. The most common allergens were: nickel (10%), gold (6.6%), thiomersal (6.6%), cobalt dichloride (2%) and p-tert-Butylphenol formaldehyde resin (2%). Balsam of Peru (0.66%), black rubber mix (0.66%), Cl+Me-Isothiazolinone (0.66%), fragrance mix 1 (0.66%), quinolone mix (0.66%), methyldibromo glutaronitrile (0.66%), mercapto mix (0.66%), epoxy resin (0.66%), paraben mix (0.66%), thiuram (0.66%) and wool alcohols (0.66%) accounted for all of the other positive reactions. CONCLUSION: This study represents the first documented patch test results in Lao medical students and in the adult Lao population. The results of this study will inform any future research into contact allergy in Laos and give an insight into the background level of contact sensitivity in this population.
Assuntos
Alérgenos/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Testes do Emplastro , 2-Naftilamina/efeitos adversos , 2-Naftilamina/análogos & derivados , Adolescente , Adulto , Alérgenos/imunologia , Bálsamos/efeitos adversos , Cobalto/efeitos adversos , Dermatite Alérgica de Contato/imunologia , Dermatite Alérgica de Contato/patologia , Resinas Epóxi/efeitos adversos , Feminino , Ouro/efeitos adversos , Humanos , Laos , Masculino , Pessoa de Meia-Idade , Níquel/efeitos adversos , Fenilenodiaminas/efeitos adversos , Resinas Sintéticas/efeitos adversos , Estudantes de Medicina , Timerosal/efeitos adversosRESUMO
INTRODUCTION: Allergic contact dermatitis (ACD) of the feet accounts for approximately 10% of all patch tested patients. OBJECTIVE: To study the clinical profile of patients with feet dermatitis and relevant contact allergens in Spain over a 10-year period. METHODS: Retrospective observational study of patients with suspected ACD from the GEIDAC (Spanish Research Group on Contact Dermatitis and Cutaneous Allergy) baseline series from eight hospitals in Spain between 2004 and 2014. The clinical data collected from each patient were age, sex, occupation, history of atopic dermatitis, and eczema location. RESULTS: A total of 450 cases clinically presented dermatitis affecting the feet; of these, 41% of were males and 5.6% were suspected to be of occupational origin. As much as 47% were diagnosed with ACD, 20% with atopic dermatitis/dyshidrotic eczema, and 5% with psoriasis. The "feet group" included statistically significantly more females in the age range of 21 to 60 years. The most frequent relevant contact allergens were potassium dichromate, cobalt(II) chloride, p-tert-butylphenol formaldehyde resin, mercapto mix, and mercaptobenzothiazole. CONCLUSIONS: ACD is the most frequent clinical diagnosis of feet dermatitis in our series. The most frequent allergens are similar to those published in other series of foot ACD in Europe and the trend has not changed in the studied decade.
Assuntos
Dermatite Alérgica de Contato/epidemiologia , Dermatoses do Pé/epidemiologia , Adulto , Cobalto/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Dermatite Atópica/epidemiologia , Dermatite Atópica/etiologia , Dermatite Irritante/epidemiologia , Dermatite Irritante/etiologia , Dermatite Ocupacional/epidemiologia , Dermatite Ocupacional/etiologia , Eczema Disidrótico/epidemiologia , Feminino , Dermatoses do Pé/induzido quimicamente , Humanos , Masculino , Dicromato de Potássio/efeitos adversos , Psoríase/induzido quimicamente , Psoríase/epidemiologia , Resinas Sintéticas/efeitos adversos , Estudos Retrospectivos , Espanha/epidemiologia , Compostos de Sulfidrila/efeitos adversosAssuntos
Corantes/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Resinas Sintéticas/efeitos adversos , Têxteis , Triazinas/efeitos adversos , Doenças da Vulva/etiologia , Adulto , Canal Anal , Compostos Azo/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Feminino , Humanos , Testes do Emplastro , Períneo , Prurido/etiologia , Doenças da Vulva/diagnósticoRESUMO
BACKGROUND: Lumbar intervertebral disc herniation is a common cause of lower back and leg pain, with surgical intervention (e.g. discectomy to remove the herniated disc) recommended after an appropriate period of conservative management, however the existing or increased breach of the annulus fibrosus persists with the potential of reherniation. Several prosthesis and techniques to reduce re-herniation have been proposed including implantation of an annular closure device (ACD) - Barricaid™ and an annular tissue repair system (AR) - Anulex-Xclose™. The aim of this meta-analysis is to assist surgeons determine a potential approach to reduce incidences of recurrent lumbar disc herniation and assess the current devices regarding their outcomes and complications. METHODS: Four electronic full-text databases were systematically searched through September 2017. Data including outcomes of annular closure device/annular repair were extracted. All results were pooled utilising meta-analysis with weighted mean difference and odds ratio as summary statistics. RESULTS: Four studies met inclusion criteria. Three studies reported the use of Barricaid (ACD) while one study reported the use of Anulex (AR). A total of 24 symptomatic reherniation were reported among 811 discectomies with ACD/AR as compared to 51 out of 645 in the control group (OR: 0.34; 95% CI: 0.20,0.56; I2 = 0%; P < 0.0001). Durotomies were lower among the ACD/AR patients with only 3 reported cases compared to 7 in the control group (OR: 0.54; 95% CI: 0.13, 2.23; I2 = 11%; P = 0.39). Similar outcomes for post-operative Oswestry Disability Index and visual analogue scale were obtained when both groups were compared. CONCLUSION: Early results showed the use of Barricaid and Anulex devices are beneficial for short term outcomes demonstrating reduction in symptomatic disc reherniation with low post-operative complication rates. Long-term studies are required to further investigate the efficacy of such devices.
Assuntos
Discotomia , Deslocamento do Disco Intervertebral/cirurgia , Disco Intervertebral/cirurgia , Vértebras Lombares/cirurgia , Resinas Sintéticas/uso terapêutico , Substituição Total de Disco/instrumentação , Adolescente , Adulto , Idoso , Fenômenos Biomecânicos , Discotomia/efeitos adversos , Feminino , Humanos , Disco Intervertebral/diagnóstico por imagem , Disco Intervertebral/fisiopatologia , Deslocamento do Disco Intervertebral/diagnóstico por imagem , Deslocamento do Disco Intervertebral/fisiopatologia , Vértebras Lombares/diagnóstico por imagem , Vértebras Lombares/fisiopatologia , Masculino , Pessoa de Meia-Idade , Curativos Periodontais/efeitos adversos , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Desenho de Prótese , Recuperação de Função Fisiológica , Recidiva , Resinas Sintéticas/efeitos adversos , Fatores de Risco , Fatores de Tempo , Substituição Total de Disco/efeitos adversos , Resultado do Tratamento , Adulto JovemRESUMO
BACKGROUND: Aircraft building exposes workers to irritant and sensitizing products. OBJECTIVE: The aim of this article was to study occupational dermatoses among aircraft workers over 25 years. METHODS: The files of aerospace workers referred between 1990 and 2015 were extracted from the database of the McGill University Health Centre contact dermatitis clinic. These were subdivided according to demographics, type of work, patch testing results, and final diagnosis. RESULTS: Of 305 workers, 58% were 40 years or younger; one third were women. Onset of dermatitis varied from 2 months to 25 years, but 120 cases (39%) occurred during the first 3 years. Fifty-one percent of the cases involved assemblers, and 27% were composite material technicians, which were overrepresented as they constitute 10% of the workforce. Of the 305 workers, 152 suffered from allergic contact dermatitis, and 96 had irritant contact dermatitis. Of those with allergic contact dermatitis, 124 reacted to epoxy-based workplace products, but only 48 had positive patch tests to commercially available epoxy allergens. CONCLUSION: More than 60% of the cases of epoxy allergy would have been missed without testing with workplace products.
Assuntos
Aeronaves , Alérgenos/efeitos adversos , Dermatite de Contato/diagnóstico , Dermatite Ocupacional/diagnóstico , Compostos de Epóxi/efeitos adversos , Indústrias , Adulto , Aeronaves/estatística & dados numéricos , Alérgenos/imunologia , Canadá/epidemiologia , Dermatite Alérgica de Contato/diagnóstico , Dermatite Alérgica de Contato/epidemiologia , Dermatite Alérgica de Contato/etiologia , Dermatite de Contato/epidemiologia , Dermatite de Contato/etiologia , Dermatite Irritante/diagnóstico , Dermatite Irritante/epidemiologia , Dermatite Irritante/etiologia , Dermatite Ocupacional/epidemiologia , Dermatite Ocupacional/etiologia , Feminino , Humanos , Indústrias/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Testes do Emplastro , Resinas Sintéticas/efeitos adversos , Adulto JovemRESUMO
We report the unusual case of a young patient with reoperation after annuloplasty using the Barricaid® (Intrinsic Therapeutics, Woburn, MA, USA) closure device. Our patient, a 32-year-old man underwent lumbar discectomy and annuloplasty of the level L5-S1. Five years later, the patient presented with a new onset of low-back pain radiating into the right leg. Imaging revealed loosening of the annulus repair device. The device was removed surgically and the patient was pain free thereafter. Annular closure devices such as the Barricaid system aim to improve outcome after lumbar discectomy by reducing the risk of recurrent disc herniation of the same level. Data on long-term follow-up are missing. Here we present, to our knowledge, the first case of symptomatic device loosening.
Assuntos
Discotomia/efeitos adversos , Deslocamento do Disco Intervertebral/cirurgia , Curativos Periodontais/efeitos adversos , Falha de Prótese/etiologia , Infecções Relacionadas à Prótese/diagnóstico , Resinas Sintéticas/efeitos adversos , Infecção dos Ferimentos/diagnóstico , Adulto , Discotomia/métodos , Humanos , Vértebras Lombares/cirurgia , Masculino , Infecções Relacionadas à Prótese/etiologiaRESUMO
PURPOSE: The aim of this systematic review was to investigate the survival and complication rates of all-ceramic resin-bonded fixed dental prostheses (RBFDPs). MATERIALS AND METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were applied. A systematic search was conducted by an electronic search in PubMed, EMBASE, Cochrane Library, and CNKI databases complemented by a manual search. Only clinical studies on all-ceramic RBFDPs with a mean follow-up period of at least 3 years qualified for data analyses. RESULTS: Among 1503 screened articles, one randomized controlled trial (RCT) and seven prospective or retrospective cohort studies were included in this study. The estimated 5-year survival rate of all-ceramic RBFDPs was 91.2%. Debonding and framework fracture were the two most frequent technical complications, and the estimated 5-year debonding rate and fracture rate were 12.2% and 4.8%, respectively. Additionally, cantilevered all-ceramic RBFDPs had a higher survival rate (p < 0.01), lower debonding rate, (p < 0.05), and fracture rate (p < 0.01) compared with two-retainer all-ceramic RBFDPs. Zirconia ceramic RBFDPs had a lower incidence of failure but a higher debonding rate compared with glass-ceramic RBFDPs (p < 0.01). CONCLUSION: Within the limitations of this systematic review, although all-ceramic RBFDPs have a favorable 5-year survival rate, this rate cannot represent the complete success of the treatment, since it may include typical complications such as debonding and fractures. There is an urgent need for long-term clinical studies, especially for well-designed RCTs on all-ceramic RBFDPs.
Assuntos
Cerâmica/uso terapêutico , Colagem Dentária , Retenção de Dentadura , Dentaduras , Resinas Sintéticas/uso terapêutico , Colagem Dentária/efeitos adversos , Colagem Dentária/métodos , Falha de Restauração Dentária , Retenção de Dentadura/efeitos adversos , Retenção de Dentadura/métodos , Dentaduras/efeitos adversos , Humanos , Resinas Sintéticas/efeitos adversosRESUMO
Irrespective of the new generation of dental materials, acrylates still have a wide indication field. Although they are classified as biomaterials, acrylates can have both local and systemic side effects. The individual components of the acrylic materials may leave the dental restorations and diffuse into saliva. The aim of this study was to point out the potentially toxic components of acrylic dental materials, as well as their possible adverse effects on oral tissues and the organism in general. The paper was based on the assumption that the appropriate selection of the type of acrylic material and the proper method of their preparation reduce their adverse effects to a minimum, which was proven using literature data.
Assuntos
Resinas Acrílicas/efeitos adversos , Dentaduras/efeitos adversos , Resinas Sintéticas/efeitos adversos , HumanosAssuntos
Dermatite Alérgica de Contato/diagnóstico , Metilmetacrilato/efeitos adversos , Resinas Sintéticas/efeitos adversos , Estomatite/diagnóstico , Úlcera/diagnóstico , Dermatite Alérgica de Contato/etiologia , Feminino , Humanos , Pessoa de Meia-Idade , Estomatite/induzido quimicamente , Úlcera/induzido quimicamenteAssuntos
Cânfora/análogos & derivados , Dermatite Alérgica de Contato/diagnóstico , Curativos Periodontais/efeitos adversos , Resinas Sintéticas/efeitos adversos , Estomatite/diagnóstico , Adulto , Cânfora/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Humanos , Masculino , Testes do Emplastro , Estomatite/etiologiaRESUMO
CONTEXT: Endodontic materials have been assessed with regards to their potential for dental staining. AIMS: To evaluate the coronal discoloration effect of Apexit Plus and Resino Seal in mandibular premolars using spectrophotometer. SETTINGS AND DESIGN: The study design was original research. MATERIALS AND METHODS: Forty human single-rooted mandibular first premolar teeth were selected for the study. They were divided into four groups of ten specimens each. Group 1 - Apexit Plus sealer, Group 2 - Resino Seal sealer, Group 3 - positive control (Blood), and Group 4 - negative control (distilled water). Teeth were resected 3 mm below at cementoenamel junction. In all samples, access cavities were prepared, instrumented, and irrigated. Sealers were mixed and placed into the pulp chamber through cervical access and control groups were filled with blood and distilled water. Coronal orifices were sealed using self-cure glass ionomer cement. Samples were analyzed using spectrophotometer to determine the discoloration in each group at 10, 17, and 24 days interval. STATISTICAL ANALYSIS USED: Statistical analysis used Wilcoxon signed-rank test. RESULTS: All sealers used in the present study caused a progressive coronal discoloration over a time period of 17-24 days. There was statistically significant difference between resino seal sealer and apexit plus sealer , with resino seal showing greater coronal discoloration. CONCLUSION: Resino seal sealer has greater potential to cause discoloration of crown as compared to apexit plus sealer over a period of time.
Assuntos
Hidróxido de Cálcio/efeitos adversos , Selantes de Fossas e Fissuras/efeitos adversos , Resinas Sintéticas/efeitos adversos , Espectrofotometria , Coroa do Dente/efeitos dos fármacos , Descoloração de Dente/induzido quimicamente , Descoloração de Dente/diagnóstico , Dente Pré-Molar/efeitos dos fármacos , HumanosRESUMO
OBJECTIVE: Eluted dental resin co-monomers can be metabolized to intermediate methacrylic acid (MA) and, further, to epoxy metabolites. Antioxidants have been studied previously, with the intention of decreasing the DNA double-strand breaks (DNA-DSBs) in human gingival fibroblasts (HGFs). In this study, the effects of the antioxidants, ascorbic acid (Asc) and N-acetylcysteine (NAC), were investigated on co-monomer metabolite-induced DNA-DSBs. METHODS: HGFs were incubated with MA, 2,3-epoxy-2-methyl-propionicacid-methylester (EMPME) and 2,3-epoxy-2-methylpropionic acid (EMPA), respectively, in the presence or absence of antioxidants (Asc or NAC). EC50 Values were obtained from an XTT-based viability assay. DNA-DSBs were determined using a γ-H2AX assay. RESULTS: The cytotoxicity of the compounds could be ranked in the following order (mean±SEM; n=4): EMPA>EMPME>MA. The average number of DSBs-foci/cell induced by each substance at EC50-concentration could be ranked in the following order (mean±SD; n=4): EMPA>EMPME>MA. EMPA (1.72mM) and EMPME (2.58mM) induced the highest number of DSBs-foci, that is 21-fold and 13-fold, respectively, compared to control (0.48±0.08 foci/cell). The addition of Asc (50; 100; 200µM) or NAC (50; 100; 200; 500µM) to MA (15.64; 5.21mM), EMPME (2.58mM), and EMPA (1.72; 0.57mM) significantly reduced the number of foci/cell in HGFs. The highest reduction could be found in HGFs with 1.72mM EMPA, the addition of NAC (50; 100; 200; 500µM) induced a 15-fold, 17-fold, 14-fold and 14-fold lower number of DSBs-foci/cell, respectively. SIGNIFICANCE: Dental co-monomer epoxy metabolites, EMPME and EMPA, can induce DNA-DSBs. The addition of antioxidants (Asc or NAC) leads to reduction of DNA-DSBs, and NAC leads to more prominent reduction of DNA-DSBs compared to Asc.