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1.
J Neurophysiol ; 125(1): 223-231, 2021 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-33326336

RESUMO

This study explores the effects of oxytocin receptor (OXTR) in the trigeminal ganglion (TG) on orofacial neuropathic pain. We demonstrate that OXTR activation in the TG relieves the orofacial ectopic pain as well as inhibits the upregulated expression of calcitonin gene-related peptide (CGRP), IL-1ß, and TNFα in the TG and spinal trigeminal nucleus caudalis (SpVc) of rats with inferior alveolar nerve transection. OXTR, a G protein-coupled receptor, has been demonstrated to play a significant role in analgesia after activation by its canonical agonist oxytocin (OXT) in the dorsal root ganglion. However, the role of OXTR in the trigeminal nervous system on the orofacial neuropathic pain is still little known. In the present study, we aimed to investigate the regulation effect and mechanism of OXTR in the TG) and SpVc) on orofacial ectopic pain induced by trigeminal nerve injury. The inferior alveolar nerve (IAN) was transected to establish a ectopic pain model. A behavioral test with electronic von Frey filament demonstrated IAN transection (IANX) evoked mechanical hypersensitivity in the whisker pad from day 1 to at least day 14 after surgery. In addition, administration of OXT (50 and 100 µM) into the TG attenuated the mechanical hypersensitivity induced by IANX, which was reversed by pretreatment with L-368,899 (a selective antagonist of OXTR) into the TG. In addition, immunofluorescence showed the expression of OXTR in neurons in the TG and SpVc. Furthermore, Western blot analysis indicated that the upregulated expression of OXTR, CGRP, IL-1ß, and TNFα in the TG and SpVc after IANX was inhibited by the administration of OXT into the TG. And the inhibition effect of OXT on the expression of CGRP, IL-1ß, and TNFα was abolished by preapplication of OXTR antagonist L-368,899 into the TG.NEW & NOTEWORTHY This study explores the effects of oxytocin receptor (OXTR) in the trigeminal ganglion (TG) on orofacial neuropathic pain. We demonstrate that OXTR activation in the TG relieves the orofacial ectopic pain as well as inhibits the upregulated expression of calcitonin gene-related peptide, IL-1ß, and TNF-α in the TG and spinal trigeminal nucleus caudalis of rats with inferior alveolar nerve transection.


Assuntos
Traumatismos do Nervo Mandibular/metabolismo , Dor/tratamento farmacológico , Receptores de Ocitocina/metabolismo , Gânglio Trigeminal/metabolismo , Animais , Peptídeo Relacionado com Gene de Calcitonina/metabolismo , Canfanos/farmacologia , Interleucina-1beta/metabolismo , Masculino , Traumatismos do Nervo Mandibular/fisiopatologia , Ocitocina/metabolismo , Ocitocina/uso terapêutico , Dor/etiologia , Piperazinas/farmacologia , Ratos , Ratos Sprague-Dawley , Receptores de Ocitocina/agonistas , Receptores de Ocitocina/antagonistas & inibidores , Fator de Necrose Tumoral alfa/metabolismo
2.
Rev Esp Anestesiol Reanim (Engl Ed) ; 66(8): 447-450, 2019 Oct.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-31395405

RESUMO

Trigeminal neuralgia (TN) is a severe and often underestimated facial pain that affects quality of life. Pharmacological treatment is insufficient for pain control in 30% of cases and, although intervention techniques may be effective, there is a possibility of relapse and associated complications. The second division of the trigeminal nerve (V2) runs through the sphenopalatine ganglion (SPG), which is anatomically accessible to blocking due to its superficial location in the nasal cavity. We report a clinical case of a patient with uncontrolled V2 TN that was put on ambulatory self-administered SPG block with nasal swabs soaked in 0.75% ropivacaine. In the follow-up visits, we confirmed that this adjuvant treatment provided a significant pain relief over 24hours with a decrease in the number of exacerbations.


Assuntos
Anestésicos Locais/administração & dosagem , Curetagem/efeitos adversos , Dor Facial/terapia , Complicações Intraoperatórias/terapia , Traumatismos do Nervo Mandibular/terapia , Seio Maxilar/cirurgia , Dor Pós-Operatória/terapia , Ropivacaina/administração & dosagem , Bloqueio do Gânglio Esfenopalatino/métodos , Neuralgia do Trigêmeo/terapia , Administração Intranasal , Idoso , Analgésicos/uso terapêutico , Antidepressivos/uso terapêutico , Terapia Combinada , Dor Facial/tratamento farmacológico , Dor Facial/etiologia , Humanos , Instilação de Medicamentos , Complicações Intraoperatórias/tratamento farmacológico , Complicações Intraoperatórias/etiologia , Complicações Intraoperatórias/fisiopatologia , Masculino , Traumatismos do Nervo Mandibular/tratamento farmacológico , Traumatismos do Nervo Mandibular/etiologia , Traumatismos do Nervo Mandibular/fisiopatologia , Dor Pós-Operatória/tratamento farmacológico , Dor Pós-Operatória/etiologia , Autoadministração , Neuralgia do Trigêmeo/tratamento farmacológico , Neuralgia do Trigêmeo/etiologia
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