RESUMO
PURPOSE: To evaluate the corkscrew collaterals in Buerger's disease by superb microvascular imaging (SMI) and power Doppler ultrasonography (PDU). METHODS: We evaluated with SMI and PDU 14 patients with Buerger's disease in whom corkscrew collaterals had been identified on digital subtraction angiography (DSA). Corkscrew collaterals were classified on DSA and PDU based on their size and morphology. RESULTS: A total of 17 vascular regions of collateral vessel formation were assessed. Based on DSA classification, there were three cases of type I collaterals (arterial diameter of >2 mm with large helical pattern), seven cases of type III collaterals (arterial diameter of 1-1.5 mm with small helical pattern), and seven cases of type IV collaterals (arterial diameter of <1 mm with tiny helical pattern). On PDU, all type I collaterals on DSA appeared as "large snake" images, all type III collaterals on DSA appeared as "small snake" images, and all type IV collaterals on DSA appeared as dots. SMI imaging, both in color and monochrome mode, provided superior demonstration of the continuity of the vessel of large or small "snake" images. In cases appearing as dot pattern on PDU, color SMI was able to show continuity of the flow signal as a helical pattern. DISCUSSION: SMI is a promising new Doppler imaging technique that is superior to conventional power Doppler imaging in depiction and identification of corkscrew collaterals in Buerger's disease.
Assuntos
Angiografia Digital , Microvasos/diagnóstico por imagem , Tromboangiite Obliterante/diagnóstico por imagem , Tromboangiite Obliterante/fisiopatologia , Ultrassonografia Doppler , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
BACKGROUND: Patients with severe Buerger disease, also known as thromboangiitis obliterans (TAO), are at risk of major limb amputation. It has been shown that autologous bone marrow mononuclear cell (BM-MNC) implantation improves the condition of critical limb ischemia in TAO patients. This study was conducted to further clarify the long-term (>10 years) results of autologous BM-MNC implantation in patients with TAO.MethodsâandâResults:An observational study was conducted of the long-term results of BM-MNC implantation in 47 lower limbs of 27 patients with TAO. The mean (±SD) follow-up period was 12.0±8.6 years. There was no major amputation event up to 10 years of follow-up in patients treated with BM-MNC implantation. The overall amputation-free survival rates were significantly higher in patients who underwent BM-MNC implantation than in internal controls and historical controls. There was no significant difference in amputation-free survival rates between the historical and internal controls. There was also no significant difference in overall survival between patients who underwent BM-MNC implantation and the historical controls. CONCLUSIONS: BM-MNC transplantation successfully prevented major limb amputation over a period of >10 years in patients with severe TAO who had no other therapeutic options.
Assuntos
Transplante de Medula Óssea , Isquemia/cirurgia , Tromboangiite Obliterante/cirurgia , Adulto , Amputação Cirúrgica , Transplante de Medula Óssea/efeitos adversos , Transplante de Medula Óssea/mortalidade , Estado Terminal , Feminino , Humanos , Isquemia/diagnóstico , Isquemia/mortalidade , Isquemia/fisiopatologia , Salvamento de Membro , Masculino , Pessoa de Meia-Idade , Intervalo Livre de Progressão , Recuperação de Função Fisiológica , Estudos Retrospectivos , Fatores de Risco , Índice de Gravidade de Doença , Tromboangiite Obliterante/diagnóstico , Tromboangiite Obliterante/mortalidade , Tromboangiite Obliterante/fisiopatologia , Fatores de Tempo , Transplante AutólogoRESUMO
OBJECTIVE: Thromboangiitis obliterans is a nonatherosclerotic occlusive disease, affecting small to moderate sized arteries of the upper and lower extremities, leading to progressive inflammation and clot formation. However, the role of humoral and cell-mediated immunity in the development of this disease has not been clearly identified. The present study was intended to investigate the humoral and cellular immune response in patients with Buerger's disease with different disease severity. METHODS: In an observational study, 80 male patients with Buerger's disease were included and categorized into three groups (mild, moderate, and severe) based on clinical manifestations. After blood sampling, cellular phenotypes were determined, and erythrocyte sedimentation rate, immunoglobulins (Ig) A, M, G, and E, as well as C3 and C4 components of the complement system and complement hemolytic activity (CH50) were measured. RESULTS: The mean age of the patient was 42.85 ± 8.39 years. Pulse abnormality, cold intolerance, and claudication were the most common symptoms. Eleven (13.75%), 46 (57.50%), and 23 (28.75%) patients had mild, moderate, and severe symptoms. Regression analyses showed that the presence of severe symptoms was significantly associated with elevated erythrocyte sedimentation rate and C4 levels (p < 0.05). CONCLUSION: Buerger's disease in severe cases was associated with increased erythrocyte sedimentation rate and abnormal C4 levels. The alterations in these inflammatory biomarkers might be due to a secondary inflammatory response to the presence of ulcer or gangrene and the inflammatory process in patients with severe symptoms.
Assuntos
Complemento C4/análise , Eritrócitos/imunologia , Imunidade Celular , Imunidade Humoral , Tromboangiite Obliterante/imunologia , Adulto , Biomarcadores/sangue , Sedimentação Sanguínea , Humanos , Masculino , Pessoa de Meia-Idade , Nefelometria e Turbidimetria , Valor Preditivo dos Testes , Sistema de Registros , Índice de Gravidade de Doença , Tromboangiite Obliterante/sangue , Tromboangiite Obliterante/fisiopatologia , Regulação para CimaRESUMO
A 48-year-old woman with severe pain and numbness of her right leg and foot was admitted to our hospital. She had never smoked and had little exposure to passive smoking. Initially, polyarteritis nodosa with anti-phospholipid antibodies was considered. Combination therapy with methylprednisolone pulse therapy, intravenous cyclophosphamide pulse therapy, vasodilators, antiplatelet agents, and anticoagulants was not effective. Vasculopathy was progressive, and she presented with gangrene of the toes. She required amputation of her right leg. The pathological findings of the amputated leg revealed thromboangiitis obliterans (TAO). TAO should be considered even in non-smoking women. Non-response to immunosuppressant and anticoagulant therapies may be a clue to the diagnosis of TAO.
Assuntos
Amputação Cirúrgica , Anticorpos Antifosfolipídeos/sangue , Pé/cirurgia , Tromboangiite Obliterante/tratamento farmacológico , Tromboangiite Obliterante/cirurgia , Dedos do Pé/cirurgia , Vasodilatadores/uso terapêutico , Feminino , Humanos , Pessoa de Meia-Idade , Tromboangiite Obliterante/diagnóstico , Tromboangiite Obliterante/fisiopatologia , Resultado do TratamentoAssuntos
Angiografia Digital/métodos , Circulação Colateral/fisiologia , Microvasos/diagnóstico por imagem , Tromboangiite Obliterante/diagnóstico , Artérias da Tíbia/diagnóstico por imagem , Ultrassonografia Doppler em Cores/métodos , Idoso , Diagnóstico Diferencial , Humanos , Masculino , Tromboangiite Obliterante/fisiopatologiaRESUMO
Due to unknown aetiology of Thromboangiitis obliterans (TAO), its effectively treating is challenging. However, angiogenesis induction is one of the acceptable treatments for TAO patients. Recently, we have noticed that TAO patients who were under long-term treatment with angiogenesis-inducing medication showed considerable improvement in terms of healing chronic ulcers over the course of one to 2 years of treatment. However, some of them developed dermal gangrene despite the warming of their feet, with or without palpable pulses in the extremities, and with hair growth on the affected skin. Unfortunately, following the progression of dermal gangrene, some of these patients had to undergo amputation and limb loss.During histopathological evaluation, we detected some changes in the amputee TAO patients under long-term angiogenic medical treatment that were not present in amputee TAO patients who had not received any treatment for many years. The greatest pathological changes were observed in the microvascular of the skin, appearing as a proliferation of endothelial cells, NETosis and thrombus formation inside the vessels with proliferation of endothelial cells. The immunohistochemistry for CD31 and Ki67 as markers of vascular endothelium differentiation and cell mitosis confirmed the proliferation of endothelial cells. However, in the patients who had not received any treatment for years the typical pathology view of BD, including preserved vascular architecture with infiltration of inflammatory cells and inflammatory cells inside the thrombus, organised thrombus with recanalisation and intimal thickening was observed. Further longitudinal cohort studies regarding long-term treatment with angiogenic medications for TAO in different geographic areas are highly recommended.
Assuntos
Neovascularização Patológica/fisiopatologia , Tromboangiite Obliterante/patologia , Tromboangiite Obliterante/fisiopatologia , Adulto , Humanos , Imuno-Histoquímica , Antígeno Ki-67/metabolismo , Masculino , Molécula-1 de Adesão Celular Endotelial a Plaquetas/metabolismoRESUMO
A case of Buerger's disease is presented where percutaneous endovascular treatment of a concomitant focal stenosis in the superficial femoral artery led to immediate remission of symptoms and aided wound healing. The existence of such lesions should never be underestimated.
Assuntos
Angioplastia/métodos , Artéria Femoral , Úlcera da Perna , Salvamento de Membro/métodos , Angiografia por Ressonância Magnética/métodos , Tromboangiite Obliterante , Constrição Patológica , Artéria Femoral/diagnóstico por imagem , Artéria Femoral/patologia , Artéria Femoral/cirurgia , Humanos , Úlcera da Perna/etiologia , Úlcera da Perna/fisiopatologia , Úlcera da Perna/cirurgia , Masculino , Pessoa de Meia-Idade , Planejamento de Assistência ao Paciente/normas , Tromboangiite Obliterante/complicações , Tromboangiite Obliterante/diagnóstico , Tromboangiite Obliterante/fisiopatologia , Tromboangiite Obliterante/terapia , Resultado do TratamentoRESUMO
OBJECTIVE: Buerger's disease is one of the worst diseases causing peripheral artery occlusions (especially lower extremity) with increased morbidity and mortality. Endovascular treatment of the diseased arteries gains preference over bypass surgery nowadays. Here, we aimed to present the clinical outcomes of 16 consecutive Buerger's disease patients underwent extended endovascular recanalization which is a new technique to restore direct blood flow to at least one foot artery, with the performance of angioplasty for each tibial and foot artery obstructions. METHODS: A total of 16 consecutive patients with confirmed diagnosis of Buerger's disease that percutaneously treated in our center between February 2014 and March 2018 were included in the study. The mean age of the patients was 44.25 ± 4.28 ranging from 36 to 50 years. After physical examination and complementary diagnostic tests, performance of extended angioplasty for occluded arteries was intended to restore direct blood flow to at least one of the blow-the-knee arteries. RESULTS: A successful extended endovascular treatment was performed in 20 of 22 limbs, achieving a technical success of 91%. All patients were successfully discharged without any complication. Mean follow-up duration was 21.43 ± 7.08 months. Reintervention was performed in one patient and minor amputation was needed in one of the failed limbs. Limb salvage rate was 100%. A significant difference was observed based on Rutherford classification, ankle brachial index, direct blood flow to foot, presence of ulcer and rest pain when compared before and after the intervention. CONCLUSION: We showed successful extended endovascular recanalization of Buerger's disease patients with a high technical success rate and sustained clinical improvement. Extended endovascular recanalization could be a therapeutic option in Buerger's disease patients, since they are not good candidates for surgery.
Assuntos
Angioplastia , Pé/irrigação sanguínea , Tromboangiite Obliterante/terapia , Adulto , Angiografia , Angioplastia/efeitos adversos , Estudos de Viabilidade , Humanos , Masculino , Pessoa de Meia-Idade , Fluxo Sanguíneo Regional , Estudos Retrospectivos , Tromboangiite Obliterante/diagnóstico por imagem , Tromboangiite Obliterante/fisiopatologia , Fatores de Tempo , Resultado do Tratamento , Grau de Desobstrução VascularRESUMO
RATIONALE: Thromboangiitis obliterans (TAOs, or Buerger's disease) present as a non-atherosclerotic segmental occlusive vasculitis within medium- and small-sized blood vessels. TAO frequently occurs in young adults and is associated with cigarette smoking. At present, there are no accurately defined treatments for TAO. PATIENT CONCERNS: A 34-year-old Asian woman with a 20-year history of heavy cigarette smoking and recurrent, small, and self-limited lower limb ulcerations since adolescence, presented with persisting unhealed ulcerations on both ankles for 6 months. Her wound healing response was poor following the 2-month administration of colchicine, prednisolone, hydroxychloroquine, and mycophenolic acid. DIAGNOSIS: The patient was diagnosed with TAO with hyperimmunoglobulin E and refractory ulcerations on her ankles. INTERVENTIONS: The patient received monthly omalizumab (300âmg) and previous medications for 2 months and shifted to omalizumab and colchicine without mycophenolic acid and hydroxychloroquine because of onychomadesis, which was considered to be a possible adverse drug reaction. OUTCOMES: The wounds healed almost completely. The administration of omalizumab and colchicine will be continued until they the wounds are fully healed. LESSONS: Mycophenolic acid has a limited function in TAO treatment, especially in cases of refractory skin ulcerations. Omalizumab can be a valuable treatment option for patients with TAO and hyperimmunoglobulin E.
Assuntos
Colchicina/uso terapêutico , Fármacos Dermatológicos/uso terapêutico , Omalizumab/uso terapêutico , Úlcera Cutânea/tratamento farmacológico , Úlcera Cutânea/etiologia , Tromboangiite Obliterante/complicações , Adulto , Tornozelo , Feminino , Humanos , Imunoglobulina E/sangue , Imunoglobulina E/efeitos dos fármacos , Úlcera Cutânea/imunologia , Fumar/efeitos adversos , Tromboangiite Obliterante/imunologia , Tromboangiite Obliterante/fisiopatologia , CicatrizaçãoRESUMO
PURPOSE: When critical limb ischemia (CLI) occurs in patients with thromboangiitis obliterans (TAO) or Buerger's disease, smoking cessation alone may be insufficient to relieve rest pain and promote wound healing. Accordingly, adjunctive measures are warranted to restore adequate blood flow required for limb salvage. This study aimed to evaluate the feasibility and efficacy of percutaneous transluminal angioplasty (PTA) for the treatment of patients with TAO and CLI. In addition, a review of the literature on endovascular management of TAO is included. METHODS: Between April 2012 and June 2017, all patients with TAO and CLI who underwent PTA were studied retrospectively. Patient demographics, presentation, procedural details, and clinical response were recorded. Patients were monitored at 1 week, 1, 2, 3, and 6 months after revascularization and at least every 6 months thereafter. RESULTS: Thirteen patients with TAO and CLI, who presented with rest pain only (n = 1), ischemic ulcer (n = 4), or gangrene (n = 8) underwent endovascular interventions with primary and assisted primary technical success of 85% and 92%, respectively. A below-knee amputation was eventually done in the only patient with technical failure (limb salvage rate: 92%). Following the procedures, 11 patients had clinical response, one of whom also received intra-arterial vasodilator to achieve complete symptom relief. The other patient who failed PTA underwent a successful lumbar sympathectomy. In addition, all ulcers healed and eight minor amputations were performed due to already established gangrene. During follow-up (mean: 19.4 months), four patients needed reintervention. Patients who continued to smoke experienced more severe ischemia ( P = .017) and were more likely to require reintervention ( P = .009). CONCLUSION: Percutaneous transluminal angioplasty can be considered as a technically feasible and potentially effective treatment for patients with TAO and CLI, as well as a last resort for limb salvage when other options have failed. However, reintervention may be required, especially in patients who continue smoking.
Assuntos
Angioplastia com Balão , Tromboangiite Obliterante/terapia , Adulto , Amputação Cirúrgica , Angioplastia com Balão/efeitos adversos , Intervalo Livre de Doença , Estudos de Viabilidade , Feminino , Humanos , Salvamento de Membro , Masculino , Pessoa de Meia-Idade , Retratamento , Estudos Retrospectivos , Fatores de Risco , Fumar/efeitos adversos , Tromboangiite Obliterante/diagnóstico por imagem , Tromboangiite Obliterante/etiologia , Tromboangiite Obliterante/fisiopatologia , Fatores de Tempo , Resultado do Tratamento , CicatrizaçãoRESUMO
We evaluated the endothelial function of patients with Buerger disease using peripheral arterial tonometry test, and examined the factors that are significantly correlated with the endothelial dysfunction in these patients. We performed the peripheral arterial tonometry test in 22 patients with Buerger disease. We recorded the patients' characteristics, including ankle brachial pressure index and reactive hyperemia index, which reflect the endothelial dysfunction. We divided the patients with Buerger disease into the conservative treatment and lumbar sympathectomy group. While the reactive hyperemia index was not significantly different between these two groups, the ankle brachial pressure index was significantly different (1.12 versus 0.83, P=0.003). Furthermore, the reactive hyperemia index was significantly correlated with the ankle brachial pressure index value in the patients in the lumbar sympathectomy group (ρ=0.848, P=0.005). Given that patients with Buerger disease show impairment of the sympathetic nervous system, we should consider the after-effects of such an impaired system on the condition of these patients. The patients treated with lumbar sympathectomy might be more appropriate to evaluate their endothelial function by a peripheral arterial tonometry test.
Assuntos
Endotélio Vascular/fisiopatologia , Doença Arterial Periférica/fisiopatologia , Tromboangiite Obliterante/fisiopatologia , Índice Tornozelo-Braço , Endotélio Vascular/inervação , Feminino , Humanos , Hiperemia/fisiopatologia , Vértebras Lombares/inervação , Masculino , Manometria , Pessoa de Meia-Idade , Doença Arterial Periférica/diagnóstico , Doença Arterial Periférica/cirurgia , Valor Preditivo dos Testes , Estudos Retrospectivos , Simpatectomia , Sistema Nervoso Simpático/fisiopatologia , Sistema Nervoso Simpático/cirurgia , Tromboangiite Obliterante/diagnóstico , Tromboangiite Obliterante/cirurgia , Resultado do TratamentoAssuntos
Angioplastia com Balão , Artéria Radial/cirurgia , Tromboangiite Obliterante/cirurgia , Angiografia Digital , Circulação Colateral , Humanos , Masculino , Pessoa de Meia-Idade , Artéria Radial/diagnóstico por imagem , Artéria Radial/fisiopatologia , Fluxo Sanguíneo Regional , Tromboangiite Obliterante/diagnóstico por imagem , Tromboangiite Obliterante/fisiopatologia , Resultado do Tratamento , Vasodilatadores/uso terapêuticoRESUMO
PURPOSE: To investigate outcomes of contemporary endovascular therapy and intravascular ultrasound (IVUS) findings in thromboangiitis obliterans (TAO) patients. METHODS: Between April 2007 and January 2016, 20 patients (mean age 45±8 years; 16 men) underwent endovascular therapy for TAO-related lesions in 25 consecutive limbs. Subjects exhibited a broad array of clinical symptoms, including critical limb ischemia (n=15) and claudication (10) in the lower (n=20) and upper (n=5) limbs. RESULTS: Procedure success was achieved in 24 (96%) limbs (complete success in 16 and partial success in 8), all of which exhibited improvements of at least 1 grade of the Rutherford category. Kaplan-Meier analysis showed that reintervention-free rates were 81.9% (95% CI 0.586 to 0.928) at 6 months and 71.7% at 10 months (95% CI 0.473 to 0.862). IVUS was performed in 20 limbs and revealed unique findings, including the "bull's-eye" appearance, "lotus-root" appearance, and "bunch of grapes" appearance. During a mean follow-up of 26±19 months, the limb salvage rate was 100% with no deaths. CONCLUSION: Contemporary endovascular therapy might be able to serve as a potential option for TAO patients with lower and upper limb symptoms. Liberal application of IVUS could help us understand the pathology of TAO to support endovascular therapy for TAO.
Assuntos
Angioplastia com Balão , Claudicação Intermitente/terapia , Isquemia/terapia , Tromboangiite Obliterante/terapia , Ultrassonografia de Intervenção , Adulto , Amputação Cirúrgica , Angiografia , Angioplastia com Balão/efeitos adversos , Estado Terminal , Feminino , Humanos , Claudicação Intermitente/diagnóstico por imagem , Claudicação Intermitente/fisiopatologia , Isquemia/diagnóstico por imagem , Isquemia/fisiopatologia , Salvamento de Membro , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Intervalo Livre de Progressão , Estudos Retrospectivos , Fatores de Risco , Tromboangiite Obliterante/diagnóstico por imagem , Tromboangiite Obliterante/fisiopatologia , Fatores de TempoRESUMO
OBJECTIVE: This study sought to compare the outcomes of endovascular recanalization (ER) vs autogenous venous bypass (AVB) for tibioperoneal arterial occlusion in thromboangiitis obliterans patients with critical lower limb ischemia. METHODS: A total of 90 limbs in 75 patients, successfully treated with ER (ER group, 35 patients, 43 limbs) and AVB (AVB group, 40 patients, 47 limbs) for tibioperoneal arterial occlusions from January 2009 to December 2015 in a single institution, were retrospectively analyzed. The characteristics and outcomes were compared between the two groups. The primary outcome was the amputation-free survival rate during follow-up; the secondary outcomes were patency rates, immediate failure, periprocedural complications, and rates of reintervention. Univariate and multivariate analysis to identify potentially significant predictors of amputation-free survival and primary patency in the whole study group was performed. RESULTS: Not all patients in the ER group were bypass candidates because of unavailable runoff arteries or adequate conduit for bypass. Other baseline characteristics were similar between groups. Patients in the ER group had a much higher incidence of immediate failure (36.36% in femoropopliteal segment and 65.52% in tibioperoneal segment vs 14.89% in AVB bypass; P = .03 and < .001). Although patients in the ER group had a significantly higher rate of reintervention (62.79% vs 27.66%; P < .001) associated with a significantly lower primary patency rate (18.96% in femoropopliteal segment and 14.37% in tibioperoneal segment vs 60.41% in AVB bypass; P = .008 and < .001) and secondary patency rate (33.85% in femoropopliteal segment and 21.29% in tibioperoneal segment vs 68.78% in AVB bypass; P = .04 and .002) at 3 years, the amputation-free survival in the ER group and AVB group was similar at 1 year (92.9% vs 93.2%; P = .81) and 3 years (87.8% and 90.6%; P = .66). Univariate and multivariate analysis showed that the presence of gangrene was independently associated with major amputation (hazard ratio, 2.24; 95% confidence interval, 1.33-4.3; P = .02); however, the presence of active ulcer was the only risk factor for poorer primary patency during follow-up (hazard ratio, 1.86; 95% confidence interval, 0.55-5.6; P = .04). CONCLUSIONS: ER is a valid strategy for limb salvage in thromboangiitis obliterans patients who are unsuitable for bypass, contributing an acceptable amputation-free survival as high as with AVB, even though it is associated with lower patency rates and a higher rate of reintervention.
Assuntos
Angioplastia com Balão , Isquemia/terapia , Doença Arterial Periférica/terapia , Veia Safena/transplante , Tromboangiite Obliterante/terapia , Artérias da Tíbia/cirurgia , Extremidade Superior/irrigação sanguínea , Adulto , Idoso , Amputação Cirúrgica , Angiografia Digital , Angioplastia com Balão/efeitos adversos , Angioplastia com Balão/instrumentação , China , Estado Terminal , Intervalo Livre de Doença , Feminino , Humanos , Isquemia/diagnóstico por imagem , Isquemia/fisiopatologia , Estimativa de Kaplan-Meier , Salvamento de Membro , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Razão de Chances , Doença Arterial Periférica/diagnóstico por imagem , Doença Arterial Periférica/fisiopatologia , Sistema de Registros , Estudos Retrospectivos , Fatores de Risco , Stents , Tromboangiite Obliterante/diagnóstico por imagem , Tromboangiite Obliterante/fisiopatologia , Artérias da Tíbia/diagnóstico por imagem , Artérias da Tíbia/fisiopatologia , Fatores de Tempo , Resultado do Tratamento , Grau de Desobstrução VascularRESUMO
BACKGROUND: Surgical revascularization for chronic critical limb ischaemia in patients with thromboangiitis obliterans (TAO) still remains controversial. Generally, besides cessation of smoking, conservative treatment supported by intravenous administration of vasoactive agents is regarded as the treatment of choice, in combination with local wound therapy or minor amputation. PATIENTS AND METHODS: In four male patients (42-47 years) surgical revascularization was chosen as therapy for established gangrene or non-healing ulceration after unsuccessful conservative treatment and cessation of smoking. Angiography was able to identify a suitable distal arterial segment for the bypass which was revascularized by means of an autologous vein graft. Grafts were followed with repetitive duplex ultrasound. Revision of the bypass graft was initiated if indicated by pathological duplex findings. RESULTS: In all cases a bypass could be constructed with either the ipsilateral greater saphenous vein or arm veins. A distal origin configuration was possible in three cases with popliteo-pedal or cruro-pedal bypasses. In the fourth case the distal superficial femoral artery was used for inflow. Two early graft thromboses underwent successful revision. During follow-up, duplex ultrasound identified graft stenoses in three bypasses which were successfully treated with endovascular techniques. All grafts are patent with complete resolution of ischaemic symptoms after 46, 42, 32, and 29 months. The patients remained non-smokers and returned to a professional life. CONCLUSIONS: Surgical therapy with distal vein bypass for persistent ischaemic symptoms after definitive cessation of smoking seems feasible in selected cases with TAO and a suitable distal artery. Close follow-ups of the patients with duplex ultrasound are necessary to identify developing vein graft stenoses. Angioplasty seems to be an important part of the long-term therapeutic concept.
Assuntos
Braço/irrigação sanguínea , Veia Safena/transplante , Tromboangiite Obliterante/cirurgia , Enxerto Vascular/métodos , Adulto , Bases de Dados Factuais , Procedimentos Endovasculares , Oclusão de Enxerto Vascular/diagnóstico por imagem , Oclusão de Enxerto Vascular/etiologia , Oclusão de Enxerto Vascular/fisiopatologia , Oclusão de Enxerto Vascular/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Flebografia , Estudos Retrospectivos , Fatores de Risco , Fumar/efeitos adversos , Abandono do Hábito de Fumar , Prevenção do Hábito de Fumar , Tromboangiite Obliterante/diagnóstico por imagem , Tromboangiite Obliterante/etiologia , Tromboangiite Obliterante/fisiopatologia , Fatores de Tempo , Transplante Autólogo , Resultado do Tratamento , Ultrassonografia Doppler Dupla , Enxerto Vascular/efeitos adversos , Grau de Desobstrução Vascular , Trombose Venosa/diagnóstico por imagem , Trombose Venosa/etiologia , Trombose Venosa/fisiopatologia , Trombose Venosa/terapiaRESUMO
BACKGROUND: This study aimed to evaluate the efficacy of endovascular radiofrequency ablation (RFA) for the treatment of thromboangiitis obliterans (TAO). METHODS: Total 30 males (median age: 46.00 years, interquartile range: 42.00-51.25 years) with unilateral TAO in the lower extremity underwent RFA were retrospectively enrolled from January 2013 and October 2013. The pre-operative and post-operative digital subtraction angiographic (DSA) images were recorded. Pain scores preoperatively and postoperatively were assessed according to the World Health Organization Pain Guideline. The values of ankle brachial index (ABI) at pre-operation, post-operation, 2 weeks and 2 years after surgery were all recorded and analyzed. Additionally, a 2-year follow up was performed by a computed tomographic angiography (CTA) image. RESULTS: The DSA images indicated that occlusion of femoral artery was improved after surgery. Moreover, there was no recurrence of TAO at 2 years of follow-up based on the CTA images. The pain score (P < 0.001) was significantly deceased after surgery. The values of ABI at postoperation, 2 weeks after surgery, and 2 years after surgery were all significantly higher than the preoperative ABI (P < 0.001). Furthermore, the values of ABI at 2 weeks after surgery and 2 years after surgery were all significantly higher than the postoperative ABI (P < 0.001). CONCLUSIONS: These results supported the application of endovascular RFA for treating TAO.
Assuntos
Ablação por Cateter/métodos , Procedimentos Endovasculares/métodos , Artéria Femoral/cirurgia , Extremidade Inferior/irrigação sanguínea , Tromboangiite Obliterante/cirurgia , Adulto , Angiografia Digital , Índice Tornozelo-Braço , Ablação por Cateter/efeitos adversos , Angiografia por Tomografia Computadorizada , Procedimentos Endovasculares/efeitos adversos , Artéria Femoral/diagnóstico por imagem , Artéria Femoral/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Abandono do Hábito de Fumar , Tromboangiite Obliterante/diagnóstico , Tromboangiite Obliterante/fisiopatologia , Fatores de Tempo , Resultado do Tratamento , Grau de Desobstrução VascularRESUMO
Thromboangiitis obliterans (Buerger's disease) is systemic vasculitis with predominant development of thrombotic occlusions of small-to-medium diameter arteries of distal portions of both upper and lower limbs. A distinctive feature of Buerger's disease from other vasculitides is the involvement of the venous bed into the pathological process in the form of migrating thrombophlebitis. The disease is encountered more often in young adult males, predominantly tobacco smokers. The clinical pattern is presented by symptoms of increasing insufficiency of blood supply of tissues of extremities. The diagnosis is made by means of ruling out other vascular diseases (atherosclerosis, diabetes mellitus, systemic diseases of connective tissue, hypercoagulation conditions) based on clinical and laboratory findings, as well as modern methods of visualization, including multislice spiral computed tomographic angiography. Of special importance is a pathomorphological examination aimed at detecting the signs specific for Buerger's disease: arteries showing intimal hyperplasia (from stenosis to complete obliteration according to the capillary angiomatosis type, vascular "recalibration", obliteration of lumens by thrombi, lack of calcification of the tunica media; venous alterations are presented by panphlebitis with intimal hyperplasia, and occlusion with thrombi. Treatment is aimed at eliminating the aetiological stimulus (i. e, smoking), improving blood circulation by means of regular, dosed physical exercises, and administration of anti-ischaemic agents (analogues of prostaglandins, calcium channel antagonists, antiaggregants and anticoagulants). Failure of conservative treatment failed should be followed by making a decision to perform revascularization (endovascular interventions, bypass reconstructive operations, arterialization of the venous blood flow of the foot, resection of the posterior tibial veins, transplantation of the greater omentum onto the crus).
Assuntos
Vasos Sanguíneos/patologia , Conduta do Tratamento Medicamentoso , Tromboangiite Obliterante , Extremidades/fisiopatologia , Humanos , Seleção de Pacientes , Avaliação de Sintomas/métodos , Tromboangiite Obliterante/diagnóstico , Tromboangiite Obliterante/fisiopatologia , Tromboangiite Obliterante/terapia , Procedimentos Cirúrgicos Vasculares/métodosRESUMO
AIM: Both vascular function and structure are independent predictors of cardiovascular events. The purpose of this study was to evaluate vascular function and structure of a leg artery in patients with peripheral artery disease (PAD). METHODS: We measured flow-mediated vasodilatation (FMD) and nitroglycerine-induced vasodilation (NID) as indices of vascular function and intima-media thickness (IMT) as an index of vascular structure of the popliteal artery in 100 subjects, including 20 patients with Buerger disease and 30 patients with atherosclerotic PAD, 20 age- and sex-matched subjects without Buerger disease (control group) and 30 age- and sex-matched patients without atherosclerotic PAD (control group). RESULTS: IMT was significantly larger in the Buerger group than in the control group (Buerger, 0.63± 0.20 mm; control, 0.50±0.07 mm; P=0.01), whereas there were no significant differences in FMD and NID between the two groups. IMT was significantly larger in the atherosclerotic PAD group than in the control group (atherosclerotic PAD, 0.80±0.22 mm; control, 0.65±0.14 mm; Pï¼0.01), and FMD and NID were significantly smaller in the atherosclerotic PAD group than in the control group (FMD: atherosclerotic PAD, 3.9%±1.1%; control, 5.0%±1.8%; Pï¼0.01; and NID: atherosclerotic PAD, 6.1%±2.0%; control, 8.4%±2.1%; Pï¼0.01). CONCLUSION: These findings suggest that vascular function is preserved in patients with Buerger disease and that both vascular function and vascular structure are impaired in patients with atherosclerotic PAD.
Assuntos
Aterosclerose/fisiopatologia , Espessura Intima-Media Carotídea , Perna (Membro)/irrigação sanguínea , Doença Arterial Periférica/fisiopatologia , Tromboangiite Obliterante/fisiopatologia , Artérias da Tíbia/fisiologia , Adulto , Idoso , Velocidade do Fluxo Sanguíneo , Estudos de Casos e Controles , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Fluxo Sanguíneo RegionalRESUMO
PURPOSE: To investigate the origin of "corkscrew" collateral vessels around the occluded popliteal artery in patients with Buerger disease by Doppler ultrasound (US) and magnetic resonance (MR) imaging in tandem with digital subtraction angiography (DSA). MATERIALS AND METHODS: Between January 2013 and June 2015, 42 patients diagnosed with Buerger disease were identified retrospectively. Patients in whom occlusion of the popliteal artery was found on DSA of the lower extremity were subjected to Doppler US and MR imaging prospectively. Fifteen of 42 patients were identified as having the required characteristics, of whom 10 participated in the present study. RESULTS: Ten patients with occlusion of the popliteal artery were selected for inclusion, and 12 lower limbs of these patients were investigated. The study cohort comprised one woman and nine men with a mean age of 41 years ± 10 (standard deviation; range, 39-58 y). Corkscrew collateral vessels identified on DSA examinations were also identified on secondary imaging (Doppler US and MR imaging) in all patients except one in whom the popliteal artery was reconstituted after short-segment occlusion. The origin of the corkscrew collateral vessels was identified as the vasa nervorum of the tibial nerve in nine patients. CONCLUSIONS: Data from the present study suggest that corkscrew collateral vessels at the knee level in patients with Buerger disease originate from the vasa nervorum of the tibial nerve rather than the vasa vasorum of the popliteal artery if the latter is occluded.
Assuntos
Angiografia Digital , Circulação Colateral , Angiografia por Ressonância Magnética , Artéria Poplítea/diagnóstico por imagem , Tromboangiite Obliterante/diagnóstico por imagem , Nervo Tibial/irrigação sanguínea , Ultrassonografia Doppler em Cores , Vasa Nervorum/diagnóstico por imagem , Vasa Vasorum/diagnóstico por imagem , Adulto , Constrição Patológica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Imagem Multimodal , Artéria Poplítea/fisiopatologia , Valor Preditivo dos Testes , Estudos Retrospectivos , Tromboangiite Obliterante/fisiopatologia , Vasa Nervorum/fisiopatologia , Vasa Vasorum/fisiopatologiaRESUMO
BACKGROUND: The aim of this paper was to evaluate the efficacy of percutaneous transluminal angioplasty and the intra-arterial infusion of thrombolytic drugs in the treatment of lower extremity (LE) arterial occlusion during thromboangiitis obliterans (TO). METHODS: Between February 2008 and October 2013, 13 consecutive patients with TO and LE arterial occlusion underwent 18 sessions of PTA. One LE was affected in 11 patients and both LEs in two patients. An antegrade approach with transfemoral access was used in 17 procedures, and a retrograde approach via the contralateral common femoral artery (CFA) in one procedure. Under fluoroscopic guidance, a 260 cm wire (0.014 inch diameter), with a stiff body and a soft tip, was passed through the occlusion, followed by a 2.5-4 mm deep balloon, and the occlusions were dilated. After dilation, the deep balloon was removed and the straight tip of a thrombolysis catheter inserted, through which to intra-arterially infuse the thrombolytic drug. RESULTS: Percutaneous transluminal angioplasty (PTA) was successful in 39 of the 61 LE occluded arteries, so the technical success was 63.9%. No mortality or serious complication related to PTA was observed. There were significant differences between The Ankle Brachial Index (ABI) at the time of admission (1st-ABI), immediately after the first PTA (2nd-ABI), and at the time of patient discharge (3rd-ABI) (P=0.000). The self-reported maximum walking distance (SRMWD) before and after PTA were also significantly different (P=0.000). All the patients were followed-up for a mean period of 28.4±11.2 months (13-46 months). CONCLUSIONS: PTA using a deep balloon combined with the intra-arterial infusion of thrombolytic drugs is an effective and safe treatment for TO in patients to recanalize the occluded LE vessels.