Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 13 de 13
Filtrar
2.
An. bras. dermatol ; 96(2): 228-230, Mar.-Apr. 2021. graf
Artigo em Inglês | LILACS | ID: biblio-1248737

RESUMO

Abstract As the treatment of infectious and parasitic diseases improved, the prevalence of these conditions declined. However, with the expansion of the use of immunobiologicals, opportunistic infections have emerged, especially under atypical presentations. The present study reports the case of a patient treated with infliximab for Crohn's disease, who presented diarrhea, weight loss, abdominal pain, fever, and subcutaneous erythematous nodules that evolved with spontaneous fluctuation and ulceration. With the finding of alcohol-resistant bacilli and Mycobacterium tuberculosis DNA in a cutaneous fragment, through polymerase chain reaction, the diagnosis of gummatous tuberculosis was confirmed, probably secondary to hematogenous dissemination from an intestinal focus.


Assuntos
Humanos , Tuberculose Cutânea/diagnóstico , Tuberculose Cutânea/induzido quimicamente , Tuberculose Cutânea/tratamento farmacológico , Doença de Crohn/tratamento farmacológico , Sífilis , Pele , Infliximab/efeitos adversos
3.
An Bras Dermatol ; 96(2): 228-230, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33593700

RESUMO

As the treatment of infectious and parasitic diseases improved, the prevalence of these conditions declined. However, with the expansion of the use of immunobiologicals, opportunistic infections have emerged, especially under atypical presentations. The present study reports the case of a patient treated with infliximab for Crohn's disease, who presented diarrhea, weight loss, abdominal pain, fever, and subcutaneous erythematous nodules that evolved with spontaneous fluctuation and ulceration. With the finding of alcohol-resistant bacilli and Mycobacterium tuberculosis DNA in a cutaneous fragment, through polymerase chain reaction, the diagnosis of gummatous tuberculosis was confirmed, probably secondary to hematogenous dissemination from an intestinal focus.


Assuntos
Doença de Crohn , Sífilis , Tuberculose Cutânea , Doença de Crohn/tratamento farmacológico , Humanos , Infliximab/efeitos adversos , Pele , Tuberculose Cutânea/induzido quimicamente , Tuberculose Cutânea/diagnóstico , Tuberculose Cutânea/tratamento farmacológico
4.
Am J Dermatopathol ; 38(12): 892-899, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26909591

RESUMO

Treatment with interferon (IFN) could be associated with variable cutaneous adverse reactions. The aim of this study was to describe the clinicopathological spectrum of cutaneous granulomas associated with IFN therapy and identify the causal relation between IFN therapy and granulomatous reactions. The study included 18 patients (16 males and 2 females) with an average age of 48 years. Clinically, most of the lesions were solitary (83.3%) and located on the face (44.4%) and/or trunk (38.9%). The lesions were commonly presented as nodules (33.3%) or plaques (27.8%) with a common size of 5-10 cm. Granulomatous reactions were localized to the injection site in 4 cases, distributed on other body areas (remote granuloma) in 11 cases, and associated with lung involvement (systemic granuloma) in 3 cases. Histologically, injection site granuloma showed suppurative reaction in 75% and sarcoidal reaction in 25%. Remote granuloma showed tuberculoid reaction in 27.3%, interstitial in 27.3%, and sarcoidal in 45.4%. Systemic granuloma showed sarcoidal reaction in all cases. After withdrawal of IFN, only 3 lesions showed spontaneous complete clearance, whereas most of the lesions (83.3%) showed only partial improvement. Our results suggested that IFN is not a causal agent of all associated cutaneous granulomas but it mostly provokes the appearance of granulomatous reactions in susceptible individuals. Findings that prove this concept include the formation of granuloma in body sites away from the injection site, the heterogeneous pattern of granuloma both clinically and histologically, and incomplete clearance of most of the lesions after withdrawal of IFN.


Assuntos
Toxidermias/etiologia , Granuloma/induzido quimicamente , Fatores Imunológicos/efeitos adversos , Interferons/efeitos adversos , Pele/efeitos dos fármacos , Tuberculose Cutânea/induzido quimicamente , Adulto , Idoso , Biópsia , DNA Bacteriano/genética , DNA Viral/genética , Toxidermias/microbiologia , Toxidermias/patologia , Toxidermias/virologia , Feminino , Granuloma/microbiologia , Granuloma/patologia , Granuloma/virologia , Vírus de Hepatite/genética , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Mycobacterium tuberculosis/genética , Reação em Cadeia da Polimerase , Ribotipagem , Pele/microbiologia , Pele/patologia , Pele/virologia , Teste Tuberculínico , Tuberculose Cutânea/microbiologia , Tuberculose Cutânea/patologia
5.
An Bras Dermatol ; 88(1): 98-101, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23539011

RESUMO

Metastatic tuberculous abscesses or cutaneous tuberculous gummas occur mostly by reactivation of ancient cutaneous foci and is triggered mainly by pharmacological immunosuppression, diabetes mellitus, alcoholism or acquired immunodeficiency syndrome. The present case report refers to a 33-year-old male patient with polymyositis and a previous diagnosis of treated pulmonary tuberculosis. He presented cutaneous abscesses and fever months after the tuberculosis regimen. The patient was diagnosed as metastatic tuberculous abscesses associated with immunosuppression as result of polymyositis treatment.


Assuntos
Abscesso/patologia , Imunossupressores/efeitos adversos , Mycobacterium tuberculosis , Polimiosite/tratamento farmacológico , Tuberculose Cutânea/patologia , Adulto , Diagnóstico Diferencial , Humanos , Masculino , Mycobacterium tuberculosis/crescimento & desenvolvimento , Tuberculose Cutânea/induzido quimicamente
7.
Actas Dermosifiliogr ; 101 Suppl 1: 62-9, 2010 May.
Artigo em Espanhol | MEDLINE | ID: mdl-20492883

RESUMO

Drugs that block the tumor necrosis factor alpha (TNFalpha) increase the risk of reactivation of latent tuberculosis infection (LTI). The risk is greater with monoclonal antibodies than with etanercept. In order to reduce this risk, screening of latent tuberculosis infection should be performed prior to the initiation of the treatment. Screening includes a complete clinical history, physical examination, tuberculin test, in vitro detection of interferon-gamma (INF-gamma) production and a chest x-ray. The limitations of the different tests should be taken into consideration by the physician. After the diagnosis of latent tuberculosis infection, the patient must receive treatment with isoniacide for 9 months. In spite of screening and adequate treatment of latent tuberculosis treatment, the patients receiving treatment with anti-TNFalpha drugs may develop active tuberculosis. Thus, the patient should undergo clinical follow-up to detect signs of active tuberculosis with atypical and disseminated pictures.


Assuntos
Imunoglobulina G/efeitos adversos , Tuberculose Latente/induzido quimicamente , Tuberculose Cutânea/induzido quimicamente , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Adulto , Algoritmos , Etanercepte , Humanos , Tuberculose Latente/diagnóstico , Masculino , Receptores do Fator de Necrose Tumoral
8.
J Dtsch Dermatol Ges ; 7(7): 616-9, 2009 Jul.
Artigo em Inglês, Alemão | MEDLINE | ID: mdl-19192011

RESUMO

A woman with oculocutaneous Behçet disease developed primary tuberculosis while being treated with infliximab. A latent tuberculosis infection had been excluded before therapy. After more than 80 weeks of treatment, the patient complained of fevers, night sweats, shivering and vigorous cough. The chest x-ray showed miliary shadowing. Mycobacterium tuberculosis was identified. The history revealed recent contact to an individual with smear-positive tuberculosis. This constellation speaks in favor of a de novo tuberculosis infection with a fulminant course.


Assuntos
Anticorpos Monoclonais/efeitos adversos , Anticorpos Monoclonais/uso terapêutico , Síndrome de Behçet/complicações , Síndrome de Behçet/tratamento farmacológico , Tuberculose Cutânea/induzido quimicamente , Tuberculose Cutânea/diagnóstico , Adulto , Anti-Inflamatórios/efeitos adversos , Anti-Inflamatórios/uso terapêutico , Feminino , Humanos , Infliximab
9.
Clin Dermatol ; 25(4): 375-82, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17697920

RESUMO

From the Eskimo in Greenland to the tribes in Polynesia-the whole world knows the art of tattoo. Despite their wide popularity the relation between the skin diseases and the tattooed pictures aren't studied in depth. With the appearance of professional tattoo studios, the risk of infectious complications was reduced. Simultaneously, on a global scale there has been an increase in pseudolymphoma and allergic reactions caused by the introduction of an exogenous pigment into the dermis. The results of our clinical and therapeutic research and review of literature on the subject outline the major problems related to tattoos, i.e. clinical complications. The summarized data showed infectious diseases transmitted through the process of tattooing and many allergic reactions, granulomas and tumors as complications of a tattoo.


Assuntos
Dermatite Alérgica de Contato/etiologia , Dermatite Atópica/induzido quimicamente , Tatuagem/efeitos adversos , Humanos , Terapia a Laser/efeitos adversos , Líquen Plano/induzido quimicamente , Transtornos de Fotossensibilidade/induzido quimicamente , Pseudolinfoma/induzido quimicamente , Psoríase/induzido quimicamente , Pioderma/induzido quimicamente , Dermatopatias Virais/induzido quimicamente , Neoplasias Cutâneas/induzido quimicamente , Sífilis/induzido quimicamente , Tuberculose Cutânea/induzido quimicamente
10.
Lepr Rev ; 76(2): 170-4, 2005 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16038252

RESUMO

Lichen scrofulosorum is a rare form of tuberculid seen in children and young adults. The cutaneous lesions are typically symptomless papular eruptions, associated with a strong Mantoux reaction, tuberculosis of lymph nodes and/or other organs or rarely following BCG vaccination. We describe an unusual case of occurrence of lichen scrofulosorum following BCG immunotherapy in a patient with lepromatous leprosy.


Assuntos
Vacina BCG/efeitos adversos , Imunoterapia/efeitos adversos , Hanseníase Virchowiana/terapia , Tuberculose Cutânea/induzido quimicamente , Adulto , Biópsia por Agulha , Seguimentos , Humanos , Imuno-Histoquímica , Imunoterapia/métodos , Hanseníase Virchowiana/diagnóstico , Masculino , Medição de Risco , Tuberculose Cutânea/patologia
11.
Rheumatol Int ; 22(1): 41-4, 2002 May.
Artigo em Inglês | MEDLINE | ID: mdl-12120911

RESUMO

We report on a 31-year-old female patient with systemic lupus erythematosus (SLE) for 24 years who had a past history of skin tuberculosis (lupus vulgaris), long-term corticosteroid therapy, and IgG deficiency. She presented with monoarthritis and concomitant meningitis from skin tuberculosis after 5 years. The diagnosis of joint and meningeal tuberculosis was defined with clinical symptoms--signs and typical histopathological findings of involved synovium. Clinical improvement was achieved with antituberculous therapy. Cutaneous, articular, and cerebral manifestations of tuberculosis might have been confused with some of the lupus manifestations or lupus activation. It should be kept in mind that tuberculosis may be encountered in SLE due to the nature of the underlying disease and/or its therapy. It is also worth mentioning that, in this patient, tissues involved with extrapulmonary tuberculosis were the primary areas of involvement with SLE.


Assuntos
Corticosteroides/efeitos adversos , Imunossupressores/efeitos adversos , Lúpus Eritematoso Sistêmico/complicações , Lúpus Eritematoso Sistêmico/imunologia , Tuberculose Cutânea/imunologia , Tuberculose Meníngea/imunologia , Tuberculose Osteoarticular/imunologia , Adulto , Antibacterianos/uso terapêutico , Humanos , Deficiência de IgG/induzido quimicamente , Deficiência de IgG/complicações , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Imageamento por Ressonância Magnética , Masculino , Meninges/imunologia , Meninges/microbiologia , Meninges/patologia , Mycobacterium tuberculosis/efeitos dos fármacos , Mycobacterium tuberculosis/imunologia , Mycobacterium tuberculosis/patogenicidade , Pele/imunologia , Pele/microbiologia , Pele/patologia , Membrana Sinovial/imunologia , Membrana Sinovial/microbiologia , Membrana Sinovial/patologia , Resultado do Tratamento , Tuberculose Cutânea/induzido quimicamente , Tuberculose Meníngea/induzido quimicamente , Tuberculose Osteoarticular/induzido quimicamente
12.
J Cutan Pathol ; 20(2): 177-9, 1993 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-8320365

RESUMO

The clinical spectrum of cutaneous M. tuberculosis infections is varied and atypical. Once a major cause of death, with the advent of antimicrobial drugs it had, until recently, been an uncommon consideration in the differential diagnosis of cutaneous disorders. Panniculitis can be caused by a variety of etiologic agents; however, only rarely has it been reported caused by tuberculosis. Herein, we describe a patient with an unusual case of neutrophilic panniculitis caused by M. tuberculosis that arose following corticosteroid therapy for presumptive polymyositis. This case illustrates the need to include mycobacterial infection in the differential diagnosis of panniculitis in immunocompromised patients, and the importance of early detection via microbiologic culture and histopathologic examination.


Assuntos
Hospedeiro Imunocomprometido , Paniculite/etiologia , Polimiosite/tratamento farmacológico , Prednisona/efeitos adversos , Tuberculose Cutânea/induzido quimicamente , Idoso , Diagnóstico Diferencial , Feminino , Humanos , Paniculite/patologia , Polimiosite/patologia , Tuberculose Cutânea/complicações , Tuberculose Cutânea/patologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA