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Nature ; 601(7893): 452-459, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34912117


Structure-based virtual ligand screening is emerging as a key paradigm for early drug discovery owing to the availability of high-resolution target structures1-4 and ultra-large libraries of virtual compounds5,6. However, to keep pace with the rapid growth of virtual libraries, such as readily available for synthesis (REAL) combinatorial libraries7, new approaches to compound screening are needed8,9. Here we introduce a modular synthon-based approach-V-SYNTHES-to perform hierarchical structure-based screening of a REAL Space library of more than 11 billion compounds. V-SYNTHES first identifies the best scaffold-synthon combinations as seeds suitable for further growth, and then iteratively elaborates these seeds to select complete molecules with the best docking scores. This hierarchical combinatorial approach enables the rapid detection of the best-scoring compounds in the gigascale chemical space while performing docking of only a small fraction (<0.1%) of the library compounds. Chemical synthesis and experimental testing of novel cannabinoid antagonists predicted by V-SYNTHES demonstrated a 33% hit rate, including 14 submicromolar ligands, substantially improving over a standard virtual screening of the Enamine REAL diversity subset, which required approximately 100 times more computational resources. Synthesis of selected analogues of the best hits further improved potencies and affinities (best inhibitory constant (Ki) = 0.9 nM) and CB2/CB1 selectivity (50-200-fold). V-SYNTHES was also tested on a kinase target, ROCK1, further supporting its use for lead discovery. The approach is easily scalable for the rapid growth of combinatorial libraries and potentially adaptable to any docking algorithm.

Algoritmos , Técnicas de Química Combinatória , Descoberta de Drogas , Bibliotecas Digitais , Ligantes , Simulação de Acoplamento Molecular , Quinases Associadas a rho
J Med Chem ; 64(24): 17744-17752, 2021 12 23.
Artigo em Inglês | MEDLINE | ID: mdl-34902252


The prediction of compound properties from chemical structure is a main task for machine learning (ML) in medicinal chemistry. ML is often applied to large data sets in applications such as compound screening, virtual library enumeration, or generative chemistry. Albeit desirable, a detailed understanding of ML model decisions is typically not required in these cases. By contrast, compound optimization efforts rely on small data sets to identify structural modifications leading to desired property profiles. In this situation, if ML is applied, one usually is reluctant to make decisions based on predictions that cannot be rationalized. Only few ML methods are interpretable. However, to yield insights into complex ML model decisions, explanatory approaches can be applied. Herein, methodologies for better understanding of ML models or explaining individual predictions are reviewed and current challenges in integrating ML into medicinal chemistry programs as well as future opportunities are discussed.

Descoberta de Drogas/métodos , Aprendizado de Máquina , Algoritmos , Química Farmacêutica , Bibliotecas Digitais
Proc Natl Acad Sci U S A ; 118(51)2021 12 21.
Artigo em Inglês | MEDLINE | ID: mdl-34916287


The surge of post-truth political argumentation suggests that we are living in a special historical period when it comes to the balance between emotion and reasoning. To explore if this is indeed the case, we analyze language in millions of books covering the period from 1850 to 2019 represented in Google nGram data. We show that the use of words associated with rationality, such as "determine" and "conclusion," rose systematically after 1850, while words related to human experience such as "feel" and "believe" declined. This pattern reversed over the past decades, paralleled by a shift from a collectivistic to an individualistic focus as reflected, among other things, by the ratio of singular to plural pronouns such as "I"/"we" and "he"/"they." Interpreting this synchronous sea change in book language remains challenging. However, as we show, the nature of this reversal occurs in fiction as well as nonfiction. Moreover, the pattern of change in the ratio between sentiment and rationality flag words since 1850 also occurs in New York Times articles, suggesting that it is not an artifact of the book corpora we analyzed. Finally, we show that word trends in books parallel trends in corresponding Google search terms, supporting the idea that changes in book language do in part reflect changes in interest. All in all, our results suggest that over the past decades, there has been a marked shift in public interest from the collective to the individual, and from rationality toward emotion.

Idioma , Livros/história , Emoções , História do Século XIX , História do Século XX , História do Século XXI , Humanos , Individualidade , Idioma/história , Bibliotecas Digitais/estatística & dados numéricos , Linguística/história , Linguística/tendências , Jornais como Assunto/história , Jornais como Assunto/tendências , Análise de Componente Principal
Revista brasileira de ciência e movimento ; 29(1): [1-31], nov. 2021. tab, ilus
Artigo em Português | LILACS | ID: biblio-1348165


Este estudo tem como objetivo comparar e discutir, a partir de estudos científicos publicados, o efeito crônico do treinamento resistido sobre a pressão arterial. Foi realizada uma revisão sistemática de ensaios clínicos controlados randomizados. A busca dos artigos foi realizada nas bases de dados SciELO, PubMed e Biblioteca Virtual da Saúde. Foram selecionados artigos publicados a partir de 2015, com avaliação da pressão arterial antes e após um período de treinamento resistido e com um grupo controle. Nos 18 estudos selecionados, 551 participantes foram identificados, incluindo idosos, obesos, hipertensos, diabéticos, indivíduos com síndrome metabólica e indivíduos saudáveis, com idade média variando entre 15,4 e 87,7 anos. A maioria dos estudos selecionados realizou uma intervenção de treinamento resistido com exercícios dinâmicos tradicionais para membros inferiores e superiores, com duração de 12 semanas e frequência de 3 vezes por semana. O volume de treinamento apresentado nos estudos variou entre 1 e 5 séries de 3 a 20 repetições por exercício. A intensidade foi apresentada em percentual de uma repetição máxima, percentual de 10 repetições máximas, repetições máximas e percepção subjetiva de esforço. O intervalo de descanso entre os exercícios variou entre 30 e 180 segundos. A metanálise indicou que o treinamento resistido reduziu significativamente a pressão arterial sistólica em -3,38 mmHg ([IC 95% = -5,82; -0,95] p < 0,01; I² = 76%) e a pressão arterial diastólica em -1,95 mmHg ([IC 95% = -3,12; -0,78] p < 0,01; I² = 58%). De acordo com os resultados desta revisão, o treinamento resistido sozinho é mais efetivo em reduzir a pressão arterial de repouso do que o não treinamento, principalmente pressão arterial sistólica; com maior redução em idosos, pré-hipertensos e hipertensos. Sendo assim, o treinamento resistido pode ser um método a ser indicado na prevenção e tratamento da hipertensão arterial sistêmica.(AU)

This study aims to compare and discuss, based on published scientific studies, the chronic effect of resistance training on blood pressure. A systematic review of randomized controlled clinical trials was performed. The search for articles was carried out in the SciELO, PubMed and Biblioteca Virtual da Saúde databases. Articles published from 2015 onwards, with blood pressure assessment before and after a period of resistance training and with a control group, were selected. In the 18 selected studies, 551 participants were identified, including the elderly, obese, hypertensive, diabetics, subjects with metabolic syndrome and healthy subjects, with a mean age ranging between 15,4 and 87,7 years. Most of the selected studies carried out a resistance training intervention with traditional dynamic exercises for lower and upper limbs, lasting 12 weeks and frequency of 3 times a week. The volume of training presented in the studies varied between 1 and 5 sets of 3 to 20 repetitions per exercise. The intensity was presented as a percentage of a maximum repetition, a percentage of 10 maximum repetitions, maximum repetitions and perceived exertion. The rest interval between exercises varied between 30 and 180 seconds. The metaanalysis indicated that resistance training significantly reduced systolic blood pressure by -3,38 mmHg ([95% CI = -5,82; -0,95] p <0,01; I² = 76%) and blood pressure diastolic at -1,95 mmHg ([95% CI = -3,12; -0,78] p <0,01; I² = 58%). According to the results of this review, resistance training alone is more effective in reducing resting blood pressure than non-training, especially systolic blood pressure; with greater reduction in elderly, pre-hypertensive and hypertensive subjects. Therefore, resistance training can be a method to be indicated in the prevention and treatment of systemic arterial hypertension.(AU)

Humanos , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Resistência Física , Exercício Físico , Síndrome Metabólica , Treinamento de Força , Pressão Arterial , Revisão Sistemática , Idoso , Metanálise , Bibliotecas Digitais , Diabetes Mellitus , Voluntários Saudáveis , Treino Aeróbico , Hipertensão , Obesidade
J Med Libr Assoc ; 109(3): 497-502, 2021 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-34629981


BACKGROUND: Prior to 2020, library orientation for first-year medical students at Weill Cornell Medicine took the form of an on-site treasure hunt competition. Due to the COVID-19 pandemic, the orientation for the MD class of 2024 was shifted to an all-virtual format. This shift mandated a full redesign of the library orientation. CASE PRESENTATION: The Samuel J. Wood Library sought to preserve the excitement and fun of the treasure hunt in the new virtual format. The competition was redesigned as a Zoom meeting using breakout rooms, with library faculty and staff serving as team facilitators. Tasks were rewritten, shifting the focus from the library's physical spaces to its virtual services and online resources. The redesigned orientation was evaluated using two data sources: a postsession survey of student participants and a debriefing of the library employees who participated. Student evaluations were positive, while the faculty and staff provided numerous suggestions for improving future virtual orientations. CONCLUSIONS: A successful virtual library orientation requires careful preparation, including testing the competition tasks, full rehearsal with library facilitators, and a thoughtful approach to technology and logistics. We have chosen to share the materials we developed for other academic health sciences libraries that may wish to take a similar approach to their own virtual orientations.

COVID-19 , Educação de Graduação em Medicina/organização & administração , Bibliotecas Digitais/organização & administração , Bibliotecas Médicas/organização & administração , Estudos de Casos Organizacionais , Adulto , Feminino , Humanos , Masculino , New York , Pandemias , SARS-CoV-2 , Estudantes de Medicina , Adulto Jovem
Int J Mol Sci ; 22(14)2021 Jul 14.
Artigo em Inglês | MEDLINE | ID: mdl-34299163


Transforming growth factor-beta (TGF-ß), a member of the TGF-ß cytokine superfamily, is known to bind to sulfated glycosaminoglycans (GAGs), but the nature of this interaction remains unclear. In a recent study, we found that preterm human milk TGF-ß2 is sequestered by chondroitin sulfate (CS) in its proteoglycan form. To understand the molecular basis of the TGF-ß2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations. All possible CS oligosaccharides were generated in a combinatorial manner to give 24 di- (CS02), 192 tetra- (CS04), and 1536 hexa- (CS06) saccharides. This library of 1752 CS oligosaccharides was first screened against TGF-ß2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity. CVLS predicted that both the chain length and level of sulfation are critical for the high affinity and high specificity recognition of TGF-ß2. Interestingly, CVLS led to identification of two distinct sites of GAG binding on TGF-ß2. CVLS also deduced the preferred composition of the high specificity hexasaccharides, which were further assessed in all-atom explicit solvent MD simulations. The MD results confirmed that both sites of binding form stable GAG-protein complexes. More specifically, the highly selective CS chains were found to engage the TGF-ß2 monomer with high affinity. Overall, this work present key principles of recognition with regard to the TGF-ß2-CS system. In the process, it led to the generation of the in silico library of all possible CS oligosaccharides, which can be used for advanced studies on other protein-CS systems. Finally, the study led to the identification of unique CS sequences that are predicted to selectively recognize TGF-ß2 and may out-compete common natural CS biopolymers.

Sulfatos de Condroitina/química , Sulfatos de Condroitina/metabolismo , Biologia Computacional/métodos , Bibliotecas Digitais , Simulação de Dinâmica Molecular , Fator de Crescimento Transformador beta2/química , Fator de Crescimento Transformador beta2/metabolismo , Humanos , Conformação Proteica
Rev. enferm. UFPE on line ; 15(2): [1-24], jul. 2021. ilus, tab, graf
Artigo em Português | BDENF - enfermagem (Brasil), BDENF - enfermagem (Brasil) | ID: biblio-1347963


Objetivo: revisar e analisar, através da literatura, as principais alterações fisiológicas e patológicas da gestação, bem como as recomendações para preveni-las. Método: trata-se de um estudo de análise bibliográfica, descritivo, tipo revisão de literatura, com buscas realizadas durante o período de 01 a 17 de abril de 2020 nas bibliotecas virtuais Scientific Electronic Library Online (SciELO) e Biblioteca Virtual em Saúde (BVS). Selecionaram-se 19 artigos, os dados foram processados no software IRAMUTEQ® e analisados descritivamente pelo método de Reinert. Resultados: organizaram-se sete classes, destas emergiram quatro categorias: Classe 1, 4 e 7 - Alterações fisiológicas no peso e a avaliação nutricional na gestação; Classes 2 e 3 ­ Processo Educativo sobre a pirâmide nutricional para um desfecho saudável da gestação; Classe 6 ­ A importância das alterações hematológicas durante a gestação; Classe 5 ­ Benefícios da vitamina D na saúde da gestante ao longo do ciclo gravídico e puerperal. Conclusão: Identificou-se, que é fundamental o conhecimento das mudanças fisiológicas e patológicas para que seja ofertado as condições assistenciais necessárias, com intuito de prevenir complicações.(AU)

Objective: to review and analyze, through the literature, the main physiological and pathological changes in pregnancy, as well as the recommendations to prevent them. Method: this is a descriptive, literature review-type study of bibliographic analysis, with searches carried out during the period from April 1st to 17th, 2020 in the Scientific Electronic Library Online (SciELO) and Virtual Health Library (VHL) virtual libraries. Nineteen articles were selected, the data were processed in the IRAMUTEQ® software and descriptively analyzed using the Reinert method. Results: seven classes were organized, from which four categories emerged: Class 1, 4 and 7 - Physiological changes in weight and nutritional assessment during pregnancy; Classes 2 and 3 ­ Educational Process on the nutritional pyramid for a healthy pregnancy outcome; Class 6 ­ The importance of hematological changes during pregnancy; Class 5 ­ Benefits of vitamin D on the health of pregnant women throughout the pregnancy and puerperal cycle. Conclusion: It was identified that it is essential to know the physiological and pathological changes so that the necessary care conditions can be offered, in order to prevent complications.(AU)

Objetivo: revisar y analizar, a través de la literatura, los principales cambios fisiológicos y patológicos del embarazo, así como las recomendaciones para prevenirlos. Método: se trata de un análisis bibliográfico, estudio descriptivo, tipo revisión de la literatura, con búsquedas realizadas durante el período del 1 al 17 de abril de 2020 en las bibliotecas virtuales de la Biblioteca Científica Electrónica en Línea (SciELO) y la Biblioteca Virtual en Salud (BVS). Se seleccionaron 19 artículos, los datos se procesaron en el software IRAMUTEQ® y se analizaron descriptivamente mediante el método Reinert. Resultados: se organizaron siete clases, de las cuales surgieron cuatro categorías: Clase 1, 4 y 7 - Cambios fisiológicos en el peso y valoración nutricional durante el embarazo; Clases 2 y 3 - Proceso educativo sobre la pirámide nutricional para un resultado de embarazo saludable; Clase 6: la importancia de los cambios hematológicos durante el embarazo; Clase 5 - Beneficios de la vitamina D sobre la salud de la gestante durante todo el embarazo y ciclo puerperal. Conclusión: Se identificó que es fundamental conocer los cambios fisiológicos y patológicos para que se puedan brindar las condiciones de atención necesarias, a fin de prevenir complicaciones.(AU)

Humanos , Feminino , Gravidez , Complicações na Gravidez , Complicações na Gravidez/prevenção & controle , Manutenção da Gravidez , Gravidez , Saúde da Mulher , Gestantes , Nutrição Pré-Natal , Ganho de Peso na Gestação , Vitamina D , Epidemiologia Descritiva , Bibliotecas Digitais
Rev. colomb. anestesiol ; 49(2): e401, Apr.-June 2021. tab, graf
Artigo em Inglês | LILACS, COLNAL | ID: biblio-1251501


Abstract Introduction Ideal body weight calculation is used in critical medicine for drug dosing and setting ventilation parameters. However, the suggested and used equations were designed on the basis of anthropometric variables that do not represent the Latin American population. Objective To map and present the current evidence on the equations used to calculate ideal weight in patients on mechanical ventilation in intensive care units in Latin America. Material and Methods Exploratory review using the Joanna Briggs Institute method conceived by Arskey / O'Malley. A search was performed in the BVS, LILLACS, REDALYC, Ovid, Google Scholar and Scielo databases using keywords and MeSH terms in Spanish, English, and Portuguese, with no time limitation. The results are presented in descriptive tables. Results Overall, 1126 studies were identified and 1120 were excluded; 6 studies were reviewed and 3 additional studies were identified through a manual search. The studies were published in Chile, Brazil, Mexico, Ecuador, and Peru. In 89%, the ARDS Network equation was used to calculate tidal volume. Acute respiratory distress syndrome was the most reported pathology (33%). Conclusions Adult intensive care units in Latin America use the equation suggested by the ARDS Network, which was designed in a population with different anthropometric characteristics.

Resumen Introducción El cálculo del peso ideal se utiliza en medicina crítica para dosificación de medicaciones y programación de parámetros ventilatorios; sin embargo, las ecuaciones sugeridas y usadas fueron diseñadas con variables antropométricas que no representan la población latinoamericana. Objetivo Mapear y presentar la evidencia actual de las ecuaciones utilizadas para calcular el peso ideal en pacientes con ventilación mecánica en unidades de cuidado intensivo de Latinoamérica. Material y métodos Revisión exploratoria con el método del Instituto Joanna Briggs concebido por Arskey y O'Malley. Se realizó una búsqueda en las bases de datos BVS, LILACS, Redalyc, Ovid, Google Scholar y SciELO con el uso de palabras clave y términos MeSH en idiomas español, inglés y portugués, sin límites de tiempo. Los resultados se presentan de forma descriptiva. Resultados Se identificaron 1.126 estudios, se excluyeron 1.120, se revisaron seis y se encontraron tres adicionales mediante búsqueda manual. Los estudios fueron publicados en Chile, Brasil, México, Ecuador y Perú. En el 89 % se usó la ecuación del ARDS Network para calcular volumen corriente. El síndrome de dificultad respiratoria aguda fue la patología más informada (33 %). Conclusiones En las unidades de cuidado intensivo adulto de Latinoamérica se usa la ecuación sugerida por el ARDS Network diseñada en población con características antropométricas diferentes.

Humanos , Respiração Artificial , Volume de Ventilação Pulmonar , Peso Corporal Ideal , Estatura , Cuidados Críticos , Bibliotecas Digitais , América Latina
Rev. colomb. anestesiol ; 49(2): e300, Apr.-June 2021. tab, graf
Artigo em Inglês | LILACS, COLNAL | ID: biblio-1251499


Abstract Introduction Although the use of matching techniques in observational studies has been increasing, it is not always adequate. Clinical trials are not always feasible in critically ill patients with renal outcomes, and observational studies are an important alternative. Objective Through a scoping review, determine the available evidence on the use of matching methods in studies involving critically ill patients and renal outcome assessments. Methods Medline, Embase, and Cochrane databases were used to identify articles published between 1992 and week 10 of 2020. Studies had to assess different exposures in critically ill patients with renal outcomes using propensity score matching. Results Most publications are cohort studies 94 (94.9%), with five (5.1%) reporting cross-sectional studies. The main pharmacological intervention was the use of antibiotics in seven studies (7.1%) and the main risk factor studied was renal injury prior to ICU admission in 10 studies (10.1%). The use of standardized means to assess balance of baseline characteristics was found in only 28 studies (28.2%). Most studies 95 (96%) used logistic regression to calculate the propensity score. Conclusion Major inconsistencies were observed regarding the use of methods and reporting of findings. Considerations related to the use of propensity score matching methods and reporting of findings are summarized.

Resumen Introducción El uso de técnicas de emparejamiento en estudios observacionales ha ido en aumento y no siempre se usa adecuadamente. Los experimentos clínicos no siempre son factibles en los pacientes críticos con desenlaces renales, por lo que los estudios observacionales son una alternativa importante. Objetivo Mediante una revisión de alcance, determinar la evidencia disponible sobre la utilización de los métodos de emparejamiento en los estudios que incluyen pacientes críticamente enfermos y que evalúan desenlaces renales. Métodos Se utilizaron las bases de datos de Medline, Embase, y Cochrane para identificar artículos publicados entre 1992 y 2020 hasta la semana 10, que estudiaran diferentes exposiciones en el paciente crítico con desenlaces renales y utilizaran métodos de emparejamiento por propensión. Resultados La mayoría de las publicaciones (94) son estudios de Cohorte (94,9 %), cinco estudios (5,1 %) correspondieron a cross-secctional. La principal intervención farmacológica fue el uso de antibióticos en siete estudios (7,1 %) y el principal factor de riesgo estudiado fue la lesión renal previa al ingreso a UCI en diez estudios (10,1 %). El balance entre las características de base evaluado mediante medias estandarizadas se encontró solo en 28 estudios (28,2 %). La mayoría de los estudios 95 (96 %) utilizaron regresión logística para calcular el índice de propensión. Conclusiones Se observaron grandes inconsistencias en la utilización de los métodos y en el informe de los hallazgos. Se hace un resumen de los aspectos por considerar en la utilización de los métodos y reporte de los hallazgos con el emparejamiento por índice de propensión.

Humanos , Estado Terminal , Terapia de Substituição Renal , Cuidados Críticos , Bibliotecas Digitais , Pontuação de Propensão , Injúria Renal Aguda , Nefropatias
Mod Pathol ; 34(9): 1686-1695, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34035438


Macroscopic examination of surgical pathology and autopsy cases is a fundamental component of anatomic pathology. The photographic documentation of such clinical specimens is essential, and it may be required in certain instances. Our department began using consumer-grade digital cameras in 2005 to improve the practice of gross photography. However, the lack of an application to correctly catalog the photographs resulted in thousands of digital image files scattered across shared network drives, with limited case and patient metadata, making image retrieval a cumbersome and sometimes impossible task. Thirteen years later, we examined the legacy method of acquiring and accessing gross photographs in our department and determined the need for a web-based digital media archive to capture images with structured metadata. Using several open-source tools, including MediaWiki, we developed a flexible platform for building our digital media archive with a data schema based on the Fast Healthcare Interoperability Resources standard. Following a short pilot, we replaced the legacy method of handling gross pathology images with a new acquisition workflow and digital media archive. Through March 2021, 233 distinct users have accessed the system, 58 of which have uploaded 21,024 images. Of those images, 13,684 (65.1%) correspond to surgical pathology images, 4045 (19.2%) belong to neuropathology cases, and 3295 (15.7%) originate from autopsies. We demonstrate the design and implementation of a customizable anatomic pathology digital media archive solution in an academic pathology department setting using a modern standard for exchanging healthcare information electronically. The system's efficiency and scalability for our current operation will enable us to integrate with other applications and pathology informatics initiatives in the future.

Curadoria de Dados/métodos , Internet , Bibliotecas Digitais/organização & administração , Patologia/métodos , Fluxo de Trabalho , Humanos
Rev. cuba. angiol. cir. vasc ; 22(1): e308, ene.-abr. 2021. fig
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1251682


Introducción: El linfangioma quístico es un tumor benigno infrecuente del sistema linfático que afecta habitualmente a los infantes. La opción terapéutica ideal es la extirpación quirúrgica. Objetivo: Sistematizar contenidos esenciales relacionados con el diagnóstico y tratamiento del linfangioma quístico. Métodos: Se realizó la búsqueda y el análisis de la información en un período de 10 años (2010-2020). Se emplearon las palabras clave: "linfangioma quístico" y "malformación linfática congénita quística", en español e inglés. Se hizo la revisión bibliográfica en un total de 62 artículos publicados en las bases de datos y bibliotecas electrónicas científicas de la salud: PubMed, Google Académico, Pubmed, Medline, Biblioteca Virtual en Salud, LILACS y SciELO, mediante el gestor de búsqueda y administrador de referencias EndNote; de ellos se seleccionaron 50 relevantes para el objetivo de la revisión. Resultados: La información se estructuró en los siguientes aspectos: sinonimia y antecedentes históricos, epidemiología, clasificación, patogenia, bases esenciales para el diagnóstico, tratamiento, complicaciones y pronóstico. Se identificaron controversias en cuanto a la terapéutica, y se mostraron las imágenes de los infantes diagnosticados y tratados por la autora en su colaboración médica en Angola en 2018. Conclusiones: Se sistematizan las bases esenciales para el diagnóstico y tratamiento del linfangioma quístico para que el cirujano general que, en su desempeño profesional, brinda asistencia médico quirúrgica a infantes fuera de Cuba, se empodere de las especificidades de este tumor linfático. También se revela como factible su resección quirúrgica íntegra para evitar recidivas, discapacidad y mejorar la calidad de vida del afectado(AU)

Introduction: Cystic lymphangioma is a rare benign tumor of the lymphatic system that usually affects infants. The ideal therapeutic option is surgical removal. Objective: Systematize essential contents related to the diagnosis and treatment of cystic lymphangioma. Methods: The search and analysis of information was carried out over a period of 10 years (2010-2020). The keywords "cystic lymphangioma" and "cystic congenital lymphatic malformation" were used in Spanish and English. The bibliographical review was carried out in a total of 62 articles published in the databases and electronic scientific health libraries: PubMed, Google Scholar, Pubmed, Medline, Virtual Library in Health, LILACS and SciELO, through the search and reference manager called EndNote; of these, 50 that were important to the objective of the review were selected. Results: The information was structured in the following aspects: synonym and historical backgrounds, epidemiology, classification, pathogenesis, essential bases for diagnosis, treatment, complications and prognosis. Therapeutic disputes were identified, and images of infants diagnosed and treated by the author in her medical collaboration in Angola in 2018 were shown. Conclusions: The essential bases for the diagnosis and treatment of cystic lymphangioma are systematized, so that the general surgeon who, in his-her professional performance, provides surgical medical assistance to infants outside Cuba is informed on the specificities of this lymphatic tumor. Its full surgical resection is also revealed as feasible to prevent recurrence, disability and to improve the quality of life of the affected person(AU)

Humanos , Bibliotecas Digitais , Cooperação Internacional , Assistência Médica
Hist Cienc Saude Manguinhos ; 2828(1): 293-300, 2021.
Artigo em Espanhol | MEDLINE | ID: mdl-33787706


This article aims to provide researchers and students with information on digital archives in libraries in Latin America and elsewhere. It is aimed at those interested in health history, focusing on Peru and Chile.

Este artículo tiene como propósito poner al alcance de investigadores y estudiantes información sobre archivos digitales de bibliotecas en América Latina y en el extranjero. Su contenido está orientado para aquellos interesados en historia de la salud, con énfasis en Perú y Chile.

Arquivos , Bibliotecas Digitais , COVID-19 , Chile , História da Medicina , América Latina , Bibliotecas , Peru
Hist. ciênc. saúde-Manguinhos ; 28(1): 293-300, mar. 2021. graf
Artigo em Espanhol | LILACS | ID: biblio-1154305


Resumen Este artículo tiene como propósito poner al alcance de investigadores y estudiantes información sobre archivos digitales de bibliotecas en América Latina y en el extranjero. Su contenido está orientado para aquellos interesados en historia de la salud, con énfasis en Perú y Chile.

Abstract This article aims to provide researchers and students with information on digital archives in libraries in Latin America and elsewhere. It is aimed at those interested in health history, focusing on Peru and Chile.

Arquivos , Bibliotecas Digitais , Peru , Chile , COVID-19 , História da Medicina , América Latina , Bibliotecas
Rev. colomb. psiquiatr ; 50(1): 34-38, Jan.-Mar. 2021. tab
Artigo em Espanhol | LILACS, COLNAL | ID: biblio-1251630


RESUMEN Introducción: El conocimiento de la frecuencia de comportamientos zoofílicos en la población general es escaso. Objetivo: Revisar casos, series de casos y estudios de prevalencia de zoofilia en adultos de la población general. Métodos: Se realizó una revisión en las bases de datos de MEDLINE, a través de PubMed, Scopus y la Biblioteca Virtual en Salud de publicaciones desde enero de 2000 hasta diciembre de 2017. Resultados: Se revisaron 13 trabajos (10 informes de casos, 2 series de casos y 1 estudio transversal). Entre los casos se describió a 12 pacientes; las series de casos sumaron a 1.556 personas y el estudio transversal incluyó a 1.015 participantes e informó de una prevalencia de comportamientos zoofílicos del 2%. Conclusiones: Es escasa la información sobre la prevalencia de comportamientos zoofílicos en la población general. Es probable que internet permita investigar mejor estos comportamientos en los próximos años.

ABSTRACT Background: Information about the frequency of zoophilic behaviour in the general population is scarce. Objective: To review cases, case series and prevalence studies of zoophilia in adults in the general population. Methods: A review of publications was carried out in MEDLINE via PubMed, Scopus and the Biblioteca Virtual en Salud [Virtual Health Library] ranging from January 2000 to December 2017. Results: Thirteen papers were reviewed (ten case reports, two case series and one cross-sectional study). Twelve patients were described, the case series totalled 1,556 people and the cross-sectional study included 1,015 participants and reported a prevalence of zoophilic behaviour of 2%. Conclusions: Information on the prevalence of zoophilic behaviour in the general population is limited. The Internet will probably be a valuable tool for further investigating these behaviours in coming years.

Humanos , Masculino , Feminino , Disfunções Sexuais Psicogênicas , Bibliotecas Digitais , População , Volição , Estudos Transversais , MEDLINE , Internet , PubMed , Métodos
Med Ref Serv Q ; 40(1): 23-34, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33625323


In March 2020, the Dean of the George Washington (GW) University School of Medicine and Health Sciences (SMHS) and the GW COVID-19 Incident Management Team asked the Senior Associate Dean for Clinical Public Health to initiate a daily report that surveyed COVID-19 literature/resources. This COVID-19 Intelligence Report would serve as a concise, authoritative source of COVID-19 information for clinicians, the Incident Management Team, and operational leaders. The Senior Associate Dean established an Intelligence Gathering Team comprised of clinicians and librarians. Himmelfarb librarians facilitated the collection, distribution, and archiving of COVID-19 resources and Intelligence Reports.

COVID-19 , Pesquisa sobre Serviços de Saúde/organização & administração , Pesquisa sobre Serviços de Saúde/estatística & dados numéricos , Disseminação de Informação/métodos , Bibliotecas Digitais/organização & administração , Bibliotecas Médicas/organização & administração , Bibliotecas Médicas/estatística & dados numéricos , Centros Médicos Acadêmicos , District of Columbia , Humanos , Bibliotecas Digitais/estatística & dados numéricos
Med Ref Serv Q ; 40(1): 67-78, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33625324


The COVID-19 pandemic has affected libraries across the globe, including academic health sciences libraries, in many ways. This manuscript describes the challenges, solutions, and practices employed by the Stony Brook University Health Sciences Library in order to maintain continuity of services to patrons including faculty, hospital staff, students, and clinicians while operating in one of the earliest epicenters of the pandemic. Some of the major changes the library underwent in response to the pandemic included implementing new online anatomy resources, contactless circulation, remote interlibrary loan services and modified operating practices.

COVID-19 , Defesa Civil/organização & administração , Planejamento em Desastres/organização & administração , Disseminação de Informação/métodos , Bibliotecas Digitais/organização & administração , Bibliotecas Médicas/organização & administração , Pandemias , Humanos , Bibliotecas Digitais/estatística & dados numéricos , Bibliotecas Médicas/estatística & dados numéricos , New York , SARS-CoV-2
Med Ref Serv Q ; 40(1): 122-129, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33625325


Telehealth services have slowly yet steadily increased over the past few decades as new technologies emerge. However, social distancing mandates, state shutdowns, and an overburdened healthcare system during the COVID-19 pandemic forced a dramatic surge forward in telehealth use and policy. While many of these emergency measures are temporary, the successes, failures and lessons learned during this period will change the way telehealth is administered, moving forward. This column will review recent changes to telehealth and telemedicine services during the pandemic and their impact on healthcare systems.

COVID-19 , Atenção à Saúde/organização & administração , Disseminação de Informação/métodos , Bibliotecários/educação , Bibliotecas Digitais/organização & administração , Bibliotecas Médicas/organização & administração , Telemedicina/organização & administração , Adulto , Feminino , Humanos , Bibliotecas Digitais/estatística & dados numéricos , Bibliotecas Médicas/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , SARS-CoV-2 , Estados Unidos
Med Ref Serv Q ; 40(1): 35-47, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33625328


In response to the COVID-19 pandemic and the subsequent Stay At Home order, the Southern Illinois University Medical Library utilized new technologies and implemented new virtual service models in order to improve internal communication, and to continue providing services and resources to patrons remotely. The changes happened quickly, and the librarians faced several challenges during this time, but things went smoothly overall and there were some considerable silver linings. Several of the newly adopted technologies, service models, and virtual resource offerings proved to be extremely effective and their use will continue beyond the duration of the pandemic.

Centros Médicos Acadêmicos/organização & administração , COVID-19 , Disseminação de Informação/métodos , Bibliotecas Digitais/organização & administração , Bibliotecas Digitais/estatística & dados numéricos , Bibliotecas Médicas/organização & administração , Bibliotecas Médicas/estatística & dados numéricos , Humanos , Illinois
Med Ref Serv Q ; 40(1): 48-55, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33625330


An ongoing collaboration between physicians and librarians provided critical information during the COVID-19 pandemic. A development team, which consisted of the hospital and medical school disaster preparedness medical director, the medical library director, professional librarians, and the Departments of IT and Marketing in a multi-state healthcare system worked together to develop a shared website to distribute and curate timely resources during COVID-19. The initial impacts of this collaboration and the website show the benefits of this novel partnership.

COVID-19 , Relações Interprofissionais , Bibliotecários/psicologia , Bibliotecas Digitais/organização & administração , Bibliotecas Médicas/organização & administração , Bibliotecas Médicas/estatística & dados numéricos , Médicos/psicologia , Adulto , Feminino , Humanos , Bibliotecários/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Pandemias , Médicos/estatística & dados numéricos , SARS-CoV-2