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1.
Edumecentro ; 13(3): 426-430, jul.-sept. 2021.
Artigo em Espanhol | LILACS, MTYCI | ID: biblio-1283607

RESUMO

Las enfermedades respiratorias infecciosas afectan con frecuencia a los pacientes que acuden a consultas; constituyen una de las más incapacitantes e incluso, si no se atienden adecuadamente generan una evolución tórpida y pueden comprometer la vida del paciente. En su tratamiento se emplean medicamentos alopáticos, así como modalidades terapéuticas de medicina natural y tradicional. Teniendo en cuenta el desarrollo de la homeopatía en Cuba en los últimos años, se propone como objetivo enfatizar en la importancia de la superación por parte de los profesionales de la salud en el uso de esta modalidad terapéutica, a fin de utilizarla en los diferentes niveles de atención por su pertinencia en tiempos de pandemia.


Infectious respiratory diseases frequently affect patients who attend consultations; they constitute one of the most incapacitating and even, if they are not taken care properly they generate a torpid evolution and can jeopardize the life of the patient. In its treatment allopathic medications are used, as well as therapeutic modalities of herbal and folk medicine. Taking into account the development of homeopathy in Cuba in recent years, it is proposed as an objective to emphasize the importance of improvement by health professionals in the use of this therapeutic modality, in order to use it at different levels of care for its relevance in times of pandemic.


Assuntos
COVID-19 , Homeopatia , Doenças Respiratórias , Cuba , Medicina Tradicional
2.
Homeopathy ; 110(3): 147-148, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34318478
4.
Hist Cienc Saude Manguinhos ; 28(2): 491-508, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34190791

RESUMO

Oscar Nerval de Gouvêa was a scientist and teacher in Rio de Janeiro, Brazil, whose work spanned engineering, medicine, the social sciences, and law. This paper presents and discusses a manuscript entitled "Table of mineral classification," which he appended to his dissertation Da receptividade mórbida , presented to the Faculty of Medicine in 1889. The foundations and features of the table provide a focus for understanding nineteenth-century mineralogy and its connections in Brazil at that time through this scientist. This text was Gouvêa's contribution to the various mineral classification systems which have emerged from different parts of the world.


Assuntos
Geologia/história , Homeopatia/história , Minerais/história , Brasil , História do Século XVI , História do Século XIX , História do Século XX , História Antiga , Minerais/classificação
5.
Urologe A ; 60(7): 953-962, 2021 Jul.
Artigo em Alemão | MEDLINE | ID: mdl-34129061

RESUMO

Complementary and alternative medicine (CAM) is widespread in oncology patients with a user rate of approximately 40-50%. An accompanying supportive effect can arise through improved adherence, especially in long-term (e.g. endocrine) therapies through active patient involvement. When assessing the evidence on frequently requested methods, there is no high-quality evidence that homeopathy or anthroposophy leads to an improved prognosis. Mistletoe therapy can be considered to improve the quality of life, although the data quality is weak. In prostate cancer, pomegranate has an influence on the prostate-specific antigen. It is currently unclear whether this will also result in an improved prognosis. In contrast the evidence on selenium and vitamin D speaks in favor of integration into the aftercare concept. Supplementation is recommended after the serum level has been determined.


Assuntos
Terapias Complementares , Homeopatia , Erva-de-Passarinho , Neoplasias , Humanos , Masculino , Fitoterapia , Qualidade de Vida
6.
PLoS One ; 16(5): e0250223, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33983955

RESUMO

BACKGROUND: Workforce studies about traditional and complementary medicine (T&CM) occupations in industrialized countries are scant; and, these occupations' position within the broader occupational workforce remains unclear. This study aims to address these gaps using a comparative approach. METHODS: Naturopaths, traditional Chinese medicine (TCM) / acupuncture practitioners, and homeopaths in Ontario, Canada were surveyed regarding their demographics, practice characteristics and self-reported income. Results were compared with parallel data from within and outside of Ontario. RESULTS: Study response rate: 23.3% (n = 1205). While predominantly female (57.9%), Ontario's TCM/acupuncture profession was less feminized than the naturopathic (77.1%) and homeopathic (78.3%) groups. Naturopaths were significantly younger than, and reported fewer years of clinical experience than, the other two groups. About half of TCM/acupuncture practitioners, and almost one-third of homeopaths had trained outside of Canada, predominantly in East and South Asia, respectively. More TCM/acupuncture practitioners (58.9%) and homeopaths (57.6%) had multilingual clinical practices than naturopaths (19.1%). Homeopaths worked fewer hours and saw fewer patients per week than the other occupations. Self-reported mean incomes varied across groups, with naturopaths earning more on average ($63,834, SD $57,101) than did TCM/acupuncture practitioners ($45,624, SD $44,081) or homeopaths ($29,230, SD $41,645). Holding other variables constant, internationally-trained practitioners reported earning one-third less than their Canadian-trained counterparts. DISCUSSION & CONCLUSIONS: Study findings echo occupationally-specific data from other industrialized jurisdictions; and, affirm that different T&CM occupations have distinctive demographic and practice characteristics. The demographic makeup of Ontario's TCM/acupuncture and homeopathy occupations suggests a role for these groups in delivering culturally-responsive care within Asian ethnic communities. T&CM practitioner incomes, in particular for internationally-trained practitioners, fell below the provincial population income median, and in many cases below the poverty line. T&CM occupations' relative socio-political marginality may be impacting clinicians' ability to earn a viable living.


Assuntos
Terapia por Acupuntura , Terapias Complementares/organização & administração , Homeopatia/organização & administração , Medicina Tradicional Chinesa , Naturopatia , Inquéritos e Questionários , Recursos Humanos , Adulto , Estudos Transversais , Feminino , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Ontário
7.
Homeopathy ; 110(3): 212-221, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34000742

RESUMO

A clear definition of its subject and correct application of its tenets are the basis of any science. Conversely, the want of a unanimous understanding of its constituting principles by the homeopathic community is undermining its scientific practice, research and discussion. To facilitate these, first and foremost the Principle of Similars, similia similibus curentur, has to be clarified and assessed in terms of its theoretical meaning, historical development, and epistemological status. Hahnemann's conceptions, explanations, and appraisals were not static but evolved and hardened over the years, especially from 1796 to 1810. While initially he related similia similibus to an imitation of similar cures by nature and proposed it as an opposition to contraria contrariis, he later generalised it to the treatment of any disease. Whilst originally he considered it to be a hermeneutical principle, or a hint towards a curative remedy, Hahnemann later dogmatised it as the only truth. Considering advances in epistemology and theory of medicine, however, the Principle of Similars may not be assessed as a final truth or natural law to be empirically verified or falsified for good, but rather as a practical maxim, guiding the artist of healing in his/her curing of diseases rationally and individually.


Assuntos
Homeopatia/métodos , História do Século XIX , Homeopatia/história , Homeopatia/tendências , Humanos
8.
Microb Pathog ; 156: 104936, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33951540

RESUMO

Motivated by conventional medicines' ineffectiveness and the appearance of bacterial resistance, homeopathic medicines are being increasingly demanded by the veterinary market. Dog feces contain high bacterial and pathogenic loads, which can cause diseases in animals and facilitate zoonotic transmission. Adequate animal immunity contributes to the elimination of potential pathogens. This work's objective was to evaluate the effects of using a homeopathic medication on blood cell counts, serum protein levels, and fecal bacterial counts in dogs. Two groups were used, each including five 19-month-old Beagle dogs. The homeopathic product Orgainfecto® was sprayed on the two daily meals in the treated group (T), at 0.5 mL/animal/day for 60 days; the group that did not receive the homeopathic was considered the control (C), who were fed only the vehicle used in the production of the homeopathic as a placebo. On days 1, 30, and 60, individual stool samples were collected for bacterial counts in the stool, blood samples for blood counts, and serum for biochemical tests. Total bacterial counts in feces were lower in group T on days 30 and 60 of the experiment, while total coliforms and E coli. were lower in this group on day 60. Total leukocyte counts were lower on day 60 in group T, unlike the neutrophil count, higher in group T on day 30, and eosinophils on day 60. However, the lymphocyte count was lower in group T on days 30 and 60. There was an increase in globulin and total protein in group T on day 60. We conclude that the tested homeopathic causes neutrophils and eosinophils' stimulation and increases globulins levels even with reduced lymphocytes. The daily consumption of homeopathic by dogs decreases the intestinal bacterial load, resulting in less environmental contamination and animal and human colibacillosis risks.


Assuntos
Homeopatia , Materia Medica , Animais , Carga Bacteriana , Cães , Escherichia coli , Fezes
9.
HNO ; 69(8): 679-690, 2021 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-34009440

RESUMO

Many publications declare homeopathy to be "controversial." However, based on the findings of extensive research on homeopathy, there has long been a broad scientific consensus that there is no reliable evidence of specific medical effectiveness. Overall, the evidence clearly denies effects beyond those of placebo and context. All the more must it be seen as a phenomenon that homeopathy is still the subject of medical and therapeutic practice. This may lie largely in the fact that the homeopathic scene appropriates medical research and the concept of evidence in a way that is suitable to maintain the appearance that there is still a scientifically relevant discourse to dispute. The following article aims to justify that this is not the case, and that homeopathy is, therefore, obsolete as a therapeutic option, even according to the principles of contemporary medical ethics.


Assuntos
Homeopatia , Medicina Baseada em Evidências
10.
Homeopathy ; 110(3): 206-211, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-33853177

RESUMO

The current COVID-19 (coronavirus disease 2019) epidemic has proved challenging due to its high impact on physical and mental health. According to Hahnemann, the founder of homeopathy, in an epidemic the most severe symptoms of the clinical condition presented by the population in question should be the basis for selecting the medication that is as similar as possible to them, and which should be administered to individuals who have been exposed to the disease but have not yet developed it. This medicine is called the genus epidemicus. This study aims to demonstrate the reasoning used to propose the homeopathic medicine Antimonium tartaricum (Ant-t) as a genus epidemicus in the COVID-19 epidemic. It was decided to develop the reasoning based on the respiratory symptoms described in the epidemiological bulletins presented by the Health Surveillance Secretariat of the Ministry of Health of Brazil, as these symptoms are the most serious of the disease. After repertorization, it was confirmed in the Materia Medica that Ant-t has a high degree of similarity with these respiratory symptoms, including the most serious situations, of COVID-19. Homeopathic Ant-t is thus a possible prophylactic genus epidemicus in the COVID-19 epidemic; further studies are needed to test this conclusion.


Assuntos
Tartarato de Antimônio e Potássio/uso terapêutico , COVID-19/tratamento farmacológico , COVID-19/epidemiologia , Epidemias/prevenção & controle , Homeopatia/métodos , Materia Medica/uso terapêutico , Avaliação de Sintomas , Brasil/epidemiologia , História do Século XIX , História do Século XX , Homeopatia/história , Humanos , Materia Medica/história , SARS-CoV-2
11.
Homeopathy ; 110(3): 198-205, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-33853178

RESUMO

As at mid-October 2020, the coronavirus disease 2019 (COVID-19) pandemic has been continuing on the rise across the globe, including in India. Historically, homeopathy has been used in a number of epidemics/pandemics. The development of homeopathic medicines is approached uniquely through "drug provings" and clinical verification; these two intrinsic processes establish the background for the application of homeopathic medicines, regardless of nosological diagnosis. This article reflects research initiatives on COVID-19 in India and identifies studies listed in the Clinical Trial Registry-India database. We identified 29 studies being undertaken in different settings, including those in conventional medicine: 20 randomized controlled trials (RCTs) and 9 observational studies. Fifteen studies are aimed at prophylaxis and 14 are aimed at treatment. Amongst the treatment studies, 11 are focused on efficacy or comparative effectiveness. The findings might provide evidence for clinically repurposing some of homeopathy's medicines, an approach that is intrinsic to the therapy, enabling their use in COVID-19 as an adjuvant or stand-alone to help reduce costs and improve patient recovery.


Assuntos
COVID-19/terapia , Estudos Clínicos como Assunto , Reposicionamento de Medicamentos , Homeopatia , Arsenicais/uso terapêutico , Humanos , Índia/epidemiologia , SARS-CoV-2
12.
Homeopathy ; 110(3): 160-167, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-33930904

RESUMO

BACKGROUND/OBJECTIVE: Coronavirus disease 2019 (COVID-19) is a new disease; its clinical profile and natural history are evolving. Each well-recorded case in homeopathic practice is important for deciding the future course of action. This study aims at identifying clinically useful homeopathic remedies and their prescribing symptoms using the prognostic factor research model. METHODS: This was an open-label, multi-centric, observational study performed from April 2020 to July 2020 at various public health care clinics. The data were collected prospectively from clinical practice at integrated COVID-19 care facilities in India. Good-quality cases were selected using a specific set of criteria. These cases were analyzed for elucidating prognostic factors by calculating the likelihood ratio (LR) of each frequently occurring symptom. The symptoms with high LR values (>1) were considered as prescribing indications of the specific remedy. RESULTS: Out of 327 COVID-19 cases reported, 211 met the selection criteria for analysis. The most common complaints were fatigue, sore throat, dry cough, myalgia, fever, dry mouth and throat, increased thirst, headache, decreased appetite, anxiety, and altered taste. Twenty-seven remedies were prescribed and four of them-Arsenicum album, Bryonia alba, Gelsemium sempervirens, and Pulsatilla nigricans-were the most frequently used. A high LR was obtained for certain symptoms, which enabled differentiation between the remedies for a given patient. CONCLUSION: Homeopathic medicines were associated with improvement in symptoms of COVID-19 cases. Characteristic symptoms of four frequently indicated remedies have been identified using prognostic factor research, findings that can contribute to accurate homeopathic prescribing during future controlled research in COVID-19.


Assuntos
COVID-19/terapia , Homeopatia , Adolescente , Adulto , Feminino , Humanos , Índia/epidemiologia , Funções Verossimilhança , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Prospectivos , SARS-CoV-2 , Adulto Jovem
13.
Homeopathy ; 110(2): 75, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33915584
14.
Can Bull Med Hist ; 38(1): 32-62, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33831312

RESUMO

Advocates of homeopathic vaccines, also known as nosodes, reimagined the risks and benefits of vaccination from 1999 to 2015 by comparing "risky" vaccines to "risk-free" nosodes. I argue that nosodes allowed for a complementary argument to anti-vaccine discourse, fundamentally altering what had been framed as a choice between the risks of vaccination and the risks of vaccine-preventable disease. Despite evidence of their efficacy being flawed, advocates presented nosodes as an alternative to vaccines and a middle ground between anti-vaccination and vaccination. While a campaign from 2013 to 2015 tried to expose nosodes as ineffective, I argue that the campaign was unsuccessful. Instead, the mainstream media brought more attention to nosodes. The history of nosodes further complicates the history of vaccines and alternative medicine in Canada by adding vaccine alternatives to the growing literature on vaccine hesitancy.


Assuntos
Homeopatia/estatística & dados numéricos , Materia Medica/uso terapêutico , Vacinação/estatística & dados numéricos , Vacinas/uso terapêutico , Canadá , Humanos
15.
J Cosmet Dermatol ; 20(7): 2062-2068, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33930256

RESUMO

This commentary examines the utility of arnica in cosmetic dermatology. For many years, arnica has been used to reduce the morbidity associated with various procedures, including surgeries and treatments with lasers and other energy-based devices. Arnica is a traditional homeopathic remedy that can reduce post-procedural edema and bruising. Although it has been used clinically by many physicians and is widely and readily available to patients, the available data is limited and often conflicting. We reviewed the relevant information on arnica and offer our own insights into its use in order to shed more light on its periprocedural utility.


Assuntos
Arnica , Contusões , Dermatologia , Homeopatia , Humanos , Extratos Vegetais/uso terapêutico
16.
Altern Ther Health Med ; 27(S1): 158-161, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33711816

RESUMO

Background: Some studies have suggested the efficacy of homeopathic treatment for irritable bowel syndrome (IBS). Objective: The aim of this pilot study was to evaluate the efficacy of individualized homeopathic treatment in patients with IBS. Methods: The study was carried out at the National Homeopathic Hospital of the Secretary of Health, Mexico City, Mexico and included 41 patients: 3 men and 38 women, mean age 54 ± 14.89 years, diagnosed with IBS as defined by the Rome IV Diagnostic criteria. Single individualized medicine was prescribed for each patient, taking into account all presenting symptoms, clinical history, and personality via repertorization using RADAR Homeopathic Software (archibel, Isnes, Belgium). The homeopathic drugs were used at fifty-millesimal (LM) potency per the Mexican Homeopathic Pharmacopoeia starting with 0/1 and increasing every month (0/2, 0/3, 0/6). Severity scales were applied at the beginning of treatment and every month for 4 months of treatment. The evaluation was based on comparing symptom severity scales during treatment. Results: The results demonstrated that 100% of patients showed some improvement and 63% showed major improvement or were cured. The study showed a significant decrease in severity of symptom scores 3 months after treatment, with the pain score showing a decrease 1 month after treatment. The results highlight the importance of individualized medicine regimens using LM potency, although the early decrease in pain observed could also be due to the fact that Lycopodium clavatum and Nux vomica were the main homeopathic medicine prescribed, and these medicines contain many types of alkaloids, which have shown significant analgesic effects on pain caused by physical and chemical stimulation. Conclusion: This pilot study suggests that individualized homeopathic treatment using LM potencies benefits patients with IBS.


Assuntos
Homeopatia , Síndrome do Intestino Irritável , Materia Medica , Adulto , Idoso , Feminino , Humanos , Síndrome do Intestino Irritável/tratamento farmacológico , Masculino , Materia Medica/uso terapêutico , Pessoa de Meia-Idade , Projetos Piloto , Medicina de Precisão , Índice de Gravidade de Doença
17.
Homeopathy ; 110(3): 222-226, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-33662992

RESUMO

The recent questions about homeopathy raised by some sceptics have focused an awareness on this therapy and led different protagonists among the scientific community to seek a much-needed re-assessment. The inputs coming from external but benevolent experts will broaden the knowledge and the consciousness of the whole medical community, and more widely of the public, about the meaning and the value of homeopathy.Looking at this from the point of view of the human sciences gives a perspective on the universality of the philosophy that underlies homeopathic thinking, which is particularly visible in the methodological similarities between homeopathic provings and sociological or anthropological observations. It also explains how this view of health and care coincides with the expectations of the public, who no longer want a limited mechanical approach to the human body or more generally to the environment.The input to homeopathy of the human sciences, with their methodological tools and approaches, and highlighting the possibilities offered by mixed-methods research, could enable these notions to be heard and shared in the wider scientific community.


Assuntos
Homeopatia/normas , Homeopatia/métodos , Homeopatia/tendências , Humanos , Projetos de Pesquisa/normas , Projetos de Pesquisa/estatística & dados numéricos
18.
Homeopathy ; 110(3): 174-179, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-33662994

RESUMO

BACKGROUND: Artesunate (ATS) is a semi-synthetic compound derived from artemisinin, which is widely accepted in the treatment of malaria. However, there is evidence that ATS, under certain in vitro conditions, induces several impairments to normal cell functions. Canova (CA) is a Brazilian homeopathic formulation indicated for patients with depressed immune system. CA shows both in vitro and in vivo protective effects against mutagenic/carcinogenic compounds. Therefore, we aimed to assess in vitro the cytoprotective effects of CA against the cytotoxicity of ATS in Vero cells. METHODS: Viability of Vero cells exposed to ATS was assessed by MTT assay, whereas the anti-cytotoxic effect of CA was evaluated by apoptosis and necrosis quantification with fluorescent dyes. RESULTS: After 24 hours of ATS treatment, a reduction in cell viability was observed at 32 and 64 µg/mL, the latter being statistically significant (p < 0.05) in relation to the negative control. The concentration of 64 µg/mL was chosen for the subsequent experiments. ATS significantly induced both apoptosis and necrosis in Vero cells in relation to controls (p < 0.01). We also observed a statistically significant decrease in the number of apoptotic cells observed in the CA 16% + ATS co-treatment compared with ATS treatment (p < 0.01). Treatment with CA alone also had no influence on either type of cell death. CONCLUSION: Our results demonstrated that ATS is cytotoxic in the assessed conditions. However, such cytotoxicity was attenuated when the cells were treated simultaneously with ATS and CA.


Assuntos
Artesunato/farmacologia , Venenos de Crotalídeos/farmacologia , Citoproteção , Extratos Vegetais/farmacologia , Animais , Antimaláricos/farmacocinética , Antimaláricos/farmacologia , Antimaláricos/uso terapêutico , Artesunato/farmacocinética , Artesunato/uso terapêutico , Brasil , Morte Celular/efeitos dos fármacos , Chlorocebus aethiops , Venenos de Crotalídeos/farmacocinética , Homeopatia/métodos , Homeopatia/normas , Humanos , Extratos Vegetais/farmacocinética
19.
Homeopathy ; 110(2): 132-136, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33618380

RESUMO

Thromboinflammation is a still not well-understood phenomenon, which has recently come to the foreground as a function of its relevance in the pathophysiology of coronavirus disease 2019 (COVID-19). The patient described in the present case report exhibited acute fever, giant urticaria, elevated acute phase reactants, and very high d-dimer levels, thus characterizing thromboinflammation. She was diagnosed as a COVID-19 suspect case, which was not confirmed; urticarial vasculitis was ruled out. Homeopathic treatment was started with the earliest clinical manifestations, resulting in rapid and drastic reduction of inflammation and hypercoagulability within the first 12 hours, and full recovery on 10-day follow-up assessment. This case demonstrates the effectiveness of homeopathy in a severe acute disorder, and points to the need to include laboratory testing in homeopathic clinical assessment to achieve an accurate picture of disease, and to avoid the risk of passing over life-threatening disorders.


Assuntos
Venenos de Abelha/uso terapêutico , Abelhas , COVID-19/complicações , Homeopatia , Inflamação/terapia , Trombose/terapia , Idoso , Animais , Proteína C-Reativa/análise , Feminino , Febre/virologia , Produtos de Degradação da Fibrina e do Fibrinogênio/análise , Humanos , Inflamação/virologia , Trombose/virologia , Urticária/virologia
20.
Trials ; 22(1): 109, 2021 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-33522951

RESUMO

OBJECTIVES: To investigate the effectiveness and safety of homeopathic medicine Natrum muriaticum (LM2) for mild cases of COVID-19 in Primary Health Care. TRIAL DESIGN: A randomized, two-armed (1:1), parallel, placebo-controlled, double-blind, clinical trial is being performed to test the following hypotheses: H0: homeopathic medicines = placebo (null hypothesis) vs. H1: homeopathic medicines ≠ placebo (alternative hypothesis) for mild cases of COVID-19 in Primary Care. PARTICIPANTS: Setting: Primary Care of São Carlos - São Paulo - Brazil. One hundred participants aged 18 years or older, with Influenza-like symptoms and a positive RT-PCR for SARS-CoV-2. Willingness to give informed consent and to comply with the study procedures is also required. Exclusion criterium: severe acute respiratory syndrome. INTERVENTION AND COMPARATOR: Homeopathy: 1 globule of Natrum muriaticum LM2 diluted in 20 mL of alcohol 30% and dispensed in a 30 ml bottle. Placebo: 20 mL of alcohol 30% dispensed in a 30 ml bottle. Posology: one drop taken orally every 4 hours (6 doses/day) while there is fever, cough, tiredness, or pain (headache, sore throat, muscle aches, chest pain, etc.) followed by one drop every 6 hours (4 doses/day) until the fourteenth day of use. The bottle of study medication should be submitted to 10 vigorous shakes (succussions) before each dose. Posology may be changed by telemedicine, with no break in blinding. Study medication should be maintained during home isolation. According to the Primary Care protocol, the home isolation period lasts until the 10th day after the appearance of the first symptom, or up to 72 hours without symptoms. MAIN OUTCOMES: The primary endpoint will be time to recovery, defined as the number of days elapsed before all COVID-19 Influenza-like symptoms are recorded as mild or absent during home isolation period. Secondary measures are recovery time for each COVID-19 symptom; score of the scale created for the study (COVID-Simile Scale); medicines used during follow-up; number of days of follow-up; number of visits to emergency services; number of hospitalizations; other symptoms and Adverse Events during home isolation period. RANDOMISATION: The study Statistician generated a block randomization list, using a 1:1 ratio of the two groups (denoted as A and B) and a web-based tool ( http://www.random.org/lists ). BLINDING (MASKING): The clinical investigators, the statistician, the Primary Care teams, the study collaborators, and the participants will remain blinded from the identity of the two treatment groups until the end of the study. NUMBERS TO BE RANDOMISED (SAMPLE SIZE): One hundred participants are planned to be randomized (1:1) to placebo (50) or homeopathy (50). TRIAL STATUS: Protocol version/date May 21, 2020. Recruitment is ongoing. First participant was recruited/included on June 29,2020. Due to recruitment adaptations to Primary Care changes, the authors anticipate the trial will finish recruiting on April 10, 2021. TRIAL REGISTRATION: COVID-Simile Study was registered at the University Hospital Medical Information Network (UMIN - https://www.umin.ac.jp/ctr/index.htm ) on June 1st, 2020, and the trial start date was June 15, 2020. Unique ID: UMIN000040602. FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.


Assuntos
COVID-19/terapia , Homeopatia/métodos , Materia Medica/administração & dosagem , Atenção Primária à Saúde/métodos , SARS-CoV-2/genética , Cloreto de Sódio na Dieta/administração & dosagem , Administração Oral , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Brasil/epidemiologia , COVID-19/epidemiologia , COVID-19/virologia , Método Duplo-Cego , Feminino , Seguimentos , Homeopatia/efeitos adversos , Humanos , Masculino , Pessoa de Meia-Idade , Ensaios Clínicos Controlados Aleatórios como Assunto , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Resultado do Tratamento , Adulto Jovem
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