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1.
J Nepal Health Res Counc ; 19(2): 316-320, 2021 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-34601523

RESUMO

BACKGROUND: Complementary and Alternative Medicine is a group of diverse medical and health care practices and products that are not presently considered to be part of conventional medicine. The purpose of study was to assess the level of awareness and attitude of Complementary and Alternative medicine among middle aged adults and to find out the correlation between awareness and attitude. METHODS: A descriptive, correlational study design was carried out on 63 subjects through convenient sampling technique. Data was collected through face to face interview method among middle aged adults of Kirtipur municipality in Kathmandu by using Nepali version of structured set of questionnaire for all respondents. Data were entered using SPSS-20 and analyzed using descriptive statistics for socio-demographic and study variables, and inferential statistics namely Spearman Rank correlation coefficient was used to assess the relation between awareness and attitude regarding Complementary and Alternative medicine. RESULTS: Highest proportion (36.5%) of respondents was aged from 41-45 years. Majority (88.9%) of the respondents were literate. It was found that majority (71.4%) of the middle aged adults pose moderate knowledge and favorable attitude (93.7%) regarding complementary and alternative medicine, with negligible relationship between awareness and attitude(r=0.171). CONCLUSIONS: This study concluded that majority of the middle aged adults pose moderate knowledge and favorable attitude regarding complementary and alternative medicine, with negligible relationship between awareness and attitude.


Assuntos
Terapias Complementares , Conhecimento , Adulto , Instalações de Saúde , Humanos , Alfabetização , Pessoa de Meia-Idade , Nepal
2.
Cien Saude Colet ; 26(9): 4087-4099, 2021 Sep.
Artigo em Português, Inglês | MEDLINE | ID: mdl-34586262

RESUMO

This review aims to understand and analyse the effects of probiotics on depression, anxiety and psychological stress. These disorders are among the leading causes of disability worldwide. Conventional pharmacotherapies usually have a poor response or adverse side effects. In this context, recent studies have demonstrated a dense bi-directional communication named gut-brain axis. Evidences are demonstrating the relationship between disturbance in the enteric microbiome and psychiatric disorders, paving the way for the emergence of alternative therapies. A systematic search for randomized double/triple blind placebo-controlled clinical trials was performed in PubMed, Scopus and Lilacs. The studies selection followed the recommendations of the main items for report systematic reviews and meta-analyses (PRISMA). Nine articles met the criteria and were analysed for effects on depression, anxiety, psychological stress and biomarkers. Seven found positive results in at least one of the items. We concluded that the use of probiotics to alleviate depressive symptoms and anxiety is promising, mainly due to its potential anti-inflammatory effect, but additional and more rigorous double blind randomized clinical trials are necessary to endorse such conclusions.


Assuntos
Terapias Complementares , Probióticos , Ansiedade/terapia , Transtornos de Ansiedade/terapia , Depressão/terapia , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto
3.
Cien Saude Colet ; 26(9): 4217-4232, 2021 Sep.
Artigo em Português, Inglês | MEDLINE | ID: mdl-34586273

RESUMO

The Brazilian National Policy on Integrative and Complementary Practices (PNPIC) was published in 2006. Integrative mind-body practices are part of that policy and they are offered in Brazilian health care services. The concept of Integrative Mind-Body Practices is not consolidated in the literature and its use in government documents is imprecise. The article aimed at proposing a definition for that concept based on the experience of groups of Integrative Mind-Body Practices in Primary Health Care in Florianópolis, Brazil, as well as offering an alternative to the problems of registration and monitoring of the PNPIC. The methodology adopted was Grounded Theory (GT) in its interpretative and constructivist perspective, upon which a formal theory was developed. The data were produced through observations of the activities, conversations with professionals, and interviews with users of groups of Yoga, Lian Gong, Qi Gong, and Circular Dances. The data were coded, validated, and analyzed according to GT steps. The process of devising the concept resulted from the interconnection of the meanings ascribed by participants in contrast to the literature. This analysis enabled us to outline the phenomenon and propose a designation aligned with the PNPIC.


Assuntos
Terapias Complementares , Brasil , Humanos , Atenção Primária à Saúde
4.
Nursing ; 51(10): 62-68, 2021 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-34580266

RESUMO

ABSTRACT: This article discusses nonpharmacologic pain management interventions for alternative or concomitant use with nonopioid medications. Potential barriers as well as facilitators to integrating nonpharmacologic interventions are discussed as they relate to nursing practice.


Assuntos
Terapias Complementares/enfermagem , Manejo da Dor/enfermagem , Humanos , Manejo da Dor/métodos
5.
Int J Psychiatry Med ; 56(5): 334-343, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34521233

RESUMO

Depression is one of the most common mental health disorders and currently affects over 17 million Americans. Up to two-thirds of patients with depression in the United States will seek complementary and alternative or integrative medical treatments and thus medical providers who treat depression should understand that many integrative medical treatments have evidence of efficacy either as monotherapies or as add-on adjuncts to other treatments. This review references guidelines from the Canadian Network for Mood and Anxiety Treatments and Michigan Medicine, along with an updated literature review, to provide a framework for reviewing medications or herbal formulation, as well as other therapies, which have evidence in the treatment of depression. In general, St. John's Wort, Omega-3 Fatty Acids, S-adenosyl-L-methionine, and crocus sativus (saffron) have the highest levels of evidence in the treatment of mild-to-moderate depression. Acetyl-l-carnitine, l-methylfolate, DHEA, and lavender have a moderate level of evidence in treating depression, whereas Vitamin D, one of the most common supplements in the United States, does not have evidence in treating depression. Of the non-medication-based therapies, exercise, light therapy, yoga, acupuncture, and probiotics have evidence in the treatment of depression, whereas a full review of dietary modifications for depression was out of scope for this article.


Assuntos
Terapias Complementares , Transtorno Depressivo Maior , Hypericum , Medicina Integrativa , Canadá , Transtorno Depressivo Maior/tratamento farmacológico , Humanos , Estados Unidos
6.
Medicine (Baltimore) ; 100(38): e27217, 2021 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-34559113

RESUMO

BACKGROUND: In chronic obstructive pulmonary disease (COPD) management, greater emphasis has been placed on symptomatic improvement and enhanced quality of life in patients. Manual therapy among respiratory rehabilitation programs has received much attention recently, with the publication of numerous studies. In South Korea, a method known as Chuna Manual Therapy (CMT) has been applied in the management of COPD patients and in clinical practice, but the clinical basis for safety and effectiveness is yet to be established. Therefore, rigorously designed randomized controlled trials are required. We aimed to evaluate the feasibility of assessing the add-on effect and safety of CMT administered with standard Western medicine therapy for the treatment of COPD. METHODS: This is a randomized, single-blind, single-center clinical pilot trial. Patients with COPD receiving standard drug therapy are randomly divided into an experimental group (n = 20) and a control group (n = 20) at a 1:1 ratio. The experimental group receives CMT adding to the standard medical therapy once a week for 8 weeks. The control group receives only the standard drug treatment. The trial is conducted with an outcome assessor and statistician blinding. The primary outcome is the 6-minute walk test. The secondary outcomes include the pulmonary function test, the Modified Medical Research Council, visual analog scale for dyspnea, COPD assessment test, quality of life using the St. George's respiratory questionnaire, EuroQOL five dimensions questionnaire, and Korean pattern identification questionnaire. Adverse events are also be evaluated. CONCLUSIONS: The results of this study will provide the feasibility of a large-scale clinical trial to establish high-quality clinical evidence of CMT for COPD. TRIAL REGISTRATION: Korean Clinical Trial Registry (http://cris.nih.go.kr; registration number: KCT0006119).


Assuntos
Protocolos Clínicos , Terapias Complementares/normas , Medicina Tradicional Chinesa/normas , Terapias Complementares/métodos , Humanos , Medicina Tradicional Chinesa/métodos , Projetos Piloto , Qualidade de Vida/psicologia , Ensaios Clínicos Controlados Aleatórios como Assunto/métodos
7.
Niger J Clin Pract ; 24(9): 1307-1312, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34531342

RESUMO

Aim: The aim of this study was to investigate prevalence and pattern of self-medication with alternative medicine (ALM) among oral submucous fibrosis (OSF) patients with emphasis on treatment-switch analysis. Methods: A total of 115 OSF patients were recruited and subjected to scientifically validated questionnaire. Two groups were identified: S-ALM: patients who have previously received modern medicinal treatment but switched to ALM; and DN-ALM: patients who started ALM from De Novo. Results: A total of 37 (32.18%) patients reported use of the ALM at some point of time. Twenty-five (67.56%) switched to ALM, whereas 12 (32.43%) patients used ALM from De Novo. The pattern of switching to ALM in short period was significantly prevalent in patients with advanced stages (stage III and IV) as compared to early stages (stage I and II) of OSF. Clarified butter, glycerin, and honey were the most commonly used ALM in both the groups. The most common reasons for switching to ALM were the cost of treatment (32.00%), longer duration of medicinal treatment (24.00%) and ineffectiveness of the medications (24.00%). Conclusions: ALM usage is common in OSMF patients with significant percentage of patient switched from modern medicine to ALM. Therapeutic efficacy of ALM in OSF needs exploration in future.


Assuntos
Terapias Complementares , Fibrose Oral Submucosa , Humanos , Fibrose Oral Submucosa/tratamento farmacológico , Fibrose Oral Submucosa/epidemiologia , Prevalência , Automedicação , Inquéritos e Questionários
8.
Integr Cancer Ther ; 20: 15347354211043199, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34581221

RESUMO

BACKGROUND: Increasingly, patients with cancer are asking for additional, complementary therapy options for treating the side effects of oncological therapy. Thus, the members of the Breast and Bowel Center Nahe at the Sankt Marienwörth Hospital Bad Kreuznach decided to define the content of this type of counseling for patients before treatment. METHODS: In 2018, a team of internal oncologists, gynecological oncologists, radio-oncologists, nutritionists, psycho-oncologists, and study nurses met several times to define the content of counseling. To inform the team, an intensive literature review was conducted. RESULTS: Counseling content was determined for complementary treatment options for the most frequent side effects of oncological therapies. Counseling sessions were formulated as frontal lectures (slide presentations), given at regular intervals for patients and relatives. These lectures were highly appreciated by patients. CONCLUSION: These counseling sessions increased patient understanding of both useful complementary measures and harmful measures they should not use.


Assuntos
Terapias Complementares , Oncologistas , Aconselhamento , Hospitais , Humanos , Oncologia
9.
Enferm. foco (Brasília) ; 12(2): 237-243, set. 2021.
Artigo em Português | LILACS, BDENF - enfermagem (Brasil) | ID: biblio-1291240

RESUMO

Objetivo: descrever a utilização da Yoga no apoio ao aleitamento materno, a partir do olhar das nutrizes. Método: trata-se de um estudo exploratório, descritivo com abordagem qualitativa, com dez mulheres lactantes, do município de Niterói - RJ, no período entre maio e setembro de 2018, utilizando-se como ferramenta de produção dos dados a entrevista estruturada, oficina de Yoga e diário de campo. Os dados foram submetidos à análise de discurso na modalidade temática. Resultados: Foram identificadas três categorias: A Yoga como apoio emocional e físico para as mães; A assistência da equipe de saúde, e os significados da vivência durante o processo de parturição e amamentação; e A relação mãe-bebê como base para o bem-estar e segurança materna e continuidade da amamentação. Conclusão: identifica-se a convergência entre Yoga e aleitamento materno, uma vez que os processos fisiológicos e psíquicos se manifestam na saúde do corpo físico, interligados holisticamente. Os sentidos e emoções negativos, relatados no processo de aleitamento, foram minimizados com a utilização da Yoga como recurso terapêutico. (AU)


Objective: Describe the use of Yoga in breastfeeding support, from the perspective of nursing mothers. Methods: This is an exploratory, descriptive study with a qualitative approach, with ten lactating women, from the municipality of Niterói - RJ, in the period between May and September 2018, using the structured interview, workshop as data production tool Yoga and field diary. The data were submitted to discourse analysis in the thematic modality. Results: Three categories were identified: Yoga as emotional and physical support for mothers; The assistance of the health team, and the meanings of the experience during the parturition and breastfeeding process; and The mother-baby relationship as a basis for maternal well-being and continuity of breastfeeding. Conclusion: The convergence between Yoga and breastfeeding is identified, since the physiological and psychic processes are manifested in the health of the physical body, holistically interconnected. The senses and negative emotions, reported in the breastfeeding process were minimized with the use of yoga as a therapeutic resource. (AU)


Objetivo: Describir el uso del Yoga en apoyo de la lactancia materna, desde la perspectiva de las madres lactantes. Métodos: Se trata de un estudio exploratorio descriptivo con enfoque cualitativo, con diez mujeres lactantes, del municipio de Niterói - RJ, en el período comprendido entre mayo y septiembre de 2018, utilizando la entrevista estructurada, el taller como herramienta de producción de datos. Yoga y diario de campo. Los datos fueron sometidos a análisis del discurso en la modalidad temática. Resultados: Se identificaron tres categorías: Yoga como apoyo emocional y físico para las madres; La asistencia del equipo de salud y los significados de la experiencia durante el parto y el proceso de lactancia materna; y La relación madre-bebé como base para el bienestar materno y la seguridad y continuidad de la lactancia materna. Conclusión: Se identifica la convergencia entre el yoga y la lactancia, ya que los procesos fisiológicos y psíquicos se manifiestan en la salud del cuerpo físico, interconectados holísticamente. Los sentidos y las emociones negativas, informados en el proceso de lactancia, se redujeron al mínimo con el uso del yoga como recurso terapéutico. (AU)


Assuntos
Enfermagem , Terapêutica , Ioga , Terapias Complementares , Aleitamento Materno
10.
BMJ Open ; 11(8): e049039, 2021 08 25.
Artigo em Inglês | MEDLINE | ID: mdl-34433602

RESUMO

INTRODUCTION: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathy in women of reproductive age. Recently, moxibustion, as a complementary and alternative therapy, has been commonly used in assisted reproduction and improvement of metabolic abnormalities in patients with PCOS. Currently, intervention efficacy of the use of moxibustion in PCOS treatment still remains controversial due to lack of high-quality evidence. Consequently, this study protocol was designed to objectively review and evaluate the effectiveness and safety of moxibustion treatment for PCOS. METHODS AND ANALYSIS: Electronic searches will be carried out from inception to May 2021 in the online databases of The Cochrane Library, PubMed, EMBASE, Chinese Biomedical Literature, Chongqing VIP Chinese Science and Technology Periodical Database (VIP) and China National Knowledge Infrastructure. The Chinese Clinical Trial Registry Center and Clinical Trials will be used for searching ongoing trials. Randomised controlled trials and the first period in randomised cross-over trials involving any type of moxibustion for patients with PCOS will be included. Primary outcomes will be the ovulation rate, pregnancy rate and sex hormone levels, and secondary outcomes will be changes in clinical symptoms and metabolic indicators, total effective rate and the incidences of side effects and adverse events. Briefly, two reviewers will independently conduct study selection and data extraction, and the risk of bias will be assessed. Prior to the formal meta-analysis, the heterogeneity of included studies will be assessed. Review Manager Statistical Software (RevMan) V.5.3 will be used for data processing. Finally, the Grading of Recommendations Assessment, Development and Evaluation method will be applied to evaluate the quality of evidence. ETHICS AND DISSEMINATION: Ethical approval is not necessary since this study is designed as a systematic review. This study will be disseminated by a peer-review journal or conference presentation.


Assuntos
Terapias Complementares , Moxibustão , Síndrome do Ovário Policístico , Feminino , Humanos , Metanálise como Assunto , Ovulação , Síndrome do Ovário Policístico/terapia , Gravidez , Taxa de Gravidez , Projetos de Pesquisa , Revisões Sistemáticas como Assunto
11.
Medicine (Baltimore) ; 100(31): e26678, 2021 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-34397800

RESUMO

BACKGROUND: Although nonpharmacological therapies are recommended as first-line treatments for insomnia, they do not widely implement in practice owing to costly or time-consuming. As a result, pharmacotherapy remains to be commonly prescribed for patients with the sleep disorder. Pharmacotherapy for insomnia consists of different types of drugs. Few studies focused on comprehensively evaluating all available drugs for insomnia. Our review aims to compare efficacy and safety of pharmacological and nonpharmacological treatments by synthesizing direct evidence and indirect evidence to help clinicians and patients make informed decisions for insomnia. METHODS: We will search the MEDLINE, EMBASE, and Cochrane Register of Controlled Trials between January 2000 and June 12, 2021. Randomized controlled trials of pharmacological and nonpharmacological interventions for insomnia will be included. Study quality will be assessed on the basis of the methodology and categories described in the Cochrane Collaboration Handbook. Eight network meta-analyses were conducted. A Bayesian network meta-analysis would be performed, and relative ranking of agents would be assessed. A node splitting method will be used to examine the inconsistency between direct and indirect comparisons when a loop connecting 3 arms exists. RESULTS: The results of this paper will be submitted to a peer-reviewed journal for publication. CONCLUSION: The conclusion of our study will provide updated evidence to rank the effectiveness and safety of pharmacological and nonpharmacological interventions for insomnia. ETHICS AND DISSEMINATION: Ethical approval is not applicable, as this study is a network meta-analysis based on published trials. INPLASY REGISTRATION NUMBER: INPLASY202160031.


Assuntos
Distúrbios do Início e da Manutenção do Sono/terapia , Antidepressivos/uso terapêutico , Benzodiazepinas/uso terapêutico , Depressores do Sistema Nervoso Central/uso terapêutico , Terapia Cognitivo-Comportamental , Terapias Complementares , Medicamentos de Ervas Chinesas/uso terapêutico , Antagonistas dos Receptores Histamínicos/uso terapêutico , Humanos , Melatonina/uso terapêutico , Metanálise como Assunto , Projetos de Pesquisa , Revisões Sistemáticas como Assunto
12.
AORN J ; 114(3): P17, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34436768
13.
Int J Mol Sci ; 22(16)2021 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-34445518

RESUMO

From all types of cancer, cervical cancer manages to be in top four most frequent types, with a 6.5% rate of occurrence. The infectious vector that induces the disease, the high-risk Human papillomavirus (HPV), which is a sexually transmitted virus, is capable of transforming the host cell by modulating some of the principal signaling pathways responsible for cell cycle arrest, proliferation, and survival. Fortunately, like other cancer types, cervical cancer can be treated by chirurgical interventions or chemoradiotherapy, but these methods are not exactly the lucky clover of modern medicine because of the adverse effects they have. That is the reason why in the last years the emphasis has been on alternative medicine, more specifically on phytochemicals, as a substantial number of studies showed that diet contributes to cancer prevention and treatment. All these studies are trying to find new chemopreventive agents with less toxicity but high effectiveness both in vitro and in vivo. The aim of this review is to evaluate the literature in order to underline the advantages and disadvantages of polyphenols, a class of dietary compounds, as chemopreventive and chemotherapeutic agents. This review also aims to present polyphenols from different perspectives, starting with mechanisms of action and ending with their toxicity. The bigger picture illustrates that polyphenols have great potential in cervical cancer prevention, with strong effects on gene modulation.


Assuntos
Compostos Fitoquímicos/uso terapêutico , Polifenóis/uso terapêutico , Neoplasias do Colo do Útero/prevenção & controle , Terapias Complementares , Feminino , Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos , Humanos , Compostos Fitoquímicos/farmacologia , Polifenóis/farmacologia , Neoplasias do Colo do Útero/genética
14.
Medicine (Baltimore) ; 100(34): e27005, 2021 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-34449470

RESUMO

BACKGROUND: Knee osteoarthritis (KOA) is a common chronic joint disease with serious health economic burden. More and more randomized controlled trials have indicated that traditional Chinese non-pharmacological therapy, including acupuncture, Tai Chi, Tuina, etc can significantly improve pain and physical function of patients with KOA. However, the effects of traditional Chinese non-pharmacological therapy for KOA remain controversial. Most previous systematic reviews did not focus on the effects of traditional Chinese non-pharmacological therapy for KOA as a whole. In Chinese community hospital, however, acupuncture, Tuina, and Tai Chi are usually in the management of KOA as whole-body treatment. METHODS: The electronic databases (PubMed, Embase, MEDLINE, Cochrane Central Register of Controlled Trials, Web of Science, China Knowledge Resource Integrated Database, and Wanfang Data) will be searched. The search will include all documents from their inception to December 2021. Two reviewers independently extracted the data and assessed the risk of bias by the Cochrane Risk of Bias Tool for randomized controlled trials. The meta-analysis will be conducted with a random or fixed effect model to calculate the standardized mean difference and 95% confidence intervals based on different heterogeneity using the Review Manager Version 5.3 software. The heterogeneity will be examined by Higgins I2 statistic. The subgroup analysis will be conducted based on different types of traditional Chinese non-pharmacological therapy and different outcomes. Quality of evidence will be assessed using the Grades of Recommendation, Assessment, Development and Evaluation. RESULTS: The current systematic review and meta-analysis will be conducted to investigate the effects of traditional Chinese non-pharmacological therapy in the management of KOA. The main outcomes will include pain and disability. The secondary outcomes will include quality of life and adverse events. CONCLUSION: To provide evidence for evidence-based medicine and clinical researchers to choose more effective traditional Chinese non-pharmacological therapy for KOA. INPLASY REGISTRATION NUMBER: INPLASY202170098.


Assuntos
Terapias Complementares/métodos , Medicina Tradicional Chinesa/métodos , Osteoartrite do Joelho/terapia , Terapias Complementares/efeitos adversos , Medicina Tradicional Chinesa/efeitos adversos , Qualidade de Vida , Ensaios Clínicos Controlados Aleatórios como Assunto , Projetos de Pesquisa
15.
Medicine (Baltimore) ; 100(32): e26864, 2021 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-34397897

RESUMO

BACKGROUND: Lung cancer is one of the most common cancers, the symptoms and treatment of which can cause negative emotions like anxiety, depression, and cancer-related fatigue (CRF). Nonpharmacological interventions, serving as alternative therapies, can greatly alleviate CRF in lung cancer patients. Previous meta-analyses have reported nonpharmacological interventions of CRF in lung cancer patients, but the results may be conflicting, and the reporting and methodological qualities remain unknown. Moreover, there is limited evidence to identify efficient and safe non-pharmacological interventions of CRF in lung cancer patients. This study aims to assess the therapeutic efficacy of nonpharmacological interventions of CRF in lung cancer patients through a network meta-analysis. METHODS: Relevant literatures reporting non-pharmacological interventions of CRF in lung cancer patients published before June 2021 will be searched in online databases, including Wanfang, VP Information Chinese Journal Service Platform, China National Knowledge Infrastructure, Chinese BioMedicine Literature Database, PubMed, Embase, Cochrane, and Web of science. Two reviewers will be independently responsible for study selection, quality appraisal, and data extraction. Data analysis will be performed using the STATA14.0 and GEMTC 0.14.3 software. RESULTS: This meta-analysis will provide additional and stronger evidences for nonpharmacological interventions of CRF in lung cancer patients. Our findings will be conductive to make therapeutic decisions by clinicians. CONCLUSION: This study will provide a reliable evidence-based basis for non-pharmacological interventions of CRF in lung cancer patients. ETHICS AND DISSEMINATION: Ethical approval was not required for this study. The systematic review will be published in a peer-reviewed journal, presented at conferences, and shared on social media platforms. This review would be disseminated in a peer-reviewed journal or conference presentations. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/QRY42.


Assuntos
Terapias Complementares/métodos , Fadiga , Neoplasias Pulmonares , Qualidade de Vida , Prática Clínica Baseada em Evidências , Fadiga/etiologia , Fadiga/terapia , Humanos , Neoplasias Pulmonares/fisiopatologia , Neoplasias Pulmonares/psicologia , Neoplasias Pulmonares/terapia , Metanálise em Rede , Projetos de Pesquisa
16.
Molecules ; 26(13)2021 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-34279434

RESUMO

Respiratory tract infections are underestimated, as they are mild and generally not incapacitating. In clinical medicine, however, these infections are considered a prevalent problem. By 2030, the third most comprehensive reason for death worldwide will be chronic obstructive pulmonary disease (COPD), according to the World Health Organization. The current arsenal of anti-inflammatory drugs shows little or no benefits against COPD. For thousands of years, herbal drugs have been used to cure numerous illnesses; they exhibit promising results and enhance physical performance. Ginseng is one such herbal medicine, known to alleviate pro-inflammatory chemokines and cytokines (IL-2, IL-4, IFN-γ, TNF-α, IL-5, IL-6, IL-8) formed by macrophages and epithelial cells. Furthermore, the mechanisms of action of ginsenoside are still not fully understood. Various clinical trials of ginseng have exhibited a reduction of repeated colds and the flu. In this review, ginseng's structural features, the pathogenicity of microbial infections, and the immunomodulatory, antiviral, and anti-bacterial effects of ginseng were discussed. The focus was on the latest animal studies and human clinical trials that corroborate ginseng's role as a therapy for treating respiratory tract infections. The article concluded with future directions and significant challenges. This review would be a valuable addition to the knowledge base for researchers in understanding the promising role of ginseng in treating respiratory tract infections. Further analysis needs to be re-focused on clinical trials to study ginseng's efficacy and safety in treating pathogenic infections and in determining ginseng-drug interactions.


Assuntos
Ginsenosídeos/farmacologia , Panax/química , Fitoterapia/métodos , Infecções Respiratórias/tratamento farmacológico , Animais , Terapias Complementares , Humanos
18.
Anticancer Res ; 41(7): 3233-3246, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34230117

RESUMO

BACKGROUND/AIM: Upper limb breast cancer-related lymphedema (BCRL) is a chronic and severe condition affecting a significant percentage of breast cancer survivors. Even though its physiopathology is well-known, there is no worldwide consensus on BCRL evaluation and a gold-standard treatment. This narrative review aims at providing a brief descriptive overview with regard to BCRL treatment modalities. MATERIALS AND METHODS: We conducted a literature search within the PubMed database, and 33 articles out of 56 were selected, including reviews, systematic reviews, and meta-analyses aiming find the most updated evidence regarding BCRL treatment modalities. RESULTS: Physical exercise (aerobic exercise, resistance exercise, aquatic therapy), bandages, and intermittent pneumatic compression were shown to be most effective in BCRL patients, in terms of swelling reduction in the acute-intensive phase. Furthermore, physical exercise was beneficial also as a maintenance tool. Manual lymphatic drainage demonstrated efficacy in preventing secondary lymphedema if applied immediately after breast cancer surgery or in early phases of BCRL or as a maintenance tool. Complementary procedures such as acupuncture, reflexology, yoga and photo-biomodulation therapy did not show conclusive results in BCRL treatment. Surgery was shown effective in managing symptoms (liposuction), preventing (lymphaticovenular anastomosis) and treating BCRL (vascularized lymph node transfer). CONCLUSION: BCRL is still a challenging condition either for breast cancer survivors and clinicians, deeply impacting patient functioning and quality of life. Due to the lack of globally accepted criteria in evaluating BCRL, to date a gold standard treatment for this widespread issue is still needed.


Assuntos
Linfedema Relacionado a Câncer de Mama/terapia , Neoplasias da Mama/cirurgia , Linfedema Relacionado a Câncer de Mama/fisiopatologia , Neoplasias da Mama/fisiopatologia , Terapias Complementares/métodos , Exercício Físico/fisiologia , Feminino , Humanos , Sobreviventes
19.
Molecules ; 26(11)2021 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-34198728

RESUMO

Bee products are sources of functional food that have been used in complementary medicine to treat a variety of acute and chronic illnesses in many parts of the world. The products vary from location to location as well as country to country. Therefore, the aim of this review was to identify various bee products with potential preventive and therapeutic values used in the treatment of male reproductive impairment. We undertook a vigorous search for bee products with preventive and therapeutic values for the male reproductive system. These products included honey, royal jelly, bee pollen, bee brood, apilarnil, bee bread, bee wax, and bee venom. We also explained the mechanisms involved in testicular steroidogenesis, reactive oxygen species, oxidative stress, inflammation, and apoptosis, which may cumulatively lead to male reproductive impairment. The effects of bee pollen, bee venom, honey, propolis, royal jelly, and bee bread on male reproductive parameters were examined. Conclusively, these bee products showed positive effects on the steroidogenic, spermatogenic, oxidative stress, inflammatory, and apoptotic parameters, thereby making them a promising possible preventive and therapeutic treatment of male sub/infertility.


Assuntos
Abelhas/química , Fatores Biológicos/uso terapêutico , Infertilidade Masculina/tratamento farmacológico , Animais , Fatores Biológicos/farmacologia , Terapias Complementares , Humanos , Infertilidade Masculina/metabolismo , Masculino , Estresse Oxidativo/efeitos dos fármacos
20.
Science ; 373(6551): 157, 2021 07 09.
Artigo em Inglês | MEDLINE | ID: mdl-34244396
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