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The topical treatment of old world cutaneous leishmaniasis with gentian violet along with cryotherapy: a pilot single-blind randomized controlled clinical trial
Sepaskhah, Mozhdeh; Behdad, Kasra; Bagheri, Zahra.
Afiliação
  • Sepaskhah, Mozhdeh; Shiraz University of Medical Sciences. Molecular Dermatology Research Center. Shiraz. IR
  • Behdad, Kasra; Shiraz University of Medical Sciences. Molecular Dermatology Research Center. Shiraz. IR
  • Bagheri, Zahra; Shiraz University of Medical Sciences. Department of Biostatistics. Shiraz. IR
Rev. Soc. Bras. Med. Trop ; 52: e20180278, 2019. tab, graf
Article em En | LILACS | ID: biblio-1041586
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

INTRODUCTION:

The promising non-clinical antileishmanial effects of gentian violet (GV) encouraged us to evaluate the additive effect of GV on cryotherapy.

METHODS:

For 8 weeks, 59/161 cutaneous leishmaniasis patients/lesions underwent cryotherapy alone (group 1) or cryotherapy accompanied by 1% GV application (group 2). The primary endpoint was clinical response.

RESULTS:

Ultimately, 54.7% and 45.3% of the significantly cured lesions belonged to groups 1 and 2, respectively, which was not statistically significant. The clinical response was significantly different between the two groups at the end of the fourth week.

CONCLUSIONS:

Although the clinical response of the two groups was significantly different at the end of the fourth week, application of GV did not increase the efficacy of cryotherapy.
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Texto completo: 1 Base de dados: LILACS Assunto principal: Leishmaniose Cutânea / Crioterapia / Violeta Genciana / Anti-Infecciosos Locais Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: LILACS Assunto principal: Leishmaniose Cutânea / Crioterapia / Violeta Genciana / Anti-Infecciosos Locais Idioma: En Ano de publicação: 2019 Tipo de documento: Article