Effects of childhood trauma on BDNF and TBARS during crack-cocaine withdrawal
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 42(2): 214-217, Mar.-Apr. 2020. tab, graf
Article
em En
| LILACS
| ID: biblio-1089244
Biblioteca responsável:
BR1.1
ABSTRACT
Objective:
To evaluate the association between childhood trauma (CT) and serum levels of brain-derived neurotrophic factor (BDNF) and thiobarbituric acid-reactive substances (TBARS) during crack-cocaine withdrawal.Method:
Thirty-three male crack-cocaine users were recruited at admission to a public addiction treatment unit. Serum BDNF and TBARS levels were evaluated at intake and discharge. Information about drug use was assessed by the Addiction Severity Index-6th Version (ASI-6); CT was reported throughout the Childhood Trauma Questionnaire (CTQ). CTQ scores were calculated based on a latent analysis model that divided the sample into low-, medium-, and high-level trauma groups.Results:
There was a significant increase in BDNF levels from admission to discharge, which did not differ across CT subgroups. For TBARS levels, we found a significant time vs. trauma interaction (F2,28 = 6.357, p = 0.005,ηp 2 = 0.312). In participants with low trauma level, TBARS decreased, while in those with a high trauma level, TBARS increased during early withdrawal.Conclusion:
TBARS levels showed opposite patterns of change in crack-cocaine withdrawal according to baseline CT. These results suggest that CT could be associated with more severe neurological impairment during withdrawal.Palavras-chave
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Base de dados:
LILACS
Assunto principal:
Síndrome de Abstinência a Substâncias
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Substâncias Reativas com Ácido Tiobarbitúrico
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Fator Neurotrófico Derivado do Encéfalo
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Transtornos Relacionados ao Uso de Cocaína
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Adultos Sobreviventes de Eventos Adversos na Infância
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article