Adherence to levothyroxine prescription in patients with hypothyroidism / Adherencia al uso de levotiroxina en pacientes con hipotiroidismo
Rev. méd. Chile
; 148(6): 740-745, jun. 2020. tab
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| ID: biblio-1139366
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ABSTRACT
ABSTRACT Background:
Hypothyroidism occurs in 1-2% of the general population, is associated with significant morbidity and requires continuous treatment with levothyroxine.Aim:
To determine the effectiveness, adherence and safety of levothyroxine therapy in patients with hypothyroidism. Material andMethods:
The Morisky-Green adherence test was applied, and effectiveness was determined by measuring thyroid-stimulating hormone (TSH) in 330 patients with with hypothyroidism; the mean age was 64+-15 years and 76% was women.Results:
Median TSH was 2.09 mIU/L (interquartile range 1.16-3.61 mIU/L). Two hundred thirty-five (71%) patients had TSH levels in the euthyroid range, 64 (19%) in the hypothyroid range and 31 (9%) in the hyperthyroid range. Complete, moderate and lack of adherence with levothyroxine was reported in 283 (86%), 29 (9%) and 18 (5%) of patients, respectively. The presence of anemia (odds ratio (OR) 0.37, 95% confidence intervals (CI) 0.15-0.98) or the need of doses over 100 µg/day (OR 0.47, 95%CI 0.28-0.80) increased the probability of having an abnormal TSH level.Conclusions:
In a large proportion of these patients, TSH levels were controlled, and most patients were adherent to levothyroxine therapy.RESUMEN
Antecedentes El hipotiroidismo se presenta entre el 1-2% de la población general, genera importante morbilidad y requiere tratamiento con levotiroxina de manera continua. Objetivo:
Determinar la efectividad, adherencia y seguridad de la terapia con levotiroxina en pacientes con hipotiroidismo. Material yMétodos:
Se aplicó test de adherencia de Morisky-Green y se determinó efectividad mediante medición de TSH en 330 pacientes con edad promedio 63 ± 15 años (76% mujeres).Resultados:
La mediana de TSH fue 2,09 mUI/l, (rango intercuartílico 1,16mUI/l-3,61mUI/l). Un total de 235 (71,2%) tenían cifras de TSH en rango de estado eutiroideo, 64 (19,4%) se catalogaron hipotiroideos y 31 (9,4%) hipertiroideos. El 86% (n = 283) manifestó tener adherencia completa al medicamento, 29 (9%) moderada y 18 (5%) se clasificaron poco adherentes. Tener diagnóstico de anemia (razón de riesgo (RR) 0,37; intervalos de confianza (IC) 95% 0,15-0,98) o necesitar dosis mayores de 100 µg/día (RR 0,47; IC95% 0,28-0,80) elevaron la probabilidad de no controlar el hipotiroidismo. Conclusiones. Una alta proporción de pacientes se encuentran controlados y con mucha frecuencia son adherentes a la terapia con levotiroxina.Palavras-chave
Texto completo:
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Base de dados:
LILACS
Assunto principal:
Tiroxina
/
Hipertireoidismo
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article