Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men
Braz. j. med. biol. res
; 55: e12110, 2022. tab, graf
Article
em En
|
LILACS-Express
| LILACS
| ID: biblio-1384141
Biblioteca responsável:
BR1.1
ABSTRACT
In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21% O2) and 10-min hyperoxia trials (100% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia 4.16±0.85 vs normoxia 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia 8.40±3.84 vs normoxia 5.73±2.15 pg/mL, P=0.04) increased, whereas matrix metalloproteinase (MMP-9) activity (hyperoxia 0.53±0.11 vs normoxia 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100% oxygen may affect endothelial activation and vascular remodeling.
Texto completo:
1
Base de dados:
LILACS
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article