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Novel sustained-release of Stryphnodendron obovatum leaves extract using natural rubber latex as carrier
Borges, Felipe Azevedo; Siguematsu, Paula Ratsue; Herculano, Rondinelli Donizetti; Santos, Catarina dos.
Afiliação
  • Borges, Felipe Azevedo; Universidade Estadual Paulista (UNESP). Departamento de Ciências Biológicas. Assis. BR
  • Siguematsu, Paula Ratsue; Universidade Estadual Paulista (UNESP). Departamento de Ciências Biológicas. Assis. BR
  • Herculano, Rondinelli Donizetti; Universidade Estadual Paulista (UNESP). Departamento de Ciências Biológicas. Assis. BR
  • Santos, Catarina dos; Universidade Estadual Paulista (UNESP). Departamento de Ciências Biológicas. Assis. BR
Rev. ciênc. farm. básica apl ; 36(3): 379-384, 01/07/2015. tab, ilus
Artigo em Inglês | LILACS | ID: biblio-2564
Biblioteca responsável: BR1851.9
ABSTRACT
Natural rubber latex biomembranes (NRL), obtained from rubber tree Hevea brasiliensis (Willd. ex A. Juss.) Mull. Arg., have been used as sustained drug release of drugs and plant extracts with medicinal properties. The Stryphnodendron obovatum Bench (Fabaceae), popularly known as "barbatimão" has anti-inflammatory and healing properties already described in literature. Thus, the aim of this work were to study the release behavior of the hydroethanolic extract from the leaves of S. obovatum loaded in the NRL by ultraviolet­visible spectroscopy (UV-VIS). The release followed a biexponential pattern and the mechanism of release was Super Case II (n > 1). FTIR analyses did not show reaction between NRL and extract, only intermolecular interaction. From SEM was possible to observe the extract at the surface, responsible for the initial fast release, which the concentrations at 5.0 mg/mL released 2.4% and at 0.1 mg/mL released 96.8%; both reached the plateau in 7 days.
Assuntos
Texto completo: Disponível Base de dados: LILACS Assunto: Borracha / Taninos / Stryphnodendron barbatimam Idioma: Inglês Revista: Rev. ciênc. farm. básica apl Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: Disponível Base de dados: LILACS Assunto: Borracha / Taninos / Stryphnodendron barbatimam Idioma: Inglês Revista: Rev. ciênc. farm. básica apl Ano de publicação: 2015 Tipo de documento: Artigo