Changes in serum cardiac myosin light chain 1 levels in children with fulminant myocarditis during continuous blood purification
Rev. Assoc. Med. Bras. (1992, Impr.)
; 63(10): 904-909, Oct. 2017. tab, graf
Article
em En
| LILACS
| ID: biblio-896298
Biblioteca responsável:
BR1.1
ABSTRACT
Summary Objective:
To investigate the changes in serum cardiac myosin light chain 1 (CMLC-1) levels in children with fulminant myocarditis (FM) during continuous blood purification (CBP), as well as to analyze its correlation with other laboratory indexes.Method:
Twenty-four (24) children with FM who underwent CBP were enrolled. Before and during treatment (48 and 72 hours after treatment, or death), the optical density value of serum CMLC-1 was measured using enzyme-linked immunosorbent assay, and then the serum CMLC-1 concentration was calculated. The correlations between CMLC-1 OD value change and laboratory indexes including creatine kinase-MB (CK-MB), troponin, myohemoglobin and N-terminal pro-brain natriuretic peptide (NT-proBNP) were analyzed.Results:
The serum CMLC-1 concentration significantly increased in the children with FM and decreased obviously during CBP therapy. In the same period, the change of CMLC-1 concentration were positively correlated with creatine kinase-MB (r=0.528), troponin (r=0.726), myohemoglobin (r=0.702), and NT-proBNP levels (r=0.589).Conclusion:
The serum CMLC-1 concentration increases significantly in children with FM, but CBP therapy can effectively control this increase.Palavras-chave
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Hemofiltração
/
Cadeias Leves de Miosina
/
Miocardite
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article