Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study
Clinics
; 74: e739, 2019. tab
Article
em En
| LILACS
| ID: biblio-989646
Biblioteca responsável:
BR1.1
ABSTRACT
OBJECTIVE:
In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated.METHOD:
DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method.RESULT:
At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study.CONCLUSION:
There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population.Palavras-chave
Texto completo:
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Base de dados:
LILACS
Assunto principal:
Polimorfismo Genético
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Osteoporose Pós-Menopausa
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Fraturas da Coluna Vertebral
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Fraturas por Osteoporose
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Vitamina K Epóxido Redutases
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article