Antileishmanial agents: synthesis of allopurinol prodrugs for oral administration
Rev. farm. bioquim. Univ. Säo Paulo
; 31(2): 71-8, jul.-dez. 1995. ilus, tab
Article
em En
| LILACS
| ID: lil-162575
Biblioteca responsável:
BR40.1
ABSTRACT
Synthesis of six prodrugs of allopurinol (4-hydroxypyrazolo-(3,4-d)pyrimidine) is described. These compounds were given orally to male and female BALB/C (sensitive) and C57BL/6 (partially resistant) strains of mice, wich had been previously infected with Leishmania mexicana. The results show that at end of the treatment there was weak regression of lesions confirmed through measurement of nodule diameter in the infected animals
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Base de dados:
LILACS
Assunto principal:
Pró-Fármacos
/
Leishmaniose
/
Alopurinol
/
Administração Oral
/
Bases de Mannich
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article