Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection
Braz. j. med. biol. res
; 32(2): 235-9, feb. 1999. ilus, tab, graf
Article
em En
| LILACS
| ID: lil-228266
Biblioteca responsável:
BR1.1
ABSTRACT
Trypanosoma cruzi, the protozoan parasite that causes Chagas' disease, does not synthesize sialic acid, but expresses a trans-sialidase (TS) that catalyzes the transfer of sialic acid from host glycoconjugates to the parasite surface. Here, we review studies that characterize the immune response to the catalytic domain of the enzyme in humans during Chagas' disease or in mice following immunization with the TS gene. In both cases, there are antibodies that strongly inhibit the enzymatic activity and generation of interferon-g-producing T cells
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Trypanosoma cruzi
/
Doença de Chagas
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Vacinas de DNA
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Neuraminidase
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article
/
Congress and conference