Síndrome de Cushing por secreción ectópica de ACTH: análisis del mecanismo fisiopatológico de la hipokalemia: comunicación de dos casos / Cushing syndrome with severe hipokalemia caused by ectopic ACTH secretion: report of two cases
Rev. méd. Chile
; 127(3): 332-6, mar. 1999. graf
Article
em Es
| LILACS
| ID: lil-243799
Biblioteca responsável:
CL1.1
ABSTRACT
We report a 42 years old male and a 66 years old female with a Cushing syndrome caused by ectopic ACTH secretion secondary to a carcinoid tumor. These patients had both severe hypokalemia, resistant to medical treatment and that subsided with bilateral adrenalectomy and supplementation with dexametasone. Cushing syndrome caused by ectopic ACTH secretion is characterized by a severe and rapidly evolving hypercortisolism. Hypokalemia is present in 90 percent of cases and is probably caused by a defect in 11 ß hydroxysteroid dehydrogenase, that limits the binding of cortisol to aldosterone receptor, metabolizing it to cortisone. Therefore, this alteration will increase the mineralocorticoid action of cortisol
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Base de dados:
LILACS
Assunto principal:
Hormônio Adrenocorticotrópico
/
Síndrome de Cushing
/
Hipopotassemia
Idioma:
Es
Ano de publicação:
1999
Tipo de documento:
Article