Efecto de la vitamina E, DL alfa-tocoferol, sobre el daño cromosómico en linfocitos de pacientes con ataxia telangiectasia / Effect of vitamin E, DL alfa-tocopherol, on chromosomal damage in lymphocytes from patients with ataxia telangiectasia
Rev. méd. Chile
; 130(9): 957-963, sept. 2002. tab
Article
em Es
| LILACS
| ID: lil-323228
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
In ataxia telangiectasia (A-T), the lack of a functional ATM kinase is associated with disturbances in the processing of DNA damage and a chronic oxidative stress. These disturbances may be responsible for an increment of chromosomal damage in A-T cells.Aim:
To study the in vitro effect of vitamin E (DL-a-tocopherol) on the frequency of chromosomal damage of lymphocytes from patients with A-T. Patients andmethods:
Seven patients with A-T and age-sex matched controls were studied. Chromosomal damage in mitosis was evaluated in lymphocytes cultures both under basal conditions and when G2 repair was prevented by 5 mM caffeine.Results:
In cells from patients with A-T, vitamin E induced a 57.1 and 47.9 percent decrease in chromosomal damage under basal and inhibited G2 repair conditions, respectively. However, there was a non significant improvement in their repair activity. Vitamin E effects on chromosomal damage was not significant in control subjects.Conclusions:
Vitamin E reduces chromosomal damage in lymphocytes from patients with ataxia telangiectasia
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Vitamina E
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Técnicas In Vitro
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Ataxia Telangiectasia
Idioma:
Es
Ano de publicação:
2002
Tipo de documento:
Article
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Project document