The secondary alcohol and aglycone metabolites of doxorubicin alter metabolism of human erythrocytes
Braz. j. med. biol. res
; 36(12): 1643-1651, Dec. 2003. ilus, tab
Article
em En
| LILACS
| ID: lil-350464
Biblioteca responsável:
BR1.1
RESUMO
Anthracyclines, a class of antitumor drugs widely used for the treatment of solid and hematological malignancies, cause a cumulative dose-dependent cardiac toxicity whose biochemical basis is unclear. Recent studies of the role of the metabolites of anthracyclines, i.e., the alcohol metabolite doxorubicinol and aglycone metabolites, have suggested new hypotheses about the mechanisms of anthracycline cardiotoxicity. In the present study, human red blood cells were used as a cell model. Exposure (1 h at 37ºC) of intact human red blood cells to doxorubicinol (40 µM) and to aglycone derivatives of doxorubicin (40 µM) induced, compared with untreated red cells...
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Via de Pentose Fosfato
/
Doxorrubicina
/
Eritrócitos
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Antibióticos Antineoplásicos
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article