Factor V Leiden y mutación de la protrombina G20210A en pacientes con trombosis venosa y arterial / Factor V Leiden and prothrombin G20210A among Chilean patients with venous and arterial thrombosis
Rev. méd. Chile
; 133(12): 1425-1433, dic. 2005. ilus, tab
Article
em Es
| LILACS
| ID: lil-428525
Biblioteca responsável:
BR1.1
RESUMO
Background:
Factor V Leiden and G20210A mutation of prothrombin gene are two important genetic polymorphisms associated with an increased risk for thrombosis.Aim:
To establish the prevalence of factor V Leiden and prothrombin G20210A mutation in the Chilean population and their association to venous and arterial thromboembolism. Material andmethods:
A case-control study was conducted where 149 patients with thrombosis (87 with arterial and 62 with venous thrombosis) confirmed by CAT-scan, electrocardiogram and cardiac enzymes or Doppler depending on the case, and 160 healthy blood donors were genetically analyzed for the presence of both polymorphisms.Results:
Factor V Leiden mutation was found in 5.4% of patients and in 1.3% of healthy controls (p=0.04). Heterozygosity for G20210A prothrombin mutation was found in 5.4% of patients and in 2.5% of the control group (p=NS). When arterial and venous thrombosis were considered as separate entities, 4.6% of patients with arterial thrombosis and 6.5% with venous thrombosis presented factor V Leiden (p=NS). Likewise, 8.1% of patients with venous thrombosis and 3.5% of patients with arterial thrombosis had G20210A prothrombin mutation (p=NS).Conclusions:
In non selected consecutive Chilean patients with arterial and venous thrombosis the frequency of factor V Leiden and prothrombin G20210A is less than we could expect from their prevalence in the general population.
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Polimorfismo Genético
/
Trombose
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Fator V
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Protrombina
Idioma:
Es
Ano de publicação:
2005
Tipo de documento:
Article