Characterization of ndh gene of isoniazid resistant and susceptible Mycobacterium tuberculosis isolates from Brazil
Mem. Inst. Oswaldo Cruz
; 102(1): 59-61, Feb. 2007. tab
Artigo
em Inglês
| LILACS
| ID: lil-440635
Biblioteca responsável:
BR1.1
ABSTRACT
Resistance in Mycobacterium tuberculosis to isoniazid (INH) is caused by mutations in the catalase-peroxidase gene (katG) , and within the inhA promoter and/or in structural gene. A small percentage (~ 10 percent) of INH-resistant strains do not present mutations in both of these loci. Other genes have been associated with INH resistance including the gene encoding for NADH dehydrogenase (ndh) . Here we report the detection of two ndh locus mutations (CGT to TGT change in codon 13 and GTG to GCG change in codon 18) by analyzing 23 INH-resistant and in none of 13 susceptible isolates from Brazilian tuberculosis patients. We also detected two isolates without a mutation in ndh, or any of the other INH resistance-associated loci examined, suggesting the existence of additional, as yet to be described, INH resistance mechanisms.
Texto completo:
Disponível
Base de dados:
LILACS
Assunto:
Isoniazida
/
Mutação
/
Mycobacterium tuberculosis
/
NADH Desidrogenase
/
Antituberculosos
Limite:
Humanos
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Ano de publicação:
2007
Tipo de documento:
Artigo
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