Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276
Electron. j. biotechnol
; 11(4): 2-3, Oct. 2008. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-531932
Biblioteca responsável:
CL1.1
ABSTRACT
Chiral diarylmethanols are versatile building blocks for the preparation of biologically active substances, but they are difficult to obtain in enantiopure form. We used Nocardia corallina B-276 for the oxidative kinetic resolution of (+/-)-4-(chlorophenyl)phenylmethanol, 1. Two experimental methods were used 1) Suspension of cells in a phosphate buffer solution and 2) Cells in the culture media, in a 3-L bioreactor. After 36 hrs using the first method, the ketone/alcohol ratio was 56/44 and the unoxidized alcohol had an enantiomeric ratio of 93/7, predominating the R-alcohol.
Texto completo:
Disponível
Base de dados:
LILACS
Assunto:
Bactérias Aeróbias
/
Oxidação Biológica
/
Reatores Biológicos
/
Metanol
/
Bactérias Gram-Positivas
Idioma:
Inglês
Revista:
Electron. j. biotechnol
Ano de publicação:
2008
Tipo de documento:
Artigo
/
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