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Tgf-β1 expression as a biomarker of poor prognosis in prostate cancer
Reis, Sabrina Thalita dos; Pontes-Júnior, Jose; Antunes, Alberto Azoubel; Sousa-Canavez, Juliana Moreira de; Abe, Daniel Kanda; Cruz, José Arnaldo Shiomi da; Dall'Oglio, Marcos Francisco; Crippa, Alexandre; Passerotti, Carlo Camargo; Ribeiro-Filho, Leopoldo A; Viana, Nayara Izabel; Srougi, Miguel; Leite, Kátia Ramos Moreira.
Afiliação
  • Reis, Sabrina Thalita dos; Universidade de São Paulo. Faculdade de Medicina. Urology Department. Laboratory of Medical Investigation (LIM55). São Paulo. BR
  • Pontes-Júnior, Jose; Universidade de São Paulo. Faculdade de Medicina. Urology Department. Laboratory of Medical Investigation (LIM55). São Paulo. BR
  • Antunes, Alberto Azoubel; Universidade de São Paulo. Faculdade de Medicina. Urology Department. Laboratory of Medical Investigation (LIM55). São Paulo. BR
  • Sousa-Canavez, Juliana Moreira de; Genoa Biotecnologia SA. São Paulo. BR
  • Abe, Daniel Kanda; Universidade de São Paulo. Faculdade de Medicina. Urology Department. Uro-Oncology Group. São Paulo. BR
  • Cruz, José Arnaldo Shiomi da; Universidade de São Paulo. Faculdade de Medicina. Urology Department. Laboratory of Medical Investigation (LIM55). São Paulo. BR
  • Dall'Oglio, Marcos Francisco; Universidade de São Paulo. Faculdade de Medicina. Urology Department. Uro-Oncology Group. São Paulo. BR
  • Crippa, Alexandre; Universidade de São Paulo. Faculdade de Medicina. Urology Department. Uro-Oncology Group. São Paulo. BR
  • Passerotti, Carlo Camargo; Universidade de São Paulo. Faculdade de Medicina. Urology Department. Laboratory of Medical Investigation (LIM55). São Paulo. BR
  • Ribeiro-Filho, Leopoldo A; Universidade de São Paulo. Faculdade de Medicina. Urology Department. Laboratory of Medical Investigation (LIM55). São Paulo. BR
  • Viana, Nayara Izabel; Universidade de São Paulo. Faculdade de Medicina. Urology Department. Laboratory of Medical Investigation (LIM55). São Paulo. BR
  • Srougi, Miguel; Universidade de São Paulo. Faculdade de Medicina. Urology Department. Laboratory of Medical Investigation (LIM55). São Paulo. BR
  • Leite, Kátia Ramos Moreira; Universidade de São Paulo. Faculdade de Medicina. Urology Department. Laboratory of Medical Investigation (LIM55). São Paulo. BR
Clinics ; 66(7): 1143-1147, 2011. ilus, tab
Artigo em Inglês | LILACS | ID: lil-596899
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVE:

To evaluate the correlation between transforming growth factor beta (TGF-β1) expression and prognosis in prostate cancer. PATIENTS AND

METHODS:

TGF-β1 expression levels were analyzed using the quantitative real-time polymerase chain reaction to amplify RNA that had been isolated from fresh-frozen malignant and benign tissue specimens collected from 89 patients who had clinically localized prostate cancer and had been treated with radical prostatectomy. The control group consisted of li patients with benign prostate hyperplasia. The expression levels of TGF-β1 were compared between the groups in terms of Gleason scores, pathological staging, and prostate-specific antigen serum levels.

RESULTS:

In the majority of the tumor samples, TGF-β1 was underexpressed 67.0 percent of PCa patients. The same expression pattern was identified in benign tissues of patients with prostate cancer. Although most cases exhibited underexpression of TGF-β1, a higher expression level was found in patients with Gleason scores >7 when compared to patients with Gleason scores <7(p = 0.002). Among the 26 cases of TGF-β1 overexpression, 92.3 percent had poor prognostic features.

CONCLUSIONS:

TGF-β1 was underexpressed in prostate cancers; however, higher expression was observed in tumors with higher Gleason scores, which suggests that TGF-β1 expression may be a useful prognostic marker for prostate cancer. Further studies of clinical specimens are needed to clarify the role of TGF-β1 in prostate carcinogenesis.
Assuntos

Texto completo: Disponível Base de dados: LILACS Assunto: Neoplasias da Próstata / Biomarcadores Tumorais / Fator de Crescimento Transformador beta1 Tipo de estudo: Estudo prognóstico Limite: Adulto / Idoso / Humanos / Masculino Idioma: Inglês Revista: Clinics Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: Disponível Base de dados: LILACS Assunto: Neoplasias da Próstata / Biomarcadores Tumorais / Fator de Crescimento Transformador beta1 Tipo de estudo: Estudo prognóstico Limite: Adulto / Idoso / Humanos / Masculino Idioma: Inglês Revista: Clinics Ano de publicação: 2011 Tipo de documento: Artigo