Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni
Mem. Inst. Oswaldo Cruz
; 106(7): 802-807, Nov. 2011.
Artigo
em Inglês
| LILACS
| ID: lil-606642
Biblioteca responsável:
BR1.1
ABSTRACT
In this paper, the authors review the literature and share their experience of the principal biological markers of fibrosis for the evaluation of periportal fibrosis (PPF) caused by mansoni schistosomiasis. These biological markers are compared to diagnostic ultrasound (US) scans as means of grading PPF. We also review procollagen type I and III, collagen type IV, laminin, hyaluronic acid (HA), immunoglobulin G, platelets, aspartate aminotransferase to platelet ratio index (APRI) and gamma-glutamyl transpeptidase as markers of the disease. Although there are several good markers for evaluating PPF and portal hypertension, such as HA, platelets or APRI, none can yet replace US. These markers may, however, be used to identify patients at greater risk of developing advanced disease in endemic areas and determine who will need further care and US studies.
Texto completo:
Disponível
Base de dados:
LILACS
Assunto:
Esquistossomose mansoni
/
Hipertensão Portal
/
Cirrose Hepática
/
Hepatopatias Parasitárias
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Ano de publicação:
2011
Tipo de documento:
Artigo
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