Aumento de interleuquinas proinflamatorias y de cortisol plasmático en bronquiolitis por virus respiratorio sincicial: relación con la gravedad de la infección / Levels of inflammatory cytokines and plasma cortisol in respiratory syncytial virus bronchiolitis
Rev. méd. Chile
; 141(5): 574-581, mayo 2013. graf, tab
Article
em Es
| LILACS
| ID: lil-684364
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
An increased inflammatory innate response may play a role in pathogenesis of respiratory syncytial virus (RSV) infection.Aim:
To quantify pro-inflammatory cytokines (IL-6-IL-8, ÍL-2-P and TNF-a) in nasopharyngeal aspirate (NPA) and plasma, and plasma cortisol in previously healthy infants with RSV bronchiolitis. Patients andMethods:
We studied 49 infants aged less than one year of age with RSV bronchiolitis and 25 healthy controls. Severity was defined using a previously described modified score. We quantified interleukins in NPA and plasma by flow cytometry and plasma cortisol by radioimmunoanalysis.Results:
Among patients with RSV bronchiolitis, 25 were classified as severe and 24 as moderate or mild. Significantly higher levels ofIL-6 and IL-8 in NPA and plasma and IL-lfi in NPA were found in children classified as severe, when compared to those with moderate or mild disease and controls. There was a positive correlation between IL-6 and cortisol in plasma (r = 0,55; p < 0,0001) and both were correlated with the severity of the disease.Conclusions:
RSV bronchiolitis severity was associated with higher levéis of inflammatory interleukins and plasma cortisol.Palavras-chave
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Hidrocortisona
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Bronquiolite
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Interleucinas
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Fator de Necrose Tumoral alfa
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Infecções por Vírus Respiratório Sincicial
Idioma:
Es
Ano de publicação:
2013
Tipo de documento:
Article
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Project document