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Effects of ovariectomy and resistance training on oxidative stress markers in the rat liver
Rodrigues, Maria Fernanda Cury; Stotzer, Uliana Sbeguen; Domingos, Mateus Moraes; Deminice, Rafael; Shiguemoto, Gilberto Eiji; Tomaz, Luciane Magri; Sousa, Nuno Manuel Frade de; Ferreira, Fabiano Candido; Leite, Richard Diego; Selistre-de-Araujo, Heloisa Sobreiro; Jordao-Junior, Alceu Afonso; Baldissera, Vilmar; Perez, Sergio Eduardo de Andrade.
Afiliação
  • Rodrigues, Maria Fernanda Cury; Federal University of Sao Carlos. Department of Physiological Sciences. Laboratory Exercise of Physiology. Sao Carlos. BR
  • Stotzer, Uliana Sbeguen; Federal University of Sao Carlos. Department of Physiological Sciences. Laboratory Exercise of Physiology. Sao Carlos. BR
  • Domingos, Mateus Moraes; Federal University of Sao Carlos. Department of Physiological Sciences. Laboratory Exercise of Physiology. Sao Carlos. BR
  • Deminice, Rafael; Federal University of Sao Carlos. Department of Physiological Sciences. Laboratory Exercise of Physiology. Sao Carlos. BR
  • Shiguemoto, Gilberto Eiji; Federal University of Sao Carlos. Department of Physiological Sciences. Laboratory Exercise of Physiology. Sao Carlos. BR
  • Tomaz, Luciane Magri; Federal University of Sao Carlos. Department of Physiological Sciences. Laboratory Exercise of Physiology. Sao Carlos. BR
  • Sousa, Nuno Manuel Frade de; Federal University of Sao Carlos. Department of Physiological Sciences. Laboratory Exercise of Physiology. Sao Carlos. BR
  • Ferreira, Fabiano Candido; Federal University of Sao Carlos. Department of Physiological Sciences. Laboratory Exercise of Physiology. Sao Carlos. BR
  • Leite, Richard Diego; Federal University of Sao Carlos. Department of Physiological Sciences. Laboratory Exercise of Physiology. Sao Carlos. BR
  • Selistre-de-Araujo, Heloisa Sobreiro; Federal University of Sao Carlos. Department of Physiological Sciences. Laboratory Exercise of Physiology. Sao Carlos. BR
  • Jordao-Junior, Alceu Afonso; Federal University of Sao Carlos. Department of Physiological Sciences. Laboratory Exercise of Physiology. Sao Carlos. BR
  • Baldissera, Vilmar; Federal University of Sao Carlos. Department of Physiological Sciences. Laboratory Exercise of Physiology. Sao Carlos. BR
  • Perez, Sergio Eduardo de Andrade; Federal University of Sao Carlos. Department of Physiological Sciences. Laboratory Exercise of Physiology. Sao Carlos. BR
Clinics ; 68(9): 1247-1254, set. 2013. tab, graf
Artigo em Inglês | LILACS | ID: lil-687758
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVE:

The objective of this study was to assess the effects of resistance training on oxidative stress markers in the livers of ovariectomized rats.

METHOD:

Adult Sprague-Dawley rats were divided into the following four groups (n = 8 per group) sham-operated sedentary, ovariectomized sedentary, sham-operated resistance training, and ovariectomized resistance training. During the resistance training period, the animals climbed a 1.1-m vertical ladder with weights attached to their tails; the sessions were conducted 3 times per week, with 4-9 climbs and 8-12 dynamic movements per climb. The oxidative stress was assessed by measuring the levels of reduced glutathione and oxidized glutathione, the enzymatic activity of catalase and superoxide dismutase, lipid peroxidation, vitamin E concentrations, and the gene expression of glutathione peroxidase.

RESULTS:

The results showed significant reductions in the reduced glutathione/oxidized glutathione ratio (4.11±0.65 nmol/g tec), vitamin E concentration (55.36±11.11 nmol/g), and gene expression of glutathione peroxidase (0.49±0.16 arbitrary units) in the livers of ovariectomized rats compared with the livers of unovariectomized animals (5.71±0.71 nmol/g tec, 100.14±10.99 nmol/g, and 1.09±0.54 arbitrary units, respectively). Moreover, resistance training for 10 weeks was not able to reduce the oxidative stress in the livers of ovariectomized rats and induced negative changes in the hepatic anti-oxidative/oxidative balance.

CONCLUSION:

Our findings indicate that the resistance training program used in this study was not able to attenuate the hepatic oxidative damage caused by ovariectomy and increased the hepatic oxidative stress. .
Assuntos

Texto completo: Disponível Base de dados: LILACS Assunto: Ovariectomia / Estresse Oxidativo / Treinamento de Força / Fígado Limite: Animais Idioma: Inglês Revista: Clinics Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: Disponível Base de dados: LILACS Assunto: Ovariectomia / Estresse Oxidativo / Treinamento de Força / Fígado Limite: Animais Idioma: Inglês Revista: Clinics Ano de publicação: 2013 Tipo de documento: Artigo