Antitumor effects of Rhodium (II) citrate in mice bearing Chrlich tumors
Braz. j. med. biol. res
; 22(3): 397-401, 1989. ilus, tab
Article
em En
| LILACS
| ID: lil-70701
Biblioteca responsável:
BR26.1
ABSTRACT
Rhodium II citrate was tested in mice for acute toxicity, antitumoral activity against Ehrlich ascites carcinoma and inhibition of DNA synthesis by Ehrlich tumor, malignant adrenocortical cells (Y-1) and normal adrenocortical cells (AR-1)_. At ip doses up to 260 mg/Kg, the compound had no toxic effects for up to 14 days. The same total dose given over 4 days significantly increased the survial rat of mice bearing Ehrlich ascites cells. Thymidine incorporation by Ehrlkich tumor, Y-1 cells in vitro was inhibited 50% by a.1 to 0.2 mM concentrations of the compound. We conclude that the increase survival of the tumor-bearing mice was due at least in part to the inhibition of DNA synthesis with a consequet reduction of cell division and tumor growth
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Base de dados:
LILACS
Assunto principal:
Ródio
/
Carcinoma de Ehrlich
/
Citratos
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article