Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
Acta cir. bras
; 30(4): 270-276, 04/2015. tab, graf
Article
em En
| LILACS
| ID: lil-744283
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS:
Forty male Wistar rats were randomly assigned to one of four groups Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.RESULTS:
The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.CONCLUSION:
Parecoxib resulted in renal protection in this experimental model. .Palavras-chave
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Traumatismo por Reperfusão
/
Modelos Animais de Doenças
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Injúria Renal Aguda
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Isoxazóis
/
Rim
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article