Does dexamethasone act in neuropeptides SP and CGRP in neurogenic inflammation of the skin? An experimental study
Acta cir. bras
; 30(8): 523-528, Aug. 2015. ilus
Article
em En
| LILACS
| ID: lil-757990
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To investigate the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) after subcutaneous injection of dexamethasone prior to skin incision in rats.METHODS:
Twenty seven Wistar-EPM-1 rats were randomly divided into three groups. The sham group (SG) of rats was injected with 0.9 % saline. The second group (Dexa) was injected with 1.0 mg/kg dexamethasone, and the third group (Dexa+) was injected with 10.0 mg/kg dexamethasone. In all groups, the three subcutaneous injections were performed 30 minutes prior to the surgical skin incision and tissue collection. SP and CGRP (15 kDa pro-CGRP and 5 kDa CGRP) were quantified by Western Blotting.RESULTS:
No statistically significant differences (p>0.05) were found in pro-CGRP, CGRP and SP values in all three groups.CONCLUSION:
The anti-inflammatory effect of dexamethasone did not occur when the substance P and calcitonin gene-related peptide levels were altered during the neurogenic inflammation process of skin wound healing in rats.Palavras-chave
Texto completo:
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Base de dados:
LILACS
Assunto principal:
Dexametasona
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Substância P
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Peptídeo Relacionado com Gene de Calcitonina
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Inflamação Neurogênica
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Dermatite
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Anti-Inflamatórios
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article
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Project document